Yasushi Saito

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi request reprint Pitavastatin: an overview
    Yasushi Saito
    Chiba University, Chiba, Japan
    Atheroscler Suppl 12:271-6. 2011
  2. ncbi request reprint Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation
    Shunsuke Furuta
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    J Immunol 180:6656-62. 2008
  3. ncbi request reprint Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells
    Meizi Jiang
    Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
    Biochem Biophys Res Commun 348:1367-77. 2006
  4. doi request reprint IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice
    Hidefumi Wakashin
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Am J Respir Crit Care Med 178:1023-32. 2008
  5. doi request reprint CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration
    Tatsushi Shimoyama
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Arterioscler Thromb Vasc Biol 30:675-82. 2010
  6. pmc Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system
    Yoshitaka Fukaya
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Chiba University, Chiba 260 0856, Japan
    Exp Mol Med 44:330-9. 2012
  7. pmc Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
    Meizi Jiang
    Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Invest 118:2733-46. 2008
  8. doi request reprint Fibrin glue is a candidate scaffold for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro
    Yasuyuki Aoyagi
    Center for Advanced Medicine, Chiba University Hospital, Chiba University, Chiba, Japan
    Exp Cell Res 318:8-15. 2012
  9. pmc Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
    Yoshihiro Oya
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Arthritis Rheum 58:2498-510. 2008
  10. ncbi request reprint A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages
    Kenji Ohwaki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Arterioscler Thromb Vasc Biol 27:1050-6. 2007

Collaborators

Detail Information

Publications64

  1. doi request reprint Pitavastatin: an overview
    Yasushi Saito
    Chiba University, Chiba, Japan
    Atheroscler Suppl 12:271-6. 2011
    ....
  2. ncbi request reprint Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation
    Shunsuke Furuta
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    J Immunol 180:6656-62. 2008
    ..These results indicate that STAT4 not only plays an indispensable role in T-bet-independent Th1 differentiation but also is involved in the maintenance of Th17 cells and the enhancement of allergic airway inflammation...
  3. ncbi request reprint Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells
    Meizi Jiang
    Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
    Biochem Biophys Res Commun 348:1367-77. 2006
    ..Modulation of the LR11/uPAR system with statins suggests a novel treatment strategy for atherogenesis based on suppression of intimal SMC migration...
  4. doi request reprint IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice
    Hidefumi Wakashin
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Am J Respir Crit Care Med 178:1023-32. 2008
    ..However, the role of the IL-23-Th17 cell axis in the regulation of allergic airway inflammation is still largely unknown. Objectives: To determine the role of IL-23 and Th17 cells in allergic airway inflammation...
  5. doi request reprint CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration
    Tatsushi Shimoyama
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Arterioscler Thromb Vasc Biol 30:675-82. 2010
    ..CCN3 belongs to the CCN family, which constitutes multifunctional secreted proteins that act as matrix cellular regulators. We investigated the pathophysiological roles of CCN3 in the vessels...
  6. pmc Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system
    Yoshitaka Fukaya
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Chiba University, Chiba 260 0856, Japan
    Exp Mol Med 44:330-9. 2012
    ..PRP may improve the outcome of transplantation of adipose tissue by enhancing the anti-apoptotic activities of the implanted preadipocytes...
  7. pmc Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
    Meizi Jiang
    Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Invest 118:2733-46. 2008
    ..Thus, we demonstrate a requirement for sLR11 in Ang II-induced SMC migration and propose what we believe is a novel role for sLR11 as a biomarker of carotid IMT...
  8. doi request reprint Fibrin glue is a candidate scaffold for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro
    Yasuyuki Aoyagi
    Center for Advanced Medicine, Chiba University Hospital, Chiba University, Chiba, Japan
    Exp Cell Res 318:8-15. 2012
    ....
  9. pmc Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
    Yoshihiro Oya
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Arthritis Rheum 58:2498-510. 2008
    ..The purpose of this study was to investigate the role of BTLA in the regulation of immune homeostasis and the pathogenesis of autoimmunity...
  10. ncbi request reprint A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages
    Kenji Ohwaki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Arterioscler Thromb Vasc Biol 27:1050-6. 2007
    ..Here we investigated whether the secreted soluble form of LR11 (solLR11) enhances adhesion, migration, and lipid accumulation in macrophages using animal models and cultured systems...
  11. ncbi request reprint LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors
    Kousei Tanaga
    Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
    Arterioscler Thromb Vasc Biol 24:1422-8. 2004
    ....
