Eiji Shimizu

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc A preliminary study of individual cognitive behavior therapy for social anxiety disorder in Japanese clinical settings: a single-arm, uncontrolled trial
    Naoki Yoshinaga
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 6:74. 2013
  2. ncbi request reprint Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Neurosci Lett 363:81-3. 2004
  3. ncbi request reprint Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    J Psychiatr Res 41:49-56. 2007
  4. ncbi request reprint Blepharospasm associated with olanzapine: a case report
    E Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8677, Japan
    Eur Psychiatry 19:389. 2004
  5. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
  6. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
  7. ncbi request reprint Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females
    Eiji Shimizu
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:99-103. 2006
  8. ncbi request reprint Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia
    Eiji Shimizu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:571-3. 2007
  9. ncbi request reprint Combined intoxication with methylone and 5-MeO-MIPT
    Eiji Shimizu
    Department of Integrative Neurophysiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:288-91. 2007
  10. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005

Detail Information

Publications85

  1. pmc A preliminary study of individual cognitive behavior therapy for social anxiety disorder in Japanese clinical settings: a single-arm, uncontrolled trial
    Naoki Yoshinaga
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 6:74. 2013
    ..We also examined the baseline predictors of outcomes associated with receiving CBT...
  2. ncbi request reprint Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Neurosci Lett 363:81-3. 2004
    ..56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group...
  3. ncbi request reprint Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    J Psychiatr Res 41:49-56. 2007
    ..These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia...
  4. ncbi request reprint Blepharospasm associated with olanzapine: a case report
    E Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8677, Japan
    Eur Psychiatry 19:389. 2004
  5. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
    ..Our results do not support the view that serum BDNF levels are associated with schizophrenia...
  6. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
    ..77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population...
  7. ncbi request reprint Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females
    Eiji Shimizu
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:99-103. 2006
    ..Taking into account the effects of multiple comparisons, this result should be interpreted with caution, and needs confirmation in a larger sample...
  8. ncbi request reprint Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia
    Eiji Shimizu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:571-3. 2007
    ..Using maintenance ECT, she was able to live in the custody of her parents after 7-years hospitalization. This case report suggests that continuation and maintenance ECT benefits patients with serious cases of refractory schizophrenia...
  9. ncbi request reprint Combined intoxication with methylone and 5-MeO-MIPT
    Eiji Shimizu
    Department of Integrative Neurophysiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:288-91. 2007
    ..This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs...
  10. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  11. doi request reprint Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction
    Daisuke Ishii
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:183-8. 2010
    ..These results suggested contextual fear conditioning could enhance acoustic PPI, and that contextual fear extinction could decrease freezing behaviors, but not acoustic PPI...
  12. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  13. doi request reprint Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 198:363-74. 2008
    ..However, differences in efficacy have also been reported, and further comparative pharmacological studies are still needed...
  14. ncbi request reprint Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004
    ..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders...
  15. doi request reprint Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:86-94. 2009
    ....
  16. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  17. doi request reprint Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:541-6. 2009
    ..We also found prepulse inhibition deficits reversed by clozapine and haloperidol in the Mdk(-/-) mice. Our results suggested that midkine deficiency may be related to neurochemical and behavioral dysfunctions in dopaminergic system...
  18. ncbi request reprint Deficits in auditory P50 inhibition in obsessive-compulsive disorder
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:288-96. 2008
    ..Our findings suggest that sensory gating deficits may be involved in the pathophysiology of OCD in a different way from clinical symptoms and executive attention dysfunction...
  19. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy
    Keisuke Kobayashi
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:658-63. 2005
    ..These results suggested that BDNF might contribute to therapeutic response of panic disorder. A potential link between an increased risk of secondary depression and BDNF remains to be investigated in the future...
  20. doi request reprint Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain
    Shingo Matsuda
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 39:273-9. 2012
    ..These results suggest that an increase in anxiety-like behavior induced by perinatal exposure to BPA may be related to decreases in DA metabolites in the brain, and there are sex differences in those BPA effects...
