Research Topics
Genomes and Genes
| Hideaki ShimadaSummaryAffiliation: Chiba University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinomaHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chiba, 260 8670, Japan
Cancer Sci 97:554-61. 2006..Observations from this study indicate that this treatment results in local antitumor effects in chemoradiation resistant esophageal squamous cell carcinoma...- Impact of the number and extent of positive lymph nodes in 200 patients with thoracic esophageal squamous cell carcinoma after three-field lymph node dissectionHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
World J Surg 30:1441-9. 2006..The purpose of this study was to evaluate the prognostic impact of the extent and number of positive lymph nodes for long-term survival of patients who underwent 3FLD... - Surgical outcome of elderly patients 75 years of age and older with thoracic esophageal carcinomaHideaki Shimada
Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chiba, Japan
World J Surg 31:773-9. 2007..This study aimed to evaluate the surgical outcome of esophagectomy in patients 75 years of age and older with thoracic esophageal carcinoma... - Surgical outcome after the clearance of abdominal metastatic lymph nodes in 138 patients with thoracic esophageal carcinomaHideaki Shimada
Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Am J Surg 193:448-52; discussion 453. 2007..The purpose of this study was to evaluate the patients' surgical outcome after the clearance of metastatic abdominal nodes... - Serological identification of tumor antigens of esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Int J Oncol 26:77-86. 2005..Antibodies against these SEREX antigens may represent a pool of candidates for serum tumor markers of esophageal squamous cell carcinoma... - Is the surgical stress associated with worse survival in patients with esophageal cancer?--Analysis of colon substitution for 37 patients with remnant stomachHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuou ku, Chiba 260 8677, Japan
Hepatogastroenterology 54:791-5. 2007..We evaluated the affect of this surgical stress on the postoperative course and long-term survival of patients with esophageal carcinoma... - Improved surgical results in thoracic esophageal squamous cell carcinoma: a 40-year analysis of 792 patientsHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuuou ku, Chiba, 260 8670, Japan
J Gastrointest Surg 12:518-26. 2008..Upper mediastinum lymphadenectomy was also an independent factor to improve survival of patients with thoracic esophageal SCC... - Long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinomaHideaki Shimada
Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
World J Surg 32:255-61. 2008..The purpose of this study was to evaluate surgical outcome after the clearance of metastatic thoracic lymph nodes... - Surgical outcome of patients with thoracic esophageal cancer positive for cervical lymph nodesHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Hepatogastroenterology 54:100-3. 2007..The purpose of this study was to predict patients with good prognosis among thoracic esophageal cancer patients with cervical node metastases... - Impact of lymph node involvement in T2 or T3 thoracic esophageal squamous cell carcinomaHideaki Shimada
Division of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona Chou, Chuou ku, Chiba 260 8717, Japan
Hepatogastroenterology 56:1039-43. 2009..Only a few study analyzed the prognostic impact of clinicopathological factors for surgical outcome of patients with esophageal carcinoma focused on T2/T3 tumors... - Prediction of lymph node status in patients with superficial esophageal carcinoma: analysis of 160 surgically resected cancersHideaki Shimada
Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Am J Surg 191:250-4. 2006..The ability to predict lymph node metastasis in cases of superficial esophageal carcinoma before surgery would allow the identification of specific patients who do not require additional surgical resection after endoscopic local resection... - Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISECTakaki Hiwasa
Department of Biochemistry and Genetics, Chiba University, Chuo Ku, Chiba 260 8670, Japan
Int J Oncol 34:641-8. 2009..These results suggested that esophageal SCC tissues produce AISEC in increased amounts, which can reduce the chemosensitivity against anticancer drugs possibly by suppressing the p53 transactivation ability... 
Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinomaHideaki Shimada
Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chiba, Japan
BMC Cancer 9:232. 2009..SEREX (serological identification of antigens by recombinant cDNA expression cloning) is suitable for large-scale screening of tumor antigens and has been applied for various types of human tumors...- Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Surgery 133:486-94. 2003..The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model... - Generation of antitumor immunity against large colon tumors by repeated runs of electrochemotherapyYoshio Gunji
Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University School of Medicine, Chiba, Japan
Hepatogastroenterology 52:770-4. 2005..This study was done to define how host antitumor immunity is generated by repeated electrochemotherapy treatments, and whether it is associated with regression of even large tumor nodules... 
