K T Suzuki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Production of ascorbate and hydroxyl radicals in the liver of LEC rats in relation to hepatitis
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 96:137-46. 1997
  2. ncbi request reprint Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se
    K T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    Food Addit Contam 19:974-83. 2002
  3. doi request reprint Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 21:678-85. 2008
  4. ncbi request reprint Preferential organ distribution of methylselenol source Se-methylselenocysteine relative to methylseleninic acid
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 227:76-83. 2008
  5. ncbi request reprint Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Biochim Biophys Acta 1770:1053-61. 2007
  6. ncbi request reprint Metabolic differences between two dimethylthioarsenicals in rats
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 218:166-73. 2007
  7. ncbi request reprint Dimethylthioarsenicals as arsenic metabolites and their chemical preparations
    Kazuo T Suzuki
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 17:914-21. 2004
  8. ncbi request reprint Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 217:185-95. 2006
  9. ncbi request reprint Distributions and chemical forms of arsenic after intravenous administration of dimethylarsinic and monomethylarsonic acids to rats
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 198:336-44. 2004
  10. ncbi request reprint Availability and metabolism of 77Se-methylseleninic acid compared simultaneously with those of three related selenocompounds
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 217:51-62. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Production of ascorbate and hydroxyl radicals in the liver of LEC rats in relation to hepatitis
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 96:137-46. 1997
    ..The present results suggest that ascorbate and hydroxyl radicals are produced in the liver of LEC rats with the onset of jaundice, depending on the relative ratio of ascorbic acid and cuprous ions...
  2. ncbi request reprint Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se
    K T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    Food Addit Contam 19:974-83. 2002
    ....
  3. doi request reprint Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 21:678-85. 2008
    ..Furthermore, this new arsenic peak was consistent with the As-BP identified in the plasma in vivo, suggesting that arsenic bound to Hb further binds to haptoglobin (Hp), forming the ternary As-Hb-Hp complex...
  4. ncbi request reprint Preferential organ distribution of methylselenol source Se-methylselenocysteine relative to methylseleninic acid
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 227:76-83. 2008
    ....
  5. ncbi request reprint Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Biochim Biophys Acta 1770:1053-61. 2007
    ....
  6. ncbi request reprint Metabolic differences between two dimethylthioarsenicals in rats
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 218:166-73. 2007
    ....
  7. ncbi request reprint Dimethylthioarsenicals as arsenic metabolites and their chemical preparations
    Kazuo T Suzuki
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 17:914-21. 2004
    ..As the chemical species produced by reduction with the Reay and Asher method are DMTA(III) and DMTA(V), and different from DMA(III), the studies carried out with DMA(III) with the Reay and Asher method have to be reexamined...
  8. ncbi request reprint Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 217:185-95. 2006
    ..TMSe was produced much efficiently from MeSeCys than from SeMet and selenite, suggesting a role of methylselenol through the beta-lyase reaction in the metabolism of Se-methylated selenoamino acids...
  9. ncbi request reprint Distributions and chemical forms of arsenic after intravenous administration of dimethylarsinic and monomethylarsonic acids to rats
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 198:336-44. 2004
    ..Injections of DMA(V) and MMA(V) induced a biliary excretion of arsenic but only at 0.2-0.3% of the dose, the arsenic in the bile being their intact free forms...
  10. ncbi request reprint Availability and metabolism of 77Se-methylseleninic acid compared simultaneously with those of three related selenocompounds
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 217:51-62. 2006
    ..However, TMSe was not detected in the liver. The organ- and selenium source-specific production of TMSe was discussed as to the differences in selenium sources, and demethylation and methylation activity...
  11. ncbi request reprint Simultaneous tracing of 76Se-selenite and 77Se-selenomethionine by absolute labeling and speciation
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 217:43-50. 2006
    ..4) Selenosugars A and B but not trimethylselenonium (TMSe) were detected in the liver. (5) Selenosugar B and TMSe were detected in the kidneys...
  12. ncbi request reprint Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 206:1-8. 2005
    ..Chondroitin 4-sulfate did not affect the ratio of the two urinary metabolites, suggesting that the sugar source is of endogenous origin and that it increases with age...
