Katsutoshi Terasawa

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint [How to accomplish the universality of Japanese-Oriental (Kampo) medicine: looking for harmonization between the eastern and western paradigms]
    Katsutoshi Terasawa
    Nihon Yakurigaku Zasshi 128:389-94. 2006
  2. ncbi request reprint Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients
    Kazuo Ogawa
    Central Research Laboratories, Tsumura and Co, Ibaraki, Japan
    Clin Biochem 40:1113-21. 2007
  3. ncbi request reprint Challenge tests and kampo medicines: case report and review of the literature
    Naoki Mantani
    Department of Integrated Japanese Oriental Medicine, Faculty of Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am J Chin Med 31:643-8. 2003
  4. ncbi request reprint The efficacy of herbal medicine (kampo) in reducing the adverse effects of IFN-beta in chronic hepatitis C
    Mosaburo Kainuma
    Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Japan
    Am J Chin Med 30:355-67. 2002
  5. pmc Lymphocyte transformation test for medicinal herbs yields false-positive results for first-visit patients
    Naoki Mantani
    Department of Integrated Japanese Oriental Medicine, Gunma University School of Medicine, Maebashi, Japan
    Clin Diagn Lab Immunol 10:479-80. 2003
  6. ncbi request reprint Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy
    Nobuyasu Sekiya
    Department of Frontier Japanese Oriental Kampo Medicine, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    J Altern Complement Med 11:895-901. 2005
  7. ncbi request reprint Herbal medicine and false-positive results on lymphocyte transformation test
    Naoki Mantani
    Department of Japanese Oriental Kampo Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Yakugaku Zasshi 122:399-402. 2002
  8. ncbi request reprint Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia
    Koichi Yokoyama
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Ethnopharmacol 95:335-43. 2004
  9. ncbi request reprint Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil
    Koichi Yokoyama
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Phytomedicine 11:478-89. 2004
  10. ncbi request reprint Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China
    Mingming Huan
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama City, Japan
    Biol Psychiatry 56:490-6. 2004

Collaborators

  • Yutaka Shimada
  • Toshiaki Kogure
  • M Kainuma
  • Naoki Mantani
  • Takako Nakagawa
  • T Yokozawa
  • Chihiro Tohda
  • Nobuyasu Sekiya
  • Hirozo Goto
  • Yasunori Nagaki
  • Iwao Sakakibara
  • Nobuko Imanishi
  • Hiroaki Hikiami
  • Naotoshi Shibahara
  • Koichi Yokoyama
  • Seiji Hayasaka
  • Shinya Sakai
  • Kei Hamazaki
  • Kazufumi Kouta
  • Mingming Huan
  • Yoriko Hayasaka
  • Nobuo Nakamura
  • Makoto Fujimoto
  • Kazuo Ogawa
  • Hiroaki Sakurai
  • Ikuo Saiki
  • Kiyoshi Minamizawa
  • Keiichi Koizumi
  • Atsushi Chino
  • Yuko Katada
  • Miyuki Sato
  • Hiroshi Ochiai
  • Kyouka Ueda
  • Shiro Watanabe
  • Tomohito Hamazaki
  • Miho Itomura
  • Hiroshi Fujinaga
  • Hisao Nishijo
  • Etsuro Hori
  • Xue Yun Zhang
  • Yohei Sasaki
  • Atsushi Niizawa
  • Le Xuan Hai
  • Koichi Tsuneyama
  • Carlo Selmi
  • M Eric Gershwin
  • Yasuo Takano
  • Tetsuo Kawasaki
  • Shuichi Takeda
  • Yukari Shibagaki
  • Masahiro Yamamoto
  • Takuya Oyama
  • Tetsuko Kojima
  • Chinami Matsumoto
  • Kozo Takahashi
  • Chizuru Kiga
  • Satoshi Kamegai
  • Hiroshi Muramoto
  • Tsugunobu Andoh
  • Akira Haji
  • Min Kyung Choo
  • Takahiro Shintani
  • Shigeki Sawazaki
  • Masatoshi Tanouchi
  • Eiichi Tahara
  • Kazunaga Yazawa
  • Hiroto Nishizawa
  • Hongyan Liu
  • Yueji Sun
  • Shinobu Takagi
  • Wei Kang
  • Chiharu Kadoi
  • Kiyoaki Tanikawa
  • Nobayasu Sekiya
  • Naoko Hattori
  • Fumiyuki Hatanaka
  • Katsuko Komatsu
  • Shigehiko Sato
  • Tomohiro Abe
  • Yuichi Endo
  • Shoko Oida
  • Hiroshi Watanabe
  • Kenji Tazawa

Detail Information

Publications36

  1. ncbi request reprint [How to accomplish the universality of Japanese-Oriental (Kampo) medicine: looking for harmonization between the eastern and western paradigms]
    Katsutoshi Terasawa
    Nihon Yakurigaku Zasshi 128:389-94. 2006
  2. ncbi request reprint Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients
    Kazuo Ogawa
    Central Research Laboratories, Tsumura and Co, Ibaraki, Japan
    Clin Biochem 40:1113-21. 2007
    ..We searched for biomarker candidates to discriminate responders from non-responders to keishibukuryogan (KBG); one of the most frequently used Kampo medicines...
