Research Topics
| Yasuhiro MasubuchiSummaryAffiliation: Chiba Institute of Science Country: Japan Publications
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Detail Information
Publications
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injuryYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288 0025, Japan
Biol Pharm Bull 34:366-70. 2011..NAC and glutathione might exert their effects, at least partially, via mechanisms that are independent of increasing hepatic glutathione, but probably act through cytokine-mediated and anti-inflammatory mechanisms...- Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a reviewYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
Drug Metab Pharmacokinet 21:347-56. 2006..In conclusion, although the TGZ is biotransformed into chemically reactive metabolites, there is currently no potential evidence for involvement of the reactive metabolite in the TGZ-induced liver injury... 
Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximineYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
Toxicology 287:54-60. 2011....- Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injuryYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Shiomi cho, Choshi, Chiba, 288 0025, Japan
Chem Biol Interact 179:273-9. 2009..It is therefore suggested that acetaminophen-induced liver injury is associated with Th1-dominant response in Th1/Th2 cytokine balance, and TNF-alpha may play a pathological role in the toxicity... - Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitisYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan
Drug Metab Dispos 36:597-603. 2008..The colitis model, instead of exogenous administration of lipopolysaccharide or cytokines, could be applied to the study on mechanisms for altered hepatic P450 expression and other liver functions under mild inflammatory conditions... - Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinedionesYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan
Toxicology 222:233-9. 2006..It is therefore possible that the troglitazone-induced opening of MPT pore, which is not induced by rosiglitazone or pioglitazone, may contribute to the hepatotoxicity induced specifically by troglitazone... - Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugsYasuhiro Masubuchi
Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Chosi, Japan
Crit Rev Toxicol 37:389-412. 2007.... - Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocketKazuto Ohkura
Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, 288 0025, Japan
Anticancer Res 29:935-42. 2009..CYP3A4 is the most abundant xenobiotic-metabolizing cytochrome P450 isoform. We examined the structural features of the CYP3A4 molecule with regard to ligand access... - Evaluation of drug-induced hepatotoxicity by plasma retinol binding proteinMasanao Isozaki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cyo, Inage-ku, Chiba 263-8522, Japan
In Vivo 16:61-5. 2002..Thus RBP seems to monitor different aspects of drug-induced hepatotoxicity than LDH and ALT and to detect the drug-induced hepatotoxicity more sensitively than albumin level under the present conditions...