Hideaki Shimada

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    World J Surg 32:255-61. 2008
  2. ncbi request reprint Impact of the number and extent of positive lymph nodes in 200 patients with thoracic esophageal squamous cell carcinoma after three-field lymph node dissection
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    World J Surg 30:1441-9. 2006
  3. ncbi request reprint Impact of lymph node involvement in T2 or T3 thoracic esophageal squamous cell carcinoma
    Hideaki Shimada
    Division of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona Chou, Chuou ku, Chiba 260 8717, Japan
    Hepatogastroenterology 56:1039-43. 2009
  4. ncbi request reprint Prediction of lymph node status in patients with superficial esophageal carcinoma: analysis of 160 surgically resected cancers
    Hideaki Shimada
    Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Am J Surg 191:250-4. 2006
  5. ncbi request reprint Improved surgical results in thoracic esophageal squamous cell carcinoma: a 40-year analysis of 792 patients
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuuou ku, Chiba, 260 8670, Japan
    J Gastrointest Surg 12:518-26. 2008
  6. ncbi request reprint Serological identification of tumor antigens of esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 26:77-86. 2005
  7. ncbi request reprint Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chiba, 260 8670, Japan
    Cancer Sci 97:554-61. 2006
  8. ncbi request reprint Is the surgical stress associated with worse survival in patients with esophageal cancer?--Analysis of colon substitution for 37 patients with remnant stomach
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuou ku, Chiba 260 8677, Japan
    Hepatogastroenterology 54:791-5. 2007
  9. ncbi request reprint Surgical outcome of patients with thoracic esophageal cancer positive for cervical lymph nodes
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Hepatogastroenterology 54:100-3. 2007
  10. ncbi request reprint Surgical outcome of elderly patients 75 years of age and older with thoracic esophageal carcinoma
    Hideaki Shimada
    Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chiba, Japan
    World J Surg 31:773-9. 2007

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    World J Surg 32:255-61. 2008
    ..The purpose of this study was to evaluate surgical outcome after the clearance of metastatic thoracic lymph nodes...
  2. ncbi request reprint Impact of the number and extent of positive lymph nodes in 200 patients with thoracic esophageal squamous cell carcinoma after three-field lymph node dissection
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    World J Surg 30:1441-9. 2006
    ..The purpose of this study was to evaluate the prognostic impact of the extent and number of positive lymph nodes for long-term survival of patients who underwent 3FLD...
  3. ncbi request reprint Impact of lymph node involvement in T2 or T3 thoracic esophageal squamous cell carcinoma
    Hideaki Shimada
    Division of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona Chou, Chuou ku, Chiba 260 8717, Japan
    Hepatogastroenterology 56:1039-43. 2009
    ..Only a few study analyzed the prognostic impact of clinicopathological factors for surgical outcome of patients with esophageal carcinoma focused on T2/T3 tumors...
  4. ncbi request reprint Prediction of lymph node status in patients with superficial esophageal carcinoma: analysis of 160 surgically resected cancers
    Hideaki Shimada
    Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Am J Surg 191:250-4. 2006
    ..The ability to predict lymph node metastasis in cases of superficial esophageal carcinoma before surgery would allow the identification of specific patients who do not require additional surgical resection after endoscopic local resection...
  5. ncbi request reprint Improved surgical results in thoracic esophageal squamous cell carcinoma: a 40-year analysis of 792 patients
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuuou ku, Chiba, 260 8670, Japan
    J Gastrointest Surg 12:518-26. 2008
    ..Upper mediastinum lymphadenectomy was also an independent factor to improve survival of patients with thoracic esophageal SCC...
  6. ncbi request reprint Serological identification of tumor antigens of esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 26:77-86. 2005
    ..Antibodies against these SEREX antigens may represent a pool of candidates for serum tumor markers of esophageal squamous cell carcinoma...
  7. ncbi request reprint Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chiba, 260 8670, Japan
    Cancer Sci 97:554-61. 2006
    ..Observations from this study indicate that this treatment results in local antitumor effects in chemoradiation resistant esophageal squamous cell carcinoma...