  12. pmc Development and characterization of IL-21-producing CD4+ T cells
    Akira Suto
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, 260 8670 Japan
    J Exp Med 205:1369-79. 2008
    ....
  13. ncbi request reprint T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways
    Michio Fujiwara
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Chiba University, Chiba, Japan
    J Allergy Clin Immunol 119:662-70. 2007
    ..However, the mechanism underlying T-bet-mediated inhibition of allergic airway inflammation is still unknown...
  14. doi request reprint Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression
    Kiyoshi Furukawa
    Department of Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi 260 8670, Japan
    Biochem Biophys Res Commun 405:521-6. 2011
    ..In conclusion, Smad3 is essential for controlling number and positioning of proliferating cells in the colonic crypts and contributes to formation of a "proliferative zone" at the bottom of colonic crypts in the normal colon...
  15. ncbi request reprint Obesity as a risk factor for coronary events in Japanese patients with hypercholesterolemia on low-dose simvastatin therapy
    Yasushi Saito
    Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Atheroscler Thromb 17:270-7. 2010
    ..In this study, the obese J-LIT subgroup was further analyzed to assess CHD risk...
  16. ncbi request reprint Increased matrix metalloproteinase-3 mRNA expression in visceral fat in mice implanted with cultured preadipocytes
    Hiroyuki Unoki
    Division of Applied Translational Research, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 350:392-8. 2006
    ..These results suggest a potential role of MMP-3, which promotes the TNF-alpha secretion, thus contributing to the disturbance of the functions in the adipocytes which accumulate in the visceral area...
  17. ncbi request reprint B and T lymphocyte attenuator inhibits antigen-induced eosinophil recruitment into the airways
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 143:50-5. 2007
    ..However, the role of B and T lymphocyte attenuator (BTLA), an inhibitory co-receptor expressed preferentially in Th1 cells, in the regulation of allergic airway inflammation remains to be determined...
  18. doi request reprint Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias
    Shio Sakai
    Department of Hematology, Chiba University Hospital, Chiba, Japan
    Clin Chim Acta 413:1542-8. 2012
    ..However, it is unknown whether LR11 is expressed on premature leukemic cells, and whether the levels of circulating soluble LR11 (sLR11) shed from leukemic cells correlate with disease state...
  19. ncbi request reprint Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation
    Naoki Tokumasa
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Chiba University, Inohana, Chiba, Japan
    Blood 110:553-60. 2007
    ....
  20. ncbi request reprint CD44 and hyaluronan engagement promotes dexamethasone resistance in human myeloma cells
    Chikako Ohwada
    Division of Hematology, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba City, Chiba, Japan
    Eur J Haematol 80:245-50. 2008
    ..Our data suggest that CD44 is not only an important mediator for the survival activity of HA, but it may also contribute to MM cell resistance to Dex...
  21. ncbi request reprint A potent activator of PPARalpha and gamma reduces the vascular cell recruitment and inhibits the intimal thickning in hypercholesterolemic rabbits
    Naoto Seki
    Department of Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Atherosclerosis 178:1-7. 2005
    ..These results suggest that the PPARalpha and gamma activator inhibits the recruitment of macrophages and SMCs in intima, possibly leading to the reduction of intimal hyperplasia in hypercholesterolemia...
  22. doi request reprint Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis preventi
    Koutaro Yokote
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Atherosclerosis 201:345-52. 2008
    ..To compare the efficacy and safety of pitavastatin and atorvastatin in Japanese patients with hypercholesterolemia...
  23. doi request reprint Ligation of CD44 leads to killing activity in human peripheral mononuclear cells via MAP kinase and tyrosine kinases
    Yasuhiro Ishizuka
    Department of Internal Medicine, Social Insurance Funabashi Central Hospital, Chiba, Japan
    Hematology 13:230-5. 2008
    ....
  24. ncbi request reprint Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes
    Hiroyuki Unoki
    Division of Applied Translational Research, Graduate School of Medicine, Chiba University, Chiba, Japan
    Diabetes Res Clin Pract 76:236-44. 2007
    ..Our present study suggests that AGE-RAGE interaction inhibits the glucose uptake through the overgeneration of intracellular ROS, thus indicating that it is involved in the development of obesity-related insulin resistance...
  25. ncbi request reprint Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison
    Yasushi Saito
    Second Department of Internal Medicine, School of Medicine, Chiba University, Chiba, Japan
    Arzneimittelforschung 52:251-5. 2002
    ..It also significantly decreased the serum levels of triglycerides (TG) within this dose range. There was no dose-dependence of the incidence of adverse reactions to pitavastatin...