  13. ncbi request reprint Distribution and reuse of 76Se-selenosugar in selenium-deficient rats
    Kazuo T Suzuki
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 216:303-8. 2006
    ..Effective use of an enriched stable isotope as an absolute label in hosts depleted of natural abundance isotopes was discussed for application in tracer experiments...
  14. ncbi request reprint Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    J Inorg Biochem 88:173-82. 2002
    ..These results suggest that MT causes the recruitment of Cu in a Cu-deficient environment by sequestering Cu from degraded Cu-enzymes and delivering it to Cu chaperones...
  15. ncbi request reprint Glutathione-conjugated arsenics in the potential hepato-enteric circulation in rats
    K T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Chem Res Toxicol 14:1604-11. 2001
    ..DMA is not excreted into the bile but into the bloodstream, accumulating in RBCs, and then excreted into the urine mostly in the form of DMA(V) in rats...
  16. ncbi request reprint Effects of dietary selenium species on Se concentrations in hair, blood, and urine
    Y Shiobara
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Toxicol Appl Pharmacol 152:309-14. 1998
    ..The results could be explained by regulated metabolism of selenite, and both nonregulated and regulated aspects of the metabolism of SeMet...
  17. ncbi request reprint Binding sites for the (Hg-Se) complex on selenoprotein P
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    Biochim Biophys Acta 1429:102-12. 1998
    ..100, while the number, m, in the [(Hg-Se)n]m-Sel P complex was estimated to be 35. The formation of the unit complex (Hg-Se)100, followed by its binding to Sel P at up to the 35 binding sites on Sel P was suggested...
  18. ncbi request reprint Copper increases in both plasma and red blood cells at the onset of acute hepatitis in LEC rats
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 103:189-94. 1999
    ..The source of the Cu increase in the RBCs was discussed, and it was assumed that the so-called free Cu ions that leak from the damaged hepatocytes are bound to albumin and/or taken up by the RBCs...
  19. ncbi request reprint Identification of the zinc-binding protein specifically present in male rat liver as carbonic anhydrase III
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    Chem Biol Interact 122:185-97. 1999
    ..The concentration of CAIII was decreased specifically by repeated injections of cupric ions without the Cu,Zn-SOD concentration being affected...
  20. ncbi request reprint Incorporation of selenium into selenoprotein P and extracellular glutathione peroxidase: HPLC-ICPMS data with enriched selenite
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Analyst 124:1749-53. 1999
    ....
  21. ncbi request reprint Metabolic transformation of methylseleninic acid through key selenium intermediate selenide
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, Japan
    Toxicol Appl Pharmacol 215:189-97. 2006
    ..MSA(IV) was suggested to be reduced to methylselenol (allowing the production of a proposed active form of selenium), and then transformed (demethylated) to selenide for utilization and excretion...
  22. ncbi request reprint Targeting of tetrathiomolybdate on the copper accumulating in the liver of LEC rats
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 70:49-55. 1998
    ..The results indicate that TTM is taken up by the liver depending on the amount of Cu accumulating in the form of MT, and then Cu is effluxed together with Mo in the form of Cu/TTM complex into the bloodstream...
  23. ncbi request reprint Metabolic fate of the insoluble copper/tetrathiomolybdate complex formed in the liver of LEC rats with excess tetrathiomolybdate
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    J Inorg Biochem 78:123-8. 2000
    ..It was concluded that, once Cu is complexed with TTM, the metal is excreted either immediately in the soluble form or slowly in the insoluble form into the bile and blood...
  24. ncbi request reprint Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium
    Yuki Ohta
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 226:169-77. 2008
    ..Organ-dependent differences in the methylation and demethylation reactions were characterized for the liver, kidney and lung...
  25. pmc Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range
    Yayoi Kobayashi
    Departments of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Proc Natl Acad Sci U S A 99:15932-6. 2002
    ..Urinary monomethylated (selenosugar) and trimethylated selenium can be used as specific indices that increase within the required to low-toxic range and with a distinct toxic dose, respectively...
