Masatoshi Tagawa

Summary

Affiliation: Chiba Cancer Center
Country: Japan

Publications

  1. pmc Interferon-β produces synergistic combinatory anti-tumor effects with cisplatin or pemetrexed on mesothelioma cells
    Quanhai Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    PLoS ONE 8:e72709. 2013
  2. pmc Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels
    Shinya Okamoto
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    PLoS ONE 8:e60297. 2013
  3. pmc A potential therapeutic strategy for malignant mesothelioma with gene medicine
    Yuji Tada
    Department of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biomed Res Int 2013:572609. 2013
  4. pmc Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-λ genes produced anti-tumour effects
    Q Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center, Chiba 260 8717, Japan
    Br J Cancer 105:1302-12. 2011
  5. pmc Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma
    G Ma
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Cancer Gene Ther 17:803-13. 2010
  6. doi request reprint CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry
    Kiyoko Kawamura
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan E mail
    Am J Clin Pathol 140:544-9. 2013
  7. doi request reprint Gene therapy for malignant mesothelioma: current prospects and challenges
    M Tagawa
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Cancer Gene Ther 20:150-6. 2013
  8. pmc A possible anticancer agent, type III interferon, activates cell death pathways and produces antitumor effects
    Masatoshi Tagawa
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Clin Dev Immunol 2011:479013. 2011
  9. ncbi request reprint Virology- and immunology-based gene therapy for cancer
    Masatoshi Tagawa
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chiba 260 8717, Japan
    Cancer Immunol Immunother 55:1420-5. 2006
  10. ncbi request reprint Cancer therapy with local oncolysis and topical cytokine secretion
    Masatoshi Tagawa
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717 Japan
    Front Biosci 13:2578-87. 2008

Collaborators

Detail Information

Publications74

  1. pmc Interferon-β produces synergistic combinatory anti-tumor effects with cisplatin or pemetrexed on mesothelioma cells
    Quanhai Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    PLoS ONE 8:e72709. 2013
    ..These data demonstrated firstly to our knowledge that IFN-β produced synergistic anti-tumor effects with cisplatin or pemetrexed on mesothelioma through up-regulated p53 expression. ..
  2. pmc Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels
    Shinya Okamoto
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    PLoS ONE 8:e60297. 2013
    ....
  3. pmc A potential therapeutic strategy for malignant mesothelioma with gene medicine
    Yuji Tada
    Department of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biomed Res Int 2013:572609. 2013
    ....
  4. pmc Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-λ genes produced anti-tumour effects
    Q Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center, Chiba 260 8717, Japan
    Br J Cancer 105:1302-12. 2011
    ..Interferon-λs (IFN-λs) are novel cytokines with multiple functions, like IFN-α and -β. We examined possible anti-tumour effects produced by adenoviruses bearing the IFN-λ1 or -λ2 gene (Ad/IFN-λ) with the type-35 fibre-knob structure...
  5. pmc Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma
    G Ma
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Cancer Gene Ther 17:803-13. 2010
    ..These data indicate that the Ad-delE1B55 produce combinatory antitumor effects with a chemotherapeutic agent irrespective of the administration schedule, but the effects depend on an agent in esophageal carcinoma...
  6. doi request reprint CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry
    Kiyoko Kawamura
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan E mail
    Am J Clin Pathol 140:544-9. 2013
    ..To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma...
  7. doi request reprint Gene therapy for malignant mesothelioma: current prospects and challenges
    M Tagawa
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Cancer Gene Ther 20:150-6. 2013
    ..Accumulating clinical data suggest that an intrapleural administration of viral vectors has distinct aspects which are not observed in other administration routes...
  8. pmc A possible anticancer agent, type III interferon, activates cell death pathways and produces antitumor effects
    Masatoshi Tagawa
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Clin Dev Immunol 2011:479013. 2011
    ..In this paper, we summarize the current knowledge on the IFN-λs-mediated tumor cell death and discuss the functional difference between type I and III IFNs...
  9. ncbi request reprint Virology- and immunology-based gene therapy for cancer
    Masatoshi Tagawa
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chiba 260 8717, Japan
    Cancer Immunol Immunother 55:1420-5. 2006
    ....
  10. ncbi request reprint Cancer therapy with local oncolysis and topical cytokine secretion
    Masatoshi Tagawa
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717 Japan
    Front Biosci 13:2578-87. 2008
    ..Combinatory gene therapy with oncolytic viruses and activation of host immune system thereby can evoke immune responses against all the tumor antigens expressed by the process of "antigen-spreading" mechanisms...