  26. ncbi request reprint Effect of rosuvastatin 5-20mg on triglycerides and other lipid parameters in Japanese patients with hypertriglyceridemia
    Yasushi Saito
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Atherosclerosis 194:505-11. 2007
    ..The current study does not suggest a dose-related effect of rosuvastatin in lowering TG in hypertriglyceridemic Japanese patients, although dose-related improvements in other elements of the atherogenic lipid profile were observed...
  27. ncbi request reprint Revascularization determines volume retention and gene expression by fat grafts in mice
    Motoko Yamaguchi
    Department of Plastic, Reconstructive, and Esthetic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Exp Biol Med (Maywood) 230:742-8. 2005
    ..Early and adequate revascularization may be important for both the supply of nutrients and vasoactive interactions between vascular endothelial cells and adipocytes in graft...
  28. doi request reprint Hyper-responsiveness of adrenal gland to vasopressin resulting in enhanced plasma cortisol in patients with adrenal nodule(s)
    Sawako Suzuki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Peptides 29:1767-72. 2008
    ..The vasopressin responders among the patients with adrenal nodule(s) frequently had CS with low autonomous cortisol secretion...
  29. ncbi request reprint LRP1B is a negative modulator of increased migration activity of intimal smooth muscle cells from rabbit aortic plaques
    Naoto Seki
    Department of Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 331:964-70. 2005
    ..The regulation of LRP1B expression is possibly involved in the activated migration of intimal SMCs in the course of atherosclerosis...
  30. pmc Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells
    Takayoshi Owada
    Departments of Allergy and Clinical Immunology, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    J Leukoc Biol 87:425-32. 2010
    ....
  31. ncbi request reprint Tumor suppressor candidate 5 (TUSC5) is expressed in brown adipocytes
    Hisashi Koide
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 360:139-45. 2007
    ..These data suggested that TUSC5 is involved in the differentiation, and its expression is regulated independently of the beta-adrenergic pathway in BAT...
  32. doi request reprint Emergence of fibrocytes showing morphological changes in the inflamed colonic mucosa
    Hirotsugu Uehara
    Department of Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, Chiba shi 260 8670, Japan
    Dig Dis Sci 55:253-60. 2010
    ....
  33. doi request reprint Ceiling culture-derived proliferative adipocytes retain high adipogenic potential suitable for use as a vehicle for gene transduction therapy
    Sakiyo Asada
    Center for Advanced Medicine, Chiba University Hospital, Chiba University, Chiba, Japan
    Am J Physiol Cell Physiol 301:C181-5. 2011
    ....
  34. ncbi request reprint Clinicopathological features in patients with hepatic graft-versus-host disease
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:1849-53. 2005
    ..The present study was intended to examine clinicopathological features in patients in which acute GVHD appeared to progress gradually into chronic GVHD...
  35. ncbi request reprint IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    J Allergy Clin Immunol 118:606-14. 2006
    ..However, the roles of IL-25 in inducing allergic airway inflammation remain unknown...
  36. ncbi request reprint Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation
    Hiroaki Takatori
    Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba, Japan
    J Immunol 174:3734-40. 2005
    ..These results indicate that Stat5a plays an indispensable role in Stat6-independent Th2 cell differentiation and subsequent Th2 cell-mediated allergic airway inflammation...
  37. doi request reprint Ligation of CD44 with low-molecular-weight hyaluronan and a monoclonal antibody leads to inhibition of drug-induced apoptosis in a human myeloid cell line
    Masahiro Onoda
    Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
    Hematology 14:213-9. 2009
    ..These data indicate that tyrosine phosphorylation via CD44 is involved in the survival of primitive myeloid cells...
  38. ncbi request reprint Roles of degree of fat deposition and its localization on VEGF expression in adipocytes
    Saori Miyazawa-Hoshimoto
    Dept of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Am J Physiol Endocrinol Metab 288:E1128-36. 2005
    ..Plasma VEGF concentration in the mice implanted in visceral fat was higher than in controls. These results suggest that both the anatomic localization and the lipid accumulation are important for the VEGF production in adipocytes...
  39. doi request reprint Enhanced circulating soluble LR11 in patients with coronary organic stenosis
    Mao Takahashi
    Department of Cardiovascular Center, Sakura Hospital, Medical Center, Toho University, Chiba, Japan
    Atherosclerosis 210:581-4. 2010
    ..01). These results suggest that the circulating sLR11 might reflect coronary organic stenosis, and that hyperglycemic condition might be promoting factor for expression of LR11 in intimal smooth muscle cells...