  21. doi request reprint d-serine enhances extinction of auditory cued fear conditioning via ERK1/2 phosphorylation in mice
    Shingo Matsuda
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:895-902. 2010
    ..The present study suggested that D-serine might enhance fear extinction through NMDA receptor-induced ERK signaling in mice, and that D-serine has potential clinical importance for the treatment of anxiety disorders...
  22. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  23. ncbi request reprint Possible role of D-serine in the pathophysiology of Alzheimer's disease
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:385-8. 2004
    ..36, p=0.018) lower than that of controls. The present study suggests that the reduced activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine may play a role in the pathophysiology of AD...
  24. ncbi request reprint Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex
    Naoe Okamura
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Brain Res 992:114-9. 2003
    ..5 mg/kg, i.p.). These results suggest that LY379268 has a protective effect on the neurotoxicity in the rat retrosplenial cortex after administration of NMDA receptor antagonists such as dizocilpine...
  25. ncbi request reprint Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Psychiatry 54:70-5. 2003
    ....
  26. ncbi request reprint No changes in serum epidermal growth factor levels in patients with schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 135:257-60. 2005
    ..Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits...
  27. ncbi request reprint Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine
    Goro Fukami
    Department of Psychiatry, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Brain Res 1016:90-5. 2004
    ....
  28. doi request reprint Impaired P50 suppression in fear extinction in obsessive-compulsive disorder
    Makoto Nanbu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:317-22. 2010
    ..The S2/S1 ratio in the extinction phase was significantly higher in the OCD patient group than in the healthy control group. In conclusion, our data suggested that P50 sensory gating in fear extinction was impaired in patients with OCD...
  29. ncbi request reprint Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Schizophr Res 76:67-72. 2005
    ..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia...
  30. ncbi request reprint Increased levels of serum basic fibroblast growth factor in schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 120:211-8. 2003
    ....
  31. ncbi request reprint Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropsychobiology 52:68-70. 2005
    ..Glutathione peroxidase 1 (GPX1) plays a role in the antioxidant defense system...
  32. ncbi request reprint The immunophilin ligand FK506 protects against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neuropharmacology 48:391-7. 2005
    ..These results suggest that FK506 shows protective effects on the MAP-induced neurotoxicity in the dopaminergic neurons of the mouse striatum...
  33. ncbi request reprint Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Japan
    Arch Gen Psychiatry 60:572-6. 2003
    ..The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls...
  34. ncbi request reprint Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 54:485-90. 2003
    ....
  35. doi request reprint Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway
    Daisuke Ishii
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neurosci Lett 471:53-7. 2010
    ..Our data suggested that aripiprazole may reverse MK-801-induced PPI deficits through regulation of MAPK phosphorylation in the same way as the atypical antipsychotic drug, clozapine...
  36. ncbi request reprint Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 124:61-3. 2004
    ..Our findings suggest that BDNF 196 A/G polymorphism might be associated with personality traits in female, but not male, healthy subjects...
  37. ncbi request reprint Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Ann N Y Acad Sci 1025:231-5. 2004
    ..Therefore, it is likely that NAC would be a suitable drug for treatment of neurotoxicity on dopaminergic nerve terminals related to chronic use of MAP in humans...
  38. pmc Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    PLoS ONE 3:e1944. 2008
    ..In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in patients...
  39. ncbi request reprint Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia
    Kimiyoshi Ozawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 59:546-54. 2006
    ..Maternal viral infection is associated with increased risk for schizophrenia. It is hypothesized that the maternal immune response to viruses may influence fetal brain development and lead to schizophrenia...
  40. ncbi request reprint Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:767-9. 2005
    ..This study suggests that synthetic or metabolic pathways of D-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia...
  41. doi request reprint Orbitofrontal cortex abnormality and deficit schizophrenia
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Schizophr Res 143:246-52. 2013
    ..These results demonstrated that at-rest hypofrontality was a common feature within the disease group and suggested that the OFC might play an important role in the development of severe negative symptoms in people with deficit syndrome...