  8. ncbi request reprint Is the surgical stress associated with worse survival in patients with esophageal cancer?--Analysis of colon substitution for 37 patients with remnant stomach
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuou ku, Chiba 260 8677, Japan
    Hepatogastroenterology 54:791-5. 2007
    ..We evaluated the affect of this surgical stress on the postoperative course and long-term survival of patients with esophageal carcinoma...
  9. ncbi request reprint Surgical outcome of patients with thoracic esophageal cancer positive for cervical lymph nodes
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Hepatogastroenterology 54:100-3. 2007
    ..The purpose of this study was to predict patients with good prognosis among thoracic esophageal cancer patients with cervical node metastases...
  10. ncbi request reprint Surgical outcome of elderly patients 75 years of age and older with thoracic esophageal carcinoma
    Hideaki Shimada
    Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chiba, Japan
    World J Surg 31:773-9. 2007
    ..This study aimed to evaluate the surgical outcome of esophagectomy in patients 75 years of age and older with thoracic esophageal carcinoma...
  11. ncbi request reprint Surgical outcome after the clearance of abdominal metastatic lymph nodes in 138 patients with thoracic esophageal carcinoma
    Hideaki Shimada
    Department of Frontier Surgery M9, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Am J Surg 193:448-52; discussion 453. 2007
    ..The purpose of this study was to evaluate the patients' surgical outcome after the clearance of metastatic abdominal nodes...
  12. pmc Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chiba, Japan
    BMC Cancer 9:232. 2009
    ..SEREX (serological identification of antigens by recombinant cDNA expression cloning) is suitable for large-scale screening of tumor antigens and has been applied for various types of human tumors...
  13. ncbi request reprint Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC
    Takaki Hiwasa
    Department of Biochemistry and Genetics, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 34:641-8. 2009
    ..These results suggested that esophageal SCC tissues produce AISEC in increased amounts, which can reduce the chemosensitivity against anticancer drugs possibly by suppressing the p53 transactivation ability...
  14. ncbi request reprint Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Surgery 133:486-94. 2003
    ..The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model...
  15. doi request reprint SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues
    Toshiko Kajiwara
    Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Sci 104:149-56. 2013
    ..Clinical implications for colorectal cancers of novel FIR splicing variants are also discussed in the present paper...
  16. ncbi request reprint Generation of antitumor immunity against large colon tumors by repeated runs of electrochemotherapy
    Yoshio Gunji
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University School of Medicine, Chiba, Japan
    Hepatogastroenterology 52:770-4. 2005
    ..This study was done to define how host antitumor immunity is generated by repeated electrochemotherapy treatments, and whether it is associated with regression of even large tumor nodules...
  17. doi request reprint Perioperative changes of serum p53 antibody titer is a predictor for survival in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona cho, Chuou ku, Chiba, 260 8717, Japan
    World J Surg 33:272-7. 2009
    ....
  18. ncbi request reprint Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin
    Takanori Nishimori
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Proteomics 6:1011-8. 2006
    ..These results suggest that periplakin could be a useful marker for detection of early esophageal cancer and evaluation of tumor progression...
  19. doi request reprint SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
    Mol Cancer Res 10:787-99. 2012
    ..In conclusion, altered FIR and c-myc pre-mRNA splicing, in addition to c-Myc expression by augmented FIR/FIRΔexon2-SAP155 complex, potentially contribute to colorectal cancer development...
  20. ncbi request reprint Synergistic antitumor effect of antiangiogenic factor genes on colon 26 produced by low-voltage electroporation
    Masaya Uesato
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University 1 8 1, Inohana, Chuou ku, Chiba City, Chiba 260 8670, Japan
    Cancer Gene Ther 11:625-32. 2004
    ..These data suggest that in vivo delivery of antiangiogenic genes with low-voltage electroporation could be a possible therapeutic strategy for established solid tumors when both genes were applied in combination...
  21. ncbi request reprint Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma
    Kazue Nakashima
    Department of Academic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    Int J Cancer 112:1029-35. 2004
    ..Thus, s-TROP2-Abs seemed useful in the diagnosis of SCC and may be a candidate for serum tumor markers...
