Masaru Miyazaki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi request reprint Hepatic S4a + S5 and bile duct resection for gallbladder carcinoma
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatobiliary Pancreat Sci 19:225-9. 2012
  2. doi request reprint Repeat pancreatectomy for pancreatic ductal cancer recurrence in the remnant pancreas after initial pancreatectomy: is it worthwhile?
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Electronic address
    Surgery 155:58-66. 2014
  3. pmc Advanced small-cell colon carcinoma: a case report
    Toshiaki Iwase
    Division of Surgery, Heiwa Hospital, 29 1 Higashiterao Nakadai Tsurumi ku, Yokohana city, Kanagawa, 230 0017, Japan
    J Med Case Rep 7:74. 2013
  4. pmc Percutaneous transhepatic metallic stent insertion for malignant afferent loop obstruction following pancreaticoduodenectomy: a case report
    Isamu Hosokawa
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Med Case Rep 6:198. 2012
  5. pmc Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot
    Mamoru Takada
    Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    BMC Cancer 13:241. 2013
  6. pmc A causal relationship between right paraduodenal hernia and superior mesenteric artery syndrome: a case report
    Tadaomi Fukada
    Department of General Surgery, Chiba Emergency Medical Center, Isobe, Mihama ku, Chiba, 260 0856, Japan
    J Med Case Reports 4:159. 2010
  7. ncbi request reprint Extensive hilar bile duct resection using a transhepatic approach for patients with hepatic hilar bile duct diseases
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Surg 196:125-9. 2008
  8. ncbi request reprint Surgical treatment for liver cancer. Current issues
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Dig Surg 24:120-5. 2007
  9. ncbi request reprint One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 0856, Japan
    J Hepatobiliary Pancreat Sci 17:470-5. 2010
  10. ncbi request reprint Decreased interstitial cells of Cajal in the neorectum after anterior resection of the rectum
    Masaki Nishimura
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 53:665-8. 2006

Detail Information

Publications123 found, 100 shown here

  1. doi request reprint Hepatic S4a + S5 and bile duct resection for gallbladder carcinoma
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatobiliary Pancreat Sci 19:225-9. 2012
    ..This surgical procedure could be a useful option for the surgical treatment of the hepatobiliary pancreatic malignancies. Surgeons should therefore master the surgical techniques for this procedure...
  2. doi request reprint Repeat pancreatectomy for pancreatic ductal cancer recurrence in the remnant pancreas after initial pancreatectomy: is it worthwhile?
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Electronic address
    Surgery 155:58-66. 2014
    ..We retrospectively analyzed our patients and evaluated the clinical implications of repeat pancreatectomy for isolated local recurrence in the remnant pancreas after initial resection for pancreatic cancer...
  3. pmc Advanced small-cell colon carcinoma: a case report
    Toshiaki Iwase
    Division of Surgery, Heiwa Hospital, 29 1 Higashiterao Nakadai Tsurumi ku, Yokohana city, Kanagawa, 230 0017, Japan
    J Med Case Rep 7:74. 2013
    ..Here we report the long-term survival of a patient with advanced small-cell colon carcinoma achieved by a combination of surgery and continuous chemotherapy...
  4. pmc Percutaneous transhepatic metallic stent insertion for malignant afferent loop obstruction following pancreaticoduodenectomy: a case report
    Isamu Hosokawa
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Med Case Rep 6:198. 2012
    ..abstract:..
  5. pmc Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemot
    Mamoru Takada
    Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    BMC Cancer 13:241. 2013
    ..The mechanisms of recurrence and biomarkers that indicate the response to the chemotherapy and outcome are not fully investigated...
  6. pmc A causal relationship between right paraduodenal hernia and superior mesenteric artery syndrome: a case report
    Tadaomi Fukada
    Department of General Surgery, Chiba Emergency Medical Center, Isobe, Mihama ku, Chiba, 260 0856, Japan
    J Med Case Reports 4:159. 2010
    ..Cases of right paraduodenal hernia and superior mesenteric artery syndrome have been reported separately, but their occurrence in combination has not been reported...
  7. ncbi request reprint Extensive hilar bile duct resection using a transhepatic approach for patients with hepatic hilar bile duct diseases
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Surg 196:125-9. 2008
    ..The purpose of this study was to show the surgical procedure and the usefulness of extensive hilar bile duct resection using a transhepatic approach for patients with hilar bile duct diseases...