  3. ncbi request reprint Challenge tests and kampo medicines: case report and review of the literature
    Naoki Mantani
    Department of Integrated Japanese Oriental Medicine, Faculty of Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am J Chin Med 31:643-8. 2003
    ..The safety and availability of challenge with a small dose of Kampo medicine should be further examined in a larger population with Kampo medicine-induced liver injury...
  4. ncbi request reprint The efficacy of herbal medicine (kampo) in reducing the adverse effects of IFN-beta in chronic hepatitis C
    Mosaburo Kainuma
    Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Japan
    Am J Chin Med 30:355-67. 2002
    ..This study indicates that Kampo medicines are useful for reducing the adverse effects accompanying IFN treatment in patients with chronic hepatitis C without reducing the antiviral effects...
  5. pmc Lymphocyte transformation test for medicinal herbs yields false-positive results for first-visit patients
    Naoki Mantani
    Department of Integrated Japanese Oriental Medicine, Gunma University School of Medicine, Maebashi, Japan
    Clin Diagn Lab Immunol 10:479-80. 2003
    ..LTTs for both herbs were positive in 12 of 14 patients, suggesting that LTTs for these herbs are unreliable for the diagnosis of Kampo medicine-induced liver injury...
  6. ncbi request reprint Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy
    Nobuyasu Sekiya
    Department of Frontier Japanese Oriental Kampo Medicine, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    J Altern Complement Med 11:895-901. 2005
    ..The aim of this study was to observe the influence of Kampo therapy on latent chronic fatigue of patients with chronic diseases...
  7. ncbi request reprint Herbal medicine and false-positive results on lymphocyte transformation test
    Naoki Mantani
    Department of Japanese Oriental Kampo Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Yakugaku Zasshi 122:399-402. 2002
    ..These examples suggest that LTT for Kampo formulae may be unreliable as a diagnostic method for drug-induced liver injury...
  8. ncbi request reprint Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia
    Koichi Yokoyama
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Ethnopharmacol 95:335-43. 2004
    ..These results suggest that one of the mechanisms of the protective effects of CSE and USE against transient brain ischemia-induced neuronal damage may be their enhancing effect on CAT activity in the brain...
  9. ncbi request reprint Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil
    Koichi Yokoyama
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Phytomedicine 11:478-89. 2004
    ..These results suggest that the oral administration of CSE or USE provides a protective effect against transient ischemia-induced delayed neuronal death by reducing oxidative damage to neurons...
  10. ncbi request reprint Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China
    Mingming Huan
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama City, Japan
    Biol Psychiatry 56:490-6. 2004
    ..Epidemiologic studies show that low fish intake is a risk factor of suicidality; however, there are no case-control studies investigating suicide attempt risk and tissue n-3 fatty acid levels...
  11. ncbi request reprint Inducible activity of ginger rhizome (Zingiber offifinale Rosc.) on the mRNA expression of macrophage-inducible nitric oxide (NO) synthase and NO production in a macrophage cell line, RAW264.7 cells
    Nobuko Imanishi
    Department of Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Am J Chin Med 32:727-35. 2004
    ..The activity of ZOR can be considered to contribute, at least in part, to the beneficial effects of ZOR through the macNOS-mediated activation of the biodefense mechanism...