  40. ncbi request reprint Activation of the Smad pathway in glomeruli from a spontaneously diabetic rat model, OLETF rats
    Yoko Furuse
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Nephron Exp Nephrol 98:e100-8. 2004
    ..Smad family proteins have been identified as signal transducers for the TGF-beta superfamily. We sought to characterize the role of Smad proteins in mediating TGF-beta responses in the development of diabetic nephropathy...
  41. doi request reprint Pancreatic polypeptide is secreted from and controls differentiation through its specific receptors in osteoblastic MC3T3-E1 cells
    Hiroaki Hosaka
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Peptides 29:1390-5. 2008
    ..These findings suggested that MC3T3-E1 cells produce and secrete PP, which may in turn stimulate the differentiation of MC3T3-E1 through its specific receptors in an autocrine manner...
  42. doi request reprint Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)
    Yasushi Saito
    Chiba University Graduate School of Medicine, Chiba, Japan
    Atherosclerosis 200:135-40. 2008
    ..Herein, we focused on risk factors other than low-density lipoprotein cholesterol (LDL-C) to investigate the effects of EPA on CAD among JELIS primary prevention cases...
  43. ncbi request reprint Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis
    Yuriko Yoshida
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Metabolism 53:1095-100. 2004
    ..05), but the insulin sensitivity index (S(i)) did not change significantly. These data suggest that weight reduction early in development of type 2 diabetes can oppose progression of diabetes by improving capacity for insulin release...
  44. doi request reprint Vasopressin responders have a high prevalence of hypertension and insulin resistance in spite of a lower secretion of cortisol in subclinical Cushing's syndrome
    Sawako Suzuki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Med Report 2:115-20. 2009
    ..Though vasopressin responders with subclinical CS had lower autonomous cortisol secretion, they had a high prevalence of hypertension, in which insulin resistance was closely correlated with cortisol response to vasopressin...
  45. doi request reprint Adsorptive depletion of alpha4 integrin(hi)- and CX3CR1hi-expressing proinflammatory monocytes in patients with ulcerative colitis
    Shin ichiro Takeda
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba shi, Japan
    Dig Dis Sci 55:1886-95. 2010
    ..The latter phenotype is elevated in patients with ulcerative colitis (UC) and is suspected to have a major role in the immunopathogenesis of UC...
  46. ncbi request reprint LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration
    Yanjuan Zhu
    Department of Clinical Cell Biology F5, Chiba University Graduate School of Medicine, Chiba, Japan
    Circ Res 94:752-8. 2004
    ..The novel mechanism of regulation of uPAR localization in SMCs accompanied with enhanced migration activity possibly constitutes an important factor in the process of atherosclerosis and arterial remodeling...
  47. ncbi request reprint Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice
    Hiroyuki Unoki-Kubota
    Division of Applied Translational Research, Chiba University Graduate School of Medicine, Chiba, Japan
    Protein Pept Lett 17:1177-81. 2010
    ..Our present study suggests the involvement of AGE in insulin resistance in KK-A(y) mice. Inhibition of AGE formation may be a novel therapeutic target for improving insulin resistance in diabetes with obesity...
  48. ncbi request reprint Activation of diacylglycerol O-acyltransferase 1 gene results in increased tumor necrosis factor-alpha gene expression in 3T3-L1 adipocytes
    Takashi Hirata
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    FEBS Lett 580:5117-21. 2006
    ..Furthermore, knockdown of DGAT1 gene significantly inhibited the TNF-alpha expression. Finally, the DGAT1 expression levels were closely related to the TNF-alpha level in 3T3-L1 adipocytes...
  49. doi request reprint A possible association between aldosterone response to vasopressin and circadian change of aldosterone in the patients with aldosterone-producing adenoma
    Sawako Suzuki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Peptides 29:2225-31. 2008
    ..These findings indicated that vasopressin might be involved in the coordination of aldosterone secretion through eutopic expression of V1a receptor in aldosterone-producing adenoma...
  50. doi request reprint A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology
    Aki Takada-Watanabe
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Geriatr Gerontol Int 12:140-6. 2012
    ..Moreover, a follow-up study of such case would be useful to understand how the various clinical symptoms in WS develop and progress over the years...
  51. ncbi request reprint The role of Smad3-dependent TGF-beta signal in vascular response to injury
    Koutaro Yokote
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Chiba University Hospital, Chiba, Japan
    Trends Cardiovasc Med 16:240-5. 2006
    ..This review summarizes the current view on involvement of TGF-beta in atherosclerotic vascular disease and discusses the role of Smad3-dependent TGF-beta signal in vascular response to injury...