  42. doi request reprint P50 suppression in human discrimination fear conditioning paradigm using danger and safety signals
    Taichi Kurayama
    Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, Japan
    Int J Psychophysiol 84:26-32. 2012
    ..These results suggest that the auditory P50 sensory gating might differ according to the cognition of the properties (potentially dangerous or safe) of the perceived signal...
  43. ncbi request reprint An open trial of outpatient group therapy for bulimic disorders: combination program of cognitive behavioral therapy with assertive training and self-esteem enhancement
    Akihiro Shiina
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Psychiatry Clin Neurosci 59:690-6. 2005
    ..06) were predictors of dropout from the CGCBT program. Our CGCBT program is a promising first-line treatment for bulimic outpatients. Lower age and the presence of comorbidity had effects on dropout rates...
  44. doi request reprint Neuronal activities of forebrain structures with respect to bladder contraction in cats
    Tatsuya Yamamoto
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Neurosci Lett 473:42-7. 2010
    ..Neurons recorded in forebrain structures were activated with respect to the contraction/relaxation cycles in the bladder. Forebrain structures may have a significant role in regulating bladder contraction in cats...
  45. ncbi request reprint Two clusters of serum midkine levels in drug-naive patients with schizophrenia
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 344:95-8. 2003
    ..018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia...
  46. ncbi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur J Pharmacol 519:114-7. 2005
    ..1 mg/kg). These findings suggest that PCP-induced cognitive deficits using the novel object recognition test may be a potential animal model of atypical antipsychotic activity...
  47. ncbi request reprint No changes in serum ghrelin levels in female patients with bulimia nervosa
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:1181-4. 2004
    ..Our study suggests that serum ghrelin levels in the patients with BN were indistinguishable from normal controls. Therefore, it is unlikely that ghrelin plays a role in the pathophysiology of BN...
  48. ncbi request reprint Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:499-504. 2005
    ..In addition, a more complete understanding of the signal transduction pathway via the p75 neurotrophin receptor (p75NTR) and TrkB receptors would provide new perspectives for treating eating disorders...
  49. ncbi request reprint Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine
    Naoe Okamura
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Neuropsychopharmacology 29:544-50. 2004
    ..These findings suggest that adenosine A(1) receptors agonists could protect against neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine...
  50. ncbi request reprint Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1381-93. 2006
    ..Therefore, minocycline could be considered as a useful drug for the treatment of several symptoms associated with METH abuse in humans...
  51. doi request reprint No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms
    Daisuke Ishii
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neurosci Lett 523:76-81. 2012
    ..These results suggested that fear extinction after retrieval in mice does not inhibit reconsolidation of previously consolidated fear memory in either a hippocampus-independent or -dependent paradigm...
  52. ncbi request reprint No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1117-21. 2006
    ..2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5)...
  53. ncbi request reprint Decreased cell proliferation in the dentate gyrus of alpha 7 nicotinic acetylcholine receptor heterozygous mice
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:517-20. 2004
    ..The results suggest that reduced levels of alpha 7 nAChRs may decrease cell proliferation of adult hippocampus...
  54. ncbi request reprint Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur J Pharmacol 544:1-9. 2006
    ..Our findings suggest that minocycline protects the neurotoxicity of the 5-HT and dopamine systems in the mouse brain after the administration of MDMA...
  55. ncbi request reprint Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex
    Naoe Okamura
    Department of Psychiatry K2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba, Chiba 260 8670, Japan
    Eur J Pharmacol 461:93-8. 2003
    ..Based on the NMDA receptor hypofunction hypothesis of schizophrenia, the efficacy of zotepine in this study may partly contribute to the unique therapeutic effects of zotepine in patients with schizophrenia...
  56. doi request reprint Possible involvement of brain-derived neurotrophic factor in eating disorders
    Michiko Nakazato
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
    IUBMB Life 64:355-61. 2012
    ..In the previous studies, serum BDNF levels in subjects with EDs are reduced significantly compared with healthy controls, hence, we proposed that levels of serum BDNF would be a useful diagnostic indicator for EDs...
