Eizo Watanabe

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis
    Tomonori Kimura
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chu ku, Chiba City, Chiba, Japan
    PLoS ONE 9:e91522. 2014
  2. pmc Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients
    Eizo Watanabe
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Cytokine 60:249-56. 2012
  3. doi request reprint Clinical application of cytokine-related gene polymorphism analysis using a newly developed DNA chip in critically ill patients
    Shunsuke Otani
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba, 260 8677, Japan
    Clin Biochem 42:1387-93. 2009
  4. doi request reprint Treatment of septic shock with continuous HDF using 2 PMMA hemofilters for enhanced intensity
    Yosuke Matsumura
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Int J Artif Organs 35:3-14. 2012
  5. doi request reprint Treatment of severe sepsis and septic shock by CHDF using a PMMA membrane hemofilter as a cytokine modulator
    Masataka Nakamura
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Contrib Nephrol 166:73-82. 2010
  6. ncbi request reprint Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients
    Taka aki Nakada
    Department of Emergency and Critical Care Medicine, Chiba University, 1 8 1 Inohana, Chuo, Chiba, Japan
    J Surg Res 129:322-8. 2005
  7. doi request reprint Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis
    Daisuke Setoguchi
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba City, Chiba, Japan
    Cytokine 57:238-44. 2012
  8. ncbi request reprint Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications
    Eizo Watanabe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba UniversityChiba City, Japan
    J Trauma 59:1181-9; discussion 1189-90. 2005
  9. doi request reprint Outcome prediction in sepsis combined use of genetic polymorphisms - A study in Japanese population
    Tadanaga Shimada
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    Cytokine 54:79-84. 2011
  10. ncbi request reprint Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients
    Ryuzo Abe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Res 147:1-8. 2008

