Y Ogra

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Chuo, Japan
    Anal Bioanal Chem 379:861-6. 2004
  2. doi request reprint Comparison of distribution and metabolism between tellurium and selenium in rats
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    J Inorg Biochem 102:1507-13. 2008
  3. ncbi request reprint Integrated strategies for identification of selenometabolites in animal and plant samples
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:1685-9. 2008
  4. ncbi request reprint In vitro translation with [34S]-labeled methionine, selenomethionine, and telluromethionine
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:45-51. 2008
  5. ncbi request reprint Simultaneous speciation of selenium and sulfur species in selenized odorless garlic (Allium sativum L. Shiro) and shallot (Allium ascalonicum) by HPLC-inductively coupled plasma-(octopole reaction system)-mass spectrometry and electrospray ionization-tand
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo, Chiba 260 8675, Japan
    J Chromatogr A 1093:118-25. 2005
  6. ncbi request reprint Metabolic fate of the insoluble copper/tetrathiomolybdate complex formed in the liver of LEC rats with excess tetrathiomolybdate
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    J Inorg Biochem 78:123-8. 2000
  7. ncbi request reprint Targeting of tetrathiomolybdate on the copper accumulating in the liver of LEC rats
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 70:49-55. 1998
  8. ncbi request reprint Copper increases in both plasma and red blood cells at the onset of acute hepatitis in LEC rats
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 103:189-94. 1999
  9. ncbi request reprint Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 75:199-204. 1999
  10. ncbi request reprint Identification of the zinc-binding protein specifically present in male rat liver as carbonic anhydrase III
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    Chem Biol Interact 122:185-97. 1999

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Chuo, Japan
    Anal Bioanal Chem 379:861-6. 2004
    ..The selenized shiitake accumulated Se as SeMet, and SeMet might be bound to the water extractable high molecular mass protein(s)...
  2. doi request reprint Comparison of distribution and metabolism between tellurium and selenium in rats
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    J Inorg Biochem 102:1507-13. 2008
    ..In contrast, Se was not accumulated in RBCs. Finally, Te was excreted in urine as trimethyltelluronium and might be exhaled as dimethyltelluride. The results suggest that the metabolism of Te was distinct from that of Se in rats...
  3. ncbi request reprint Integrated strategies for identification of selenometabolites in animal and plant samples
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:1685-9. 2008
  4. ncbi request reprint In vitro translation with [34S]-labeled methionine, selenomethionine, and telluromethionine
    Yasumitsu Ogra
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:45-51. 2008
    ..figure: see text] TeMet was less incorporated into GFP than Met and SeMet due to its instability in WGE...
  5. ncbi request reprint Simultaneous speciation of selenium and sulfur species in selenized odorless garlic (Allium sativum L. Shiro) and shallot (Allium ascalonicum) by HPLC-inductively coupled plasma-(octopole reaction system)-mass spectrometry and electrospray ionization-tand
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo, Chiba 260 8675, Japan
    J Chromatogr A 1093:118-25. 2005
    ..At least, four unidentified sulfur-containing compounds were detected in odorless garlic and shallot. Moreover, these Allium plants showed chemopreventive effects against human leukemia cells...
  6. ncbi request reprint Metabolic fate of the insoluble copper/tetrathiomolybdate complex formed in the liver of LEC rats with excess tetrathiomolybdate
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    J Inorg Biochem 78:123-8. 2000
    ..It was concluded that, once Cu is complexed with TTM, the metal is excreted either immediately in the soluble form or slowly in the insoluble form into the bile and blood...
  7. ncbi request reprint Targeting of tetrathiomolybdate on the copper accumulating in the liver of LEC rats
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 70:49-55. 1998
    ..The results indicate that TTM is taken up by the liver depending on the amount of Cu accumulating in the form of MT, and then Cu is effluxed together with Mo in the form of Cu/TTM complex into the bloodstream...
  8. ncbi request reprint Copper increases in both plasma and red blood cells at the onset of acute hepatitis in LEC rats
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 103:189-94. 1999
    ..The source of the Cu increase in the RBCs was discussed, and it was assumed that the so-called free Cu ions that leak from the damaged hepatocytes are bound to albumin and/or taken up by the RBCs...
  9. ncbi request reprint Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper
    Y Ogra
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Inorg Biochem 75:199-204. 1999
    ..Although both TTM and DTM remove Cu from MT, DTM is not appropriate as a therapeutic agent for Wilson disease due to its easy hydrolysis and production of sulfide...
  10. ncbi request reprint Identification of the zinc-binding protein specifically present in male rat liver as carbonic anhydrase III
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Japan
    Chem Biol Interact 122:185-97. 1999
    ..The concentration of CAIII was decreased specifically by repeated injections of cupric ions without the Cu,Zn-SOD concentration being affected...