  57. doi request reprint Tuning of the excitability of transcortical cutaneous reflex pathways during mirror-like activity
    Hiroyuki Ohtsuka
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Exp Brain Res 216:135-44. 2012
    ..These findings suggest that long latency reflexes, possibly transcortical cutaneous reflexes, are finely tuned in relation to mirror-like activity...
  58. ncbi request reprint Critical role of brain-derived neurotrophic factor in mood disorders
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res Brain Res Rev 45:104-14. 2004
    ..New agents capable of enhancing BDNF levels may lead aid the development of novel therapeutic drugs for patients with mood disorders...
  59. ncbi request reprint Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropsychopharmacology 29:2018-23. 2004
    ..Therefore, it is likely that NAC would be a suitable drug for treatment of neurotoxicity in dopaminergic nerve terminals related to chronic use of MAP in humans...
  60. ncbi request reprint [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]
    Eiji Shimizu
    Department of Psychiatry K2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:147-50. 2004
    ..In order to determine the precise mechanism underlying the relationship between reduced BDNF levels and the etiology of major depression under both genetic and environmental backgrounds, further detailed study will be necessary...
  61. doi request reprint Alterations of responsibility beliefs through cognitive-behavioural group therapy for obsessive-compulsive disorder
    Tadashi Haraguchi
    Chiba University Graduate School of Medicine, Japan
    Behav Cogn Psychother 39:481-6. 2011
    ..Inflated responsibility is the main feature of cognitive-behavioural models of obsessive-compulsive disorder (OCD). However, few studies have examined the effect of cognitive-behavioural group therapy (CBGT) on inflated responsibility...
  62. pmc Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    BMC Psychiatry 5:6. 2005
    ..This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients...
  63. doi request reprint Does hypofrontality expand to global brain area in progression of schizophrenia?: a cross-sectional study between first-episode and chronic schizophrenia
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:410-5. 2009
    ..The present study suggested that the reduction in rCBF occurs in the posterior brain area in addition to the frontal lobe across all clinical stages of schizophrenia...
  64. doi request reprint Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses
    Shingo Matsuda
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, Japan
    Chemosphere 78:894-906. 2010
    ..The present results suggest that BPA exposure at lower doses than environmentally relevant levels may have a great impact on monoamine levels in neonatal brain over 28d after its disappearance...
  65. ncbi request reprint Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 126:43-5. 2004
    ..007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects...
  66. doi request reprint Alterations of auditory p50 suppression in human fear conditioning and extinction
    Taichi Kurayama
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 65:495-502. 2009
    ..The processes of fear conditioning are thought to play roles in pathophysiology of anxiety disorders. Our aim was to investigate whether sensory gating would be physiologically altered by fear conditioning...
  67. ncbi request reprint The raphe magnus/pallidus regulates sweat secretion and skin vasodilation of the cat forepaw pad: a preliminary electrical stimulation study
    Masato Asahina
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Neurosci Lett 415:283-7. 2007
    ..Stimulation of the mid to caudal raphe magnus/pallidus elicited an increase in both sweat secretion and SkBF. The raphe magnus/pallidus may play a crucial role in skin vasomotor and sudomotor responses in the cat footpad...
  68. ncbi request reprint Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells
    Eiji Shimizu
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Neuropharmacology 43:434-43. 2002
    ..In addition, we found that NAC might work as a beneficial catecholaminergic neuron-survival factor more efficiently than exogenous glutathione or L-cystine...
  69. doi request reprint Referred sensations induced by a mirror box in healthy subjects
    Jun Takasugi
    Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Psychol Res 75:54-60. 2011
    ..In conclusion, an RS could be induced in healthy subjects on the mirror image of the hand by tactile stimulations, although this effect differed substantially among individuals...