  22. ncbi request reprint Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation
    Hiroyuki Kitabayashi
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncol Rep 15:913-8. 2006
    ..These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC...
  23. ncbi request reprint Location and clinical impact of solitary lymph node metastasis in patients with thoracic esophageal carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8677, Japan
    Am J Surg 192:306-10. 2006
    ..The location and clinical impact of solitary lymph node metastasis from thoracic esophageal carcinoma have not been evaluated sufficiently...
  24. ncbi request reprint Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
    Cancer Sci 94:628-32. 2003
    ..Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival...
  25. ncbi request reprint c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy
    Kazuyuki Matsushita
    Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670
    Front Biosci (Landmark Ed) 14:3401-8. 2009
    ..Together, one clue to the development of cancer diagnosis and therapies directed against c-Myc may go through FIR and its splicing variant...
  26. ncbi request reprint Have surgical outcomes of pathologic T4 esophageal squamous cell carcinoma really improved? Analysis of 268 cases during 45 years of experience
    Hideaki Shimada
    Department of Frontier Surgery and the Research Center for Frontier Medical Engineering, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 206:48-56. 2008
    ....
  27. ncbi request reprint Inhibitory remnant stomach motility by duodenal distention after B-I gastrectomy
    Nobuo Hirayama
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Hepatogastroenterology 52:633-8. 2005
    ..We found few reports so far concerned with the mechanical effect of balloon distention of the duodenum on the remnant stomach in B-I dogs...
  28. ncbi request reprint Elevation of preoperative serum C-reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Oncol 83:248-52. 2003
    ..The aim of this study was to analyze the clinicopathological significance and the prognostic value of preoperative CRP levels in patients with esophageal squamous cell carcinomas...
  29. ncbi request reprint Prognostic significance of CYFRA 21-1 in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba, Japan 260 8677
    J Am Coll Surg 196:573-8. 2003
    ..The aim of this study was to analyze the clinicopathologic and prognostic significance of preoperative CYFRA 21-1 in patients with esophageal squamous cell carcinoma...
  30. ncbi request reprint Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma
    Mari Kuboshima
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Sci 97:380-6. 2006
    ..013). s-TRIM21-Abs may be a useful tumor marker to diagnose and predict disease progression in patients with esophageal SCC...
  31. ncbi request reprint Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
    Int J Oncol 30:97-103. 2007
    ..Consequently, s-MMGL-Abs may be a useful tumor marker to diagnose and establish a prognosis in patients with esophageal SCC...
  32. doi request reprint Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma
    Atsushi Kitamura
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer Sci 102:1366-73. 2011
    ..Combination therapy with SeV/ΔF/FIR plus cisplatin has therapeutic potential against HMPM. SeV/ΔF/FIR plus cisplatin will be an attractive modality against HMPM in the future...
  33. pmc Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels
    Shinya Okamoto
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    PLoS ONE 8:e60297. 2013
    ....
  34. ncbi request reprint High en bloc resection rate achieved by endoscopic mucosal resection with IT knife for early gastric cancer
    Shinichi Miyazaki
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 52:954-8. 2005
    ..Circumferential endoscopic mucosal resection (EMR) around lesions performed by an insulation-tipped diathermic knife (IT knife) increases en bloc resection rates, suggesting the possibility of expanding indications for EMR...
  35. ncbi request reprint Carbon-ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma
    Akinao Matsunaga
    Department of Gene Therapy, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer 116:3740-8. 2010
    ..However, to date, few clinical or experimental studies have investigated the effects of CIB treatment on tumor recurrence and antitumor immunity...
  36. doi request reprint Total laparoscopic resection of the gallbladder together with the gallbladder bed
    Akihiro Cho
    Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chiba, 260 8717, Japan
    J Hepatobiliary Pancreat Surg 15:585-8. 2008
    ..We believe that this procedure represents a valid therapeutic option for carefully selected patients with T2 carcinoma of the gallbladder...
