Hiroshi Nakajima

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
    Hiroshi Nakajima
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Immune Netw 10:1-4. 2010
  2. pmc IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells
    Kotaro Suzuki
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    J Exp Med 198:1717-27. 2003
  3. pmc Coinhibitory molecules in autoimmune diseases
    Norihiko Watanabe
    Center for Rheumatic Diseases, Saiseikai Narashino Hospital, Narashino 275 8580, Japan
    Clin Dev Immunol 2012:269756. 2012
  4. ncbi request reprint Role of cytokines in allergic airway inflammation
    Hiroshi Nakajima
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 142:265-73. 2007
  5. ncbi request reprint Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing
    Hiroshi Nakajima
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    Cytokine Growth Factor Rev 14:375-80. 2003
  6. ncbi request reprint Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation
    Shunsuke Furuta
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    J Immunol 180:6656-62. 2008
  7. doi request reprint B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses
    Daisuke Kashiwakuma
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Japan
    J Immunol 185:2730-6. 2010
  8. ncbi request reprint Role of Th2 cells in IgG4-related lacrimal gland enlargement
    Hiroko Kanari
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 152:47-53. 2010
  9. ncbi request reprint Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression
    Hiroaki Takatori
    Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba City, Japan
    J Immunol 174:4105-12. 2005
  10. ncbi request reprint Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation
    Naoki Tokumasa
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Chiba University, Inohana, Chiba, Japan
    Blood 110:553-60. 2007

Collaborators

Detail Information

Publications72

  1. pmc Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
    Hiroshi Nakajima
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Immune Netw 10:1-4. 2010
    ..In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized...
  2. pmc IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells
    Kotaro Suzuki
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    J Exp Med 198:1717-27. 2003
    ..These results suggest that IL-4-Stat6 signaling induces TTP expression and, thus, destabilizes TNF-alpha mRNA in an ARE-dependent manner...
  3. pmc Coinhibitory molecules in autoimmune diseases
    Norihiko Watanabe
    Center for Rheumatic Diseases, Saiseikai Narashino Hospital, Narashino 275 8580, Japan
    Clin Dev Immunol 2012:269756. 2012
    ..Particularly, administration of CTLA-4 Ig has shown great promise in animal models of autoimmune diseases and has been gaining increasing attention in clinical investigation in several autoimmune diseases in humans...
  4. ncbi request reprint Role of cytokines in allergic airway inflammation
    Hiroshi Nakajima
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 142:265-73. 2007
    ..In this review, we discuss the role of individual cytokines in the pathogenesis of asthma...
  5. ncbi request reprint Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing
    Hiroshi Nakajima
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    Cytokine Growth Factor Rev 14:375-80. 2003
    ..These findings indicate that the proteolytic processing of STAT proteins by the nucleus-associated protease functions as a lineage-specific negative-regulator of STAT-mediated signaling...
  6. ncbi request reprint Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation
    Shunsuke Furuta
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    J Immunol 180:6656-62. 2008
    ..These results indicate that STAT4 not only plays an indispensable role in T-bet-independent Th1 differentiation but also is involved in the maintenance of Th17 cells and the enhancement of allergic airway inflammation...
  7. doi request reprint B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses
    Daisuke Kashiwakuma
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Japan
    J Immunol 185:2730-6. 2010
    ..These results suggest that BTLA signaling suppresses IL-21 production from Tfh cells and subsequent Tfh cell-mediated IgG responses...
  8. ncbi request reprint Role of Th2 cells in IgG4-related lacrimal gland enlargement
    Hiroko Kanari
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 152:47-53. 2010
    ..However, little is known about the role of CD4+ T cells and their cytokines in IgG4-related diseases. The aim of this study was to evaluate the characteristics of CD4+ T cells in patients with IgG4-related diseases...
  9. ncbi request reprint Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression
    Hiroaki Takatori
    Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba City, Japan
    J Immunol 174:4105-12. 2005
    ..These results suggest that Stat5a forces the Th1/Th2 balance toward a Th2-type by preventing IL-12-induced Th1 cell differentiation through the induction of SOCS3...
  10. ncbi request reprint Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation
    Naoki Tokumasa
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Chiba University, Inohana, Chiba, Japan
    Blood 110:553-60. 2007
    ....
  11. doi request reprint STAT6 inhibits T-bet-independent Th1 cell differentiation
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Chiba University, Chiba City, Chiba, Japan
    Biochem Biophys Res Commun 382:751-5. 2009
    ..These results indicate that STAT6 inhibits T-bet-independent Th1 cell differentiation by suppressing IL-12-STAT4 signaling...