  8. ncbi request reprint Surgical treatment for liver cancer. Current issues
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Dig Surg 24:120-5. 2007
    ..Nowadays transplantation is one of the therapeutic options for HCC patients, even in Japan. Herein the surgical treatment of HCC in Japan is reviewed and current issues in the surgical treatment of HCC are discussed...
  9. ncbi request reprint One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 0856, Japan
    J Hepatobiliary Pancreat Sci 17:470-5. 2010
    ..However, the adoption of new innovative therapeutic approaches might be required for further improvement of surgical outcome of hilar cholangiocarcinoma...
  10. ncbi request reprint Decreased interstitial cells of Cajal in the neorectum after anterior resection of the rectum
    Masaki Nishimura
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 53:665-8. 2006
    ..The aim of this study was to examine the expression of interstitial cells of Cajal (ICCs) in the sigmoid colon used for constructing the neorectum after anterior resection of the rectum...
  11. ncbi request reprint Combined vascular resection in operative resection for hilar cholangiocarcinoma: does it work or not?
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Surgery 141:581-8. 2007
    ..Our aim was to evaluate implications of combined vascular resection in patients with hilar cholangiocarcinoma by analyzing the outcomes of all patients who underwent operative resection...
  12. ncbi request reprint Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy
    Shigetsugu Takano
    The Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 15:3157-68. 2008
    ..The purpose of this study was to determine novel factors that make pancreatic cancer resistant to gemcitabine...
  13. ncbi request reprint Effects of perioperative immunonutrition on cell-mediated immunity, T helper type 1 (Th1)/Th2 differentiation, and Th17 response after pancreaticoduodenectomy
    Daisuke Suzuki
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Surgery 148:573-81. 2010
    ....
  14. ncbi request reprint Angiopoietin-2 levels in the hepatic vein as a useful predictor of tumor invasiveness and prognosis in human hepatocellular carcinoma
    Satoshi Kuboki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e157-64. 2008
    ....
  15. ncbi request reprint A randomized phase II trial of adjuvant chemotherapy with uracil/tegafur and gemcitabine versus gemcitabine alone in patients with resected pancreatic cancer
    Hideyuki Yoshitomi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 113:2448-56. 2008
    ..There have been few randomized studies of adjuvant chemotherapy using gemcitabine (GEM) in patients with resected pancreatic cancer...
  16. ncbi request reprint Upregulation of topoisomerase IIalpha expression in advanced gallbladder carcinoma: a potential chemotherapeutic target
    Mitsutsune Washiro
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba, 260 8670, Japan
    J Cancer Res Clin Oncol 134:793-801. 2008
    ..The aim of this study was to identify cancer-specific cellular targets that would form the basis for some therapeutic approaches for this disease...
  17. ncbi request reprint Sentinel node micrometastasis and distant failure in breast cancer patients
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Breast Cancer 13:186-91. 2006
    ..The present study attempts to clarify the occurrence of distant failure after SN biopsy, especially in breast cancer patients with SN micrometastasis...
  18. doi request reprint Interleukin-18 exacerbates pulmonary injury after hepatic ischemia/reperfusion in mice
    Dan Takeuchi
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba shi, Chiba, Japan
    J Surg Res 158:87-93. 2010
    ..The objective of this study was to determine whether IL-18 contributes to pulmonary injury induced by hepatic ischemia/reperfusion...
  19. ncbi request reprint Surgical treatment for extrahepatic recurrence after hepatectomy for colorectal metastases
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Hepatogastroenterology 51:1805-9. 2004
    ..While regional chemotherapy may reduce recurrence of the liver, appropriate therapy for extrahepatic metastases needs to be elucidated...
  20. ncbi request reprint Preoperative GATA3 mRNA expression in peripheral blood mononuclear cells is up-regulated in patients with postoperative infection following hepatobiliary pancreatic surgery
    Jun Kawamoto
    Department of General Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Surg Res 152:118-27. 2009
    ..Correlations of Th1/Th2 balance and toll-like receptor (TLR) 2/4 expression with postoperative infection following surgery were prospectively evaluated...
  21. ncbi request reprint The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Mod Pathol 21:1363-70. 2008
    ....