  26. ncbi request reprint [Biological regulation of copper and selective removal of copper: therapy for Wilson disease and its molecular mechanism]
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Yakugaku Zasshi 120:899-908. 2000
    ....
  27. ncbi request reprint Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 75:199-204. 1999
    ..Although both TTM and DTM remove Cu from MT, DTM is not appropriate as a therapeutic agent for Wilson disease due to its easy hydrolysis and production of sulfide...
  28. ncbi request reprint Trivalent arsenicals are bound to proteins during reductive methylation
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Chem Res Toxicol 19:1010-8. 2006
    ..We also discussed the in vitro formation of dimethylthioarsenicals after incubating dimethylarsinous acid with liver homogenate...
  29. ncbi request reprint Animal species difference in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells
    Y Shiobara
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
    Chem Res Toxicol 14:1446-52. 2001
    ..The present results suggest that the uptake of DMA by RBCs is an additional contributing factor to the animal species difference in the metabolism of arsenic in addition to the reduction and methylation capacity in the liver...
  30. ncbi request reprint Speciation and metabolism of selenium injected with 82Se-enriched selenite and selenate in rats
    Y Kobayashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Chromatogr B Biomed Sci Appl 760:73-81. 2001
    ..These results suggest that although parenteral selenate is utilized less efficiently by the body, it is utilized in the liver in a similar manner to selenite much more safely...
  31. ncbi request reprint Arsenic metabolism and thioarsenicals in hamsters and rats
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 20:616-24. 2007
    ..In addition, arsenic was thiolated more in hamsters than in rats excreting mono and dimethylated thioarsenicals in urine...
  32. ncbi request reprint Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India
    B K Mandal
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Chem Res Toxicol 14:371-8. 2001
    ....
  33. ncbi request reprint Copper balance and ceruloplasmin in chronic hepatitis in a Wilson disease animal model, LEC rats
    Yutaka Komatsu
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Arch Toxicol 76:502-8. 2002
    ..The plasma Cu concentration and ferroxidase activity were proposed to be specific indicators of the appearance of non-metallothionein-bound Cu in the liver of LEC rats...
  34. doi request reprint Comparison of distribution and metabolism between tellurium and selenium in rats
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    J Inorg Biochem 102:1507-13. 2008
    ..In contrast, Se was not accumulated in RBCs. Finally, Te was excreted in urine as trimethyltelluronium and might be exhaled as dimethyltelluride. The results suggest that the metabolism of Te was distinct from that of Se in rats...
  35. doi request reprint Systemic distribution and speciation of diphenylarsinic acid fed to rats
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 237:214-20. 2009
    ..Furthermore, we also detected two unknown arsenic metabolites in rat urine, which were assumed to be hydroxylated arsenic metabolites...
  36. ncbi request reprint In vitro translation with [34S]-labeled methionine, selenomethionine, and telluromethionine
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:45-51. 2008
    ..figure: see text] TeMet was less incorporated into GFP than Met and SeMet due to its instability in WGE...
  37. ncbi request reprint Impact of arsenic in foodstuffs on the people living in the arsenic-affected areas of West Bengal, India
    Badal K Mandal
    Redox Regulation Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1741-52. 2007
    ..Inorganic As (iAs) predominates in rice (67.17-86.62%) and in spices (40-90.35%), respectively over organic As. So, As in the food chain is a real threat to human health...
  38. ncbi request reprint Nuclear trafficking of metallothionein requires oxidation of a cytosolic partner
    Yukihisa Takahashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, Japan
    J Cell Physiol 202:563-9. 2005
    ..Nuclear MT was proposed to protect the nuclei from the oxidation occurring with progression of the cell cycle...
  39. ncbi request reprint Simultaneous speciation of selenium and sulfur species in selenized odorless garlic (Allium sativum L. Shiro) and shallot (Allium ascalonicum) by HPLC-inductively coupled plasma-(octopole reaction system)-mass spectrometry and electrospray ionization-tand
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo, Chiba 260 8675, Japan
    J Chromatogr A 1093:118-25. 2005
    ..At least, four unidentified sulfur-containing compounds were detected in odorless garlic and shallot. Moreover, these Allium plants showed chemopreventive effects against human leukemia cells...