  37. ncbi request reprint Evaluation of D3/D4 lymph node dissection for patients with grossly N2 positive advanced gastric cancer
    Yoshio Gunji
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuou ku, Chiba, 260 8670, Japan
    Hepatogastroenterology 50:1178-82. 2003
    ..However, the clinical evaluation of the superextended lymphadenectomy (D3/D4) for advanced type of gastric cancer has not been established...
  38. ncbi request reprint Prognostic significance of serum p53 antibody in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Japan
    Surgery 132:41-7. 2002
    ..There is little information about the clinicopathologic and prognostic significance of preoperative serum p53 antibody in patients with esophageal cancer...
  39. doi request reprint Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Mol Cancer Res 11:689-98. 2013
    ....
  40. ncbi request reprint Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 20:405-12. 2008
    ..Overexpression of NMES1 in ESCC cell lines increased cell motility. Down-regulation of NMES1 might play an important role in the cell motility of ESCC or be a potent marker of malignancy...
  41. ncbi request reprint Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8677, Japan
    Oncol Rep 10:411-4. 2003
    ..This S-MK positivity rate for detecting SESCC was significantly higher than for other tumor markers. Thus, S-MK may be useful as a tumor marker to detect SESCC...
  42. ncbi request reprint Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo
    Yoshinori Nimura
    21st Century Center of Excellence Program, Chiba University Graduate School of Medicine, Chiba 260 8677, Japan
    Int J Oncol 30:1477-84. 2007
    ..Our results indicate that combined therapy consisting of Ku80 siRNA and irradiation contributes to inhibition of tumor growth and may be a novel strategy for cancer treatment...
  43. ncbi request reprint Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: initial clinical results
    Koichi Hayano
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260 8677, Japan
    Oncol Rep 18:901-8. 2007
    ..006). Multivariate analysis identified blood flow as a significant independent prognostic factor (P=0.01). Therefore, Perfusion CT may help to identify patients with advanced esophageal squamous cell carcinoma who will benefit from CRT...
  44. doi request reprint Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma: a possible new serum marker for esophageal cancer
    Hideaki Shimada
    Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitona cho, Chuou ku, Chiba, 260 8717, Japan
    J Gastroenterol 44:691-6. 2009
    ..Antibodies to SEREX antigens may be useful for the detection of esophageal squamous cell carcinoma (SCC)...
  45. ncbi request reprint [Clinical application of alternative splicing form of c-myc suppressor FUSE-binding protein-interacting repressor for cancer detection and treatment]
    Kazuyuki Matsushita
    Department of Molecular Diagnosis and Division of Clinical Genetics and Proteomics, Graduate School of Medicine, Chiba University, Japan
    Rinsho Byori 57:1151-8. 2009
    ..Together, FIR splicing variant, FIRDelta(exon)2 mRNA or proteins and its interacting proteins are applicable for novel screening tumor markers in colorectal cancer detection...
  46. ncbi request reprint Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma
    Mari Kuboshima
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 28:463-8. 2006
    ..Because s-SLC2A1-Abs were not associated with the positivity of other conventional serum markers, a combination assay of s-SLC2A1-Abs with these conventional serum markers may be useful for the diagnosis and monitoring of esophageal SCC...
  47. ncbi request reprint Evaluation of Ki-67 and p53 expression in primary and repeated liver metastases of GISTs
    Yoshio Gunji
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:829-32. 2005
    ..Immunohistochemical assessment of Ki-67 LI and p53 might be useful for evaluating changes related to tumor cell proliferation between primary and metastatic tumors of GISTs...
  48. ncbi request reprint Laparoscopic major hepato-biliary-pancreatic surgery: formidable challenge to standardization
    Akihiro Cho
    Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba, 260 8717, Japan
    J Hepatobiliary Pancreat Surg 16:705-10. 2009
    ..However, laparoscopic major hepato-biliary-pancreatic surgery, such as hepatic lobectomy and pancreaticoduodenectomy, has not been widely developed because of technical difficulties...
  49. ncbi request reprint Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene
    Fumio Nomura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Alcohol Clin Exp Res 27:42S-46S. 2003
    ..In this study, we determined how this tandem repeat polymorphism alters transcriptional activities of the human CYP2E1 gene by transfection studies...