  22. ncbi request reprint Hepatocyte nuclear factor-kappa beta (NF-kappaB) activation is protective but is decreased in the cholestatic liver with endotoxemia
    Ayako Iida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Surgery 148:477-89. 2010
    ..The aim of the current study was to examine whether NF-kappaB activation can decrease hepatocyte apoptosis and liver injury over the time course of OJ in response to lipopolysaccharide (LPS) administration...
  23. ncbi request reprint Treatment with an oral fluoropyrimidine, S-1, plus cisplatin in patients who failed postoperative gemcitabine treatment for pancreatic cancer: a pilot study
    Akira Togawa
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba, 260 0856, Japan
    Int J Clin Oncol 12:268-73. 2007
    ..This study set out to evaluate, in patients with gemcitabine-resistant pancreatic cancer, the response rate and toxicity of S-1 plus cisplatin (CDDP)...
  24. ncbi request reprint Interval period tumor progression: does delayed hepatectomy detect occult metastases in synchronous colorectal liver metastases?
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 0856, Japan
    J Gastrointest Surg 12:1391-8. 2008
    ..We evaluated the tumor progression during interval periods to determine whether delayed hepatic resection detects occult metastases...
  25. ncbi request reprint Endothelin-1 aggravates hepatic ischemia/reperfusion injury during obstructive cholestasis in bile duct ligated mice
    Hiroyuki Nagai
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Res 162:46-53. 2010
    ..However, the mechanism of liver injury in cholestatic liver is not fully understood. The goal of this study was to investigate the process of liver injury due to hepatic ischemia/reperfusion in obstructive cholestasis...
  26. ncbi request reprint Circulating cytokines, chemokines, and stress hormones are increased in patients with organ dysfunction following liver resection
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    J Surg Res 133:102-12. 2006
    ....
  27. ncbi request reprint Increased plasma levels of IL-6 and IL-8 are associated with surgical site infection after pancreaticoduodenectomy
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Pancreas 32:178-85. 2006
    ..Cytokines and chemokines potentially modulate postoperative immune response. Association of circulating cytokines and chemokines with postoperative infectious complications after pancreaticoduodenectomy was evaluated...
  28. ncbi request reprint Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 0856, Japan
    J Hepatobiliary Pancreat Surg 14:463-8. 2007
    ..Herein, we describe the results of aggressive surgical approaches in our series, and we also review the outcomes of hepatic resection with combined vascular resection in the previously reported literature...
  29. ncbi request reprint Accumulation of regulatory T cells in sentinel lymph nodes is a prognostic predictor in patients with node-negative breast cancer
    Rikiya Nakamura
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuoku, Chiba 260 8677, Japan
    Eur J Cancer 45:2123-31. 2009
    ..012). Our data indicate that Treg may increase in the microenvironment of SLNs along with pathologically undetectable micrometastases and is a prognostic predictor in patients with node-negative breast cancer...
  30. ncbi request reprint Surgical strategy for mucin-producing bile duct tumor
    Masayuki Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba, 260 8670, Japan
    J Hepatobiliary Pancreat Sci 17:236-40. 2010
    ..All ten patients with MPBT resected at our institution according to these strategies are still alive without tumor recurrence, with a median survival of 48.0 months...
  31. doi request reprint Treatment strategy for hepatocellular carcinoma with major portal vein or inferior vena cava invasion: a single institution experience
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 212:796-803. 2011
    ..The prognosis of patients with hepatocellular carcinoma (HCC) invading the main trunk of the portal vein and the inferior vena cava is dismal. The best strategy for treatment is not well known...
  32. ncbi request reprint Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma
    Yuichi Hirasawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncology 71:77-85. 2006
    ....
  33. ncbi request reprint Should the inferior vena cava be reconstructed after resection for malignant tumors?
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856 Japan
    Am J Surg 189:419-24. 2005
    ..Caval replacement after circumferential resection of the inferior vena cava remains controversial. The aim of the current study is to determine whether or not inferior vena cava replacement should be performed...
  34. pmc Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma
    Seiki Miura
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 0856, Japan
    BMC Cancer 12:56. 2012
    ..FGF19, a member of the FGF family, has unique specificity for its receptor FGFR4. This study aimed to clarify the involvement of FGF19 in the development of HCC...