  12. ncbi request reprint Oren-gedoku-to and Keishi-bukuryo-gan-ryo inhibit the progression of atherosclerosis in diet-induced hypercholesterolemic rabbits
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Biol Pharm Bull 28:294-8. 2005
    ..These results suggest that OGT and KBG prevent the progression of atheromatous plaque by creating a sounder antioxidant defense system than vitamin E...
  13. ncbi request reprint Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages
    Atsushi Chino
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Int Immunopharmacol 5:871-82. 2005
    ..These results suggest that selective modulation of the TLR4 signaling pathways by TJ-48 is involved in enhanced production of IL-12 in PEMs...
  14. ncbi request reprint [Clinical application of kampo medicine for aged patients]
    Katsutoshi Terasawa
    Nihon Ronen Igakkai Zasshi 42:25-6. 2005
  15. ncbi request reprint Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial
    Kei Hamazaki
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Nutrition 21:705-10. 2005
    ..Therefore, we performed another intervention study to test their effect on catecholamines with healthy subjects under no chronic stress...
  16. ncbi request reprint Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus
    Nobuko Imanishi
    Department of Oriental Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Am J Chin Med 34:157-69. 2006
    ..These data suggested that ZOR itself has no inhibitory effect on the growth of influenza virus, but could exert its effect via macrophage activation leading to production of TNF-alpha...
  17. ncbi request reprint Effects of eppikahangeto, a Kampo formula, and Ephedrae herba against citric acid-induced laryngeal cough in guinea pigs
    Kiyoshi Minamizawa
    Department of Japanese Oriental Medicine, Faculty of Medicine, University of Toyama, Japan
    J Pharmacol Sci 101:118-25. 2006
    ..3 +/- 6.0%, P<0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH...
  18. ncbi request reprint Population of CD40L-expressing cells was slightly but not significantly decreased in lymphoid tissues of collagen-induced arthritic mice treated with Hochu-Ekki-To
    Toshiaki Kogure
    Dept of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, Maebashi City, Japan
    Yakugaku Zasshi 127:547-50. 2007
    ..To clarify the mechanism of the action of Hochu-Ekki-To (HET) on collagen-induced arthritic (CIA) mice by analyzing the CD40L-expressing cells population...
  19. ncbi request reprint The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study
    Mosaburo Kainuma
    Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Japan
    Hum Psychopharmacol 19:235-41. 2004
    ..To evaluate the efficacy of a herbal medicine (Mao-to) on psychiatric complications caused by IFN, and to examine the relationship between depression and microcirculation...
  20. ncbi request reprint Suppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritis
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Phytother Res 18:247-9. 2004
    ..The findings of this study suggest that the suppressive effect of ST administration on excessive granulocyte activation resulted in the improvement of inflammation with rheumatoid arthritis...
  21. ncbi request reprint Effects of oral administration of Gardeniae fructus extract and intravenous injection of crocetin on lipopolysaccharide- and prostaglandin E2-induced elevation of aqueous flare in pigmented rabbits
    Yasunori Nagaki
    Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Chin Med 31:729-38. 2003
    ..Pretreatment with 3 or 30 microg/kg of crocetin did not inhibit PGE2-induced aqueous flare elevation, but 300 microg/kg of crocetin inhibited PGE2-induced aqueous flare elevation (AUC: 918 arbitrary units)...
  22. ncbi request reprint Rhubarb use in patients treated with Kampo medicines--a risk for gastric cancer?
    Naoki Mantani
    Department of Japanese Oriental Kampo Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Yakugaku Zasshi 122:403-5. 2002
    ..Rhubarb use may have little connection with the development of gastric cancer in practice, even if some ingredients in rhubarb have shown carcinogenic activity in experimental studies...
  23. ncbi request reprint Inhibitory effects of Keishi-bukuryo-gan on free radical induced lysis of rat red blood cells
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Phytother Res 16:373-6. 2002
    ..The inhibitory effect was dose dependent at concentrations of 100-1000 microg/mL. Furthermore, the ingestion of 200 mg of KBG was associated with a significant decrease in susceptibility of RBC to haemolysis in rats...
  24. ncbi request reprint Suppressive effect of hochu-ekki-to on collagen induced arthritis in DBA1J mice
    Le Xuan Hai
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
    J Rheumatol 29:1601-8. 2002
    ..To investigate the effect of hochu-ekki-to (HET) decoction on the development of collagen-induced arthritis (CIA) in mice...