  11. ncbi request reprint T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Cancer Gene Ther 10:451-6. 2003
    ....
  12. ncbi request reprint Cutting edge: a novel role for Fas ligand in facilitating antigen acquisition by dendritic cells
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute, Graduate School of Medicine, Chiba University, Japan
    J Immunol 169:2241-5. 2002
    ..These results identify a novel role for FasL in augmenting tumor-DC interactions and subsequent tumor Ag acquisition by DCs, and suggest that FasL-expressing tumor cells could be used to generate tumor-specific DC vaccines...
  13. ncbi request reprint Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein
    Rumana Bahar
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
    J Biol Chem 277:40012-9. 2002
    ..These findings indicate that Clast3 is a novel cell cycle-regulated protein and that its constitutive overexpression induces polyploidy and multinucleation by interfering with the mitotic spindle checkpoint...
  14. ncbi request reprint Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
    Masako Chiyo
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Int J Cancer 115:437-42. 2005
    ..These data collectively suggest that expressed IL-27 in tumors produces T cell-dependent and-independent antitumor effects and is a possible therapeutic strategy for cancer...
  15. pmc The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Center Research Institute, Nitona, Chiba, Japan
    Immunology 117:22-8. 2006
    ..p40 can thereby antagonize IL-23 and is a possible therapeutic agent for suppression of IL-23 functions...
  16. ncbi request reprint Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene in human tumors and enhance the sensitivity to a prodrug
    Kiyoko Kawamura
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 27:89-93. 2007
    ..These data collectively suggest that the survivin regulatory region induces the expression of an exogenous gene in tumors, but the transcriptional activity is not directly linked with M-phase induction...
  17. ncbi request reprint Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects
    Shin ichi Ugai
    Division of Pathology, Chiba Cancer Center Research Institute, and Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Cancer Gene Ther 10:771-8. 2003
    ..These data collectively suggest that expression of IL-21 and IL-23 in tumors can produce NK cell-dependent and -independent antitumor effects in an alpha beta T cell-defective condition, respectively...
  18. ncbi request reprint Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Oncol Rep 10:1301-5. 2003
    ..The transcriptional activity of the MK promoter could be regulated by cell growth and in part P53-dependent pathways...
  19. doi request reprint E1B-55 kDa-defective adenoviruses activate p53 in mesothelioma and enhance cytotoxicity of anticancer agents
    Makako Yamanaka
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    J Thorac Oncol 7:1850-7. 2012
    ..Genetic characterization of malignant mesothelioma shows a homozygous deletion of the INK4A/ARF locus, which results in inactivation of the p53 pathways...
  20. ncbi request reprint DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers
    Kiyoko Kawamura
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Int J Cancer 109:9-16. 2004
    ..These results implicate that Pol theta may have a specialized function in lymphocytes and that its overexpression may contribute to tumor progression...
  21. ncbi request reprint Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells
    Yan Qing Wang
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Int J Cancer 105:820-4. 2003
    ..These data suggest that expression of IL-23 in tumors produces T cell-dependent antitumor effects and induces systemic immunity...
  22. ncbi request reprint Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Oncol Rep 14:831-5. 2005
    ....
  23. ncbi request reprint Expression of CD40 ligand in CD40-positive murine tumors activates transcription of the interleukin-23 subunit genes and produces antitumor responses
    Akihiko Wada
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba, Japan
    Anticancer Res 24:2713-6. 2004
    ..Since expression of IL-23 in tumors can produce antitumor effects, the present data suggest that the CD40/CD40L interaction can activate cytokine transcripts in certain tumors and consequently contribute to antitumor responses...
  24. pmc The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Centre Research Institute, Nitona, Chiba, Japan
    Immunology 128:e816-25. 2009
    ..We propose that p28 can be a regulatory subunit for IL-27-mediated cellular immune responses and a possible therapeutic agent to suppress unfavourable immune responses...
  25. doi request reprint Zoledronic acid produces antitumor effects on mesothelioma through apoptosis and S-phase arrest in p53-independent and Ras prenylation-independent manners
    Shinya Okamoto
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Thorac Oncol 7:873-82. 2012
    ....
  26. doi request reprint Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma
    Atsushi Kitamura
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer Sci 102:1366-73. 2011
    ..Combination therapy with SeV/ΔF/FIR plus cisplatin has therapeutic potential against HMPM. SeV/ΔF/FIR plus cisplatin will be an attractive modality against HMPM in the future...
