Research Topics
Genomes and Genes | Koichi UenoSummaryAffiliation: Chiba University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cellsTomonori Nakamura
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
J Nat Med 63:15-20. 2009..It is expected that these compounds will show anti-inflammatory activities via inhibition of the expressions of iNOS and COX-2...- Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7Tomonori Nakamura
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
J Nat Med 63:21-7. 2009..It was expected that these compounds show anti-inflammatory activities... 
A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cellsEriko Fujimoto
Department of Food Science Research for Health, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan; Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan
Life Sci 76:2711-20. 2005..These results suggest that PP1 potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells through the reduction of anti-apoptotic molecules...- New 2-aryl-1,4-naphthoquinone-1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosisHiromi Sato
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
J Pharmacol Sci 118:467-78. 2012..Consistent with these results, cells with DNA fragmentation and multinucleated cells were increased time-dependently after QO-1 exposure. In conclusion, QO-1 has promising antitumor effects via microtubule depolymerization... - Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 geneEriko Fujimoto
Department of Geriatric Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan
J Pharmacol Sci 97:294-8. 2005..These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis... - Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cellsHiromi Sato
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba, Japan
J Pharmacol Sci 110:466-75. 2009..Moreover, Src inhibition reinforced CDDP cytotoxicity in parental H28 cells. These data suggest that Cx43 could improve the resistance to CDDP in a GJIC-independent manner, which may be partly mediated by the suppression of Src activity... - Expression of histamine H4 receptor in synovial cells from rheumatoid arthritic patientsEmi Ohki
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
Biol Pharm Bull 30:2217-20. 2007..Furthermore, the culture system used here will be useful for future studies concerning basic molecular mechanisms underlying the pharmacology of H4R... - Association of Rsa polymorphism of the estrogen receptor-β gene with rheumatoid arthritisHiromi Sato
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Rheumatol Int 32:2143-8. 2012..Above all, the presence of the GG genotype could be a risk factor for RA and such trend might be different in gender, although additional larger scale study is needed... - Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in miceHiroki Iwata
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan
Eur J Pharmacol 600:130-2. 2008..Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice... - Association of isoniazid-metabolizing enzyme genotypes and isoniazid-induced hepatotoxicity in tuberculosis patientsTakayo Sotsuka
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
In Vivo 25:803-12. 2011..We studied the possible influence of genetic polymorphisms of INH-metabolizing enzymes on serum concentrations of INH and its metabolites, as well as on the incidence of hepatotoxicity... - A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinomaHiroki Iwata
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Int J Oncol 38:1653-61. 2011..More-over, the cytotoxicity of VBL was enhanced in vitro in three RCC cell lines by Aza treatment. These findings suggest that the combination treatment with Aza and VBL is effective against RCC... - Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental modelEriko Suwa
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Eur J Pharmacol 667:383-8. 2011..These results indicate that treatment with a H(4) receptor antagonist may be effective for amelioration of both skin inflammation and pruritus in patients with allergic dermatitis such as atopic dermatitis... - Lower expression of histamine H₄ receptor in synovial tissues from patients with rheumatoid arthritis compared to those with osteoarthritisKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
Rheumatol Int 32:3309-13. 2012..52) or H(2)R (r = 0.23). This study supports the supposition that H(4)R in synovial tissue may play a role in cartilage and bone destruction by influencing the secretion of MMP-3 in patients with RA... - 2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activityTsutomu Ishikawa
Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi, Inage, Chiba, Japan
Chem Pharm Bull (Tokyo) 59:472-5. 2011.... - Sex differences in PPARgamma expressions in rat adipose tissuesKyoko Kadowaki
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Biol Pharm Bull 30:818-20. 2007..Expressions of PPARgamma2 in perigonadal adipose tissues in females significantly decreased during diestrus. It can be suggested that the sex hormones might affect the expressions of PPARgamma2 in adipose tissues... - The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamineKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
J Pharmacol Sci 92:43-9. 2003..These observations may provide critical insights into the pathogenesis of the bone pathology seen in patients with RA... - Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulationKatsunori Yamaura
Dept of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba Univ, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
J Food Sci 77:H262-7. 2012.... 
Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in miceKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Pharmacognosy Res 4:234-6. 2012..In this study, we examined whether an extract from immature natsumikan peel prevents lethal hepatotoxicity induced by a lethal dose of APAP in mice...- Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitisKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
J Toxicol Sci 37:1127-34. 2012..Topical glucocorticoids may exacerbate pruritus in a mouse model of allergic contact dermatitis via inhibition of PGD(2) production in antigen-mediated activated mast cells in the skin... - Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cellsKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
J Cell Biochem 113:1054-60. 2012.... - Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of haptenKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
J Toxicol Sci 36:669-74. 2011..This animal model will be useful for investigating the mechanism underlying the increased risk of development of eczema caused by regular APAP use and for examining safer and more effective therapy with APAP... - Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patientsKatsumi Fukino
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
J Toxicol Sci 33:187-95. 2008..In these cases, we think it's necessary to pay attention to the development of hepatic disorder caused by Hz... - Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in ratsKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Pharmacognosy Res 3:250-5. 2011..The aim of this study was to investigate the hepatoprotective effects of orally administrated goldenseal against APAP-induced acute liver failure (ALF) via inhibition of CYP2E1... - Association of gamma-glutamyltransferase with incidence of type 2 diabetes in JapanMisuzu Fujita
Department of Public Health, Chiba University, Japan
Exp Biol Med (Maywood) 235:335-41. 2010..The association between GGT and DM in non-drinkers was significantly stronger than that in drinkers. Furthermore, in women, obesity is no longer a risk factor for DM when GGT level is low... - [Mechanism of sex differences and the clinical significance of PPARgamma targeted drugs]Koichi Ueno
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
Nihon Rinsho 68:224-8. 2010..Moreover, we also considered about the effects of such differences on clinical applications from our research of prescribing data in 20 hospitals and also the result of PRospective ACTos practICAL experience (PRACTICAL)... - Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming testKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Pharmacognosy Res 4:22-6. 2012..In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice... - [Pharmacological gender-specific medicine]Koichi Ueno
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675
Rinsho Byori 54:51-8. 2006..Such information has not been investigated in Japan. Since these results are thought to be useful, we will perform a detailed examination and accumulate evidence for their future exploitation in drug therapy... - Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritisKatsumi Fukino
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
J Toxicol Sci 32:449-52. 2007..No correlations were found between these genotypes and serum MTX levels... - Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1Tomohiko Yoshida
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
FEBS Lett 580:5203-7. 2006..These results suggest that the decrement of GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved... - Activation of diacylglycerol O-acyltransferase 1 gene results in increased tumor necrosis factor-alpha gene expression in 3T3-L1 adipocytesTakashi Hirata
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
FEBS Lett 580:5117-21. 2006..Furthermore, knockdown of DGAT1 gene significantly inhibited the TNF-alpha expression. Finally, the DGAT1 expression levels were closely related to the TNF-alpha level in 3T3-L1 adipocytes... - Expression of the histamine H4 receptor in dermal and articular tissuesKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Life Sci 92:108-13. 2013..Further understanding of the functions of H(4) receptors in non-hematopoietic cells might lead to novel treatments for diseases with unmet needs... - Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugsKoichi Ueno
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
Hypertens Res 35:245-50. 2012..There are still large gaps in our knowledge of sex-specific differences in clinical pharmacology and much more research is needed... - Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamideTomonori Nakamura
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Biol Pharm Bull 29:1167-74. 2006..The present mouse model, therefore, well exhibits the recent diabetic pathophysiological characteristics of a majority of Asian patients... - Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicineTomonori Nakamura
Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Jpn J Pharmacol 88:217-21. 2002.... - [Surveillance study about the use actual of prescription drugs from the viewpoint of gender]Etsuko Negishi
Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Yakugaku Zasshi 125:821-7. 2005..This information had not previously been investigated in Japan. Since the results appear useful, we to improve perform more detailed analyses and accumulate evidence to improve drug therapy... - Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitisKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Pharmacognosy Res 3:173-7. 2011..Here, we examined whether bilberry extract (Bilberon-25) alleviates pruritus in a mouse model of chronic allergic contact dermatitis... - [Gender differences in pharmacokinetics of anesthetics]Koichi Ueno
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8677
Masui 58:51-8. 2009..Moreover, there is an obvious need for more research in this area in order to further optimize drug treatment in anesthesia... - Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritisYoshiko Ikawa
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University; Chiba 260-8675, Japan
Biol Pharm Bull 28:2016-8. 2005.... - Inhibition of the antibody production by acetaminophen independent of liver injury in miceKatsunori Yamaura
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Biol Pharm Bull 25:201-5. 2002..These findings indicate that the APAP-induced depression of antibody production may not be a secondary response to APAP-hepatitis, but may be a primary response to APAP... - Association of cytosine-adenine repeat polymorphism of the estrogen receptor-beta gene with menopausal symptomsChikari Takeo
Department of General Medicine, Chiba Pre fectural Togane Hospital, Chiba, Japan
Gend Med 2:96-105. 2005..Polymorphisms of the estrogen receptor-beta (ERbeta) gene, such as cytosine-adenine (CA) dinucleotide repeats in intron 5, have been implicated in various diseases... - A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skinKatsunori Yamaura
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
J Toxicol Sci 36:395-401. 2011.... - Negative growth control of renal cell carcinoma cell by connexin 32: possible involvement of Her-2Eriko Fujimoto
Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Mol Carcinog 40:135-42. 2004..These data suggest that Cx32 has negative growth control of Caki-2 cells, partly due to the inhibition of the Her-2 activation... - Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in miceNoriyuki Nakayama
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Pharmacognosy Res 3:155-9. 2011..In this study, we examined whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice...