Noboru Mitsuhashi

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models
    Noboru Mitsuhashi
    Cardiothoracic Surgery, The Saban Research Institute of Childrens Hospital Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Mol Cell Biochem 296:1-9. 2007
  2. ncbi Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
  3. ncbi Angiopoietin-2 levels in the hepatic vein as a useful predictor of tumor invasiveness and prognosis in human hepatocellular carcinoma
    Satoshi Kuboki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e157-64. 2008
  4. ncbi Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection
    Gordon D Wu
    Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Heart Lung Transplant 24:2160-9. 2005
  5. ncbi Interval period tumor progression: does delayed hepatectomy detect occult metastases in synchronous colorectal liver metastases?
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 0856, Japan
    J Gastrointest Surg 12:1391-8. 2008
  6. ncbi Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen
    Noboru Mitsuhashi
    Childrens Hospital of Los Angeles, Department of Cardiothoracic Surgery, Los Angeles, CA 90027, USA
    Blood 107:2286-93. 2006
  7. ncbi Endothelin-1 aggravates hepatic ischemia/reperfusion injury during obstructive cholestasis in bile duct ligated mice
    Hiroyuki Nagai
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Res 162:46-53. 2010
  8. ncbi Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma
    Seiki Miura
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 0856, Japan
    BMC Cancer 12:56. 2012
  9. ncbi Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    World J Gastroenterol 11:7254-60. 2005
  10. ncbi Preoperative GATA3 mRNA expression in peripheral blood mononuclear cells is up-regulated in patients with postoperative infection following hepatobiliary pancreatic surgery
    Jun Kawamoto
    Department of General Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Surg Res 152:118-27. 2009