  11. ncbi request reprint Incorporation of selenium into selenoprotein P and extracellular glutathione peroxidase: HPLC-ICPMS data with enriched selenite
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Analyst 124:1749-53. 1999
    ....
  12. pmc Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range
    Yayoi Kobayashi
    Departments of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Proc Natl Acad Sci U S A 99:15932-6. 2002
    ..Urinary monomethylated (selenosugar) and trimethylated selenium can be used as specific indices that increase within the required to low-toxic range and with a distinct toxic dose, respectively...
  13. ncbi request reprint Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se
    K T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    Food Addit Contam 19:974-83. 2002
    ....
  14. ncbi request reprint Speciation and metabolism of selenium injected with 82Se-enriched selenite and selenate in rats
    Y Kobayashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Chromatogr B Biomed Sci Appl 760:73-81. 2001
    ..These results suggest that although parenteral selenate is utilized less efficiently by the body, it is utilized in the liver in a similar manner to selenite much more safely...
  15. ncbi request reprint Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India
    B K Mandal
    Faculty of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Chem Res Toxicol 14:371-8. 2001
    ....
  16. ncbi request reprint Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes
    Yoshiro Tsuji
    Graduate School of Pharmaceutical Sciences, Chiba University
    J Toxicol Sci 34:191-200. 2009
    ..The results suggest that MeSeCys was transformed into selenide via methylselenol by beta-lyase. Consequently, it is surmised that MeSeCys is a precursor of methylselenol under long-term ingestion...
  17. ncbi request reprint Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 206:1-8. 2005
    ..Chondroitin 4-sulfate did not affect the ratio of the two urinary metabolites, suggesting that the sugar source is of endogenous origin and that it increases with age...
  18. ncbi request reprint Nuclear trafficking of metallothionein requires oxidation of a cytosolic partner
    Yukihisa Takahashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, Japan
    J Cell Physiol 202:563-9. 2005
    ..Nuclear MT was proposed to protect the nuclei from the oxidation occurring with progression of the cell cycle...
  19. ncbi request reprint Distributions and chemical forms of arsenic after intravenous administration of dimethylarsinic and monomethylarsonic acids to rats
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 198:336-44. 2004
    ..Injections of DMA(V) and MMA(V) induced a biliary excretion of arsenic but only at 0.2-0.3% of the dose, the arsenic in the bile being their intact free forms...
  20. ncbi request reprint Dimethylthioarsenicals as arsenic metabolites and their chemical preparations
    Kazuo T Suzuki
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 17:914-21. 2004
    ..As the chemical species produced by reduction with the Reay and Asher method are DMTA(III) and DMTA(V), and different from DMA(III), the studies carried out with DMA(III) with the Reay and Asher method have to be reexamined...
  21. ncbi request reprint Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice
    Kazuo T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    J Inorg Biochem 88:173-82. 2002
    ..These results suggest that MT causes the recruitment of Cu in a Cu-deficient environment by sequestering Cu from degraded Cu-enzymes and delivering it to Cu chaperones...
  22. ncbi request reprint Copper balance and ceruloplasmin in chronic hepatitis in a Wilson disease animal model, LEC rats
    Yutaka Komatsu
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Arch Toxicol 76:502-8. 2002
    ..The plasma Cu concentration and ferroxidase activity were proposed to be specific indicators of the appearance of non-metallothionein-bound Cu in the liver of LEC rats...
  23. ncbi request reprint Animal species difference in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells
    Y Shiobara
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
    Chem Res Toxicol 14:1446-52. 2001
    ..The present results suggest that the uptake of DMA by RBCs is an additional contributing factor to the animal species difference in the metabolism of arsenic in addition to the reduction and methylation capacity in the liver...
  24. ncbi request reprint Glutathione-conjugated arsenics in the potential hepato-enteric circulation in rats
    K T Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263 8522, Japan
    Chem Res Toxicol 14:1604-11. 2001
    ..DMA is not excreted into the bile but into the bloodstream, accumulating in RBCs, and then excreted into the urine mostly in the form of DMA(V) in rats...
  25. doi request reprint Systemic distribution and speciation of diphenylarsinic acid fed to rats
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 237:214-20. 2009
    ..Furthermore, we also detected two unknown arsenic metabolites in rat urine, which were assumed to be hydroxylated arsenic metabolites...
  26. ncbi request reprint Metabolism of tellurium, antimony and germanium simultaneously administered to rats
    Akihiro Kobayashi
    Graduate School of Pharmaceutical Sciences, Chiba University
    J Toxicol Sci 34:295-303. 2009
    ..Ge was also not methylated in rats. These results suggest that each metalloid is metabolized via a unique pathway...
  27. doi request reprint Effects of chemical species of selenium on maternal transfer during pregnancy and lactation
    Yasumi Anan
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Life Sci 84:888-93. 2009
    ..This study compares the transfer from mother to fetuses and pups of selenium (Se) in the form of selenite, selenate, and selenomethionine (SeMet) labeled with different homo-elemental isotopes...