  50. doi request reprint E1B-55 kDa-defective adenoviruses activate p53 in mesothelioma and enhance cytotoxicity of anticancer agents
    Makako Yamanaka
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    J Thorac Oncol 7:1850-7. 2012
    ..Genetic characterization of malignant mesothelioma shows a homozygous deletion of the INK4A/ARF locus, which results in inactivation of the p53 pathways...
  51. doi request reprint Activation of NFAT signal by p53-K120R mutant
    Natsuko Shinmen
    Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chuo Ku, Chiba, Japan
    FEBS Lett 583:1916-22. 2009
    ..This suggests that acetylation at Lys-120 of p53 negatively regulates a signaling pathway leading to NFAT activation...
  52. doi request reprint Safe and feasible inflow occlusion in laparoscopic liver resection
    Akihiro Cho
    Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba 260 8717, Japan
    Surg Endosc 23:906-8. 2009
    ..A major challenge in laparoscopic liver resection to avoid massive hemorrhage from the transection plane...
  53. doi request reprint Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents
    Quanhai Li
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Eur J Cancer 46:180-90. 2010
    ....
  54. ncbi request reprint High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer
    Hideaki Shimada
    Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
    Gastric Cancer 13:170-6. 2010
    ..An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer...
  55. ncbi request reprint Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8677, Japan
    J Am Coll Surg 198:737-41. 2004
    ..The aim of this study is to analyze the clinicopathologic significance and prognostic value of platelet counts in patients with esophageal cancer...
  56. ncbi request reprint Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy
    Takeshi Tomonaga
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Cancer Res 65:4683-9. 2005
    ..These results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers...
  57. ncbi request reprint S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer
    Mikito Mori
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 11:1287-93. 2004
    ..It may also help clinicians predict the development of lymph node metastases and assist researchers in identifying novel therapeutic targets for patients with gastric cancer...
  58. doi request reprint Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer
    Hiroshi Kawahira
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuoh ku, Chiba, Japan
    Cancer Sci 101:289-91. 2010
    ..Although adenoviral DNA fragments may be pathogen-free, patients' feces and gargling saliva contain adenoviral DNA fragments for 12 days after injection...
  59. ncbi request reprint Treatment response and prognosis of patients after recurrence of esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery and Radiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Surgery 133:24-31. 2003
    ..The aim of this study was to explore treatment responses and prognostic factors in patients with recurrent esophageal cancer...
  60. doi request reprint CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry
    Kiyoko Kawamura
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan E mail
    Am J Clin Pathol 140:544-9. 2013
    ..To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma...
  61. ncbi request reprint Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba, Japan, 260 8677
    Cancer 94:1947-54. 2002
    ....
  62. ncbi request reprint Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells
    Ling Yu
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Oncol Rep 14:831-5. 2005
    ....
  63. doi request reprint A phase I/II clinical trial of preoperative short-course carbon-ion radiotherapy for patients with squamous cell carcinoma of the esophagus
    Yasunori Akutsu
    Investigators of the Working Group for Gastrointestinal Tumors, Chiba, Japan
    J Surg Oncol 105:750-5. 2012
    ..Carbon-ion radiotherapy (CIR) has been under development. We report the results of a phase I/II clinical trial of preoperative CIR for esophageal squamous cell carcinoma (ESCC)...
  64. doi request reprint Extended left hepatectomy of the left and middle hepatic venous drainage areas along the anterior fissure
    Akihiro Cho
    Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba, Japan
    Am J Surg 200:186-90. 2010
    ..Extended left hepatectomy including the middle hepatic vein (MHV) may potentially induce right paramedian sector congestion of the remnant liver...
  65. ncbi request reprint Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases
    Tomoaki Karube
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Oncol 87:32-8. 2004
    ..This study aimed to estimate the clinical usefulness of SN mapping using a dual procedure with dye- and gamma probe-guided techniques for gastric cancers, based on immunohistochemical staining (IHC) analysis...