  12. ncbi request reprint Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation
    Hiroaki Takatori
    Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba, Japan
    J Immunol 174:3734-40. 2005
    ..These results indicate that Stat5a plays an indispensable role in Stat6-independent Th2 cell differentiation and subsequent Th2 cell-mediated allergic airway inflammation...
  13. ncbi request reprint c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells
    Yukiko Hiramatsu
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Leukoc Biol 87:703-12. 2010
    ..Taken together, these results suggest that c-Maf induces IL-21 production directly in CD4(+) T cells by activating IL-21P and the CNS-2 enhancer and that TGF-beta suppresses c-Maf-induced IL-21 production in CD4(+) T cells...
  14. ncbi request reprint B and T lymphocyte attenuator inhibits antigen-induced eosinophil recruitment into the airways
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 143:50-5. 2007
    ..However, the role of B and T lymphocyte attenuator (BTLA), an inhibitory co-receptor expressed preferentially in Th1 cells, in the regulation of allergic airway inflammation remains to be determined...
  15. ncbi request reprint IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice
    Hidefumi Wakashin
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Am J Respir Crit Care Med 178:1023-32. 2008
    ..However, the role of the IL-23-Th17 cell axis in the regulation of allergic airway inflammation is still largely unknown...
  16. doi request reprint Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells
    Shin ichiro Kagami
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba, Japan
    Int Immunol 21:679-89. 2009
    ..Taken together, these results indicate that protein geranylgeranylation enhances the differentiation of T(h)17 cells and inhibits the differentiation of Foxp3(+) Tregs partly via the inhibition of SOCS3 expression...
  17. pmc Development and characterization of IL-21-producing CD4+ T cells
    Akira Suto
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, 260 8670 Japan
    J Exp Med 205:1369-79. 2008
    ....
  18. ncbi request reprint Stat5a is essential for the proliferation and survival of murine mast cells
    Kei Ikeda
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan
    Int Arch Allergy Immunol 137:45-50. 2005
    ..These results indicate that Stat5a plays an important role in mast cell development, proliferation, and survival...
  19. ncbi request reprint Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells
    Akira Suto
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba City, Japan
    Blood 100:4565-73. 2002
    ....
  20. pmc Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism
    Kotaro Suzuki
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Exp Med 196:27-38. 2002
    ....
  21. doi request reprint Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis
    Arifumi Iwata
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    J Immunol 184:127-33. 2010
    ..These results suggest that BTLA functions as the inhibitory coreceptor of NKT cells and plays a critical role in the prevention of NKT cell-mediated liver injury...
  22. ncbi request reprint T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways
    Michio Fujiwara
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Chiba University, Chiba, Japan
    J Allergy Clin Immunol 119:662-70. 2007
    ..However, the mechanism underlying T-bet-mediated inhibition of allergic airway inflammation is still unknown...
  23. ncbi request reprint Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice
    Yohei Seto
    Department of Internal Medicine II, Chiba University School of Medicine, Japan
    J Immunol 170:1077-83. 2003
    ....
  24. ncbi request reprint IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    J Allergy Clin Immunol 118:606-14. 2006
    ..However, the roles of IL-25 in inducing allergic airway inflammation remain unknown...
  25. ncbi request reprint Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation
    Kei Ikeda
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Blood 101:3594-6. 2003
    ..Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance T(H)2-type immune response by producing IL-25...
  26. pmc Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
    Yoshihiro Oya
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Arthritis Rheum 58:2498-510. 2008
    ..The purpose of this study was to investigate the role of BTLA in the regulation of immune homeostasis and the pathogenesis of autoimmunity...
  27. pmc B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells
    Yoshihisa Kobayashi
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 110:5121-6. 2013
    ..These results suggest that BTLA directly inhibits LPS responses in DCs and Mϕs and that agonistic agents for BTLA might have therapeutic potential for LPS-induced endotoxic shock...
  28. doi request reprint β-glucan curdlan induces IL-10-producing CD4+ T cells and inhibits allergic airway inflammation
    Saki Kawashima
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Immunol 189:5713-21. 2012
    ....
  29. ncbi request reprint Tyk2 is essential for IFN-alpha-induced gene expression in mast cells
    Yumiko Mori
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Int Arch Allergy Immunol 134:25-9. 2004
    ..These results indicate that IFN-alpha induces the expression of TNF-alpha and the chemokines IP-10 and MCP-5 in mast cells and thatTyk2 plays a nonredundant role in IFN-alpha signaling in mast cells...
