Research Topics
| Kinnosuke YahiroSummaryAffiliation: Chiba University Country: Japan Publications
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Detail Information
Publications
Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cellsKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Infect Immun 80:1803-14. 2012..Thus, SubAB-induced ER stress is caused by BiP cleavage, leading to PERK activation, not by accumulation of ubiquitinated proteins, which undergo PERK-dependent degradation via the ubiquitin-proteasome system...- Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cellsKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Infect Immun 79:617-27. 2011.... - Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signalingKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
Microb Pathog 49:153-63. 2010.... 
Identification and characterization of receptors for vacuolating activity of subtilase cytotoxinKinnosuke Yahiro
Departments of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Mol Microbiol 62:480-90. 2006..These results suggested that SubAB recognizes alpha2beta1 integrin as a functional receptor; this first interaction may be an important key step leading to the SubAB-induced morphological changes in Vero cells...- Two distinct cytotoxic activities of subtilase cytotoxin produced by shiga-toxigenic Escherichia coliNaoko Morinaga
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
Infect Immun 75:488-96. 2007.... - Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activationHiroyasu Tsutsuki
Departments of Molecular Infectiology, Chiba University, Chiba, Japan
Infect Immun 80:3939-51. 2012..coli survival in macrophages. Thus, we hypothesize that SubAB might represent a novel bacterial strategy to circumvent host defense during STEC infection... - Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in vero cells via mitochondrial membrane damageGen Matsuura
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Infect Immun 77:2919-24. 2009..These data suggested that SubAB induced caspase-dependent apoptosis in Vero cells through mitochondrial membrane damage... - Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1Naoko Morinaga
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 Inohana, Chiba 260 8670, Japan
Cell Microbiol 10:921-9. 2008..SubAB-treated cells showed cell cycle arrest in G1 phase, which may result from cyclin D1 downregulation caused by both SubAB-induced translational inhibition and continuous prolonged proteasomal degradation... - Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal alpha-toxinOksun Choi
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ward, Chiba 260 8670, Japan
Microb Pathog 42:215-24. 2007..Inhibition of alpha-toxin by HBT and ACT was dose dependent, suggesting that these polyphenols may be a useful adjunct to current treatments for alpha-toxin catalyzed Staphylococcal infectious diseases... - Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxinKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Helicobacter 10:231-9. 2005..pylori VacA, suggesting that HBT may be useful as a new type of therapeutic agent for the prevention of gastric ulcer and inflammation caused by VacA... - Characterization of Cholix toxin-induced apoptosis in HeLa cellsKohei Ogura
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
J Biol Chem 286:37207-15. 2011..In conclusion, we showed that Cholix-induced caspase activation plays an essential role in generation of apoptotic signals, which are mediated by both mitochondria-dependent and -independent pathways... - Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacAKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
J Biol Chem 287:31104-15. 2012..Other VacA receptors such as RPTPα, RPTPβ, and fibronectin did not affect VacA-induced autophagy or apoptosis. Therefore, we propose that the cell surface receptor, LRP1, mediates VacA-induced autophagy and apoptosis... 
Effect of Gb3 in lipid rafts in resistance to Shiga-like toxin of mutant Vero cellsTatsuo Hanashima
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
Microb Pathog 45:124-33. 2008..However, Stx1 bound to Gb3 separated by thin-layer chromatograms from the DRMs of mutant cells. The results indicate that not only presence of Gb3 but also Gb3 density on lipid rafts were important for Stx binding...- Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cellsNaoko Morinaga
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Toxicon 56:29-35. 2010..These data suggest that resveratrol may inhibit CT-induced activity directly by associating with CT and suppressing its enzymatic activity, and indirectly by inhibiting CT endocytosis into cells... - Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cellsNaoko Morinaga
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Japan
J Biol Chem 280:23303-9. 2005..In contrast, RG-tannin binding to CT did not interfere with its binding to Vero cells or GM1, but it did inhibit internalization... - Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coliTakeshi Furukawa
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Microb Pathog 50:159-67. 2011..Thus, our results indicate that death in SubAB-treated mice may be associated with severe inflammatory response and hemorrhage of the small intestine, accompanied by coagulopathy and IL6 production... - Acidic conditions enhance bactericidal effects of sodium bisulfite on Helicobacter pyloriAkiyuki Murano
Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku Chiba, 260-8670, Japan
Helicobacter 10:132-5. 2005..CONCLUSIONS: The bactericidal effect of sodium bisulfite on H. pylori was greater under acidic conditions and independent of urease activity...