  27. ncbi request reprint Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects
    Yan Qing Wang
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Oncol Rep 10:909-13. 2003
    ..The antitumor effects by Mig could be independent of anti-angiogenesis and recruitment of T and NK cells...
  28. ncbi request reprint Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines
    Akihiko Wada
    Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 25:299-303. 2005
    ..These data collectively suggest that the immune suppression induced by UV-treated FasL-expressing tumors was not attributable to tolerance of DCs, but due to cytokine-induced suppression of cell-mediated immunity...
  29. ncbi request reprint Gene therapy for malignant pleural mesothelioma: present and future
    Yuji Tada
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Res 17:239-46. 2008
    ..In this article, we review the current status of gene therapy and clinical trials targeting mesothelioma and address possible directions to improve the efficacy...
  30. ncbi request reprint Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter
    Ling Yu
    Division of Pathology, Chiba Cancer Center, Chiba, Japan
    Oncology 66:143-9. 2004
    ..These data showed that the MK promoter activated a therapeutic gene in a wider range of human breast cancer than the c-erbB-2 promoter and suggest that MK promoter-mediated gene therapy is potentially more favorable in clinical settings...
  31. ncbi request reprint Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner
    Shigeru Sakiyama
    Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Adv Enzyme Regul 43:57-66. 2003
  32. doi request reprint Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents
    Quanhai Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Eur J Cancer 46:180-90. 2010
    ....
  33. ncbi request reprint Adenovirus type 5 substituted with type 11 or 35 fiber structure increases its infectivity to human cells enabling dual gene transfer in CD46-dependent and -independent manners
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 27:2311-6. 2007
    ....
  34. ncbi request reprint Fas ligand-expressing tumors induce tumor-specific protective immunity in the inoculated hosts but vaccination with the apoptotic tumors suppresses antitumor immunity
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute and Department of Respirology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Cancer Gene Ther 10:134-40. 2003
    ..Our results indicated that apoptotic FasL-expressing tumor cells could impair host immune responses against the tumors, in contrast to potent antitumor immunity generated by viable FasL-expressing tumors...
  35. ncbi request reprint Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice
    Mika Seimiya
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Eur J Immunol 34:1322-32. 2004
    ..These results reveal a critical role for Clast5/Stra13/DEC1 in negatively regulating lymphocyte development and function in vivo...
  36. ncbi request reprint Glioma-specific cytotoxic T cells can be effectively induced by subcutaneous vaccination of irradiated wild-type tumor cells without artificial cytokine production
    Yasuo Iwadate
    Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Int J Oncol 23:483-8. 2003
    ..c. transplantation of IL-2-producers. These results suggest that glioma-specific CTLs could be effectively induced by s.c. immunization of irradiated wild-type tumor cells without artificial cytokine production...
  37. ncbi request reprint Expression of the TNF-alpha gene on mouse lung carcinoma cells suppresses spontaneous lung metastasis without affecting tumorigenicity
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute, Chuo Ku, Chiba 260 8717, Japan
    Oncol Rep 9:585-8. 2002
    ..Expressed TNF-alpha on tumors is released by matrix metalloproteinases from surrounding tissues and anti-tumor effects by TNF-alpha can be influenced by local environmental conditions...
  38. doi request reprint Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects
    Hiroyasu Nagakawa
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Cell Immunol 275:90-7. 2012
    ..Transduction of murine tumors with adenoviruses expressing the human IL-24 gene however suppressed the viability and decreased the tumor growth. These data suggest that mIL-24 is functionally irrelevant to the human counterpart...
  39. ncbi request reprint Antitumor effects are produced by forced expression of membrane-bound but not soluble Fas ligand in murine lung carcinoma cells
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute, Japan
    Anticancer Res 22:831-6. 2002
    ..The antitumor activity induced by expressed FasL seems to be correlated with the apoptosis-inducing activity through the Fas/FasL interaction but not directly with the chemotactic activity for neutrophils...
  40. ncbi request reprint Regulatory regions of growth-related genes can activate an exogenous gene of the alpha-fetoprotein promoter to a comparable degree in human hepatocellular carcinoma cells
    Minoru Tomizawa
    Division of Pathology, Chiba Cancer Center Research Institute, Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Anticancer Res 23:3273-7. 2003
    ....
  41. ncbi request reprint Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, 260 8717 Chiba, Japan
    Cancer Lett 203:51-7. 2004
    ....
  42. ncbi request reprint Recombinant Sendai virus vector induces complete remission of established brain tumors through efficient interleukin-2 gene transfer in vaccinated rats
    Yasuo Iwadate
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:3821-7. 2005
    ..We also estimated the therapeutic efficacy of the novel vector system against a rat glioblastoma model...
