Research Topics
Genomes and GenesSpecies | Michiko NakazatoSummaryAffiliation: Chiba University Country: Japan Publications
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Detail Information
Publications
Possible involvement of brain-derived neurotrophic factor in eating disordersMichiko Nakazato
Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
IUBMB Life 64:355-61. 2012..In the previous studies, serum BDNF levels in subjects with EDs are reduced significantly compared with healthy controls, hence, we proposed that levels of serum BDNF would be a useful diagnostic indicator for EDs...
No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recoveryMichiko Nakazato
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba, 260 8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 30:1117-21. 2006..2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5)...- No changes in serum ghrelin levels in female patients with bulimia nervosaMichiko Nakazato
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba 260 8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 28:1181-4. 2004..Our study suggests that serum ghrelin levels in the patients with BN were indistinguishable from normal controls. Therefore, it is unlikely that ghrelin plays a role in the pathophysiology of BN... - No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorderEiji Shimizu
Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005..77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population... - Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressantsEiji Shimizu
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
Biol Psychiatry 54:70-5. 2003.... - Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disordersMichiko Nakazato
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
Biol Psychiatry 54:485-90. 2003..435, p=.015) between the BITE symptom scale score and HDRS in these patients. CONCLUSIONS: The present study suggests that BDNF may play a role in the pathophysiology of eating disorders... - Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controlsEiji Shimizu
Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
Neurosci Lett 351:111-4. 2003..Our results do not support the view that serum BDNF levels are associated with schizophrenia... - Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapyKeisuke Kobayashi
Department of Psychiatry (K2, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 29:658-63. 2005..These results suggested that BDNF might contribute to therapeutic response of panic disorder. A potential link between an increased risk of secondary depression and BDNF remains to be investigated in the future... - Increased levels of serum basic fibroblast growth factor in schizophreniaKenji Hashimoto
Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
Psychiatry Res 120:211-8. 2003.... - Tropisetron improves deficits in auditory P50 suppression in schizophreniaKaori Koike
Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
Schizophr Res 76:67-72. 2005..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia... - Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humansEiji Shimizu
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
Neurosci Lett 363:81-3. 2004..56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group... - No changes in serum epidermal growth factor levels in patients with schizophreniaKenji Hashimoto
Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
Psychiatry Res 135:257-60. 2005..Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits... - A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia: a preliminary studyTomihisa Niitsu
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
J Clin Psychopharmacol 32:593-601. 2012..Nevertheless, a further study using a large sample size will be needed to confirm the secondary analyses findings... - Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficitsEiji Shimizu
Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
J Psychiatr Res 41:49-56. 2007..These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia... - An open trial of outpatient group therapy for bulimic disorders: combination program of cognitive behavioral therapy with assertive training and self-esteem enhancementAkihiro Shiina
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
Psychiatry Clin Neurosci 59:690-6. 2005..06) were predictors of dropout from the CGCBT program. Our CGCBT program is a promising first-line treatment for bulimic outpatients. Lower age and the presence of comorbidity had effects on dropout rates... - Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophreniaTomihisa Niitsu
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
Prog Neuropsychopharmacol Biol Psychiatry 35:1836-40. 2011..Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia... 
Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorderTaisuke Yoshida
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
PLoS ONE 7:e42676. 2012..In this study, we examined whether serum levels of proBDNF, mature BDNF, and matrix metalloproteinase-9 (MMP-9), which converts proBDNF to mature BDNF, are altered in patients with MDD...- Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disordersHiroki Koizumi
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders... - Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implicationsKenji Hashimoto
Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 29:499-504. 2005..In addition, a more complete understanding of the signal transduction pathway via the p75 neurotrophin receptor (p75NTR) and TrkB receptors would provide new perspectives for treating eating disorders... - Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophreniaEiji Shimizu
Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
Prog Neuropsychopharmacol Biol Psychiatry 31:571-3. 2007..Using maintenance ECT, she was able to live in the custody of her parents after 7-years hospitalization. This case report suggests that continuation and maintenance ECT benefits patients with serious cases of refractory schizophrenia... - Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophreniaKenji Hashimoto
Department of Psychiatry, Graduate School of Medicine, Chiba University, Japan
Arch Gen Psychiatry 60:572-6. 2003..The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls... - Attitudes of Japanese psychiatrists toward forensic mental health as revealed by a national surveyTadashi Haraguchi
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
Psychiatry Clin Neurosci 65:150-7. 2011..However, the shortage of psychiatrists dedicated to this service is a problem. Therefore, we investigated the attitudes of general psychiatrists in Japan toward this field in order to develop measures for dealing with this issue... - A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophreniaAkihiro Shiina
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Ann Gen Psychiatry 9:27. 2010..Therefore, it is of particular interest to investigate the effects of tropisetron on the cognitive deficits in patients with schizophrenia... - Two clusters of serum midkine levels in drug-naive patients with schizophreniaEiji Shimizu
Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
Neurosci Lett 344:95-8. 2003..018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia... - Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophreniaMasaomi Iyo
Prog Neuropsychopharmacol Biol Psychiatry 32:1072-3. 2008