  30. ncbi request reprint Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046
    Kotaro Suzuki
    Department of Internal Medicine II, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 309:768-73. 2003
    ..In addition, both NE and PR3 could also cleave Stat5, but they differed from Stat5-protease in myeloid progenitors. These results suggest that Stat6-protease may belong to the elastase family but differs from NE or PR3...
  31. doi request reprint HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells
    Shin ichiro Kagami
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 146:61-6. 2008
    ..In this study, we examined the effect of a representative statin, simvastatin, on proinflammatory cytokine production from murine mast cells...
  32. doi request reprint Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells
    Hirotoshi Kawashima
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Immunol 191:3614-23. 2013
    ..Taken together, these results suggest that p53 expressed in T cells functions as a suppressor for autoimmunity by inducing Treg differentiation. ..
  33. doi request reprint Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β
    Shigeru Tanaka
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    Rheumatology (Oxford) 52:1963-72. 2013
    ..Therefore the purpose of this study was to identify miRNAs that play a role in the pathogenesis of SSc by quantitative PCR screening of serum miRNAs...
  34. ncbi request reprint Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation
    Akira Suto
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 175:5681-9. 2005
    ..Furthermore, IL-4 did not induce IFN-gamma production in Stat4-/- PDCs. These results indicate that PDCs preferentially produce IFN-gamma upon IL-4 stimulation by Stat6- and Stat4-dependent mechanisms...
  35. doi request reprint Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells
    Junichi Hosokawa
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 161:37-43. 2013
    ..However, the roles of Ca(2+) signaling and PKCβ in the activation of IKK2 in mast cells remain largely unknown...
  36. ncbi request reprint Interleukin 25 in allergic airway inflammation
    Tomohiro Tamachi
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 140:59-62. 2006
    ..Thus, it is suggested that IL-25 plays an important role in enhancing allergic airway inflammation by a CD4+ T-cell-dependent mechanism...
  37. doi request reprint IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation
    Kentaro Takahashi
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Allergy Clin Immunol 128:1067-76.e1-6. 2011
    ..However, the roles of IL-22 in the regulation of allergic airway inflammation are still largely unknown...
  38. pmc Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells
    Takayoshi Owada
    Departments of Allergy and Clinical Immunology, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    J Leukoc Biol 87:425-32. 2010
    ....
  39. doi request reprint Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice
    Yoshihiro Oya
    Department of Allergy and Clinical Immunology, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    Int Immunol 23:335-44. 2011
    ..These results suggest that BTLA plays a protective role in autoimmune diseases in MRL-lpr mice and that AIH-like disease develops in BTLA(-/-) mice even in the absence of Fas-dependent signaling...
  40. doi request reprint Interleukin-25 induces pulmonary arterial remodeling via natural killer T cell-dependent mechanisms
    Saki Kawashima
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 161:118-24. 2013
    ..However, the role of interleukin-25 (IL-25; which promotes this inflammation) in the development of the pulmonary arterial remodeling remains unknown...
  41. doi request reprint STAT4 is required for IFN-β-induced MCP-1 mRNA expression in murine mast cells
    Kazuma Iida
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 155:71-6. 2011
    ..However, it is still largely unknown whether signal transducers and activators of transcription 4 (STAT4), one of the STAT proteins under type I IFN signaling, is involved in type I IFN-mediated gene expression in mast cells...
  42. doi request reprint Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity
    Daiki Nakagomi
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Invest Dermatol 133:702-11. 2013
    ..In vivo injection of 6A6 suppressed DNFB-induced CHS and IFN-γ production of CD8(+) T cells. Taken together, these results suggest that stimulation of BTLA with agonistic agents has therapeutic potential in CHS...
  43. ncbi request reprint Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling
    Yuko Maezawa
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 176:1013-8. 2006
    ..Taken together, these results indicate that TRAF6 plays a critical role in IL-25R-mediated NF-kappaB activation and gene expression...
  44. pmc A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis
    Mie Oki
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chuo Ku, Chiba 260 8670, Japan
    Clin Dev Immunol 2011:305656. 2011
    ..These results suggest that BTLA is an RA-susceptibility gene and is involved in the protection from autoimmunity in humans...
  45. doi request reprint Role of IL-23-Th17 cell axis in allergic airway inflammation
    Hidefumi Wakashin
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba 260 8670, Japan
    Int Arch Allergy Immunol 149:108-12. 2009
    ..In this review, we will discuss the roles of IL-23 and Th17 cells in airway inflammation in asthma...