  43. ncbi request reprint Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer
    Haruko Yamaji
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Immunol Immunother 53:786-92. 2004
    ..The presence of IL-6 and tumor-infiltrating lymphocytes (TILs) within tumor tissues was examined by immunohistochemical staining...
  44. ncbi request reprint Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53
    Yanqing Wang
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
    Int J Oncol 25:161-5. 2004
    ..These results link p53 status with POLkappa expression and suggest that loss of p53 function may in part contribute to the observed POLkappa upregulation in human lung cancers...
  45. ncbi request reprint Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells
    Masako Chiyo
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 24:3763-7. 2004
    ..The parent tumor growth influenced by the cytokine producers was similar to each other. Combinatory antitumor effects were not produced by the cytokine producers and application of the cytokines did not show any synergistic effects...
  46. ncbi request reprint Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas
    Mika Seimiya
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
    Int J Oncol 22:301-4. 2003
    ..These results reveal stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation and implicates its possible involvement in B cell malignancies...
  47. ncbi request reprint Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker
    Minoru Tomizawa
    Division of Pathology, Chiba Cancer Center Research Institute, Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Anticancer Res 23:351-4. 2003
    ..These data imply that the comparison of C/EBP alpha and C/EBP beta expression between tumors and non-tumorous regions could be a prognostic marker for patients with hepatocellular carcinoma...
  48. ncbi request reprint Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis
    Kiyoko Kawamura
    Division of Pathology, Chiba Cancer Center, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 26:4647-51. 2006
    ..These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU...
  49. doi request reprint Interaction and cross-resistance of cisplatin and pemetrexed in malignant pleural mesothelioma cell lines
    Miyako Kitazono-Saitoh
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncol Rep 28:33-40. 2012
    ..The information together with the experimental model presented here would be useful for further investigating therapeutic targets of malignant mesothelioma...
  50. ncbi request reprint Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
    Cancer Sci 94:628-32. 2003
    ..Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival...
  51. ncbi request reprint Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice
    Baoen Shan
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 24:79-82. 2004
    ..Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition...
  52. ncbi request reprint A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer
    Yu Yoshida
    Division of Pathology, Chiba Cancer Center Research Institute, Japan
    Anticancer Res 22:117-20. 2002
    ..The present study suggests that preferential cytotoxic effects for pancreatic tumors can be achieved by using the MK promoter...
  53. ncbi request reprint Novel type III interferons produce anti-tumor effects through multiple functions
    Quanhai Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Front Biosci (Landmark Ed) 18:909-18. 2013
    ..In this review, we encapsulate recent understandings about type III IFNs in particular the anti-tumor effects, and discuss possible mechanisms and a potential use for cancer therapy...
  54. ncbi request reprint Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors
    Kiyoko Kawamura
    Division of Pathology, Chiba Cancer Center Research Institute, Japan
    Cancer Gene Ther 9:109-15. 2002
    ..The present study showed that production of IL-10 from tumor cells impaired T cell- and non-T cell-mediated systemic antitumor immunity in hosts...
  55. ncbi request reprint Recent advances in esophageal cancer gene therapy
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Thorac Cardiovasc Surg 14:3-8. 2008
    ..Lastly we review the available experimental therapeutic models from the literature and our experimental work over the past few years are reviewed...
  56. doi request reprint Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis
    Di Wu
    Dept of Pathology, Tokyo Women s Medical University Yachiyo Medical Center, Owada shinden, Yachiyo, Chiba, Japan
    Am J Clin Pathol 139:39-46. 2013
    ..Methylation of p16 was observed in 7 (20.6%) of 34 informative cases. p16 FISH analysis can be a reliable test for distinguishing between sarcomatoid mesothelioma and fibrous pleuritis and a prognostic factor for MPM...
  57. doi request reprint Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin
    Toshihiko Fukamachi
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Cancer Lett 297:182-9. 2010
    ..These results suggested that screening under acidic conditions would be useful for developing new chemotherapeutic reagents...
  58. ncbi request reprint Clast5/Stra13 is a negative regulator of B lymphocyte activation
    Mika Seimiya
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Biochem Biophys Res Commun 292:121-7. 2002
    ..Moreover, Clast5/Stra13 inhibited the colony formation in fibroblasts. Our results suggest that Clast5/Stra13 functions as a negative regulator of B cell activation by inhibiting cell cycle progression and cell growth...
  59. ncbi request reprint Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas
    Minoru Tomizawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City 260 8670, Japan
    Int J Mol Med 9:597-600. 2002
    ....