  66. ncbi request reprint Rapid detection of metastasis of gastric cancer using reverse transcription loop-mediated isothermal amplification
    Daisuke Horibe
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Cancer 120:1063-9. 2007
    ..This method is expected to play an essential role in the performance of tailor-made surgeries in the near future...
  67. ncbi request reprint Hyperbaric oxygen therapy as a prophylactic and treatment against ileus and recurrent intestinal obstruction soon after surgery to relieve adhesive intestinal obstruction
    Satoshi Ambiru
    Departments of General Surgery, Surgical Center, Chiba University Hospital, Chiba University Graduate School of Medicine, Chiba, Japan
    J Gastroenterol Hepatol 23:e379-83. 2008
    ....
  68. ncbi request reprint An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis
    Kazuyuki Matsushita
    Departments of Frontier Surgery, Molecular Diagnosis, and Molecular Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan 160 8670
    Cancer Res 66:1409-17. 2006
    ..These results strongly suggest the expression of this splicing variant promotes tumor development by disabling FIR repression and sustaining high levels of c-Myc and opposing apoptosis in colorectal cancer...
  69. ncbi request reprint Sensitization against anticancer drugs by transfection with UBE2I variant gene into ras-NIH3H3 mouse fibroblasts
    Tooru Shiratori
    Departments of Frontier Surgery, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba, Japan
    Anticancer Res 27:3227-33. 2007
    ..Thus, it is possible that UBE21-v5 plays a role in carcinogenesis by suppressing the function of CIEBPa and/or p53 via RPA2-like activity...
  70. doi request reprint Mode of lymphadenectomy and surgical outcome of upper thoracic esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitonacho, Chuou ku, Chiba, 260 8717, Japan
    J Gastrointest Surg 13:619-25. 2009
    ..Only a few studies have evaluated the impact of clinicopathological variables and cervical lymphadenectomy on survival in patients with upper thoracic esophageal squamous cell carcinoma (SCC)...
  71. ncbi request reprint Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33(ING1) in T.Tn human esophageal carcinoma cells
    Hideaki Shimada
    Department of Academic Surgery, Chiba University, Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Oncogene 21:1208-16. 2002
    ..These results imply a synergistic effect between p33 and p53 in the induction of apoptosis of human esophageal carcinoma cells. A role for Mdm2 in this synergism is suggested...
  72. ncbi request reprint Gene therapy for esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine 1 8 1 Inohana Chuo ku Chiba shi, Chiba, Japan
    Front Biosci 13:3364-72. 2008
    ..This clinical trial was planned to evaluate vector tolerability and efficacy. A total of 10 patients were enrolled into this phase I/II trial...
  73. ncbi request reprint Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer
    Takeshi Tomonaga
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Cancer Res 63:3511-6. 2003
    ..These results suggest that overexpression of CENP-A could play an important role for aneuploidy in colorectal cancers...
  74. ncbi request reprint [Gene therapy for esophageal cancer]
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Nihon Geka Gakkai Zasshi 103:371-5. 2002
    ..After giving informed consent, the first patient received injections of Ad5 CMV-p53 on December 19, 2000. No serious adverse events have occurred so far in these patients, and the trial has been conducted safely...
  75. ncbi request reprint Serum cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as a prognostic tumor marker in patients with esophageal squamous cell carcinoma
    Yoshihiro Nabeya
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 94:940-9. 2002
    ..The objective of this work was to evaluate the value of serum ICTP as a tumor marker in patients with esophageal squamous cell carcinoma (SCC)...
  76. ncbi request reprint p53 gene therapy for esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Gastroenterol 37:87-91. 2002
    ..Up to December 1, 2001, four patients were enrolled in this phase I/II trial. No serious adverse events related to Ad5CMV-p53 have occurred so far in these patients, and the trial has been safely conducted...
  77. ncbi request reprint Analysis of experimental liver metastasis from tumors inoculated in the mouse stomach cavity
    Yoshio Gunji
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Japan
    Surg Today 32:142-7. 2002
    ..This study was conducted to develop a patient-like hematogenous metastatic model of gastric-cancer in order to gain an understanding of the tumor biology and to search for new methods of treatment...