  35. ncbi request reprint Dynamic enhanced MRI predicts chemosensitivity in breast cancer patients
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Eur J Radiol 60:270-4. 2006
    ..The present study attempts to clarify quantitative parameters on MRI which can be used to predict the sensitivity to treatment in breast cancer patients...
  36. ncbi request reprint Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
    ..However, there have been few reports on the reasons for poor prognosis...
  37. ncbi request reprint [Hilar cholangiocarcinoma]
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Nihon Geka Gakkai Zasshi 106:291-6. 2005
    ..By using several useful pre-operative and intra-operative therapeutic modalities, hilar cholangiocarcinoma should be surgically resected with curative intent and without increasing surgical morbidity and mortality rates...
  38. doi request reprint Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression
    Hiroshi Fujimoto
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan
    Int J Cancer 125:1276-84. 2009
    ..105). These findings indicate that stromal MCP-1 produced as a result of tumor-stromal interactions may be important for the progression of human breast cancer and macrophages may play an important role in this tumor-stroma interaction...
  39. doi request reprint Clinical significance of axillary microresiduals after neoadjuvant chemotherapy in breast cancer patients with cytologically proven metastases
    Masahiro Sakakibara
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Surg Oncol 16:2470-8. 2009
    ..This study evaluated the clinical significance of residual micrometastases and discusses screening methods after NAC in patients with cytologically proven axillary metastases...
  40. ncbi request reprint Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, 260 0856, Japan
    J Hepatobiliary Pancreat Surg 14:358-65. 2007
    ..Survival and prognostic factors were analyzed in patients with stage IV disease, based on the Japanese Society of Biliary Surgery (JSBS) classification, to identify the group of patients who could benefit from radical surgery...
  41. ncbi request reprint Long-term survival after extended surgical resection of intrahepatic cholangiocarcinoma with extensive lymph node metastasis
    Hiroyuki Asakura
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 52:722-4. 2005
    ..The extensive surgical approach may have contributed to the long-term survival of this patient, while the recurrent tumor was sensitive to antitumoral agents...
  42. doi request reprint Does prolonged biliary obstructive jaundice sensitize the liver to endotoxemia?
    Ayako Iida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Shock 31:397-403. 2009
    ..In prolonged OJ with LPS administration, hepatocyte apoptosis depending on Fas ligand expression significantly increased in association with a decrease in ATP contents, thus resulting in liver necrapoptosis...
  43. ncbi request reprint Ezrin expression is associated with hepatocellular carcinoma possibly derived from progenitor cells and early recurrence after surgical resection
    Daiki Okamura
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 21:847-55. 2008
    ..Measurement of ezrin expression might be used to identify patients with an increased risk of early recurrence...
  44. ncbi request reprint Hepatic vein reconstruction using autologous vein graft for resection of advanced hepatobiliary malignancy
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 51:1581-5. 2004
    ....
  45. ncbi request reprint Effect of excessive acute-phase response on liver regeneration after partial hepatectomy in rats
    Kimihiko Kusashio
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 56:824-8. 2009
    ..In this study, the effect of excessive APR on liver regeneration was investigated using a rat hepatectomized model...
  46. doi request reprint Surgical resection after downsizing chemotherapy for initially unresectable locally advanced biliary tract cancer: a retrospective single-center study
    Atsushi Kato
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Surg Oncol 20:318-24. 2013
    ..The aim of this study was to evaluate the effect of downsizing chemotherapy in patients with initially unresectable locally advanced BTC...
  47. doi request reprint Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatobiliary Pancreat Surg 15:508-14. 2008
    ..We investigated the potential utility of an infrared camera system as a tool for evaluating local anatomy during hepatobiliary surgery...
  48. ncbi request reprint [A patient with bile duct cancer who showed rapid obstruction after insertion of a non covered stent, but in this case obtained a stent opening and better QOL after reinsertion of a covered stent]
    Seiki Miura
    Dept of General Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 33:1950-2. 2006
    ..A covered stent can be more potentially and clinically effective than a non-covered stent especially for a papillary tumor in the bile duct...
  49. doi request reprint Reg IV expression and clinicopathologic features of gallbladder carcinoma
    Hidehiko Tamura
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hum Pathol 40:1686-92. 2009
    ..The serum level of Reg IV may be of use or indicative of neoplasia...
