Koichi Ueno

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi request reprint The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
    J Nat Med 63:15-20. 2009
  2. doi request reprint Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
    J Nat Med 63:21-7. 2009
  3. ncbi request reprint A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells
    Eriko Fujimoto
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Life Sci 76:2711-20. 2005
  4. ncbi request reprint New 2-aryl-1,4-naphthoquinone-1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosis
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Sci 118:467-78. 2012
  5. ncbi request reprint Cyclolepis genistoides D. Don (palo azul) promotes differentiation of adipocytes and regulates adipokine expression
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan Electronic address
    Nutr Res 33:922-31. 2013
  6. doi request reprint Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells
    Guligena Tuerdi
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8675, Japan
    Cancer Lett 339:116-27. 2013
  7. ncbi request reprint Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba, Japan
    J Pharmacol Sci 110:466-75. 2009
  8. ncbi request reprint Expression of histamine H4 receptor in synovial cells from rheumatoid arthritic patients
    Emi Ohki
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Biol Pharm Bull 30:2217-20. 2007
  9. ncbi request reprint Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene
    Eriko Fujimoto
    Department of Geriatric Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Sci 97:294-8. 2005
  10. ncbi request reprint Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Toxicol Sci 37:1127-34. 2012

Collaborators

Detail Information

Publications52

  1. doi request reprint The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
    J Nat Med 63:15-20. 2009
    ..It is expected that these compounds will show anti-inflammatory activities via inhibition of the expressions of iNOS and COX-2...
  2. doi request reprint Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
    J Nat Med 63:21-7. 2009
    ..It was expected that these compounds show anti-inflammatory activities...
  3. ncbi request reprint A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells
    Eriko Fujimoto
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Life Sci 76:2711-20. 2005
    ..These results suggest that PP1 potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells through the reduction of anti-apoptotic molecules...
  4. ncbi request reprint New 2-aryl-1,4-naphthoquinone-1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosis
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Sci 118:467-78. 2012
    ..Consistent with these results, cells with DNA fragmentation and multinucleated cells were increased time-dependently after QO-1 exposure. In conclusion, QO-1 has promising antitumor effects via microtubule depolymerization...
  5. ncbi request reprint Cyclolepis genistoides D. Don (palo azul) promotes differentiation of adipocytes and regulates adipokine expression
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan Electronic address
    Nutr Res 33:922-31. 2013
    ..Results suggest an increase in adiponectin secretion and a decrease in insulin-resistant factors such as leptin and resistin. ..
  6. doi request reprint Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells
    Guligena Tuerdi
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8675, Japan
    Cancer Lett 339:116-27. 2013
    ..Overall, the combination of γ-T3 and statins could be useful for MM therapy and functions in a complementary style...
  7. ncbi request reprint Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba, Japan
    J Pharmacol Sci 110:466-75. 2009
    ..Moreover, Src inhibition reinforced CDDP cytotoxicity in parental H28 cells. These data suggest that Cx43 could improve the resistance to CDDP in a GJIC-independent manner, which may be partly mediated by the suppression of Src activity...
  8. ncbi request reprint Expression of histamine H4 receptor in synovial cells from rheumatoid arthritic patients
    Emi Ohki
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Biol Pharm Bull 30:2217-20. 2007
    ..Furthermore, the culture system used here will be useful for future studies concerning basic molecular mechanisms underlying the pharmacology of H4R...
  9. ncbi request reprint Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene
    Eriko Fujimoto
    Department of Geriatric Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Sci 97:294-8. 2005
    ..These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis...
  10. ncbi request reprint Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Toxicol Sci 37:1127-34. 2012
    ..Topical glucocorticoids may exacerbate pruritus in a mouse model of allergic contact dermatitis via inhibition of PGD(2) production in antigen-mediated activated mast cells in the skin...
  11. doi request reprint Association of Rsa polymorphism of the estrogen receptor-β gene with rheumatoid arthritis
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Rheumatol Int 32:2143-8. 2012
    ..Above all, the presence of the GG genotype could be a risk factor for RA and such trend might be different in gender, although additional larger scale study is needed...
  12. doi request reprint Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice
    Hiroki Iwata
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan
    Eur J Pharmacol 600:130-2. 2008
    ..Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice...
  13. ncbi request reprint Association of isoniazid-metabolizing enzyme genotypes and isoniazid-induced hepatotoxicity in tuberculosis patients
    Takayo Sotsuka
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
    In Vivo 25:803-12. 2011
    ..We studied the possible influence of genetic polymorphisms of INH-metabolizing enzymes on serum concentrations of INH and its metabolites, as well as on the incidence of hepatotoxicity...
  14. ncbi request reprint Sex-related differences in SLIGRL-induced pruritus in mice
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan Electronic address
    Life Sci 94:54-7. 2014