Collaborators

Detail Information

Publications31

  1. pmc Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis
    Tomonori Kimura
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chu ku, Chiba City, Chiba, Japan
    PLoS ONE 9:e91522. 2014
    ..We examined the association between genetic polymorphism and clinical course/outcome in severely septic patients...
  2. pmc Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients
    Eizo Watanabe
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Cytokine 60:249-56. 2012
    ..Therefore, we wished to determine the influence of heredity on predisposition to poor outcome and on duration of ventilator support of intensive care unit (ICU) patients...
  3. doi request reprint Clinical application of cytokine-related gene polymorphism analysis using a newly developed DNA chip in critically ill patients
    Shunsuke Otani
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba, 260 8677, Japan
    Clin Biochem 42:1387-93. 2009
    ..To investigate the usefulness of analysis of single nucleotide polymorphism (SNP) using a newly developed DNA chip assay involving single base extension(SBE) and subsequent hybridization in cytokine-related genes in critical care patients...
  4. doi request reprint Treatment of septic shock with continuous HDF using 2 PMMA hemofilters for enhanced intensity
    Yosuke Matsumura
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Int J Artif Organs 35:3-14. 2012
    ..The aim of this study was to investigate the clinical efficacy of enhanced intensity PMMA-CHDF in treating refractory septic shock...
  5. doi request reprint Treatment of severe sepsis and septic shock by CHDF using a PMMA membrane hemofilter as a cytokine modulator
    Masataka Nakamura
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Contrib Nephrol 166:73-82. 2010
    ..These findings suggest that PMMA-CHDF is useful for the treatment of patients with severe sepsis/septic shock as a cytokine modulator...
  6. ncbi request reprint Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients
    Taka aki Nakada
    Department of Emergency and Critical Care Medicine, Chiba University, 1 8 1 Inohana, Chuo, Chiba, Japan
    J Surg Res 129:322-8. 2005
    ....
  7. doi request reprint Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis
    Daisuke Setoguchi
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba City, Chiba, Japan
    Cytokine 57:238-44. 2012
    ....
  8. ncbi request reprint Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications
    Eizo Watanabe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba UniversityChiba City, Japan
    J Trauma 59:1181-9; discussion 1189-90. 2005
    ....
  9. doi request reprint Outcome prediction in sepsis combined use of genetic polymorphisms - A study in Japanese population
    Tadanaga Shimada
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    Cytokine 54:79-84. 2011
    ..In addition, combined use of these genetic parameters with APACHE II score may enable more accurate prediction of outcome in septic patients...
  10. ncbi request reprint Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients
    Ryuzo Abe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Res 147:1-8. 2008
    ..None of the parameters can predict the deterioration of sepsis early enough. A new predictor allowing earlier detection of changes in septic patients' condition is indispensable...
  11. doi request reprint Continuous hemodiafiltration with a cytokine-adsorbing hemofilter for sepsis
    Hiroyuki Hirasawa
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Blood Purif 34:164-70. 2012
    ..Based on the understanding of the recent pathophysiology, we suggest that CAH-CHDF is an alternate therapy to direct hemoperfusion with endotoxin-adsorbing column in the treatment of sepsis...
  12. doi request reprint Blood ammonia and lactate levels on hospital arrival as a predictive biomarker in patients with out-of-hospital cardiac arrest
    Koichiro Shinozaki
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8677, Japan
    Resuscitation 82:404-9. 2011
    ..No reliable predictor for the prognosis of out-of-hospital cardiac arrest (OHCA) on arrival at hospital has been identified so far. We speculate that ammonia and lactate may predict patient outcome...
  13. doi request reprint Non-renal indications for continuous renal replacement therapy: current status in Japan
    Shigeto Oda
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Contrib Nephrol 166:47-53. 2010
    ..g. cytokines). IL-6 blood level appears to be useful as a variable for this evaluation. It is expected that evidence endorsing the validity of these methods now being attempted in Japan will be reported near future...
  14. doi request reprint Association between lymphotoxin-alpha (tumor necrosis factor-beta) intron polymorphism and predisposition to severe sepsis is modified by gender and age
    Eizo Watanabe
    Department of Surgery, Section of Acute Critical Care Surgery, Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 38:181-93. 2010
    ....
  15. ncbi request reprint Management of intra-abdominal hypertension in patients with severe acute pancreatitis with continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter
    Shigeto Oda
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ther Apher Dial 9:355-61. 2005
    ..Continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter appears to be effective for prevention and treatment of IAH in patients with SAP through the removal of causative cytokines of hyperpermeability...
  16. ncbi request reprint Intracranial pressure monitoring in patients with fulminant hepatic failure treated with plasma exchange and continuous hemodiafiltration
    Kazuya Nakanishi
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chuo, Japan
    Blood Purif 23:113-8. 2005
    ..To study the influence of our artificial liver support (ALS) on intracranial pressure (ICP) and to evaluate the significance of ICP monitoring in fulminant hepatic failure (FHF) patients treated with ALS...
  17. ncbi request reprint The change in renal replacement therapy on acute renal failure in a general intensive care unit in a university hospital and its clinical efficacy: a Japanese experience
    Yoh Hirayama
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chuou, Chiba, Japan
    Ther Apher Dial 7:475-82. 2003
    ..These results suggest that CHDF should be the first-line therapy for patients with ARF and that we are moving in the right direction regarding the application of RRT to treat ARF in ICU patients...
  18. doi request reprint Duration of well-controlled core temperature correlates with neurological outcome in patients with post-cardiac arrest syndrome
    Koichiro Shinozaki
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8677, Japan
    Am J Emerg Med 30:1838-44. 2012
    ..We examined how duration of well-controlled core temperature within the first 24 hours after cardiac arrests (CA) correlated with neurological outcomes of successfully resuscitated out-of-hospital CA (OHCA) patients...
  19. pmc IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
    Jacqueline Unsinger
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:3768-79. 2010
    ..If additional animal studies support its efficacy in sepsis and if current clinical trials continue to confirm its safety in diverse settings, rhIL-7 should be strongly considered for clinical trials in sepsis...
  20. ncbi request reprint Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms
    Eizo Watanabe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    Crit Care Med 33:89-97; discussion 242-3. 2005
    ....
  21. doi request reprint Comparison of interleukin-6 removal properties among hemofilters consisting of varying membrane materials and surface areas: an in vitro study
    Yo Hirayama
    Departments of Emergency and Critical Care Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Blood Purif 31:18-25. 2011
    ..We sought to identify the most relevant hemofilter for cytokine removal based on the mechanisms of filtration and adsorption...
  22. doi request reprint Auditory evoked potential P50 as a predictor of neurologic outcome in resuscitated cardiac arrest patients
    Nobuyuki Takai
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    J Clin Neurophysiol 28:302-7. 2011
    ..As a consequence, the evaluation of the P50 in resuscitated cardiac arrest patients would have a possibility to predict neurologically good outcome...
  23. pmc Correlation between high blood IL-6 level, hyperglycemia, and glucose control in septic patients
    Masataka Nakamura
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo, Chiba city 2608677, Japan
    Crit Care 16:R58. 2012
    ..The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients...
  24. doi request reprint Trends in and perspectives on extracorporeal membrane oxygenation for severe adult respiratory failure
    Tomohito Sadahiro
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuoku, Chiba, 260 8677, Japan
    Gen Thorac Cardiovasc Surg 60:192-201. 2012
    ..This, in combination with a new technique, interventional lung assist, will further extend the indications for ECMO. ECMO can be expected to gain importance as a respiratory support technique...
  25. doi request reprint Experimental examination of anti-inflammatory effects of a 5-HT3 receptor antagonist, tropisetron, and concomitant effects on autonomic nervous function in a rat sepsis model
    Daisuke Setoguchi
    Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Japan
    Int Immunopharmacol 11:2073-8. 2011
    ..We investigated whether overproduction of cytokines could be controlled by intervention with tropisetron in an animal model of sepsis and also examined the effects of tropisetron on autonomic nervous activity...
  26. ncbi request reprint [Basic concept and definition of SIRS and sepsis--present consideration and future perspectives]
    Hiroyuki Hirasawa
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University
    Nihon Rinsho 62:2177-83. 2004
    ..Therefore, we must also consider genetic aspect of cytokine biology in future study...
  27. ncbi request reprint [New anti-cytokine strategy against patients with hypercytokinemia stratified by cytokine-related genetic polymorphisms]
    Eizo Watanabe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University
    Nihon Rinsho 62:2317-22. 2004
    ..Therefore, we should apply new stronger anti-cytokine strategies toward those high-risk genotype patients...
  28. pmc Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study
    Eizo Watanabe
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Lab Invest 89:549-61. 2009
    ..However, it is not possible to determine whether the increase in autophagic vacuolization is an adaptive response or a harbinger of cell death...
  29. pmc Mechanisms of cardiac and renal dysfunction in patients dying of sepsis
    Osamu Takasu
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 187:509-17. 2013
    ..The mechanistic basis for cardiac and renal dysfunction in sepsis is unknown. In particular, the degree and type of cell death is undefined...
  30. pmc Targeted delivery of siRNA to cell death proteins in sepsis
    Pavan Brahmamdam
    Department of Surgery, Washington University in St Louis, School of Medicine, St Louis, Missouri 63110, USA
    Shock 32:131-9. 2009
    ....
  31. ncbi request reprint A patient with severe acute pancreatitis successfully treated with a new critical care procedure
    Takeshi Moriguchi
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ther Apher 6:221-4. 2002
    ..Thus, this case report suggests that CHDF aimed at removing causative humoral mediators and SDD for the prevention of BT are useful new tools for the management of SAP...