Yuichiro Nagai

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Squamous predominance in mixed-epithelial papillary cystadenomas of borderline malignancy of mullerian type arising in endometriotic cysts: a study of four cases
    Yuichiro Nagai
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Japan
    Am J Surg Pathol 27:242-7. 2003
  2. ncbi request reprint Impact of p53 immunostaining in predicting advanced or recurrent placental site trophoblastic tumors: a study of 12 cases
    Yuichiro Nagai
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, and Department of Obstetrics and Gynecology, Chiba Hokuso Hospital, Chiba 260 8670, Japan
    Gynecol Oncol 106:446-52. 2007
  3. ncbi request reprint Evidence for hepatocellular differentiation in alpha-fetoprotein-negative gastric adenocarcinoma with hepatoid morphology: a study with in situ hybridisation for albumin mRNA
    Yana Supriatna
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathology 37:211-5. 2005
  4. doi request reprint Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma
    Tomoo Matsutani
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba, 260 8670, Japan
    Acta Neurochir (Wien) 151:263-8; discussion 268. 2009
  5. ncbi request reprint Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor
    Koichiro Hirashiki
    Department of Molecular Pathology E3, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba 260 8670, Japan
    Exp Mol Pathol 78:247-56. 2005
  6. ncbi request reprint MR imaging of normal perivascular space expansion at midbrain
    Naokatsu Saeki
    Department of Neurological Surgery and Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    AJNR Am J Neuroradiol 26:566-71. 2005
  7. ncbi request reprint Dexamethasone modifies the susceptibility to serum cytotoxicity and increases the metastatic efficiency of a colon carcinoma cell line
    Yukio Yoshida
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Exp Mol Pathol 81:77-84. 2006
  8. ncbi request reprint Regulatory role of hepatocyte nuclear factor-4alpha on gastric choriocarcinoma function
    Naobumi Tochigi
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Exp Mol Pathol 80:77-84. 2006
  9. ncbi request reprint The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas
    Kazuhiro Kojima
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathology 38:548-54. 2006
  10. doi request reprint Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma
    Yutaka Yonemitsu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 40:1304-11. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Squamous predominance in mixed-epithelial papillary cystadenomas of borderline malignancy of mullerian type arising in endometriotic cysts: a study of four cases
    Yuichiro Nagai
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Japan
    Am J Surg Pathol 27:242-7. 2003
    ..Intraepithelial infiltration by neutrophilic leukocytes was prominent. The differential diagnosis of MEBMMSO includes proliferating Brenner tumors...
  2. ncbi request reprint Impact of p53 immunostaining in predicting advanced or recurrent placental site trophoblastic tumors: a study of 12 cases
    Yuichiro Nagai
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, and Department of Obstetrics and Gynecology, Chiba Hokuso Hospital, Chiba 260 8670, Japan
    Gynecol Oncol 106:446-52. 2007
    ..To identify an indicator that can predict tumor cell spread beyond the uterine corpus...
  3. ncbi request reprint Evidence for hepatocellular differentiation in alpha-fetoprotein-negative gastric adenocarcinoma with hepatoid morphology: a study with in situ hybridisation for albumin mRNA
    Yana Supriatna
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathology 37:211-5. 2005
    ..We investigated ALB mRNA to address whether adenocarcinoma with hepatoid morphology, regardless of AFP production, can be diagnosed solely by morphological criteria as a hepatoid adenocarcinoma...
  4. doi request reprint Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma
    Tomoo Matsutani
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba, 260 8670, Japan
    Acta Neurochir (Wien) 151:263-8; discussion 268. 2009
    ..In an attempt to find a novel prognostic marker of diffuse astrocytoma, we performed an immunohistochemical analysis of Akt/PKB with regard to patient survival and regrowth patterns...
  5. ncbi request reprint Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor
    Koichiro Hirashiki
    Department of Molecular Pathology E3, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba 260 8670, Japan
    Exp Mol Pathol 78:247-56. 2005
    ..These results indicate that C/EBP-beta plays a role in the production of plasma proteins of yolk sac tumors...