    ..Thus, the present work investigated sex-related differences in animal pruritus using pruritogens, which are often used to create experimental animal models of itching...
  15. doi request reprint Degradation Index for quality evaluation of commercial dietary supplements of bilberry extract
    Masao Yamamoto
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    J Food Sci 78:S477-83. 2013
    ..7-fold. These results suggest that DI could be a useful quality control index for detecting deteriorated supplements...
  16. ncbi request reprint The effect of sex hormones on peroxisome proliferator-activated receptor gamma expression and activity in mature adipocytes
    Hiromi Sato
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chiba 260 8675, Japan
    Biol Pharm Bull 36:564-73. 2013
    ..Taken together, our results suggest that sex hormones may influence PPARγ expression and function, which may explain the observed sex-specific different effect of pioglitazone...
  17. doi request reprint A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma
    Hiroki Iwata
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Int J Oncol 38:1653-61. 2011
    ..More-over, the cytotoxicity of VBL was enhanced in vitro in three RCC cell lines by Aza treatment. These findings suggest that the combination treatment with Aza and VBL is effective against RCC...
  18. ncbi request reprint Lower expression of histamine H₄ receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritis
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Rheumatol Int 32:3309-13. 2012
    ..52) or H(2)R (r = 0.23). This study supports the supposition that H(4)R in synovial tissue may play a role in cartilage and bone destruction by influencing the secretion of MMP-3 in patients with RA...
  19. doi request reprint Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation
    Katsunori Yamaura
    Dept of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba Univ, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    J Food Sci 77:H262-7. 2012
    ....
  20. doi request reprint Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model
    Eriko Suwa
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Eur J Pharmacol 667:383-8. 2011
    ..These results indicate that treatment with a H(4) receptor antagonist may be effective for amelioration of both skin inflammation and pruritus in patients with allergic dermatitis such as atopic dermatitis...
  21. doi request reprint Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress
    Katsunori Yamaura
    1 Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Zoolog Sci 30:1019-24. 2013
    ..Moreover, our findings suggest a link between the sex differences in this behavioral response to stress and differential stress reactivity in the production of BDNF in the hippocampus. ..
  22. ncbi request reprint 2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity
    Tsutomu Ishikawa
    Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi, Inage, Chiba, Japan
    Chem Pharm Bull (Tokyo) 59:472-5. 2011
    ....
  23. ncbi request reprint Sex differences in PPARgamma expressions in rat adipose tissues
    Kyoko Kadowaki
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Biol Pharm Bull 30:818-20. 2007
    ..Expressions of PPARgamma2 in perigonadal adipose tissues in females significantly decreased during diestrus. It can be suggested that the sex hormones might affect the expressions of PPARgamma2 in adipose tissues...
  24. ncbi request reprint The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Sci 92:43-9. 2003
    ..These observations may provide critical insights into the pathogenesis of the bone pathology seen in patients with RA...
  25. doi request reprint Expression of the histamine H4 receptor in dermal and articular tissues
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Life Sci 92:108-13. 2013
    ..Further understanding of the functions of H(4) receptors in non-hematopoietic cells might lead to novel treatments for diseases with unmet needs...
  26. pmc Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Pharmacognosy Res 4:234-6. 2012
    ..In this study, we examined whether an extract from immature natsumikan peel prevents lethal hepatotoxicity induced by a lethal dose of APAP in mice...
  27. doi request reprint Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cells
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    J Cell Biochem 113:1054-60. 2012
    ....
  28. pmc Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Pharmacognosy Res 3:250-5. 2011
    ..The aim of this study was to investigate the hepatoprotective effects of orally administrated goldenseal against APAP-induced acute liver failure (ALF) via inhibition of CYP2E1...
  29. pmc Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Pharmacognosy Res 4:22-6. 2012
    ..In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice...
  30. ncbi request reprint Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    J Toxicol Sci 36:669-74. 2011
    ..This animal model will be useful for investigating the mechanism underlying the increased risk of development of eczema caused by regular APAP use and for examining safer and more effective therapy with APAP...
  31. ncbi request reprint Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
    Katsumi Fukino
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Toxicol Sci 33:187-95. 2008
    ..In these cases, we think it's necessary to pay attention to the development of hepatic disorder caused by Hz...
  32. ncbi request reprint Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis
    Katsumi Fukino
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Toxicol Sci 32:449-52. 2007
    ..No correlations were found between these genotypes and serum MTX levels...
  33. ncbi request reprint Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1
    Tomohiko Yoshida
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    FEBS Lett 580:5203-7. 2006
    ..These results suggest that the decrement of GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved...
  34. ncbi request reprint Activation of diacylglycerol O-acyltransferase 1 gene results in increased tumor necrosis factor-alpha gene expression in 3T3-L1 adipocytes
    Takashi Hirata
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    FEBS Lett 580:5117-21. 2006
