Kinnosuke Yahiro

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Infect Immun 80:1803-14. 2012
  2. pmc Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Infect Immun 79:617-27. 2011
  3. pmc Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Microb Pathog 49:153-63. 2010
  4. ncbi request reprint Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin
    Kinnosuke Yahiro
    Departments of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Microbiol 62:480-90. 2006
  5. pmc Two distinct cytotoxic activities of subtilase cytotoxin produced by shiga-toxigenic Escherichia coli
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Infect Immun 75:488-96. 2007
  6. pmc Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation
    Hiroyasu Tsutsuki
    Departments of Molecular Infectiology, Chiba University, Chiba, Japan
    Infect Immun 80:3939-51. 2012
  7. pmc Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in vero cells via mitochondrial membrane damage
    Gen Matsuura
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Infect Immun 77:2919-24. 2009
  8. pmc Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 Inohana, Chiba 260 8670, Japan
    Cell Microbiol 10:921-9. 2008
  9. ncbi request reprint Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal alpha-toxin
    Oksun Choi
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ward, Chiba 260 8670, Japan
    Microb Pathog 42:215-24. 2007
  10. pmc Characterization of Cholix toxin-induced apoptosis in HeLa cells
    Kohei Ogura
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    J Biol Chem 286:37207-15. 2011

Collaborators

Detail Information

Publications18

  1. pmc Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Infect Immun 80:1803-14. 2012
    ..Thus, SubAB-induced ER stress is caused by BiP cleavage, leading to PERK activation, not by accumulation of ubiquitinated proteins, which undergo PERK-dependent degradation via the ubiquitin-proteasome system...
  2. pmc Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Infect Immun 79:617-27. 2011
    ....
  3. pmc Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Microb Pathog 49:153-63. 2010
    ....
  4. ncbi request reprint Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin
    Kinnosuke Yahiro
    Departments of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Microbiol 62:480-90. 2006
    ..These results suggested that SubAB recognizes alpha2beta1 integrin as a functional receptor; this first interaction may be an important key step leading to the SubAB-induced morphological changes in Vero cells...
  5. pmc Two distinct cytotoxic activities of subtilase cytotoxin produced by shiga-toxigenic Escherichia coli
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Infect Immun 75:488-96. 2007
    ....
  6. pmc Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation
    Hiroyasu Tsutsuki
    Departments of Molecular Infectiology, Chiba University, Chiba, Japan
    Infect Immun 80:3939-51. 2012
    ..coli survival in macrophages. Thus, we hypothesize that SubAB might represent a novel bacterial strategy to circumvent host defense during STEC infection...
  7. pmc Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in vero cells via mitochondrial membrane damage
    Gen Matsuura
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Infect Immun 77:2919-24. 2009
    ..These data suggested that SubAB induced caspase-dependent apoptosis in Vero cells through mitochondrial membrane damage...
  8. pmc Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 Inohana, Chiba 260 8670, Japan
    Cell Microbiol 10:921-9. 2008
    ..SubAB-treated cells showed cell cycle arrest in G1 phase, which may result from cyclin D1 downregulation caused by both SubAB-induced translational inhibition and continuous prolonged proteasomal degradation...
  9. ncbi request reprint Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal alpha-toxin
    Oksun Choi
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ward, Chiba 260 8670, Japan
    Microb Pathog 42:215-24. 2007
    ..Inhibition of alpha-toxin by HBT and ACT was dose dependent, suggesting that these polyphenols may be a useful adjunct to current treatments for alpha-toxin catalyzed Staphylococcal infectious diseases...
  10. pmc Characterization of Cholix toxin-induced apoptosis in HeLa cells
    Kohei Ogura
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    J Biol Chem 286:37207-15. 2011
    ..In conclusion, we showed that Cholix-induced caspase activation plays an essential role in generation of apoptotic signals, which are mediated by both mitochondria-dependent and -independent pathways...
  11. doi request reprint Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cells
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Toxicon 56:29-35. 2010
    ..These data suggest that resveratrol may inhibit CT-induced activity directly by associating with CT and suppressing its enzymatic activity, and indirectly by inhibiting CT endocytosis into cells...
  12. pmc Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Biol Chem 287:31104-15. 2012
    ..Other VacA receptors such as RPTPα, RPTPβ, and fibronectin did not affect VacA-induced autophagy or apoptosis. Therefore, we propose that the cell surface receptor, LRP1, mediates VacA-induced autophagy and apoptosis...
  13. doi request reprint Effect of Gb3 in lipid rafts in resistance to Shiga-like toxin of mutant Vero cells
    Tatsuo Hanashima
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Microb Pathog 45:124-33. 2008
    ..However, Stx1 bound to Gb3 separated by thin-layer chromatograms from the DRMs of mutant cells. The results indicate that not only presence of Gb3 but also Gb3 density on lipid rafts were important for Stx binding...
  14. ncbi request reprint Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin
    Kinnosuke Yahiro
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Helicobacter 10:231-9. 2005
    ..pylori-induced gastritis and ulceration. The aim of this study is to assess whether several naturally occurring polyphenols inhibit VacA activities in vitro and in vivo...
  15. ncbi request reprint Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Japan
    J Biol Chem 280:23303-9. 2005
    ..In contrast, RG-tannin binding to CT did not interfere with its binding to Vero cells or GM1, but it did inhibit internalization...
  16. pmc Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli
    Takeshi Furukawa
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Microb Pathog 50:159-67. 2011
    ..Thus, our results indicate that death in SubAB-treated mice may be associated with severe inflammatory response and hemorrhage of the small intestine, accompanied by coagulopathy and IL6 production...
  17. ncbi request reprint Helicobacter pylori induces mono-(adenosine 5'-diphosphate)-ribosylation in human gastric adenocarcinoma
    Takashi Akai
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 29:965-72. 2006
    ..pylori itself. The possible roles underlying our observations on carcinogenesis or development of human gastric carcinoma are yet to be elucidated...
  18. ncbi request reprint Acidic conditions enhance bactericidal effects of sodium bisulfite on Helicobacter pylori
    Akiyuki Murano
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo ku Chiba, 260 8670, Japan
    Helicobacter 10:132-5. 2005
    ..The growth of H. pylori, however, is inhibited by sodium bisulfite. In this study, the effect of sodium bisulfite was compared with several antioxidants and quantified under acidic conditions, mimicking the gastric environment...