  40. ncbi request reprint Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Chuo, Japan
    Anal Bioanal Chem 379:861-6. 2004
    ..The selenized shiitake accumulated Se as SeMet, and SeMet might be bound to the water extractable high molecular mass protein(s)...
  41. doi request reprint Effects of chemical species of selenium on maternal transfer during pregnancy and lactation
    Yasumi Anan
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Life Sci 84:888-93. 2009
    ..This study compares the transfer from mother to fetuses and pups of selenium (Se) in the form of selenite, selenate, and selenomethionine (SeMet) labeled with different homo-elemental isotopes...
  42. ncbi request reprint Formation of dimethylthioarsenicals in red blood cells
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 227:390-9. 2008
    ..It was proposed that arsenic is excreted from hepatocytes into the bloodstream in the form of DMAIII and then taken up by RBCs in humans, where it is transformed into DMMTA(V) and then excreted again into the bloodstream...
  43. ncbi request reprint Speciation of arsenic in biological samples
    Badal Kumar Mandal
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 198:307-18. 2004
    ..Therefore, total As concentrations of nails could be considered as biomarker to As exposure in the endemic areas...
  44. doi request reprint Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism
    Takamitsu Miyayama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:1799-803. 2008
    ....
  45. doi request reprint Reaction mechanism underlying the in vitro transformation of thioarsenicals
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 231:328-35. 2008
    ....
  46. ncbi request reprint Identification of a novel selenium metabolite, Se-methyl-N-acetylselenohexosamine, in rat urine by high-performance liquid chromatography--inductively coupled plasma mass spectrometry and--electrospray ionization tandem mass spectrometry
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 767:301-12. 2002
    ..Thus, the major urinary Se metabolite was assigned as a diastereomer of a selenosugar, Se-methyl-N-acetyl-selenohexosamine...
  47. ncbi request reprint Protective role of metallothionein against copper depletion
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Arch Biochem Biophys 451:112-8. 2006
    ..Thus, MT was shown to be induced under Cu-deficient conditions to maintain the activities of intracellular cuproenzymes such as cytochrome c oxidase and Cu,zinc-superoxide dismutase...
  48. ncbi request reprint Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Chem Res Toxicol 20:1120-5. 2007
    ....
  49. doi request reprint Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1
    Takamitsu Miyayama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 237:205-13. 2009
    ..Cu imaging showed that the elevated Cu was compartmentalized in cytoplasmic vesicles. Together, the results point to the novel roles of MT and cytoplasmic vesicles in the detoxification of Cu in mammalian cells...
  50. ncbi request reprint Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry
    Badal Kumar Mandal
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Toxicol Appl Pharmacol 189:73-83. 2003
    ..DMA(III) content in fingernails and DMA(V) contents in both fingernails and hair could be the biomarker to As exposure...
  51. doi request reprint Theoretical calculations and reaction analysis on the interaction of pentavalent thioarsenicals with biorelevant thiol compounds
    Noriyuki Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Chem Res Toxicol 21:550-3. 2008
    ....
  52. ncbi request reprint Synchronized generation of reactive oxygen species with the cell cycle
    Yukihisa Takahashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chuo, Chiba 260 8675, Japan
    Life Sci 75:301-11. 2004
    ..Based on the present observations, we proposed for the first time that ROS are generated synchronously with the normal cell cycle, and that they have to be controlled at certain level for normal progress of the cell cycle...
  53. ncbi request reprint Heavy metal tolerance of transgenic tobacco plants over-expressing cysteine synthase
    Cintia Goulart Kawashima
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Biotechnol Lett 26:153-7. 2004
    ..These results suggest that the transgenic plants over-expressing cysteine synthase both in cytosol and chloroplasts can be applicable to phyto-remediation of Cd from contaminated soils...