Perioperative changes of serum p53 antibody titer is a predictor for survival in patients with esophageal squamous cell carcinomaHideaki Shimada
Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona cho, Chuou ku, Chiba, 260 8717, Japan
World J Surg 33:272-7. 2009....- Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiationHiroyuki Kitabayashi
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Oncol Rep 15:913-8. 2006..These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC... - Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinomaKazue Nakashima
Department of Academic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
Int J Cancer 112:1029-35. 2004..Thus, s-TROP2-Abs seemed useful in the diagnosis of SCC and may be a candidate for serum tumor markers... - SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expressionKazuyuki Matsushita
Department of Molecular Diagnosis F8, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
Mol Cancer Res 10:787-99. 2012..In conclusion, altered FIR and c-myc pre-mRNA splicing, in addition to c-Myc expression by augmented FIR/FIRΔexon2-SAP155 complex, potentially contribute to colorectal cancer development... - c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapyKazuyuki Matsushita
Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670
Front Biosci 14:3401-8. 2009..Together, one clue to the development of cancer diagnosis and therapies directed against c-Myc may go through FIR and its splicing variant... - Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporationMasaya Uesato
Department of Academic Surgery (M9, Graduate School of Medicine, Chiba University 1-8-1, Inohana, Chuou-ku, Chiba-city, Chiba 260-8670, Japan
Cancer Gene Ther 11:625-32. 2004..These data suggest that in vivo delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination... - Have surgical outcomes of pathologic T4 esophageal squamous cell carcinoma really improved? Analysis of 268 cases during 45 years of experienceHideaki Shimada
Department of Frontier Surgery and the Research Center for Frontier Medical Engineering, Chiba University Graduate School of Medicine, Chiba, Japan
J Am Coll Surg 206:48-56. 2008.... - Elevation of preoperative serum C-reactive protein level is related to poor prognosis in esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
J Surg Oncol 83:248-52. 2003..The aim of this study was to analyze the clinicopathological significance and the prognostic value of preoperative CRP levels in patients with esophageal squamous cell carcinomas... - Prognostic significance of CYFRA 21-1 in patients with esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba, Japan 260-8677
J Am Coll Surg 196:573-8. 2003..043). CONCLUSIONS: A high CYFRA 21-1 level is associated with tumor progression and poor survival in patients with esophageal squamous cell carcinoma... - Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinomaMari Kuboshima
Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Cancer Sci 97:380-6. 2006..013). s-TRIM21-Abs may be a useful tumor marker to diagnose and predict disease progression in patients with esophageal SCC... - Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakinTakanori Nishimori
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Proteomics 6:1011-8. 2006..These results suggest that periplakin could be a useful marker for detection of early esophageal cancer and evaluation of tumor progression... - Inhibitory remnant stomach motility by duodenal distention after B-I gastrectomyNobuo Hirayama
Department of Academic Surgery (M9, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
Hepatogastroenterology 52:633-8. 2005..CONCLUSIONS: Motility of the remnant stomach in B-I dogs was inhibited by duodenal distension. Increased levels of plasma CCK during distention might play a role in this feedback mechanism... - Location and clinical impact of solitary lymph node metastasis in patients with thoracic esophageal carcinomaHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8677, Japan
Am J Surg 192:306-10. 2006..CONCLUSIONS: The solitary positive lymph nodes were broadly distributed depending on the tumor location and tumor depth. Tumor depth and venous invasion were risk factors for poor survival in these patients... - Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesotheliomaAtsushi Kitamura
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
Cancer Sci 102:1366-73. 2011..Combination therapy with SeV/ΔF/FIR plus cisplatin has therapeutic potential against HMPM. SeV/ΔF/FIR plus cisplatin will be an attractive modality against HMPM in the future... - Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinomaHideaki Shimada
Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
