Yoichi Suzuki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Large scale genotyping study for asthma in the Japanese population
    Yoshiko Imada
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305 8577 Japan
    BMC Res Notes 2:54. 2009
  2. ncbi request reprint Mutations in the holocarboxylase synthetase gene HLCS
    Yoichi Suzuki
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Hum Mutat 26:285-90. 2005
  3. ncbi request reprint Novel IRF6 mutations in Japanese patients with Van der Woude syndrome: two missense mutations (R45Q and P396S) and a 17-kb deletion
    Shuji Kayano
    Department of Medical Genetics, Tohoku University School of Medicine, Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 48:622-8. 2003
  4. ncbi request reprint Significant association between nonsyndromic oral clefts and arylhydrocarbon receptor nuclear translocator (ARNT)
    Shuji Kayano
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Am J Med Genet A 130:40-4. 2004
  5. ncbi request reprint A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation
    Fumiaki Kamada
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 51:455-60. 2006
  6. ncbi request reprint Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population
    Kiyoshi Kanno
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Am J Med Genet A 127:11-6. 2004
  7. ncbi request reprint Linkage and association of childhood asthma with the chromosome 12 genes
    Chenchen Shao
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 49:115-22. 2004
  8. ncbi request reprint Germline mutations in HRAS proto-oncogene cause Costello syndrome
    Yoko Aoki
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Nat Genet 37:1038-40. 2005
  9. doi request reprint Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study
    Hisako Enomoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    J Hum Genet 53:615-21. 2008
  10. ncbi request reprint Mutation analysis of the MMAA and MMAB genes in Japanese patients with vitamin B(12)-responsive methylmalonic acidemia: identification of a prevalent MMAA mutation
    Xue Yang
    Department of Medical Genetics, Tohoku University School of Medicine, Japan
    Mol Genet Metab 82:329-33. 2004

Detail Information

Publications41

  1. pmc Large scale genotyping study for asthma in the Japanese population
    Yoshiko Imada
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305 8577 Japan
    BMC Res Notes 2:54. 2009
    ..CONCLUSION: No association attained genome-wide significance, but several loci for possible association emerged. Future studies are required to validate these results for the prevention and treatment of asthma...
  2. ncbi request reprint Mutations in the holocarboxylase synthetase gene HLCS
    Yoichi Suzuki
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Hum Mutat 26:285-90. 2005
    ..Patients who have mutant HLCS with higher residual activity develop symptom after the neonatal period and show a good clinical response to biotin therapy...
  3. ncbi request reprint Novel IRF6 mutations in Japanese patients with Van der Woude syndrome: two missense mutations (R45Q and P396S) and a 17-kb deletion
    Shuji Kayano
    Department of Medical Genetics, Tohoku University School of Medicine, Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 48:622-8. 2003
    ..Our simple methods to identify deletions and to determine the boundaries of a deletion would facilitate the identification of such patients...
  4. ncbi request reprint Significant association between nonsyndromic oral clefts and arylhydrocarbon receptor nuclear translocator (ARNT)
    Shuji Kayano
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Am J Med Genet A 130:40-4. 2004
    ..021). The SNPs studied in AHR and CYP1A1 were not associated with the disease. Our results suggest that ARNT is involved in the development of nonsyndromic oral clefts in the Japanese population...
  5. ncbi request reprint A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation
    Fumiaki Kamada
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 51:455-60. 2006
    ..The phenotypic difference may be caused by the difference in pathogenic mechanisms: haploinsufficiency in deletions and dominant-negative effect in missense mutations...
  6. ncbi request reprint Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population
    Kiyoshi Kanno
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Am J Med Genet A 127:11-6. 2004
    ..0077). Our data suggest that GAD67 is involved in the pathogenesis of NSCLP in the Japanese population...
  7. ncbi request reprint Linkage and association of childhood asthma with the chromosome 12 genes
    Chenchen Shao
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Hum Genet 49:115-22. 2004
    ..Our results suggest that NOS1 and STAT6 are asthma-susceptibility genes and that chromosome region 12q24.23-q24.33 contains other susceptibility gene(s)...
  8. ncbi request reprint Germline mutations in HRAS proto-oncogene cause Costello syndrome
    Yoko Aoki
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Nat Genet 37:1038-40. 2005
    ..Our observations suggest that germline mutations in HRAS perturb human development and increase susceptibility to tumors...