Collaborators

Detail Information

Publications31

  1. ncbi Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models
    Noboru Mitsuhashi
    Cardiothoracic Surgery, The Saban Research Institute of Childrens Hospital Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Mol Cell Biochem 296:1-9. 2007
    ..These results indicate that, like the other CXCR3 chemokines, rat CXCL11 seems to have a role in the homing of CD4(+) T cells in both acute and chronic rejection models of heart allotransplantation...
  2. ncbi Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
    ..However, there have been few reports on the reasons for poor prognosis...
  3. ncbi Angiopoietin-2 levels in the hepatic vein as a useful predictor of tumor invasiveness and prognosis in human hepatocellular carcinoma
    Satoshi Kuboki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e157-64. 2008
    ....
  4. ncbi Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection
    Gordon D Wu
    Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Heart Lung Transplant 24:2160-9. 2005
    ..This study examines the role of MPC in tissue repair of heart allografts in a rat model of chronic rejection...
  5. ncbi Interval period tumor progression: does delayed hepatectomy detect occult metastases in synchronous colorectal liver metastases?
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 0856, Japan
    J Gastrointest Surg 12:1391-8. 2008
    ..We evaluated the tumor progression during interval periods to determine whether delayed hepatic resection detects occult metastases...
  6. ncbi Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen
    Noboru Mitsuhashi
    Childrens Hospital of Los Angeles, Department of Cardiothoracic Surgery, Los Angeles, CA 90027, USA
    Blood 107:2286-93. 2006
    ..Mice reconstituted with GalT accepted alphaGal+ heart grafts over 100 days. Transduction with lentiviral vectors results in chimerism at levels sufficient to induce long-term tolerance under nonmyeloablative conditions...
  7. ncbi Endothelin-1 aggravates hepatic ischemia/reperfusion injury during obstructive cholestasis in bile duct ligated mice
    Hiroyuki Nagai
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Res 162:46-53. 2010
    ..However, the mechanism of liver injury in cholestatic liver is not fully understood. The goal of this study was to investigate the process of liver injury due to hepatic ischemia/reperfusion in obstructive cholestasis...
  8. ncbi Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma
    Seiki Miura
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 0856, Japan
    BMC Cancer 12:56. 2012
    ..FGF19, a member of the FGF family, has unique specificity for its receptor FGFR4. This study aimed to clarify the involvement of FGF19 in the development of HCC...
  9. ncbi Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    World J Gastroenterol 11:7254-60. 2005
    ..To study the regulatory mechanisms of sinusoidal regeneration after partial hepatectomy...
  10. ncbi Preoperative GATA3 mRNA expression in peripheral blood mononuclear cells is up-regulated in patients with postoperative infection following hepatobiliary pancreatic surgery
    Jun Kawamoto
    Department of General Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Surg Res 152:118-27. 2009
    ..Correlations of Th1/Th2 balance and toll-like receptor (TLR) 2/4 expression with postoperative infection following surgery were prospectively evaluated...
  11. ncbi Increased plasma levels of IL-6 and IL-8 are associated with surgical site infection after pancreaticoduodenectomy
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Pancreas 32:178-85. 2006
    ..Cytokines and chemokines potentially modulate postoperative immune response. Association of circulating cytokines and chemokines with postoperative infectious complications after pancreaticoduodenectomy was evaluated...
  12. ncbi Surgical strategy for mucin-producing bile duct tumor
    Masayuki Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba, 260 8670, Japan
    J Hepatobiliary Pancreat Sci 17:236-40. 2010
    ..All ten patients with MPBT resected at our institution according to these strategies are still alive without tumor recurrence, with a median survival of 48.0 months...
  13. ncbi Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatobiliary Pancreat Surg 15:508-14. 2008
    ..We investigated the potential utility of an infrared camera system as a tool for evaluating local anatomy during hepatobiliary surgery...
  14. ncbi Surgical management of occluded biliary expandable metallic stent for benign stricture of bilioenteric anastomosis: usefulness of anterior transhepatic procedure
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Hepatogastroenterology 56:50-3. 2009
    ..The anterior transhepatic approach may be a very useful procedure for approach to the second or more proximal biliary ducts without hepatic resection...
  15. ncbi Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 0856, Japan
    J Hepatobiliary Pancreat Surg 14:463-8. 2007
    ..Herein, we describe the results of aggressive surgical approaches in our series, and we also review the outcomes of hepatic resection with combined vascular resection in the previously reported literature...
  16. ncbi Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:1105-13. 2003
    ..In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC...
  17. ncbi Intrahepatic cholangiojejunostomy (Longmire procedure) for recurrent bilioenteric anastomotic stricture with hepatolithiasis
    Hiroaki Shimizu
    Department of General Surgery, Chiba University, Chiba, Japan
    Hepatogastroenterology 59:1023-5. 2012
    ....
  18. ncbi [Development for combination of surgery and chemotherapy on biliary tract cancer]
    Atsushi Kato
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Gan To Kagaku Ryoho 35:1685-89. 2008
  19. ncbi Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat
    Noboru Mitsuhashi
    Division of Cardiothoracic Surgery, Department of Cardiothoracic Surgery, Children s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Immunology 112:87-93. 2004
    ..These findings indicate that rat CXCL9 has an in vivo role in the infiltration of CD4+ T cells in the transplanted graft...
  20. ncbi Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, 260 0856, Japan
    J Hepatobiliary Pancreat Surg 14:358-65. 2007
    ..Survival and prognostic factors were analyzed in patients with stage IV disease, based on the Japanese Society of Biliary Surgery (JSBS) classification, to identify the group of patients who could benefit from radical surgery...
  21. ncbi Excessive inflammation but decreased immunological response renders liver susceptible to infection in bile duct ligated mice
    Yasuhiro Morita
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Res 146:262-70. 2008
    ..Obstructive jaundice (OJ) is associated with increased surgical morbidity and infectious complication. The aim of the current study was to clarify the mechanism of excessive inflammation and susceptibility to infection in OJ...
  22. ncbi Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts
    Mary Kearns-Jonker
    Department of Cardiothoracic Surgery, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
    Transplantation 77:1748-54. 2004
    ..Limitations to the success of this methodology include short-term expression of the introduced gene and rejection of gal hearts transplanted into these animals within a month...
  23. ncbi Induction of antitumor response by in vivo allogeneic major histocompatibility complex gene transfer using electroporation
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Res 154:60-7. 2009
    ..In this study, we investigated whether allogeneic MHC gene transfer into the low-antigenic tumor might induce cell-mediated immunity, and provide an immunotherapeutic effect in vivo...
  24. ncbi Circulating cytokines, chemokines, and stress hormones are increased in patients with organ dysfunction following liver resection
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    J Surg Res 133:102-12. 2006
    ....
  25. ncbi The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix
    Hui Zhu
    Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, California 90048, USA
    Stem Cells 24:928-35. 2006
    ..Such a migratory mechanism could be critical for recruitment of MSCs into wound sites for the proposition of tissue regeneration, as well as for migration of fibroblast progenitors to allografts in the development of graft fibrosis...
  26. ncbi Clinical implications of unusual NeuroD and mASH1 expression in a patient with primary large-cell neuroendocrine carcinoma of the duodenum: report of a case
    Seiki Miura
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Surg Today 38:857-61. 2008
    ..The expression patterns of NeuroD and mASH1 suggest a favorable prognosis...
  27. ncbi Effect of cold-ischemia time on C-X-C chemokine expression and neutrophil accumulation in the graft liver after orthotopic liver transplantation in rats
    Masaaki Kataoka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-0856, Japan
    Transplantation 73:1730-5. 2002
    ..CONCLUSION: Extended cold preservation of the graft liver might up-regulate MIP-2 and CINC expression of hepatocytes, most probably through elevated TNF-alpha, and might contribute to PMN recruitment and activation after reperfusion...
  28. ncbi Gene transfer of heme oxygenase-1 using an adeno-associated virus serotype 6 vector prolongs cardiac allograft survival
    Jacqueline M Evans
    Department of Anesthesiology Critical Care Medicine, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Transplant 2012:740653. 2012
    ..Conclusions. Pretreatment of cardiac allografts with AAV6-HO-1 plus cyclosporine A prolonged graft survival. HO-1 gene therapy represents a beneficial adjunct to immunosuppressive therapy in cardiac transplantation...
  29. ncbi Aggressive surgical resection for hepatocellular carcinoma with tumor thrombus extending to inferior vena cava and synchronous pulmonary metastasis
    Daisuke Kitayama
    Department of General Surgery, Chiba University Graduate School of Medicine, Japan
    Hepatogastroenterology 51:1326-9. 2004
    ..In conclusion, aggressive surgical resection for advanced hepatocellular carcinoma concomitant with pulmonary resection may bring about better prognosis in highly selected patients...
  30. ncbi [A successful treatment with down-staging chemotherapy for sigmoid colon cancer with unresectable multiple liver and lung metastases]
    Satoru Nomura
    Dept of General Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 34:2032-4. 2007
    ..Recently, a progression of the systemic chemotherapy for colorectal cancer has been a promising modality to improve a poor prognosis for unresectable multiple liver or extrahepatic metastases from advanced colorectal cancer...
  31. ncbi [Aggressive surgical treatment prolonged survival of a patient with synchronous hepatocellular carcinoma with tumor thrombus in the inferior vena cava and sigmoid colon cancer]
    Daiki Okamura
    Dept of General Surgery, Chiba University Graduate School of Medicine
    Gan To Kagaku Ryoho 34:2022-4. 2007
    ....