Int J Oncol 30:97-103. 2007..Consequently, s-MMGL-Abs may be a useful tumor marker to diagnose and establish a prognosis in patients with esophageal SCC... - High en bloc resection rate achieved by endoscopic mucosal resection with IT knife for early gastric cancerShinichi Miyazaki
Department of Frontier Surgery (M9, Graduate School of Medicine, Chiba University, Chiba, Japan
Hepatogastroenterology 52:954-8. 2005..CONCLUSIONS: EMR by means of the IT knife under general anesthesia can be performed safely and adequately. It is a useful treatment modality for early gastric cancer... - Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
Cancer Sci 94:628-32. 2003..Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival... - Prognostic significance of serum p53 antibody in patients with esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, Japan
Surgery 132:41-7. 2002..001). CONCLUSIONS: We found that serum p53 antibody was useful to detect esophageal cancer and to identify those with a high risk of tumor recurrence and a poor prognosis... - Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancerHideaki Shimada
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8677, Japan
Oncol Rep 10:411-4. 2003..This S-MK positivity rate for detecting SESCC was significantly higher than for other tumor markers. Thus, S-MK may be useful as a tumor marker to detect SESCC... - Total laparoscopic resection of the gallbladder together with the gallbladder bedAkihiro Cho
Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chiba, 260 8717, Japan
J Hepatobiliary Pancreat Surg 15:585-8. 2008..We believe that this procedure represents a valid therapeutic option for carefully selected patients with T2 carcinoma of the gallbladder... - Evaluation of D3/D4 lymph node dissection for patients with grossly N2 positive advanced gastric cancerYoshio Gunji
Department of Academic Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuou ku, Chiba, 260 8670, Japan
Hepatogastroenterology 50:1178-82. 2003..However, the clinical evaluation of the superextended lymphadenectomy (D3/D4) for advanced type of gastric cancer has not been established... - Carbon-ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinomaAkinao Matsunaga
Department of Gene Therapy, Chiba University Graduate School of Medicine, Chiba, Japan
Cancer 116:3740-8. 2010..However, to date, few clinical or experimental studies have investigated the effects of CIB treatment on tumor recurrence and antitumor immunity... - Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma: a possible new serum marker for esophageal cancerHideaki Shimada
Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona cho, Chuou ku, Chiba, 260 8717, Japan
J Gastroenterol 44:691-6. 2009..Antibodies to SEREX antigens may be useful for the detection of esophageal squamous cell carcinoma (SCC)... - Laparoscopic major hepato-biliary-pancreatic surgery: formidable challenge to standardizationAkihiro Cho
Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba, 260 8717, Japan
J Hepatobiliary Pancreat Surg 16:705-10. 2009..However, laparoscopic major hepato-biliary-pancreatic surgery, such as hepatic lobectomy and pancreaticoduodenectomy, has not been widely developed because of technical difficulties... - Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: initial clinical resultsKoichi Hayano
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260 8677, Japan
Oncol Rep 18:901-8. 2007..006). Multivariate analysis identified blood flow as a significant independent prognostic factor (P=0.01). Therefore, Perfusion CT may help to identify patients with advanced esophageal squamous cell carcinoma who will benefit from CRT... - [Clinical application of alternative splicing form of c-myc suppressor FUSE-binding protein-interacting repressor for cancer detection and treatment]Kazuyuki Matsushita
Department of Molecular Diagnosis and Division of Clinical Genetics and Proteomics, Graduate School of Medicine, Chiba University, Japan
Rinsho Byori 57:1151-8. 2009..Together, FIR splicing variant, FIRDelta(exon)2 mRNA or proteins and its interacting proteins are applicable for novel screening tumor markers in colorectal cancer detection... - Evaluation of Ki-67 and p53 expression in primary and repeated liver metastases of GISTsYoshio Gunji
Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
Hepatogastroenterology 52:829-32. 2005..Immunohistochemical assessment of Ki-67 LI and p53 might be useful for evaluating changes related to tumor cell proliferation between primary and metastatic tumors of GISTs... - Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinomaMari Kuboshima
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo-ku, Chiba 260-8670, Japan
Int J Oncol 28:463-8. 2006..Because s-SLC2A1-Abs were not associated with the positivity of other conventional serum markers, a combination assay of s-SLC2A1-Abs with these conventional serum markers may be useful for the diagnosis and monitoring of esophageal SCC... - Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 geneFumio Nomura
Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
Alcohol Clin Exp Res 27:42S-46S. 2003..In this study, we determined how this tandem repeat polymorphism alters transcriptional activities of the human CYP2E1 gene by transfection studies... - Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agentsQuanhai Li
Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
Eur J Cancer 46:180-90. 2010.... - Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinomaMakoto Arai
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
Oncol Rep 20:405-12. 2008..Overexpression of NMES1 in ESCC cell lines increased cell motility. Down-regulation of NMES1 might play an important role in the cell motility of ESCC or be a potent marker of malignancy... - Activation of NFAT signal by p53-K120R mutantNatsuko Shinmen
Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chuo Ku, Chiba, Japan
FEBS Lett 583:1916-22. 2009..This suggests that acetylation at Lys-120 of p53 negatively regulates a signaling pathway leading to NFAT activation... - Safe and feasible inflow occlusion in laparoscopic liver resectionAkihiro Cho
Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba 260 8717, Japan
Surg Endosc 23:906-8. 2009..A major challenge in laparoscopic liver resection to avoid massive hemorrhage from the transection plane... - Treatment response and prognosis of patients after recurrence of esophageal cancerHideaki Shimada
Department of Academic Surgery and Radiology, Chiba University Graduate School of Medicine, Chiba, Japan
Surgery 133:24-31. 2003..CONCLUSION: The status of S-p53-Abs and S-CRP may predict response and outcome of patients with recurrence of esophageal cancer after radical operation... - Thrombocytosis associated with poor prognosis in patients with esophageal carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8677, Japan
J Am Coll Surg 198:737-41. 2004..52, 95% CI = 1.11 to 2.08, p = 0.009). CONCLUSIONS: A high platelet count is associated with tumor progression and poor survival in patients with esophageal carcinoma... - Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinomaHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba, Japan, 260 8677
Cancer 94:1947-54. 2002.... - Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancerHiroshi Kawahira
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuoh ku, Chiba, Japan
Cancer Sci 101:289-91. 2010..Although adenoviral DNA fragments may be pathogen-free, patients' feces and gargling saliva contain adenoviral DNA fragments for 12 days after injection... - S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancerMikito Mori
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
Oncol Rep 11:1287-93. 2004..It may also help clinicians predict the development of lymph node metastases and assist researchers in identifying novel therapeutic targets for patients with gastric cancer... - Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidyTakeshi Tomonaga
Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
Cancer Res 65:4683-9. 2005..These results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers... - High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancerHideaki Shimada
Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
Gastric Cancer 13:170-6. 2010..An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer... - A phase I/II clinical trial of preoperative short-course carbon-ion radiotherapy for patients with squamous cell carcinoma of the esophagusYasunori Akutsu
Investigators of the Working Group for Gastrointestinal Tumors, Chiba, Japan
J Surg Oncol 105:750-5. 2012..Carbon-ion radiotherapy (CIR) has been under development. We report the results of a phase I/II clinical trial of preoperative CIR for esophageal squamous cell carcinoma (ESCC)... - Rapid detection of metastasis of gastric cancer using reverse transcription loop-mediated isothermal amplificationDaisuke Horibe
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Int J Cancer 120:1063-9. 2007..This method is expected to play an essential role in the performance of tailor-made surgeries in the near future... - Hyperbaric oxygen therapy as a prophylactic and treatment against ileus and recurrent intestinal obstruction soon after surgery to relieve adhesive intestinal obstructionSatoshi Ambiru
Departments of General Surgery, Surgical Center, Chiba University Hospital, Chiba University Graduate School of Medicine, Chiba, Japan
J Gastroenterol Hepatol 23:e379-83. 2008.... - Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivoYoshinori Nimura
21st Century Center of Excellence Program, Chiba University Graduate School of Medicine, Chiba 260 8677, Japan
