Yasuhiro Masubuchi

Summary

Affiliation: Chiba Institute of Science
Country: Japan

Publications

  1. ncbi request reprint Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288 0025, Japan
    Biol Pharm Bull 34:366-70. 2011
  2. ncbi request reprint Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
    Drug Metab Pharmacokinet 21:347-56. 2006
  3. doi request reprint Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Toxicology 287:54-60. 2011
  4. doi request reprint Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Shiomi cho, Choshi, Chiba, 288 0025, Japan
    Chem Biol Interact 179:273-9. 2009
  5. ncbi request reprint Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
    Drug Metab Dispos 36:597-603. 2008
  6. ncbi request reprint Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Toxicology 222:233-9. 2006
  7. ncbi request reprint Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Chosi, Japan
    Crit Rev Toxicol 37:389-412. 2007
  8. ncbi request reprint Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket
    Kazuto Ohkura
    Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, 288 0025, Japan
    Anticancer Res 29:935-42. 2009
  9. ncbi request reprint Evaluation of drug-induced hepatotoxicity by plasma retinol binding protein
    Masanao Isozaki
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cyo, Inage Ku, Chiba 263 8522, Japan
    In Vivo 16:61-5. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288 0025, Japan
    Biol Pharm Bull 34:366-70. 2011
    ..NAC and glutathione might exert their effects, at least partially, via mechanisms that are independent of increasing hepatic glutathione, but probably act through cytokine-mediated and anti-inflammatory mechanisms...
  2. ncbi request reprint Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
    Drug Metab Pharmacokinet 21:347-56. 2006
    ..In conclusion, although the TGZ is biotransformed into chemically reactive metabolites, there is currently no potential evidence for involvement of the reactive metabolite in the TGZ-induced liver injury...
  3. doi request reprint Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Toxicology 287:54-60. 2011
    ....
  4. doi request reprint Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Shiomi cho, Choshi, Chiba, 288 0025, Japan
    Chem Biol Interact 179:273-9. 2009
    ..It is therefore suggested that acetaminophen-induced liver injury is associated with Th1-dominant response in Th1/Th2 cytokine balance, and TNF-alpha may play a pathological role in the toxicity...
  5. ncbi request reprint Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
    Drug Metab Dispos 36:597-603. 2008
    ..The colitis model, instead of exogenous administration of lipopolysaccharide or cytokines, could be applied to the study on mechanisms for altered hepatic P450 expression and other liver functions under mild inflammatory conditions...
  6. ncbi request reprint Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Toxicology 222:233-9. 2006
    ..It is therefore possible that the troglitazone-induced opening of MPT pore, which is not induced by rosiglitazone or pioglitazone, may contribute to the hepatotoxicity induced specifically by troglitazone...
  7. ncbi request reprint Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs
    Yasuhiro Masubuchi
    Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Chosi, Japan
    Crit Rev Toxicol 37:389-412. 2007
    ....
  8. ncbi request reprint Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket
    Kazuto Ohkura
    Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, 288 0025, Japan
    Anticancer Res 29:935-42. 2009
    ..CYP3A4 is the most abundant xenobiotic-metabolizing cytochrome P450 isoform. We examined the structural features of the CYP3A4 molecule with regard to ligand access...
  9. ncbi request reprint Evaluation of drug-induced hepatotoxicity by plasma retinol binding protein
    Masanao Isozaki
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cyo, Inage Ku, Chiba 263 8522, Japan
    In Vivo 16:61-5. 2002
    ..Thus RBP seems to monitor different aspects of drug-induced hepatotoxicity than LDH and ALT and to detect the drug-induced hepatotoxicity more sensitively than albumin level under the present conditions...