  6. ncbi request reprint MR imaging of normal perivascular space expansion at midbrain
    Naokatsu Saeki
    Department of Neurological Surgery and Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    AJNR Am J Neuroradiol 26:566-71. 2005
    ..To clarify the anatomical distinctions between normally expanded and pathologically expanding PV spaces, we defined their distribution in the normal midbrain by using high-spatial-resolution MR imaging...
  7. ncbi request reprint Dexamethasone modifies the susceptibility to serum cytotoxicity and increases the metastatic efficiency of a colon carcinoma cell line
    Yukio Yoshida
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Exp Mol Pathol 81:77-84. 2006
    ..It is thus expected that the acquisition of resistance against serum cytotoxicity is among the mechanisms that contribute to the efficiency of hematogeneous metastasis...
  8. ncbi request reprint Regulatory role of hepatocyte nuclear factor-4alpha on gastric choriocarcinoma function
    Naobumi Tochigi
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Exp Mol Pathol 80:77-84. 2006
    ....
  9. ncbi request reprint The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas
    Kazuhiro Kojima
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathology 38:548-54. 2006
    ..However, adult gastric mucosa does not express HNF-4alpha. We investigated the possible involvement of HNF-4alpha in intestinal metaplasia and the intestinalisation of gastric adenocarcinomas...
  10. doi request reprint Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma
    Yutaka Yonemitsu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 40:1304-11. 2009
    ..029) and BMI1 (P = .039) than in their negative counterparts, as determined by Kaplan-Meier analysis. These data indicate that EZH2 and BMI1 may cooperate in initiation and progression of hepatocellular carcinoma...
  11. ncbi request reprint Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    ....
  12. ncbi request reprint High serum level of plasminogen activator inhibitor-1 predicts histological grade of intracerebral gliomas
    Yasuo Iwadate
    Department of Neurological Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Anticancer Res 28:415-8. 2008
    ..No serum marker is currently available for the diagnosis and treatment of gliomas. Plasminogen activator inhibitor-1 (PAI-1) controls the proteolytic activity in cancer cells and cellular migration during angiogenesis...
  13. ncbi request reprint Cathepsin D is a potential serum marker for poor prognosis in glioma patients
    Mieko E Fukuda
    Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Res 65:5190-4. 2005
    ..0081, chi2 test). These results collectively suggest that cathepsin D could be a potential serum marker for the prediction of aggressive nature of human gliomas...
  14. ncbi request reprint Sentinel node micrometastasis and distant failure in breast cancer patients
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Breast Cancer 13:186-91. 2006
    ..The present study attempts to clarify the occurrence of distant failure after SN biopsy, especially in breast cancer patients with SN micrometastasis...
  15. ncbi request reprint [MR studies of perivascular spaces with main emphasis on space-occupying lesions]
    Naokatsu Saeki
    Department of Neurosurgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    No Shinkei Geka 34:885-98. 2006
  16. doi request reprint Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland
    Yoriko Nakajima
    Department of Plastic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Pathology 41:634-9. 2009
    ..In addition, AR gene amplification and single-nucleotide polymorphism were investigated...
  17. ncbi request reprint Increased in situ gelatinolytic activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion
    Naoto Kamiya
    Department of Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Cancer 106:480-5. 2003
    ..The intensity of the activity seems to affect the biology of RCT tissues. Our results also indicate a major role for MMP-2 in in situ gelatinolysis in RCT tissues...
  18. ncbi request reprint Genetic origin and imprinting in hydatidiform moles. Comparison between DNA polymorphism analysis and immunoreactivity of p57KIP2
    Maki Kihara
    Department of Reproductive Medicine and Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Reprod Med 50:307-12. 2005
    ..To evaluate whether p57KIP2 expression is concordant with the result of DNA polymorphism analysis in molar pregnancy...
  19. ncbi request reprint Ovarian hyperstimulation caused by gonadotroph cell adenoma: a case report and review of the literature
    Maki Kihara
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Gynecol Endocrinol 22:110-3. 2006
    ..We present a case of spontaneous ovarian hyperstimulation caused by pituitary gonadotroph macroadenoma, and include a review of the literature...