  50. doi request reprint Response rate to neoadjuvant chemotherapy measured on imaging predicts early recurrence and death in breast cancer patients with lymph node involvements
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Japan
    Acta Radiol 52:241-6. 2011
    ..Although pathological response is the strongest prognostic factor, response rates vary according to various parameters, such as dissociation between breast and axillary node responses...
  51. ncbi request reprint Sonic Hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas
    Takashi Shida
    Departments of Molecular Pathology, General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Biol Ther 5:1530-8. 2006
    ..Blockade of Hh pathway using cyclopamine or its synthetic derivatives might open an effective therapeutic strategy to NECs, not only by suppressing tumor viability but also by altering tumor cell nature...
  52. ncbi request reprint Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct
    Toshio Tsuyuguchi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuou ku, Chiba, 260 8670, Japan
    J Hepatobiliary Pancreat Sci 17:230-5. 2010
    ..The purpose of this study was to evaluate the diagnostic utility of endoscopic cholangiography (ERC) with subsequent peroral cholangioscopy (POCS) and/or intraductal ultrasonography (IDUS) for this tumor...
  53. ncbi request reprint Possible involvement of persistent activity of the mammalian target of rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells
    Shigeyuki Kamata
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Biol Ther 6:1036-43. 2007
    ..In conclusion rapamycin may be a potential supplemental agent for the treatment of AFPGC when used in combination with cisplatin...
  54. ncbi request reprint Increased expression of toll-like receptor 4 enhances endotoxin-induced hepatic failure in partially hepatectomized mice
    Tsukasa Takayashiki
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana Chuo ku, Chiba, 260 0856 Japan
    J Hepatol 41:621-8. 2004
    ..It has recently been reported that toll-like receptor 4 (TLR4) is involved in recognizing lipopolysaccharides (LPS). The aim of this study was to investigate the role of TLR4 in endotoxin-induced liver injury after hepatectomy...
  55. ncbi request reprint Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    World J Gastroenterol 11:7254-60. 2005
    ..To study the regulatory mechanisms of sinusoidal regeneration after partial hepatectomy...
  56. doi request reprint Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy
    Toshiaki Aida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Surgery 155:124-33. 2014
    ....
  57. doi request reprint Clinical usefulness of repeated pancreatic juice cytology via endoscopic naso-pancreatic drainage tube in patients with pancreatic cancer
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ward, Chiba 260 8670, Japan
    J Gastroenterol 48:866-73. 2013
    ..The aim of this study was to evaluate the usefulness of repeated pancreatic juice cytology (PJC) via the endoscopic naso-pancreatic drainage (ENPD) tube in patients with pancreatic cancer compared with conventional PJC...
  58. ncbi request reprint Protective effects of simultaneous splenectomy on small-for-size liver graft injury in rat liver transplantation
    Takuya Yoichi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Transpl Int 27:106-13. 2014
    ..Downregulation of intragraft ET-1 expression plays important roles in the protective mechanism of splenectomy in SFS liver transplantation. ..
  59. ncbi request reprint Anterior transhepatic approach for hepatocellular carcinoma located in deep positions of segment VIII
    Tadaomi Fukada
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Hepatogastroenterology 54:536-8. 2007
    ..This anterior transhepatic approach provides a wide operating field and easy hemostasis, and could preserve the liver parenchyma as much as possible in a patient with liver dysfunction...
  60. pmc Advanced moderately differentiated neuroendocrine carcinoma of the rectum with favorable prognosis by postoperative chemoradiation
    Hiroyuki Nojima
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    World J Surg Oncol 8:29. 2010
    ..A total dose of 46 Gy of radiotherapy was delivered with 800 mg of daily oral doxifluridine. At 5 years post-surgery, the patient demonstrated no clinical evidence of intrapelvic recurrence or distant metastases...
  61. doi request reprint Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Chemother Pharmacol 65:889-93. 2010
    ..The purpose of the present study was to determine the activation of mTOR in gastropancreatic neuroendocrine tumors, especially in poorly differentiated neuroendocrine carcinomas...
  62. pmc Stenting and interventional radiology for obstructive jaundice in patients with unresectable biliary tract carcinomas
    Toshio Tsuyuguchi
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Hepatobiliary Pancreat Surg 15:69-73. 2008
    ..In spite of these shortcomings, evidence is expected to demonstrate its superiority over other types of stent...