  60. ncbi request reprint Interleukin-12-mediated induction of systemic immunity in the periphery and recruitment of activated T cells into the brain produce limited antitumor effects compared with interleukin-2
    Yasuo Iwadate
    Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Int J Mol Med 10:741-7. 2002
    ..These results collectively suggest that the antitumor activity with IL-2 was superior to IL-12 both in the induction of cytotoxic T cells and in the recruitment of activated T cells into brain tumors...
  61. ncbi request reprint Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors
    Masahiko Nezu
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 335:843-9. 2005
    ....
  62. ncbi request reprint T cell dependent and independent antitumor immunity generated by the expression of Fas ligand on mouse lung carcinoma cells
    Yuji Tada
    Division of Pathology, Chiba Cancer Center Research Institute, Chuo Ku, Chiba 260 8717, Japan
    Int J Mol Med 9:281-5. 2002
    ..In contrast to previous reports, the present study implies that T cells can also be effectors of FasL-mediated antitumor responses and neutrophils are not absolutely required for the responses...
  63. ncbi request reprint An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic death
    Jiyang O-Wang
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Biochem Biophys Res Commun 293:1132-7. 2002
    ..These results reveal an essential role for REV3 in the survival and growth of mammalian cells and suggest that Rev3(-/-) embryonic death occurs in a p53-independent pathway...
  64. ncbi request reprint Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy
    Shohei Kohno
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Oncol Rep 12:73-8. 2004
    ..These findings indicate that midkine promoter-based conditionally replicative adenovirus might be a promising new modality of gene therapy for malignant glioma...
  65. pmc Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer
    Eiji Toyoda
    Department of Hepato Biliary Pancreatic Surgery and Transplantation, Kyoto University, Japan
    J Exp Clin Cancer Res 27:30. 2008
    ..To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus...
  66. ncbi request reprint IL-28 elicits antitumor responses against murine fibrosarcoma
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 178:5086-98. 2007
    ..Moreover, IL-12 augmented IL-28-mediated antitumor activity in the presence or absence of IFN-gamma. These findings indicate that IL-28 has bioactivities that induce innate and adaptive immune responses against tumors...
  67. ncbi request reprint Carrier cell-mediated delivery of a replication-competent adenovirus for cancer gene therapy
    Katsuyuki Hamada
    Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime, Japan
    Mol Ther 15:1121-8. 2007
    ..This novel carrier cell-mediated viral transfection system might prove useful in a variety of cancer therapies...
  68. ncbi request reprint A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells
    Toshiro Shirakawa
    Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Cancer Res 10:4342-8. 2004
    ..In the present study, we examined the feasibility of using Cox-2 promoter-based replication-selective adenovirus for targeting bladder cancer cells that express Cox-2 transcriptional activity...
  69. ncbi request reprint Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy
    Katsuyuki Hamada
    Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Japan
    Cancer Res 63:2506-12. 2003
    ..These results demonstrate the usefulness of the IAI.3B promoter for generation of ovarian cancer-specific adenoviral vectors and provide a potential for the development of ovarian cancer-specific oncolytic viral therapies...
  70. ncbi request reprint Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model
    Shuji Terao
    Laboratory of Cell and Gene Therapy Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya shi, Hyogo, Japan
    Urology 70:1009-13. 2007
    ..To develop a novel therapeutic strategy against human bladder cancer using Ad-MK-E1a-a midkine (MK) promoter-regulated, conditionally replicating, adenovirus...
  71. ncbi request reprint [Biological and antitumor effects of CD40L on ovarian cancer cell line OVHM]
    Zheng Mao Zhang
    Department of Gynecology and Obstetrics and Research Center, The Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050011, P R China
    Ai Zheng 25:1102-7. 2006
    ..This study was to investigate the biological and antitumor effects of CD40L on ovarian cancer cell line OVHM (CD40-positive)...
  72. ncbi request reprint Antitumor activity and immune enhancement of murine interleukin-23 expressed in murine colon carcinoma cells
    Bao En Shan
    Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
    Cell Mol Immunol 3:47-52. 2006
    ..However, the level of IL-4 was not enhanced significantly. These data suggested that IL-23 secreted by tumor cells can induce antitumor activity by enhancing immune response...
  73. ncbi request reprint Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis
    Clarisse Bavoux
    Institute of Pharmacology and Structural Biology, Centre National de la Recherche Scientifique, Toulouse, France
    Cancer Res 65:325-30. 2005
    ..These data suggest that altered regulation of DNA metabolism might be related to cancer-associated genetic changes and phenotype...