  46. doi request reprint Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents
    Kei Ikeda
    From the Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    J Rheumatol 40:1967-76. 2013
    ..We also investigated the difference between antirheumatic agents...
  47. doi request reprint [18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis
    Shigeru Tanaka
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    Rheumatology (Oxford) 52:1271-8. 2013
    ....
  48. ncbi request reprint Roles of CRTH2+ CD4+ T cells in immunoglobulin G4-related lacrimal gland enlargement
    Yukari Saito
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Int Arch Allergy Immunol 158:42-6. 2012
    ....
  49. ncbi request reprint AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation
    Yukari Saito
    Chiba University, Chiba, Japan
    Arthritis Rheumatol 66:1185-94. 2014
    ..We undertook this study to clarify the mechanisms underlying the efficacy of IL-6 blockade in RA and to find a novel target for treatment of RA...
  50. ncbi request reprint Role of IgE in Th2 cell-mediated allergic airway inflammation
    Yuko Maezawa
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Int Arch Allergy Immunol 131:2-6. 2003
    ..These findings suggest that IgE-dependent mast cell activation plays an important role in allergic airway inflammation by recruiting Th2 cells into the site of allergic inflammation...
  51. ncbi request reprint [Pathogenesis of asthma]
    Hiroshi Nakajima
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University
    Nihon Rinsho 63:53-7. 2005
  52. ncbi request reprint Prediction of therapeutic responses to tocilizumab in patients with rheumatoid arthritis: biomarkers identified by analysis of gene expression in peripheral blood mononuclear cells using genome-wide DNA microarray
    Yoshie Sanayama
    Chiba University Hospital, Chiba, Japan
    Arthritis Rheumatol 66:1421-31. 2014
    ..The aim of this prospective multicenter study was to identify biomarkers that can be used to predict therapeutic responses to tocilizumab in patients with rheumatoid arthritis (RA)...
  53. doi request reprint Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model
    Akihiro Hasegawa
    Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Allergy Clin Immunol 125:461-468.e6. 2010
    ..T(H)2-cell migration into the lung is crucial for the initiation of asthma phenotype, but the dynamics of this process are poorly understood because it has been difficult to visualize this process...
  54. ncbi request reprint Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice
    Ayako Norimoto
    1 Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Respir Cell Mol Biol 51:201-9. 2014
    ..In conclusion, Dectin-2 expressed on CD11b(+) DCs promotes HDM-induced Th2 and Th17 cell differentiation and allergic airway inflammation. ..
  55. ncbi request reprint Interleukin-21-Producing c-Maf-Expressing CD4+ T Cells Induce Effector CD8+ T Cells and Enhance Autoimmune Inflammation in Scurfy Mice
    Taro Iwamoto
    Chiba University Graduate School of Medicine, Chiba, Japan
    Arthritis Rheumatol 66:2079-90. 2014
    ..However, the precise mechanisms of FoxP3 in the prevention of autoimmune diseases remain unknown. We undertook this study to determine the regulatory roles of FoxP3 in autoimmune inflammation by using FoxP3-mutant sf mice...
  56. ncbi request reprint CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms
    Akira Suto
    Department of Internal Medicine II, the Core Research for Evolutional Science and Technology Project, and Chiba University, Japan
    Blood 99:555-60. 2002
    ..Together, these results indicate that the development of CD4(+)CD25(+) T cells in thymus and the homeostasis of CD4(+)CD25(+) T cells in periphery are regulated by distinct mechanisms...
  57. pmc Efficacy of abatacept for arthritis in patients with an overlap syndrome between rheumatoid arthritis and systemic lupus erythematosus
    Kei Ikeda
    Department of Allergy and Clinical Immunology, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Clin Dev Immunol 2013:697525. 2013
    ..This study aimed to investigate the efficacy of abatacept for arthritis in patients with rhupus, an overlap syndrome between rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
  58. pmc Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation
    Hiroyasu Tsutsuki
    Departments of Molecular Infectiology, Chiba University, Chiba, Japan
    Infect Immun 80:3939-51. 2012
    ..coli survival in macrophages. Thus, we hypothesize that SubAB might represent a novel bacterial strategy to circumvent host defense during STEC infection...
  59. doi request reprint Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients
    Arifumi Iwata
    Department of Allergy and Clinical Immunology, Chiba University Hospital, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Mod Rheumatol 23:357-64. 2013
    ..Although pre-meal administration of PPIs is recommended in Western countries, the benefit of this administration timing in Japanese CTD patients with refractory GERD symptoms has not been proven...