  63. pmc Guidelines for chemotherapy of biliary tract and ampullary carcinomas
    Junji Furuse
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital East, Kashiwa shi, Chiba, Japan
    J Hepatobiliary Pancreat Surg 15:55-62. 2008
    ..It is recommended that further clinical trials, especially large multi-institutional RCTs (phase III studies) using novel agents such as gemcitabine should be performed as soon as possible in order to establish a standard treatment...
  64. doi request reprint Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion
    Masayuki Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Surg Pathol 35:512-21. 2011
    ..In conclusion, IPNB-M showed striking similarities to IPMN-P, but IPNB-NM contained heterogeneous disease groups...
  65. ncbi request reprint [A successful treatment with down-staging chemotherapy for sigmoid colon cancer with unresectable multiple liver and lung metastases]
    Satoru Nomura
    Dept of General Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 34:2032-4. 2007
    ..Recently, a progression of the systemic chemotherapy for colorectal cancer has been a promising modality to improve a poor prognosis for unresectable multiple liver or extrahepatic metastases from advanced colorectal cancer...
  66. ncbi request reprint Surgical management of occluded biliary expandable metallic stent for benign stricture of bilioenteric anastomosis: usefulness of anterior transhepatic procedure
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Hepatogastroenterology 56:50-3. 2009
    ..The anterior transhepatic approach may be a very useful procedure for approach to the second or more proximal biliary ducts without hepatic resection...
  67. ncbi request reprint Extended cold preservation of the graft liver enhances neutrophil-mediated pulmonary injury after liver transplantation
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 52:1172-5. 2005
    ..The precise mechanisms of pulmonary injury after liver transplantation, especially those associated with cold ischemia time, are not yet clear...
  68. pmc Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy
    Hironobu Makino
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 0856, Japan
    World J Gastroenterol 12:2053-9. 2006
    ..To study the effects of obstructive jaundice on liver regeneration after partial hepatectomy...
  69. ncbi request reprint Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 34:923-30. 2009
    ..The MCP-1 expression in colorectal liver metastases, at least in part, may be associated with angiogenesis and be a predictive marker for hepatic recurrence after hepatic resection for colorectal liver metastases...
  70. ncbi request reprint Thymidylate synthase and dihydropyrimidine dehydrogenase are related to histological effects of 5-fluorouracil and cisplatin neoadjuvant chemotherapy for primary gastric cancer patients
    Hiroyuki Fukuda
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer Invest 24:235-41. 2006
    ..In this study, we studied the correlation between these markers and the histological chemotherapeutic effect in advanced gastric cancer with neoadjuvant chemotherapy...
  71. doi request reprint Specific expression of endoglin (CD105) in endothelial cells of intratumoral blood and lymphatic vessels in pancreatic cancer
    Hideyuki Yoshitomi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pancreas 37:275-81. 2008
    ..The aim of this study was to analyze the expression pattern of endoglin in pancreatic cancer and assess the involvement of this molecule in cancer progression...
  72. ncbi request reprint [Portal vein stenting for portal hypertension caused by local recurrence following hepato-pancreatoduodenectomy for bile duct cancer]
    Jun Kawamoto
    Dept of General Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 32:1866-9. 2005
    ..Our experience suggests that the portal vein stenting using the SMART stent is useful palliative therapy for portal vein stenosis...
  73. ncbi request reprint Neoadjuvant chemotherapy with CDDP and 5-fluorouracil for gastric cancer with serosal invasion
    Nobuhiro Takiguchi
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Oncol Rep 10:433-8. 2003
    ..0042). In conclusion, neoadjuvant chemotherapy with 5-FU +/- CDDP for gastric cancer patients with serosal invasion may reduce positive peritoneal cytology, eliminate cancer cells from the serosal surface, and improve prognosis...
  74. doi request reprint Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma
    Yutaka Yonemitsu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 40:1304-11. 2009
    ..029) and BMI1 (P = .039) than in their negative counterparts, as determined by Kaplan-Meier analysis. These data indicate that EZH2 and BMI1 may cooperate in initiation and progression of hepatocellular carcinoma...
  75. ncbi request reprint Aggressive surgical resection for hepatocellular carcinoma with tumor thrombus extending to inferior vena cava and synchronous pulmonary metastasis
    Daisuke Kitayama
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Hepatogastroenterology 51:1326-9. 2004
    ..In conclusion, aggressive surgical resection for advanced hepatocellular carcinoma concomitant with pulmonary resection may bring about better prognosis in highly selected patients...