  78. ncbi request reprint Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer
    Takashi Uno
    Department of Radiation Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Anticancer Res 24:2483-6. 2004
    ..To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 75 and older...
  79. ncbi request reprint [Gene therapy for esophageal cancer]
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine
    Nihon Rinsho 63:517-21. 2005
  80. ncbi request reprint Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ
    Kazuyuki Matsushita
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8677, Japan
    Cancer Sci 97:57-63. 2006
    ....
  81. ncbi request reprint Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transfer
    Gaku Oohira
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Japan
    Int J Oncol 25:563-9. 2004
    ..These data suggest that heavy carbon-ion beam irradiation combined with Ad.p53 may be a potentially effective therapeutic strategy for locally advanced esophageal SCC...
  82. ncbi request reprint Recent advances in esophageal cancer gene therapy
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Thorac Cardiovasc Surg 14:3-8. 2008
    ..Lastly we review the available experimental therapeutic models from the literature and our experimental work over the past few years are reviewed...
  83. ncbi request reprint Impact of preoperative dental plaque culture for predicting postoperative pneumonia in esophageal cancer patients
    Yasunori Akutsu
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Dig Surg 25:93-7. 2008
    ..We evaluated the interaction between preoperative dental plaque and postoperative pneumonia in patients undergoing esophagectomy...
  84. ncbi request reprint Recombinant Sendai virus vector induces complete remission of established brain tumors through efficient interleukin-2 gene transfer in vaccinated rats
    Yasuo Iwadate
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:3821-7. 2005
    ..We also estimated the therapeutic efficacy of the novel vector system against a rat glioblastoma model...
  85. ncbi request reprint Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration
    Takeshi Miyamoto
    Department of Immunology, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Int Immunol 17:759-68. 2005
    ..C-H2(bm1)/ByJ transplants. Thus, a direct manipulation of T cells through the introduction of the immunosuppressive cytokine gene IL-10 may be a novel strategy for the control of allograft rejection...
  86. ncbi request reprint [Gene therapy for esophageal cancer]
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine
    Nihon Rinsho 63:464-7. 2005
    ..Six of ten patients were alive more than one-year after initiation of gene therapy. No severe side effects were observed. Although no significant response was observed, seven cases showed stable disease...
  87. ncbi request reprint Sentinel lymph node mapping for gastric cancer using a dual procedure with dye- and gamma probe-guided techniques
    Hideki Hayashi
    Department of Academic Surgery M9, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 196:68-74. 2003
    ..The objective of this study was to test the feasibility of SN mapping in gastric cancers by using the dual-mapping procedure with dye and radioactive colloid...
  88. ncbi request reprint Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancer
    Takashi Sugimoto
    Department of Public Health, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 18:465-72. 2007
    ..Thus, the integration of DNA and RNA profiles provides a highly productive entry point for the discovery of genes involved in the development and progression of esophageal cancer...
  89. ncbi request reprint Endoscopic mucosal resection of adenocarcinoma arising in ectopic gastric mucosa in the cervical esophagus: case report
    Nobuo Hirayama
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Gastrointest Endosc 57:263-6. 2003
  90. ncbi request reprint Possible involvement of antitumor immunity in the eradication of colon 26 induced by low-voltage electrochemotherapy with bleomycin
    Shinichi Miyazaki
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 33:39-44. 2003
    ..This study was done to define the precise nature of the involvement of antitumor immunity in the regression of tumor nodules in electrochemotherapy, and to evaluate the effectiveness of using low-voltage electroporation...
  91. ncbi request reprint Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, 860 8555, Japan
    Toxicology 203:189-97. 2004
    ..We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats...
  92. ncbi request reprint Cancer therapy with local oncolysis and topical cytokine secretion
    Masatoshi Tagawa
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717 Japan
    Front Biosci 13:2578-87. 2008
    ..Combinatory gene therapy with oncolytic viruses and activation of host immune system thereby can evoke immune responses against all the tumor antigens expressed by the process of "antigen-spreading" mechanisms...