Michiko Nakazato

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi request reprint Possible involvement of brain-derived neurotrophic factor in eating disorders
    Michiko Nakazato
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
    IUBMB Life 64:355-61. 2012
  2. ncbi request reprint No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1117-21. 2006
  3. ncbi request reprint No changes in serum ghrelin levels in female patients with bulimia nervosa
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:1181-4. 2004
  4. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
  5. ncbi request reprint Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1836-40. 2011
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia: a preliminary study
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Psychopharmacol 32:593-601. 2012
  7. ncbi request reprint Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 54:485-90. 2003
  8. ncbi request reprint Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Psychiatry 54:70-5. 2003
  9. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
  10. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy
    Keisuke Kobayashi
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:658-63. 2005

Collaborators

Detail Information

Publications30

  1. doi request reprint Possible involvement of brain-derived neurotrophic factor in eating disorders
    Michiko Nakazato
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
    IUBMB Life 64:355-61. 2012
    ..In the previous studies, serum BDNF levels in subjects with EDs are reduced significantly compared with healthy controls, hence, we proposed that levels of serum BDNF would be a useful diagnostic indicator for EDs...
  2. ncbi request reprint No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1117-21. 2006
    ..2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5)...
  3. ncbi request reprint No changes in serum ghrelin levels in female patients with bulimia nervosa
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:1181-4. 2004
    ..Our study suggests that serum ghrelin levels in the patients with BN were indistinguishable from normal controls. Therefore, it is unlikely that ghrelin plays a role in the pathophysiology of BN...
  4. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
    ..77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population...
  5. ncbi request reprint Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1836-40. 2011
    ..Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia...
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia: a preliminary study
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Psychopharmacol 32:593-601. 2012
    ..Nevertheless, a further study using a large sample size will be needed to confirm the secondary analyses findings...
  7. ncbi request reprint Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 54:485-90. 2003
    ....
  8. ncbi request reprint Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Psychiatry 54:70-5. 2003
    ....
  9. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
    ..Our results do not support the view that serum BDNF levels are associated with schizophrenia...
  10. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy
    Keisuke Kobayashi
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:658-63. 2005
    ..These results suggested that BDNF might contribute to therapeutic response of panic disorder. A potential link between an increased risk of secondary depression and BDNF remains to be investigated in the future...
  11. ncbi request reprint No changes in serum epidermal growth factor levels in patients with schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 135:257-60. 2005
    ..Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits...
  12. ncbi request reprint Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Schizophr Res 76:67-72. 2005
    ..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia...
  13. ncbi request reprint Increased levels of serum basic fibroblast growth factor in schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 120:211-8. 2003
    ....
  14. ncbi request reprint Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Neurosci Lett 363:81-3. 2004
    ..56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group...
  15. pmc Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder
    Taisuke Yoshida
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 7:e42676. 2012
    ..In this study, we examined whether serum levels of proBDNF, mature BDNF, and matrix metalloproteinase-9 (MMP-9), which converts proBDNF to mature BDNF, are altered in patients with MDD...
  16. ncbi request reprint An open trial of outpatient group therapy for bulimic disorders: combination program of cognitive behavioral therapy with assertive training and self-esteem enhancement
    Akihiro Shiina
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Psychiatry Clin Neurosci 59:690-6. 2005
    ..06) were predictors of dropout from the CGCBT program. Our CGCBT program is a promising first-line treatment for bulimic outpatients. Lower age and the presence of comorbidity had effects on dropout rates...
  17. ncbi request reprint Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    J Psychiatr Res 41:49-56. 2007
    ..These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia...
  18. doi request reprint A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia
    Tomihisa Niitsu
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan Electronic address
    Psychiatry Res 215:268-73. 2014
    ..These findings suggest that neither mature BDNF nor MMP-9 is a suitable biomarker for schizophrenia, although further studies using large samples are needed. ..
  19. ncbi request reprint Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Japan
    Arch Gen Psychiatry 60:572-6. 2003
    ..The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls...
  20. ncbi request reprint Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004
    ..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders...
  21. doi request reprint Attitudes of Japanese psychiatrists toward forensic mental health as revealed by a national survey
    Tadashi Haraguchi
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Psychiatry Clin Neurosci 65:150-7. 2011
    ..However, the shortage of psychiatrists dedicated to this service is a problem. Therefore, we investigated the attitudes of general psychiatrists in Japan toward this field in order to develop measures for dealing with this issue...
  22. ncbi request reprint Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:499-504. 2005
    ..In addition, a more complete understanding of the signal transduction pathway via the p75 neurotrophin receptor (p75NTR) and TrkB receptors would provide new perspectives for treating eating disorders...
  23. ncbi request reprint Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia
    Eiji Shimizu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:571-3. 2007
    ..Using maintenance ECT, she was able to live in the custody of her parents after 7-years hospitalization. This case report suggests that continuation and maintenance ECT benefits patients with serious cases of refractory schizophrenia...
  24. pmc Changes in self-regulation-related prefrontal activities in eating disorders: a near infrared spectroscopy study
    Chihiro Sutoh
    Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University Chiba Chuo, Chiba, Japan
    PLoS ONE 8:e59324. 2013
    ..The aim of this study is to clarify the symptomatology of the eating disorders examining the prefrontal function and activity associated with self-regulation among participants with or without eating disorders...
  25. pmc A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia
    Akihiro Shiina
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Ann Gen Psychiatry 9:27. 2010
    ..Therefore, it is of particular interest to investigate the effects of tropisetron on the cognitive deficits in patients with schizophrenia...
  26. pmc The psychological impact of a dual-disaster caused by earthquakes and radioactive contamination in Ichinoseki after the Great East Japan Earthquake
    Tomihisa Niitsu
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    BMC Res Notes 7:307. 2014
    ..This study investigated the impact of a dual-disaster (earthquakes and radioactive contamination) on the prevalence of psychological distress in a landlocked city within the Tohoku area, Japan...
  27. pmc Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series
    Kyoji Okita
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba, 260 8677, Japan
    Ann Gen Psychiatry 12:7. 2013
    ..In addition, a 6-month follow-up showed maintenance of these effects. In this disorder, tandospirone may be an effective drug for long-term use with good patient compliance...
  28. pmc A preliminary study of individual cognitive behavior therapy for social anxiety disorder in Japanese clinical settings: a single-arm, uncontrolled trial
    Naoki Yoshinaga
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 6:74. 2013
    ..We also examined the baseline predictors of outcomes associated with receiving CBT...
  29. ncbi request reprint Two clusters of serum midkine levels in drug-naive patients with schizophrenia
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 344:95-8. 2003
    ..018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia...
  30. doi request reprint Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia
    Masaomi Iyo
    Prog Neuropsychopharmacol Biol Psychiatry 32:1072-3. 2008