  9. doi request reprint Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study
    Hisako Enomoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    J Hum Genet 53:615-21. 2008
    ..The combined P value for the family and case-control data was significant for the S2554X and combined null mutations. Our data further support the importance of FLG in AD development...
  10. ncbi request reprint Mutation analysis of the MMAA and MMAB genes in Japanese patients with vitamin B(12)-responsive methylmalonic acidemia: identification of a prevalent MMAA mutation
    Xue Yang
    Department of Medical Genetics, Tohoku University School of Medicine, Japan
    Mol Genet Metab 82:329-33. 2004
    ..This finding may facilitate the DNA diagnosis of vitamin B(12)-responsive MMA within the Japanese population...
  11. ncbi request reprint The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene
    Fumiaki Kamada
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Int Arch Allergy Immunol 144:275-86. 2007
    ..Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily...
  12. pmc Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans
    Ayumi Narisawa
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Hum Mol Genet 21:1496-503. 2012
    ..Overall, our findings suggest that loss-of-function mutations in GCS genes predispose to NTDs in mice and humans. These data highlight the importance of adequate function of mitochondrial folate metabolism in neural tube closure...
  13. pmc Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations
    Emiko Noguchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    PLoS Genet 7:e1002170. 2011
    ..5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations...
  14. doi request reprint A genome-wide association study identifies RNF213 as the first Moyamoya disease gene
    Fumiaki Kamada
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 56:34-40. 2011
    ..8, 95% confidence interval = 71.7-507.9). Three additional missense mutations were identified in the p.R4859K-negative patients. These results indicate that RNF213 is the first identified susceptibility gene for MMD...
  15. ncbi request reprint Mutation spectrum of the PCCA and PCCB genes in Japanese patients with propionic acidemia
    Xue Yang
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Mol Genet Metab 81:335-42. 2004
    ..7, and 13.3%, respectively. In conclusion, a limited number of mutations are predominant in both PCCA and PCCB genes among Japanese patients with propionic acidemia...
  16. ncbi request reprint Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness
    Takayuki Kudo
    Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Mol Genet 12:995-1004. 2003
    ....
  17. ncbi request reprint IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population
    Eduardo Jose Campos Alberto
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pediatr Allergy Immunol 19:716-21. 2008
    ..Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children...
  18. ncbi request reprint CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population
    Yuzaburo Inoue
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Infect Dis 195:1618-24. 2007
    ....
  19. ncbi request reprint Evaluation of clinical usefulness of second-generation HCV core antigen assay: comparison with COBAS AMPLICOR HCV MONITOR assay version 2.0
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:1136-41. 2005
    ..Hepatitis C virus (HCV) is an important etiologic agent for chronic liver diseases...
  20. ncbi request reprint No association of polymorphisms in the 5' region of the CD14 gene and food allergy in a Japanese population
    Eduardo Campos
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, and National Shimoshizu Hospital, Japan
    Allergol Int 56:23-7. 2007
    ..Although it has been shown that a polymorphism in the 5' region of the CD14 gene is associated with food allergy in white subjects, it is not clear whether this association is also present in the Japanese population...
  21. pmc Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families
    Hisako Enomoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    BMC Dermatol 7:5. 2007
    ..The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population...
  22. ncbi request reprint Lack of evidence for a significant association between nonsyndromic cleft lip with or without cleft palate and the retinoic acid receptor alpha gene in the Japanese population
    Kiyoshi Kanno
    Department of Plastic Surgery, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 47:269-74. 2002
    ..No association between this polymorphism and NSCLP was observed. Our findings suggest that the RARA gene variations do not contribute to the development of NSCLP in the Japanese population...
  23. ncbi request reprint Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency
    Shigeo Kure
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Mol Genet Metab 83:150-6. 2004
    ....
  24. ncbi request reprint Heterozygous GLDC and GCSH gene mutations in transient neonatal hyperglycinemia
    Shigeo Kure
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Ann Neurol 52:643-6. 2002
    ..Heterozygous mutations were identified in all of the three patients, suggesting that transient neonatal hyperglycinemia develops in some heterozygous carriers for nonketotic hyperglycinemia...
  25. ncbi request reprint Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia
    Tetsuya Niihori
    Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    J Hum Genet 50:192-202. 2005
    ..A comparison of the phosphatase activity in each mutant and a review of previously reported cases showed that high phosphatase activity observed in mutations at codons 61, 71, 72, and 76 was significantly associated with leukemogenesis...