  52. doi request reprint Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome
    Daijiro Abe
    Division of Hematology, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
    Blood 112:836-9. 2008
    ..1%. The IGLJ3*02 gene was used in 11 of 11 re-arrangements with an average homology of 92.2%. These data suggest that the highly restricted use of IGL V lambda 1 germlines plays an important role in the pathogenesis of POEMS syndrome...
  53. ncbi request reprint Randomized dose-response study of rosuvastatin in Japanese patients with hypercholesterolemia
    Yasushi Saito
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Atheroscler Thromb 10:329-36. 2003
    ..Rosuvastatin produces good dose-related reductions in LDL-C and beneficial changes in other lipid fractions in Japanese hypercholesterolemic patients and is well tolerated...
  54. ncbi request reprint Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling
    Yuko Maezawa
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 176:1013-8. 2006
    ..Taken together, these results indicate that TRAF6 plays a critical role in IL-25R-mediated NF-kappaB activation and gene expression...
  55. doi request reprint Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia
    Junji Moriya
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Circ Cardiovasc Interv 2:245-54. 2009
    ..However, the long-term outcome of such therapy has not been investigated...
  56. ncbi request reprint Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers
    Hidekazu Morita
    Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, 260 8670, Chuo Ward, Japan
    Exp Cell Res 298:1-8. 2004
    ..These results suggest that Cx26-mediated GJIC may play a crucial role in enhancing the barrier function of Caco-2 cell monolayers...
  57. ncbi request reprint Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation
    Toru Sato
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Gene 379:166-74. 2006
    ..We suggest that PcG complexes may act to mediate certain inductive signals maybe through IL-7Ralpha to allow sufficient proliferation of lymphoid inducer cells during PP organogenesis...
  58. doi request reprint Strong correlation between the concentration of dioxins and total PCBs in current Japanese people
    Chisato Mori
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Chemosphere 73:S235-8. 2008
    ..In conclusion, measurement of total PCBs concentration is useful for exposure assessment of dioxins in human blood...
  59. doi request reprint Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy
    Mayumi Higurashi
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Diabetes Complications 23:178-84. 2009
    ..These results suggest that these three CXC chemokines may be involved in the progression of human Type 2 diabetic nephropathy and that CXCL5 may be of use for telling diabetic nephropathy from primary renal diseases...
  60. pmc Critical appraisal of the role of pitavastatin in treating dyslipidemias and achieving lipid goals
    Yasushi Saito
    Chiba University, Chiba, Japan
    Vasc Health Risk Manag 5:921-36. 2009
    ..Pitavastatin produces adequate control of LDL-C and TG, along with potent and incremental HDL-C elevation, with a low frequency of DDIs...
  61. ncbi request reprint Clostridium butyricum TO-A culture supernatant downregulates TLR4 in human colonic epithelial cells
    Atsushi Isono
    Department of Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Dig Dis Sci 52:2963-71. 2007
    ..1 to the promoter region of the TLR4 gene was markedly inhibited when the cells were treated with butyrate. This study suggested that butyrate produced by C. butyricum TO-A downregulates TLR4 mRNA level in human colonic epithelial cells...
  62. ncbi request reprint Incidence of symptomatic vertebral fracture with high-dose glucocorticoid treatment in the Chiba-Shimoshizu Rheumatic Cohort between 1986 and 2006
    Takao Sugiyama
    Department of Rheumatology, National Hospital Organization Shimoshizu National Hospital, Chiba, Japan
    Endocr J 56:591-9. 2009
    ..Age, female, higher initial GC dose and GC dose-increase are the risk factors for the symptomatic vertebral fracture in those patients...
  63. ncbi request reprint Tyk2 is essential for IFN-alpha-induced gene expression in mast cells
    Yumiko Mori
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Int Arch Allergy Immunol 134:25-9. 2004
    ..These results indicate that IFN-alpha induces the expression of TNF-alpha and the chemokines IP-10 and MCP-5 in mast cells and thatTyk2 plays a nonredundant role in IFN-alpha signaling in mast cells...
  64. doi request reprint Clinical outcome and mechanism of soft tissue calcification in Werner syndrome
    Satoshi Honjo
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Rejuvenation Res 11:809-19. 2008
    ..An overexpression of Pit-1 therefore seems to play a key role in the formation of soft tissue calcification in this syndrome...