  70. ncbi request reprint [The neurobiological approaches to obsessive-compulsive disorder]
    Eiji Shimizu
    Department of Psychiatry K2, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuouku, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 22:111-9. 2002
    ..Further research, genetic, neuroimmunological, and neuroimaging works may ultimately be useful in developing new treatments of OCD...
  71. doi request reprint Effects of electrical stimulation of the striatum on bladder activity in cats
    Tatsuya Yamamoto
    Department of Neurology, Chiba University, Chiba, Japan
    Neurourol Urodyn 28:549-54. 2009
    ..We assert that striatal dysfunction might contribute to the pathogenesis of detrusor overactivity in PD patients. However, the role of the striatum in bladder contraction remains unclear...
  72. ncbi request reprint Further analysis of microsatellite marker in the BDNF gene
    Hiroki Koizumi
    Am J Med Genet B Neuropsychiatr Genet 135:103. 2005
  73. ncbi request reprint Underrecognition of the severity of asthma and undertreatment of asthma in a rural area of Japan
    Katsuyuki Tomita
    Third Department of Internal Medicine, Tottori University, Yonago, and Department of Respiratory Medicine, San in Rosai Hospital, Japan
    J Asthma 42:689-96. 2005
    ..We reassessed the severity and possible undertreatment of asthma according to these guidelines in stable asthmatics...
  74. ncbi request reprint Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 394:101-4. 2006
    ....
  75. ncbi request reprint Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits
    Eiji Shimizu
    Am J Med Genet B Neuropsychiatr Genet 126:122-3. 2004
  76. ncbi request reprint Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder
    Naoe Okamura
    Department of Pharmacology, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1444-8. 2007
    ..These results provide evidence for a gender-specific effect of NPSR in the pathogenesis of panic disorder...
  77. ncbi request reprint Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Biol Psychiatry 57:1493-503. 2005
    ....
  78. ncbi request reprint Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele
    Hiroshi Takane
    Department of Pharmacy, Tottori University Hospital, Yonago, Japan
    Ther Drug Monit 29:666-8. 2007
    ..Screening of SLCO1B1*15 is suggested to be useful in irinotecan chemotherapy to avoid unpredicted severe toxicity, although the homozygous genotype is rare among the Japanese...
  79. ncbi request reprint Increased midkine levels in sera from patients with Alzheimer's disease
    Ragaa H M Salama
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:611-6. 2005
    ..We found that serum MK levels in patients with AD were increased in comparison with those of normal controls...
  80. ncbi request reprint Effect of Erabu sea snake (Laticauda semifasciata) lipids on the swimming endurance of mice
    Guihua Zhang
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu City, Japan
    Ann Nutr Metab 51:281-7. 2007
    ..This study was designed to investigate the effect of Erabu sea snake (Laticauda semifasciata) lipids on the swimming endurance of mice...
  81. ncbi request reprint Effect of Erabu sea snake (Laticauda semifasciata) lipids on the swimming endurance of aged mice
    Guihua Zhang
    United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:476-81. 2007
    ....
  82. ncbi request reprint Lithium augmentation in milnacipran-refractory depression for the prevention of relapse following electroconvulsive therapy
    Hideki Okamoto
    Aust N Z J Psychiatry 39:108. 2005
  83. pmc Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain
    Huimin Wang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 100:4287-92. 2003
    ....
  84. ncbi request reprint [Case of an HTLV-1 carrier complicated with chronic pulmonary histoplasmosis]
    Jun Kurai
    Division of Respiratory Medicine, Matsue City Hospital
    Nihon Kokyuki Gakkai Zasshi 46:737-42. 2008
    ..We raised the possibility that the development of pulmonary histoplasmosis might be associated with the HTLV-1 carrier...
  85. ncbi request reprint Schedule-dependent synergism of vinorelbine and 5-fluorouracil/UFT against non-small cell lung cancer
    Shingo Matsumoto
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, 36 1 Nishimachi, Yonago 683 8504, Japan
    Int J Oncol 25:1311-8. 2004
    ..This synergistic activity may be attributed to increased chemosensitivity to UFT caused by vinorelbine-induced suppression of TS...