Int J Oncol 30:1477-84. 2007..Our results indicate that combined therapy consisting of Ku80 siRNA and irradiation contributes to inhibition of tumor growth and may be a novel strategy for cancer treatment... - An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesisKazuyuki Matsushita
Departments of Frontier Surgery, Molecular Diagnosis, and Molecular Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan 160 8670
Cancer Res 66:1409-17. 2006..These results strongly suggest the expression of this splicing variant promotes tumor development by disabling FIR repression and sustaining high levels of c-Myc and opposing apoptosis in colorectal cancer... - Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastasesTomoaki Karube
Department of Academic Surgery (M9, Graduate School of Medicine, Chiba University, Chiba, Japan
J Surg Oncol 87:32-8. 2004..CONCLUSIONS: The method was accurate in predicting nodal status and could be an indicator for less invasive treatment in patients with gastric cancer... - Extended left hepatectomy of the left and middle hepatic venous drainage areas along the anterior fissureAkihiro Cho
Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba, Japan
Am J Surg 200:186-90. 2010..Extended left hepatectomy including the middle hepatic vein (MHV) may potentially induce right paramedian sector congestion of the remnant liver... - Mode of lymphadenectomy and surgical outcome of upper thoracic esophageal squamous cell carcinomaHideaki Shimada
Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitonacho, Chuou ku, Chiba, 260 8717, Japan
J Gastrointest Surg 13:619-25. 2009..Only a few studies have evaluated the impact of clinicopathological variables and cervical lymphadenectomy on survival in patients with upper thoracic esophageal squamous cell carcinoma (SCC)... - Sensitization against anticancer drugs by transfection with UBE2I variant gene into ras-NIH3H3 mouse fibroblastsTooru Shiratori
Departments of Frontier Surgery, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba, Japan
Anticancer Res 27:3227-33. 2007..Thus, it is possible that UBE21-v5 plays a role in carcinogenesis by suppressing the function of CIEBPa and/or p53 via RPA2-like activity... - Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33(ING1) in T.Tn human esophageal carcinoma cellsHideaki Shimada
Department of Academic Surgery, Chiba University, Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
Oncogene 21:1208-16. 2002..These results imply a synergistic effect between p33 and p53 in the induction of apoptosis of human esophageal carcinoma cells. A role for Mdm2 in this synergism is suggested... - Gene therapy for esophageal squamous cell carcinomaHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine 1 8 1 Inohana Chuo ku Chiba shi, Chiba, Japan
Front Biosci 13:3364-72. 2008..This clinical trial was planned to evaluate vector tolerability and efficacy. A total of 10 patients were enrolled into this phase I/II trial... - Overexpression and mistargeting of centromere protein-A in human primary colorectal cancerTakeshi Tomonaga
Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
Cancer Res 63:3511-6. 2003..These results suggest that overexpression of CENP-A could play an important role for aneuploidy in colorectal cancers... - Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancerTakashi Uno
Department of Radiation Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
Anticancer Res 24:2483-6. 2004..To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older... - [Gene therapy for esophageal cancer]Hideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Nippon Geka Gakkai Zasshi 103:371-5. 2002..After giving informed consent, the first patient received injections of Ad5 CMV-p53 on December 19, 2000. No serious adverse events have occurred so far in these patients, and the trial has been conducted safely... - Recombinant Sendai virus vector induces complete remission of established brain tumors through efficient interleukin-2 gene transfer in vaccinated ratsYasuo Iwadate
Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan
Clin Cancer Res 11:3821-7. 2005..We also estimated the therapeutic efficacy of the novel vector system against a rat glioblastoma model... - [Gene therapy for esophageal cancer]Hideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine
Nippon Rinsho 63:517-21. 2005 - Serum cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as a prognostic tumor marker in patients with esophageal squamous cell carcinomaYoshihiro Nabeya
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Cancer 94:940-9. 2002..The objective of this work was to evaluate the value of serum ICTP as a tumor marker in patients with esophageal squamous cell carcinoma (SCC)... - Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situKazuyuki Matsushita
Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8677, Japan