  28. doi request reprint Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism
    Takamitsu Miyayama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, 260 8675, Japan
    Anal Bioanal Chem 390:1799-803. 2008
    ....
  29. ncbi request reprint Identification of a novel selenium metabolite, Se-methyl-N-acetylselenohexosamine, in rat urine by high-performance liquid chromatography--inductively coupled plasma mass spectrometry and--electrospray ionization tandem mass spectrometry
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 767:301-12. 2002
    ..Thus, the major urinary Se metabolite was assigned as a diastereomer of a selenosugar, Se-methyl-N-acetyl-selenohexosamine...
  30. ncbi request reprint Protective role of metallothionein against copper depletion
    Yasumitsu Ogra
    Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Arch Biochem Biophys 451:112-8. 2006
    ..Thus, MT was shown to be induced under Cu-deficient conditions to maintain the activities of intracellular cuproenzymes such as cytochrome c oxidase and Cu,zinc-superoxide dismutase...
  31. ncbi request reprint Speciation of arsenic in biological samples
    Badal Kumar Mandal
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 198:307-18. 2004
    ..Therefore, total As concentrations of nails could be considered as biomarker to As exposure in the endemic areas...
  32. doi request reprint Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1
    Takamitsu Miyayama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Toxicol Appl Pharmacol 237:205-13. 2009
    ..Cu imaging showed that the elevated Cu was compartmentalized in cytoplasmic vesicles. Together, the results point to the novel roles of MT and cytoplasmic vesicles in the detoxification of Cu in mammalian cells...
  33. ncbi request reprint Synchronized generation of reactive oxygen species with the cell cycle
    Yukihisa Takahashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chuo, Chiba 260 8675, Japan
    Life Sci 75:301-11. 2004
    ..Based on the present observations, we proposed for the first time that ROS are generated synchronously with the normal cell cycle, and that they have to be controlled at certain level for normal progress of the cell cycle...
  34. ncbi request reprint Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry
    Badal Kumar Mandal
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Toxicol Appl Pharmacol 189:73-83. 2003
    ..DMA(III) content in fingernails and DMA(V) contents in both fingernails and hair could be the biomarker to As exposure...
  35. ncbi request reprint Soy protein isolate enhances hepatic copper accumulation and cell damage in LEC rats
    Kayo Yonezawa
    Department of Nutritional Science, Tokyo University of Agriculture, 1 1 Sakuragaoka 1, Setagaya, Tokyo 156 8502, USA
    J Nutr 133:1250-4. 2003
    ..However, this did not occur in the livers of F344 rats with wild-type Atp7b. Recommendations to individuals suffering from Wilson's disease to avoid consuming soy protein may be warranted...
  36. ncbi request reprint Liquid chromatography-mass spectrometry (LC-MS): a powerful combination for selenium speciation in garlic (Allium sativum)
    Emmie Dumont
    Department of Analytical Chemistry, Ghent University, UGent, Proeftuinstraat 86, 9000 Gent, Belgium
    Anal Bioanal Chem 384:1196-206. 2006
    ..In both the simulated gastric and intestinal digests, Se-methionine, Se-methylselenocysteine, and gamma-glutamyl-Se-methylselenocysteine could be determined by LC-ESI-MS-MS by measuring their typical product ions...
  37. ncbi request reprint Effects of soy protein isolate on LEC rats, a model of Wilson disease: mechanisms underlying enhancement of liver cell damage
    Kayo Yonezawa
    Department of Nutritional Science, Tokyo University of Agriculture, 1 1 Sakuragaoka, 1, Setagaya, Tokyo, Japan
    Biochem Biophys Res Commun 302:271-4. 2003
    ..It is thus suggested that SPI enhances liver cell copper uptake through induction of Ctr1 expression and this might be the mechanism underlying increased liver damage in LEC rats...
  38. ncbi request reprint Determination of selenomethionine and selenocysteine in human serum using speciated isotope dilution-capillary HPLC-inductively coupled plasma collision cell mass spectrometry
    Jorge Ruiz Encinar
    Group of Bio Inorganic Analytical Chemistry, CNRS UMR 5034, Helioparc, 2, av Pr Angot, F 64053 Pau, France
    Anal Chem 76:6635-42. 2004
    ..5 ng g(-1) for a 450-mg serum sample). The precision was less than 5% RSD. The method was validated by the mass balance of selenium (amino acid incorporated vs total)...
  39. ncbi request reprint A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p
    Koichiro Kako
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tenno Dai, Tsukuba, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 324:1379-85. 2004
    ..These results suggest that the stringent selectivity of Cox17p for copper is required for CCO activation, to prevent copper overload, or promote the supply of copper...