  20. ncbi request reprint Successful pregnancy and delivery after removal of gonadotrope adenoma secreting follicle-stimulating hormone in a 29-year-old amenorrheic woman
    Tatsuya Sugita
    Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba University School of Medicine, Chiba, Japan
    Gynecol Obstet Invest 59:138-43. 2005
    ..During pregnancy, estradiol increased and FSH and LH decreased. The finding confirms restoration of negative feedback of estradiol on FSH and LH secretion. The pregnancy course was uneventful and enlargement of ovaries did not occur...
  21. ncbi request reprint Inter- and intratumoral variability in magnetic resonance imaging of pleomorphic adenoma: an attempt to interpret the variable magnetic resonance findings
    Ken Motoori
    Departments of Radiology and Otolaryngology, Chiba University Hospital, Chiba, Japan
    J Comput Assist Tomogr 28:233-46. 2004
    ..The purpose of our study was to describe the various magnetic resonance (MR) findings of pleomorphic adenoma and to interpret these findings...
  22. ncbi request reprint Hepatoid carcinoma of the ovary: a report of three cases admixed with a common surface epithelial carcinoma
    Naobumi Tochigi
    Department of Molecular Pathalogy, Chiba University Graduate School of Medicine, Chiba University Hospital, Chiba, Japan
    Int J Gynecol Pathol 22:266-71. 2003
    ..These findings suggest that hepatoid carcinoma of the ovary is probably derived from carcinomas of surface epithelial origin by a process of neometaplasia or transdifferentiation...
  23. ncbi request reprint Histologic characteristics of normal perivascular spaces along the optic tract: new pathogenetic mechanism for edema in tumors in the pituitary region
    Naokatsu Saeki
    Department of Neurologic Surgery, Chiba University Graduate School of Medicine, Japan
    AJNR Am J Neuroradiol 25:1218-22. 2004
    ..Our purpose was to evaluate how often large PV spaces are present along the OT and demonstrate their superficial communication points to adjacent subarachnoid spaces...
  24. ncbi request reprint Primary synovial sarcoma in fallopian tube: case report and literature review
    Akira Mitsuhashi
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Gynecol Pathol 26:34-7. 2007
    ..This is the first report of a synovial sarcoma arising in the fallopian tube...
  25. ncbi request reprint Tumor-derived interleukin (IL)-6 induced anti-tumor effect in immune-compromised hosts
    Hiroshi Ishiguro
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Cancer Immunol Immunother 54:1191-9. 2005
    ..Natural killer (NK) activity was augmented in the spleen of mIL-6H-inoculated scid mice. This study indicated a possible vaccination effect with tumor-derived IL-6 in immune-compromised hosts...
  26. ncbi request reprint Molecular classification and survival prediction in human gliomas based on proteome analysis
    Yasuo Iwadate
    Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Res 64:2496-501. 2004
    ..The proteins identified here could be novel biomarkers for survival prediction and rational targets for antiglioma therapy...
  27. ncbi request reprint Cytologic features of functioning stromal cells in a yolk sac tumor of the ovary. A case report
    Fumio Horiuchi
    Division of Pathology, Chiba University Hospital
    Acta Cytol 48:83-6. 2004
    ..Functioning stromal cells are sometimes seen in primary and metastatic ovarian neoplasms. However, the cytologic features of functioning stromal cells have been described only rarely...
  28. ncbi request reprint Warthin tumor of the parotid gland: diagnostic value of MR imaging with histopathologic correlation
    Mitsuaki Ikeda
    Department of Radiology, Chiba University Hospital, Chiba, Japan
    AJNR Am J Neuroradiol 25:1256-62. 2004
    ..The purpose of our study was to describe the MR imaging appearance of Warthin tumors multiple MR imaging techniques and to interpret the difference in appearance from that of malignant parotid tumors...
  29. ncbi request reprint Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines
    Ying Yi Li
    Division of Molecular Bioregulation and Center for Target Drug Development, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Cancer Res 66:6741-7. 2006
    ..This may contribute to the net increase in tumor volume or tumor growth in pancreatic cancer...