Cancer Sci 97:57-63. 2006.... - Analysis of experimental liver metastasis from tumors inoculated in the mouse stomach cavityYoshio Gunji
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Japan
Surg Today 32:142-7. 2002..CONCLUSION: This experimental model of liver metastases will provide a useful means of understanding tumor biology and the regulation of liver metastases by host immunocompetent cells, and for assessing new therapeutic agents... - Recent advances in esophageal cancer gene therapyHideaki Shimada
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Ann Thorac Cardiovasc Surg 14:3-8. 2008..Lastly we review the available experimental therapeutic models from the literature and our experimental work over the past few years are reviewed... - p53 gene therapy for esophageal cancerHideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
J Gastroenterol 37:87-91. 2002..Up to December 1, 2001, four patients were enrolled in this phase I/II trial. No serious adverse events related to Ad5CMV-p53 have occurred so far in these patients, and the trial has been safely conducted... - Impact of preoperative dental plaque culture for predicting postoperative pneumonia in esophageal cancer patientsYasunori Akutsu
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Dig Surg 25:93-7. 2008..We evaluated the interaction between preoperative dental plaque and postoperative pneumonia in patients undergoing esophagectomy... - Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transferGaku Oohira
Department of Academic Surgery, Graduate School of Medicine, Chiba University, Japan
Int J Oncol 25:563-9. 2004..These data suggest that heavy carbon-ion beam irradiation combined with Ad.p53 may be a potentially effective therapeutic strategy for locally advanced esophageal SCC... - Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulationHideaki Shimada
Faculty of Education, Kumamoto University, 2 40 1, Kurokami, 860 8555, Japan
Toxicology 203:189-97. 2004..We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats... - [Gene therapy for esophageal cancer]Hideaki Shimada
Department of Academic Surgery, Chiba University Graduate School of Medicine
Nippon Rinsho 63:464-7. 2005..Six of ten patients were alive more than one-year after initiation of gene therapy. No severe side effects were observed. Although no significant response was observed, seven cases showed stable disease... - Possible involvement of antitumor immunity in the eradication of colon 26 induced by low-voltage electrochemotherapy with bleomycinShinichi Miyazaki
Department of Academic Surgery (M9, Graduate School of Medicine, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Surg Today 33:39-44. 2003..CONCLUSION: Our results suggest that the generation of T-cell-dependent, tumor-specific protective immunity might be involved in the process of tumor nodule regression in low-voltage electrochemotherapy... - Endoscopic mucosal resection of adenocarcinoma arising in ectopic gastric mucosa in the cervical esophagus: case reportNobuo Hirayama
Department of Academic Surgery(M9, Graduate School of Medicine, Chiba University, Japan
Gastrointest Endosc 57:263-6. 2003 - Cancer therapy with local oncolysis and topical cytokine secretionMasatoshi Tagawa
Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717 Japan
Front Biosci 13:2578-87. 2008..Combinatory gene therapy with oncolytic viruses and activation of host immune system thereby can evoke immune responses against all the tumor antigens expressed by the process of "antigen-spreading" mechanisms... - Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administrationTakeshi Miyamoto
Department of Immunology, Chiba University, Chuo-ku, Chiba 260-8670, Japan
Int Immunol 17:759-68. 2005..C-H2(bm1)/ByJ transplants. Thus, a direct manipulation of T cells through the introduction of the immunosuppressive cytokine gene IL-10 may be a novel strategy for the control of allograft rejection... - Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cellsLing Yu
Division of Pathology, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan
Oncol Rep 14:831-5. 2005.... - Sentinel lymph node mapping for gastric cancer using a dual procedure with dye- and gamma probe-guided techniquesHideki Hayashi
Department of Academic Surgery (M9, Chiba University Graduate School of Medicine, Chiba, Japan
J Am Coll Surg 196:68-74. 2003..CONCLUSIONS: SN mapping is feasible in gastric cancer, but the dye-guided and gamma probe-guided techniques are complementary. So we recommend the dual-mapping procedure... - Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancerTakashi Sugimoto
Department of Public Health, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
Oncol Rep 18:465-72. 2007..Thus, the integration of DNA and RNA profiles provides a highly productive entry point for the discovery of genes involved in the development and progression of esophageal cancer...