  54. ncbi request reprint Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl
    Ryoya Takahashi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Mech Ageing Dev 123:1605-15. 2002
    ..The contradictory age-related change in the heat-shock response is discussed with the differences in biochemical and genetic properties of substrains of F344 rats...
  55. ncbi request reprint Soy protein isolate enhances hepatic copper accumulation and cell damage in LEC rats
    Kayo Yonezawa
    Department of Nutritional Science, Tokyo University of Agriculture, 1 1 Sakuragaoka 1, Setagaya, Tokyo 156 8502, USA
    J Nutr 133:1250-4. 2003
    ..However, this did not occur in the livers of F344 rats with wild-type Atp7b. Recommendations to individuals suffering from Wilson's disease to avoid consuming soy protein may be warranted...
  56. ncbi request reprint DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan
    Hiromi Sato
    Research Centre for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Environ Res 93:36-44. 2003
    ..This activity of ambient roadside air can be estimated using experimental animals, indicating that biological monitoring of DNA-adduct formation may be a powerful tool to assess the effect of ambient air on human health...
  57. ncbi request reprint Reaction of para-hydroxybenzoic acid esters with singlet oxygen in the presence of glutathione produces glutathione conjugates of hydroquinone, potent inducers of oxidative stress
    Chiho Nishizawa
    National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Free Radic Res 40:233-40. 2006
    ..The results obtained in this study indicate that parabens may induce oxidative stress in the skin after conversion to GSH conjugates of HQ by reacting with (1)O(2) and GSH...
  58. ncbi request reprint Early pathophysiological features in canine renal papillary necrosis induced by nefiracetam
    Yoshimi Tsuchiya
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Toxicol Pathol 33:561-9. 2005
    ..These results demonstrate that the epithelial cell in the papillary ducts is the primary target site for the onset of RPN evoked by nefiracetam...
  59. ncbi request reprint Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam
    Yoshimi Tsuchiya
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co Ltd, 16 13, Kita Kasai 1 Chome, Edogawa ku, Tokyo 134 8630, Japan
    Arch Toxicol 79:500-7. 2005
    ..These results demonstrate that changes in renal clusterin mRNA may reflect the progression or severity of RPN, whereas upregulation of tissue kallikrein mRNA may subsequently play a compensating role in the prevention of RPN...
  60. ncbi request reprint A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p
    Koichiro Kako
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tenno Dai, Tsukuba, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 324:1379-85. 2004
    ..These results suggest that the stringent selectivity of Cox17p for copper is required for CCO activation, to prevent copper overload, or promote the supply of copper...
  61. ncbi request reprint Effects of soy protein isolate on LEC rats, a model of Wilson disease: mechanisms underlying enhancement of liver cell damage
    Kayo Yonezawa
    Department of Nutritional Science, Tokyo University of Agriculture, 1 1 Sakuragaoka, 1, Setagaya, Tokyo, Japan
    Biochem Biophys Res Commun 302:271-4. 2003
    ..It is thus suggested that SPI enhances liver cell copper uptake through induction of Ctr1 expression and this might be the mechanism underlying increased liver damage in LEC rats...
  62. ncbi request reprint Hydroxyl radical generation caused by the reaction of singlet oxygen with a spin trap, DMPO, increases significantly in the presence of biological reductants
    Chiho Nishizawa
    Redox Regulation Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Free Radic Res 38:385-92. 2004
    ..These results suggest that biological reductants enhance the ESR signal of DMPO-OH produced by DMPO-mediated generation of *OH from 1O2, and that spin trap-mediated *OH generation hardly occurs with DEPMPO...
  63. ncbi request reprint Liquid chromatography-mass spectrometry (LC-MS): a powerful combination for selenium speciation in garlic (Allium sativum)
    Emmie Dumont
    Department of Analytical Chemistry, Ghent University, UGent, Proeftuinstraat 86, 9000 Gent, Belgium
    Anal Bioanal Chem 384:1196-206. 2006
    ..In both the simulated gastric and intestinal digests, Se-methionine, Se-methylselenocysteine, and gamma-glutamyl-Se-methylselenocysteine could be determined by LC-ESI-MS-MS by measuring their typical product ions...