  76. ncbi request reprint Clinical significance of biliary vascular anatomy of the right liver for hilar cholangiocarcinoma applied to left hemihepatectomy
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Ann Surg 249:435-9. 2009
    ..To evaluate the influence of confluence pattern of the right posterior sectional bile duct (RPSBD) on clinocopathological outcome in patients with hilar cholangiocarcinoma who underwent left hemihepatectomy (LH)...
  77. ncbi request reprint Renal function is well maintained after use of left renal vein graft for vascular reconstruction in hepatobiliary-pancreatic surgery
    Takeshi Suzuki
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 202:87-92. 2006
    ..We used a left renal vein graft to reconstruct resected vessels in some patients. In this study, we evaluated early and late renal complications of this procedure...
  78. ncbi request reprint Effects of partial hepatic venous congestion on hepatic hemodynamics and histology
    Atsushi Okuno
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Hepatogastroenterology 57:127-33. 2010
    ..Extensive liver resection potentially causes hepatic venous congestion resulting in critical liver damage. The effects of partial hepatic venous congestion on hepatic hemodynamics and histology were studied...
  79. ncbi request reprint Protein profiling in pancreatic juice for detection of intraductal papillary mucinous neoplasm of the pancreas
    Yoshihiko Shirai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Hepatogastroenterology 55:1824-9. 2008
    ..Recent advances in proteomic analysis are remarkable; therefore we explored novel biomarkers for IPMN using Surface-Enhanced Laser Desorption and Ionization (SELDI) Mass Spectrometry...
  80. ncbi request reprint Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Breast Cancer 9:226-30. 2002
    ..The present study attempts to clarify the quantitative assessment of dynamic data, and examines the correlation between MRI enhancement and breast carcinoma metastasis...
  81. ncbi request reprint Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:1105-13. 2003
    ..In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC...
  82. ncbi request reprint Follow-up of cases with false-negative pathologic sentinel nodes in breast cancer
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Breast Cancer 11:175-9. 2004
    ..The present study examines the pathological false-negative cases on intraoperative sentinel lymph node investigations and evaluates their outcomes...
  83. ncbi request reprint [Preoperative chemo-radiotherapy for the treatment of advanced middle to lower rectal cancers]
    Keiji Koda
    Department of General Surgery, Graduate School of Medicine, Chiba University
    Nihon Rinsho 61:468-71. 2003
  84. ncbi request reprint [Surgical treatment for extrahepatic bile duct cancer]
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University
    Nihon Rinsho 64:479-83. 2006
  85. ncbi request reprint Heparin-induced thrombocytopenia after coronary artery bypass grafting with cardiopulmonary bypass: report of a case
    Keiichi Ishida
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Surg Today 34:1041-3. 2004
    ..Heparin-induced thrombocytopenia, which causes thrombosis, is a serious side effect of heparin therapy and few cases of HIT associated with CPB surgery have been reported in Japan...
  86. ncbi request reprint Postoperative adjuvant chemotherapy is effective in gastric cancer with serosal invasion: significance in patients chosen for multivariate analysis
    Nobuhiro Takiguchi
    Department of General Surgery, Chiba University, Graduate School of Medicine, Chiba City 260 8677, Japan
    Oncol Rep 9:801-6. 2002
    ..However, 5'-DFUR produced a better survival time of patients with serosal invasion than 5-FU, that might be attributed to the prevention of peritoneal recurrence in this subset...
  87. ncbi request reprint Should the extrahepatic bile duct be resected for locally advanced gallbladder cancer?
    Yasuhito Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 560 8670, Japan
    Surgery 136:1012-7; discussion 1018. 2004
    ..The incidence and mode of spread of carcinoma of the gallbladder into the hepatoduodenal ligament have not been well described pathologically for gallbladder carcinoma extending into the subserosa and beyond...
  88. ncbi request reprint Aggressive surgical resection for hilar cholangiocarcinoma of the left-side predominance: radicality and safety of left-sided hepatectomy
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg 251:281-6. 2010
    ..To evaluate the clinicopathologic outcomes in patients with hilar cholangiocarcinoma (HC) after left-sided hepatectomy (L-H)...