  60. doi request reprint Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment
    Daiki Nakagomi
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Arthritis Rheum 65:890-8. 2013
    ..We undertook this study to determine the optimized definition of ultrasound-detected synovitis for the 2010 ACR/EULAR criteria and to assess the impact of its use on the accuracy of RA classification...
  61. ncbi request reprint Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis: two case reports and a review of 36 reported cases
    Daiki Nakagomi
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Rheumatol Int 33:793-7. 2013
    ..Most of these cases (90.3%) showed improvement of yellow nail after discontinuation of bucillamine, whereas lymphedema and pulmonary manifestations improved only in 30.8 and 35.0% of the patients, respectively...
  62. doi request reprint Critical roles of IĸB kinase subunits in mast cell degranulation
    Daiki Nakagomi
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 158:92-5. 2012
    ..This review focuses on the functions of IKK2 and ELKS in mast cell degranulation...
  63. ncbi request reprint Analysis of the factors which influence the measurement of synovial power Doppler signals with semi-quantitative and quantitative measures - a pilot multicenter exercise in Japan
    Kei Ikeda
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
    Mod Rheumatol 24:419-25. 2014
    ..This pilot multicenter exercise aimed to evaluate the inter-observer reproducibility of synovial power Doppler (PD) signals in rheumatoid arthritis (RA) patients and to determine the factors influencing the measurements...
  64. pmc Clinical characteristics of Nocardia infection in patients with rheumatic diseases
    Mieko Yamagata
    Department of Allergy and Clinical Immunology, Chiba University Hospital, 1 8 1 Inohana, Chiba, Chiba City 260 8677, Japan
    Clin Dev Immunol 2013:818654. 2013
    ..All patients had pulmonary Nocardiosis, and six of them had disseminated Nocardiosis when their pulmonary lesions were identified. ..
  65. ncbi request reprint Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice
    Shungo Hikoso
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 110:2631-7. 2004
    ..This suggests that STAT6 may be involved in the pathogenesis of cardiac hypertrophy and heart failure. For this study we used STAT6-deficient (STAT6-/-) mice to examine the in vivo role of STAT6...
  66. pmc Roles of IL-22 in Allergic Airway Inflammation
    Koichi Hirose
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    J Allergy (Cairo) 2013:260518. 2013
    ..In this paper, we summarize the recent progress on the roles of IL-22 in the regulation of allergic airway inflammation and discuss its therapeutic potential in asthma...
  67. ncbi request reprint GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice
    Koichi Hirose
    Department of Allergy and Clinical Immunology, Chiba University Hospital, Japan
    Biochem Biophys Res Commun 374:507-11. 2008
    ..Moreover, GS143 inhibited antigen-induced differentiation of Th2 cells but not of Th1 cells in vitro. Taken together, these results suggest that IkappaB ubiquitination inhibitor may have therapeutic potential against asthma...
  68. ncbi request reprint Spectroscopic and redox properties of a CooA homologue from Carboxydothermus hydrogenoformans
    Sayaka Inagaki
    Department of Structural Molecule Science, The Graduate University for Advanced Studies, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    J Biol Chem 280:3269-74. 2005
    ....
  69. ncbi request reprint [Isolation of enteroaggregative escherichia coli (EAggEC) from patients with diarrheal disease in an outbreak case of overseas tour]
    Hiroshi Nakajima
    Department of Bacteriology, Okayama Prefectural Institute for Environmental Science and Public Health
    Kansenshogaku Zasshi 79:314-21. 2005
    ..So we recommend to perform stepwise EAggEC screening tests by the PCR and the clump formation, and final confirmation test by the aggregative adhesion to HEp-2 cells...
  70. ncbi request reprint Restoration of promyelocytic leukemia protein-nuclear bodies in neuroblastoma cells enhances retinoic acid responsiveness
    Jiang Hong Yu
    Department of Medicine, Harvard Medical School, USA
    Cancer Res 64:928-33. 2004
    ..Pharmacological therapies that increase PML expression may prove to be important components of combined modalities for the treatment of neuroblastoma...
  71. ncbi request reprint Stat5 expression is required for IgE-mediated mast cell function
    Brian O Barnstein
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Immunol 177:3421-6. 2006
    ..These data have a direct impact on MC-associated inflammatory and autoimmune diseases...
  72. ncbi request reprint Effect of mutation on the dissociation and recombination dynamics of CO in transcriptional regulator CooA: a picosecond infrared transient absorption study
    Tieqiao Zhang
    School of Materials Science, Japan Advanced Institute of Science and Technology, Tatsunokuchi, Ishikawa 923 1292, Japan
    Biochemistry 45:9246-53. 2006
    ....