  26. doi request reprint Association of the GABRB3 gene with nonsyndromic oral clefts
    Hiroki Inoue
    Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan
    Cleft Palate Craniofac J 45:261-6. 2008
    ..The GABRB3 gene is therefore a strong candidate gene for nonsyndromic oral clefts. We investigated here whether genetic variations of the GABRB3 gene affect the risk for nonsyndromic oral clefts...
  27. ncbi request reprint Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma
    Koichi Hasegawa
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Hum Genet 115:295-301. 2004
    ..4 x 10(-6)) and adult BA (P = 0.00063). These results suggest that the C3 and C5 pathways of the complement system play important roles in the pathogenesis of BA and that polymorphisms of these genes affect susceptibility to BA...
  28. ncbi request reprint Fas polymorphisms influence susceptibility to autoimmune hepatitis
    Akira Hiraide
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    Am J Gastroenterol 100:1322-9. 2005
    ..Polymorphisms of the gene encoding Fas have been linked to a variety of autoimmune diseases. We hypothesized that Fas gene polymorphisms might be genetic markers for AIH and PBC...
  29. ncbi request reprint Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa 230 0045, Japan
    J Hum Genet 49:370-5. 2004
    ..These results indicated that specific variants of the DAP3 gene might be associated with the mechanisms responsible for adult BA and contribute to airway inflammation and remodeling...
  30. ncbi request reprint Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease
    Kazunobu Ouchi
    Department of Pediatrics, Kawasaki Medical School, Kurashiki, Japan
    J Infect Dis 187:326-9. 2003
    ..This suggests possible explanations for both the infectious etiology of this disease and the genetic risk in the Japanese population...
  31. doi request reprint Association of TNFRSF4 gene polymorphisms with essential hypertension
    Yoichi Mashimo
    Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hypertens 26:902-13. 2008
    ..Since essential hypertension is a well-known risk factor for myocardial infarction, we hypothesized that TNFRSF4 could be a susceptibility gene for essential hypertension...
  32. ncbi request reprint Functional haplotypes of IL-12B are associated with childhood atopic asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism Research Center, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Allergy Clin Immunol 116:789-95. 2005
    ..Although associations between polymorphisms of IL-12B on chromosome 5q31-33 and asthma have been reported, the genetic influences of the polymorphisms and haplotype of IL-12B are unclear...
  33. pmc Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction model on childhood allergic asthma
    Yasuyuki Tomita
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    BMC Bioinformatics 5:120. 2004
    ..Here, we propose a susceptible marker-selectable artificial neural network (ANN) for predicting development of allergic disease...
  34. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  35. ncbi request reprint A functional polymorphism in MMP-9 is associated with childhood atopic asthma
    Kazuko Nakashima
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa 230 0045, Japan
    Biochem Biophys Res Commun 344:300-7. 2006
    ..Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms...
  36. ncbi request reprint [Relationship between allergy and fermented milk intake in school children]
    Yoichi Suzuki
    Arerugi 57:37-45. 2008
  37. ncbi request reprint Association of the RIP2 gene with childhood atopic asthma
    Kazuko Nakashima
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Kanagawa, Japan
    Allergol Int 55:77-83. 2006
    ..The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population...
  38. ncbi request reprint Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma
    Michishige Harada
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Am J Respir Cell Mol Biol 36:491-6. 2007
    ..These findings suggest that the SOCS1 gene might be involved in the development of adult asthma through functional genetic polymorphism...
  39. ncbi request reprint Pharmacogenetics of hormone replacement therapy for climacteric symptoms
    Chikari Takeo
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 374:604-8. 2008
    ..30, 95% CI 0.14-0.65, P=0.002) gene decreased HRT. rs2228480 in ERalpha gene also increased HRT. Tailored decisions can be expected on the future use of HRT referring genetic polymorphisms of individuals...
  40. ncbi request reprint An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
    Kazuko Nakashima
    Laboratory for Genetics of Allergic Diseases, RIKEN SNP Research Center, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    J Hum Genet 51:284-91. 2006
    ..Our results indicate that polymorphisms in IRAK-M and SIGIRR are not likely to be associated with the development of asthma in the Japanese population...
  41. doi request reprint Association study of the C3 gene with adult and childhood asthma
    Hiroki Inoue
    Department of Public Health, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 8670, Japan
    J Hum Genet 53:728-38. 2008
    ..Our results suggest that LD block 4 confers susceptibility to adult BA with mechanisms relevant to the effector phase of allergic inflammation...