  89. ncbi request reprint Intraoperative cytologic diagnosis of sentinel node metastases in breast cancer
    Takeshi Nagashima
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Acta Cytol 47:1028-32. 2003
    ..To clarify the usefulness of imprint cytology for intraoperative investigations of sentinel lymph nodes in breast cancer, comparing the results with those of examinations using frozen and permanent sections...
  90. doi request reprint Breast cancer with cartilaginous and/or osseous metaplasia
    Takuya Yoichi
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 0856, Japan
    Breast Cancer 16:234-7. 2009
    ..Breast cancer with cartilaginous and/or osseous metaplasia belongs to a special type of invasive carcinoma, and the incidence is very low. We here present our case and a review of the literature...
  91. ncbi request reprint Relationship between pancreatic secretory trypsin inhibitor and early recurrence of intrahepatic cholangiocarcinoma following surgical resection
    Akihiko Tonouchi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Gastroenterol 101:1601-10. 2006
    ..The aim of this study was to identify the molecules associated with early recurrence of ICC following resection...
  92. ncbi request reprint Breast-conserving surgery using supine magnetic resonance imaging in breast cancer patients receiving neoadjuvant chemotherapy
    Rikiya Nakamura
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Breast 17:245-51. 2008
    ..We developed a new procedure (NIPR) in which initial naked magnetic resonance images are projected onto the skin before BCS...
  93. ncbi request reprint Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy
    Toshiaki Sato
    Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan
    Diabetes Metab Res Rev 22:341-7. 2006
    ..Hence, a sulfonylurea that does not block mitoK(ATP) channels would be desirable to avoid damage to the heart. Accordingly, we examined the effects of sulfonylureas on the mitoK(ATP) channel and mitochondrial Ca(2+) overload...
  94. ncbi request reprint Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma
    Rikiya Nakamura
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Breast Cancer 14:245-9. 2007
    ..The patient was the treated with chemotherapy (weekly paclitaxel, 80 mg/m2 x cycles) and has remained well without evidence of local or distant recurrence...
  95. ncbi request reprint Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy
    Taketo Yamaguchi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Cancer 104:2830-6. 2005
    ..The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice...
  96. doi request reprint Breast-conserving surgery using projection and reproduction techniques of surgical-position breast MRI in patients with ductal carcinoma in situ of the breast
    Masahiro Sakakibara
    Department of General Surgery, Chiba University Graduate School of Medicine, Chuoku, Chiba, Japan
    J Am Coll Surg 207:62-8. 2008
    ....
  97. ncbi request reprint The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma
    Yoshiaki Shimizu
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Hepatogastroenterology 55:699-703. 2008
    ..The aims of this study are to evaluate experience with ampullary carcinoma and distal cholangiocarcinoma at a single institution...
  98. ncbi request reprint Long-term follow-up of intraductal papillary mucinous neoplasm of the pancreas with ultrasonography
    Taketo Yamaguchi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 01 Inohana, Chuoku, Chiba 260 0805, Japan
    Clin Gastroenterol Hepatol 3:1136-43. 2005
    ..This study was undertaken to clarify the clinical course of IPMNs and to set the criteria for surgical treatment on the basis of long-term follow-up by periodic transabdominal ultrasonography (US)...
  99. ncbi request reprint Natural killer cell activity and distant metastasis in rectal cancers treated surgically with and without neoadjuvant chemoradiotherapy
    Keiji Koda
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Am Coll Surg 197:254-60. 2003
    ..In addition, we examined if preoperative chemoradiotherapy for rectal cancers impairs NK cell activity and contributes to the induction of distant metastasis...
  100. ncbi request reprint Extended hepatic resection and outcomes in intrahepatic cholangiocarcinoma
    Masayuki Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8670, Japan
    J Hepatobiliary Pancreat Surg 10:259-64. 2003
    ..The aim of this report was to assess the outcome of aggressive surgical treatment for intrahepatic cholangiocarcinoma...
  101. ncbi request reprint Intermediate dose pre-operative irradiation for carcinoma of the rectum
    Takashi Uno
    Department of Radiation Oncology, Chiba University, Graduate School of Medicine, Inohana 1 8 1, Chuou ku, Chiba City, Chiba 260 8670, Japan
    Anticancer Res 22:3013-7. 2002
    ..To assess the locoregional control, survival and toxicities of combined intermediate-dose pre-operative irradiation and surgery for rectal cancer patients...