    ..Furthermore, knockdown of DGAT1 gene significantly inhibited the TNF-alpha expression. Finally, the DGAT1 expression levels were closely related to the TNF-alpha level in 3T3-L1 adipocytes...
  35. ncbi request reprint [Pharmacological gender-specific medicine]
    Koichi Ueno
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675
    Rinsho Byori 54:51-8. 2006
    ..Such information has not been investigated in Japan. Since these results are thought to be useful, we will perform a detailed examination and accumulate evidence for their future exploitation in drug therapy...
  36. ncbi request reprint [Mechanism of sex differences and the clinical significance of PPARgamma targeted drugs]
    Koichi Ueno
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    Nihon Rinsho 68:224-8. 2010
    ..Moreover, we also considered about the effects of such differences on clinical applications from our research of prescribing data in 20 hospitals and also the result of PRospective ACTos practICAL experience (PRACTICAL)...
  37. doi request reprint Association of gamma-glutamyltransferase with incidence of type 2 diabetes in Japan
    Misuzu Fujita
    Department of Public Health, Chiba University, Japan
    Exp Biol Med (Maywood) 235:335-41. 2010
    ..The association between GGT and DM in non-drinkers was significantly stronger than that in drinkers. Furthermore, in women, obesity is no longer a risk factor for DM when GGT level is low...
  38. doi request reprint Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin-8 mRNA expression in HaCaT keratinocytes
    Eriko Suwa
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Exp Dermatol 23:138-40. 2014
    ..These increases in expression were significantly inhibited by the H4 receptor antagonist JNJ7777120. Our results indicate that IL-8 mRNA expression might be enhanced by histamine and TNFα via H4 receptor stimulation in keratinocytes. ..
  39. pmc Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Pharmacogn Mag 9:9-13. 2013
    ..Little is known, however, about the pharmacologic efficacy of topical royal jelly. Therefore, we investigated the antipruritic activity of topical royal jelly on chronic pruritus in experimental allergic contact dermatitis in mice...
  40. doi request reprint Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs
    Koichi Ueno
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Hypertens Res 35:245-50. 2012
    ..There are still large gaps in our knowledge of sex-specific differences in clinical pharmacology and much more research is needed...
  41. pmc Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Pharmacognosy Res 3:173-7. 2011
    ..Here, we examined whether bilberry extract (Bilberon-25) alleviates pruritus in a mouse model of chronic allergic contact dermatitis...
  42. ncbi request reprint [Surveillance study about the use actual of prescription drugs from the viewpoint of gender]
    Etsuko Negishi
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Yakugaku Zasshi 125:821-7. 2005
    ..This information had not previously been investigated in Japan. Since the results appear useful, we to improve perform more detailed analyses and accumulate evidence to improve drug therapy...
  43. ncbi request reprint Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Biol Pharm Bull 29:1167-74. 2006
    ..The present mouse model, therefore, well exhibits the recent diabetic pathophysiological characteristics of a majority of Asian patients...
  44. ncbi request reprint Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine
    Tomonori Nakamura
    Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Jpn J Pharmacol 88:217-21. 2002
    ....
  45. ncbi request reprint [Gender differences in pharmacokinetics of anesthetics]
    Koichi Ueno
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8677
    Masui 58:51-8. 2009
    ..Moreover, there is an obvious need for more research in this area in order to further optimize drug treatment in anesthesia...
  46. doi request reprint The pharmacological differences in antianginal effects of long-lasting calcium channel blockers: azelnidipine and amlodipine
    Michio Fujisawa
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Cardiovasc Pharmacol 61:63-9. 2013
    ..The antianginal effect with azelnidipine may be accounted for by its high affinity to the coronary blood vessels and the heart rate slowing effect, both of which are not shared with amlodipine...
  47. ncbi request reprint Association of cytosine-adenine repeat polymorphism of the estrogen receptor-beta gene with menopausal symptoms
    Chikari Takeo
    Department of General Medicine, Chiba Pre fectural Togane Hospital, Chiba, Japan
    Gend Med 2:96-105. 2005
    ..Polymorphisms of the estrogen receptor-beta (ERbeta) gene, such as cytosine-adenine (CA) dinucleotide repeats in intron 5, have been implicated in various diseases...
  48. ncbi request reprint A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
    Katsunori Yamaura
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Toxicol Sci 36:395-401. 2011
    ....
  49. pmc Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice
    Noriyuki Nakayama
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Pharmacognosy Res 3:155-9. 2011
    ..In this study, we examined whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice...
  50. ncbi request reprint Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis
    Yoshiko Ikawa
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University Chiba 260 8675, Japan
    Biol Pharm Bull 28:2016-8. 2005
    ....
  51. ncbi request reprint Negative growth control of renal cell carcinoma cell by connexin 32: possible involvement of Her-2
    Eriko Fujimoto
    Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Mol Carcinog 40:135-42. 2004
    ..These data suggest that Cx32 has negative growth control of Caki-2 cells, partly due to the inhibition of the Her-2 activation...
  52. ncbi request reprint Inhibition of the antibody production by acetaminophen independent of liver injury in mice
    Katsunori Yamaura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Biol Pharm Bull 25:201-5. 2002
    ..These findings indicate that the APAP-induced depression of antibody production may not be a secondary response to APAP-hepatitis, but may be a primary response to APAP...