  25. ncbi request reprint Keishi-bukuryo-gan preserves the endothelium dependent relaxation of thoracic aorta in cholesterol-fed rabbit by limiting superoxide generation
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Japan
    Phytother Res 16:524-8. 2002
    ..Thus, KBG protects the vascular endothelium function by its antioxidative effect and by inhibiting the release of free radicals from neutrophils in vivo...
  26. ncbi request reprint Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to
    Naoki Mantani
    Department of Japanese Oriental Kampo Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Psychiatry Clin Neurosci 56:617-20. 2002
    ..These Kampo medicines may be useful as additional or alternative treatments for panic disorder...
  27. ncbi request reprint Effects of Orengedoku-to and Scutellariae radix extract on aqueous flare elevation induced by intravitreal IL-1alpha in pigmented rabbits
    Nobuo Nakamura
    Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    Am J Chin Med 30:543-50. 2002
    ..05) suppressed elevation of aqueous flare induced by IL-1alpha. Thus, orengedoku-to and Scutellariae radix extract have an inhibitory effect on experimental elevation of aqueous flare induced by IL-1alpha in rabbits...
  28. ncbi request reprint Inhibitory effects of Oren-Gedoku-To (Huanglian-Jie-Du-Tang) on free radical-induced lysis of human red blood cells
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Phytother Res 17:147-51. 2003
    ..The direct protection of RBC membrane from free-radical attack as observed in the present study could provide an important pathophysiological basis for making use of the favorable hemorheological effect of OGT...
  29. ncbi request reprint Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells
    Nobuyasu Sekiya
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Phytother Res 17:160-2. 2003
    ....
  30. ncbi request reprint Therapeutic usefulness of Keishi-bukuryo-gan for diabetic nephropathy
    Takako Nakagawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 55:219-27. 2003
    ....
  31. ncbi request reprint Choto-san prevents occurrence of stroke and prolongs life span in stroke-prone spontaneously hypertensive rats
    Yutaka Shimada
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama 930 0194, Japan
    Am J Chin Med 31:79-85. 2003
    ..3% choto-san group was significantly inhibited compared to the control (p < 0.05). These results suggested that choto-san prevents the occurrence of stroke and prolongs the life span of SHR-SPs...
  32. ncbi request reprint Effects of goshajinkigan on corneal sensitivity, superficial punctate keratopathy and tear secretion in patients with insulin-dependent diabetes mellitus
    Yasunori Nagaki
    Department of Ophthalmology, Faculty of Medicine Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Chin Med 31:103-9. 2003
    ..Several components in goshajinkigan were found on high performance liquid chromatography. In conclusion, goshajinkigan improved ocular surface disorders in patients with insulin-dependent diabetes mellitus...
  33. ncbi request reprint Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits
    Yasunori Nagaki
    Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Jpn J Ophthalmol 47:249-53. 2003
    ..To evaluate the effect of topical instillation of traditional herbal medicines, herbal extracts, and their components on the elevation of aqueous flare induced by prostaglandin E(2) (PGE(2)) in pigmented rabbits...
  34. ncbi request reprint Clinical evaluation of the effect of daio (rhei rhizoma) on the progression of diabetic nephropathy with overt proteinuria
    Hirozo Goto
    Department of Kampo Diagnostics, Institute of Natural Medicine Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Am J Chin Med 31:267-75. 2003
    ..In this retrospective study, traditional herbal medicines with Daio were considered to be effective in prolonging the pre-dialysis period of diabetic nephropathy...
  35. ncbi request reprint Effects of curcuma drugs on vasomotion in isolated rat aorta
    Yohei Sasaki
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    Biol Pharm Bull 26:1135-43. 2003
    ..Therefore, all Curcuma drugs tested in the present study can be effective for vasodilation. Moreover, the drug derived from C. zedoaria has potential to cure Oketsu with its various acting points...
  36. doi request reprint Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver
    Makoto Fujimoto
    Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Exp Biol Med (Maywood) 233:328-37. 2008
    ..01). In conclusion, there was a statistically significant benefit of Kampo formulas (KBG in particular) on a dietary model of NAFLD/NASH. Future studies need to be directed at the mechanisms in the treatment of NASH...