S Kuwabara

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Nodal persistent Na+ currents in human diabetic nerves estimated by the technique of latent addition
    Sonoko Misawa
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 117:815-20. 2006
  2. doi request reprint Axonal Guillain-Barré syndrome: concepts and controversies
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan Electronic address
    Lancet Neurol 12:1180-8. 2013
  3. doi request reprint Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cochrane Database Syst Rev 6:CD006828. 2012
  4. doi request reprint Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis
    Kazuaki Kanai
    Department of Neurology, Chiba University, Chuo Ku, Chiba, Japan
    J Neurol Neurosurg Psychiatry 83:734-8. 2012
  5. doi request reprint Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy
    Saiko Nasu
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 83:476-9. 2012
  6. doi request reprint The split hand syndrome in amyotrophic lateral sclerosis
    Andrew Eisen
    University of British Columbia, Vancouver, British Columbia, Canada
    J Neurol Neurosurg Psychiatry 83:399-403. 2012
  7. pmc Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica
    Akiyuki Uzawa
    Department of Neurology Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Neurol 10:113. 2010
  8. doi request reprint Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 82:1174-7. 2011
  9. ncbi request reprint Guillain-Barré syndrome: epidemiology, pathophysiology and management
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Drugs 64:597-610. 2004
  10. ncbi request reprint Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neuroimmunol 189:158-62. 2007

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Nodal persistent Na+ currents in human diabetic nerves estimated by the technique of latent addition
    Sonoko Misawa
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 117:815-20. 2006
    ..However, the time constant is also affected by changes in passive membrane properties. Latent addition using computerized threshold tracking is a new method that can separately evaluate Na+ currents and passive membrane properties...
  2. doi request reprint Axonal Guillain-Barré syndrome: concepts and controversies
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan Electronic address
    Lancet Neurol 12:1180-8. 2013
    ..Improved understanding of the disease mechanism and pathophysiology might lead to new treatment options and improve the outlook for patients with AMAN. ..
  3. doi request reprint Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cochrane Database Syst Rev 6:CD006828. 2012
    ..There is a need for efficacious therapy to improve prognosis. This is the first update of a review first published in 2008...
  4. doi request reprint Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis
    Kazuaki Kanai
    Department of Neurology, Chiba University, Chuo Ku, Chiba, Japan
    J Neurol Neurosurg Psychiatry 83:734-8. 2012
    ..Previous nerve excitability studies suggested increased persistent sodium currents in motor axons of patients with ALS, which lead to axonal hyperexcitability and potentially enhance neuronal death...
  5. doi request reprint Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy
    Saiko Nasu
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 83:476-9. 2012
    ..Objective To elucidate whether POEMS syndrome and CIDP are differentiated based on profiles of neuropathy...
  6. doi request reprint The split hand syndrome in amyotrophic lateral sclerosis
    Andrew Eisen
    University of British Columbia, Vancouver, British Columbia, Canada
    J Neurol Neurosurg Psychiatry 83:399-403. 2012
    ..The split hand is a useful diagnostic sign in early ALS, and recent objective studies indicate that the sign has a high degree of specificity...
  7. pmc Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica
    Akiyuki Uzawa
    Department of Neurology Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Neurol 10:113. 2010
    ..Therefore, we examined the expression of chemokine receptors on peripheral blood lymphocytes (PBL) in MS and NMO...
  8. doi request reprint Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 82:1174-7. 2011
    ..If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain--Barré syndrome (GBS)...
  9. ncbi request reprint Guillain-Barré syndrome: epidemiology, pathophysiology and management
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Drugs 64:597-610. 2004
    ..Corticosteroids alone do not alter the outcome of GBS...
  10. ncbi request reprint Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neuroimmunol 189:158-62. 2007
    ..Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscles. The different findings in mouse and human may be explained by the extent of expression of GQ1b on the motor nerve terminals in the muscle examined...
  11. ncbi request reprint Autologous peripheral blood stem cell transplantation for POEMS syndrome
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, Japan
    Neurology 66:105-7. 2006
    ..The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved...
  12. ncbi request reprint Isolated posterior interosseous nerve palsy subsequent to Campylobacter jejuni enteritis
    Satoshi Kuwabara
    Department of Clinical Neurophysiology, Dowa kai Chiba Hospital, Chiba, Japan
    Eur Neurol 52:63-4. 2004
  13. pmc Long term prognosis of chronic inflammatory demyelinating polyneuropathy: a five year follow up of 38 cases
    S Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, 260 8670, Japan
    J Neurol Neurosurg Psychiatry 77:66-70. 2006
    ..Little is known about long term prognosis and course after immune treatments in chronic inflammatory demyelinating polyneuropathy (CIDP)...
  14. ncbi request reprint Axonal ionic pathophysiology in human peripheral neuropathy and motor neuron disease
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Curr Neurovasc Res 1:373-9. 2004
    ..Investigating ionic mechanisms is of clinical relevance, because once a specific ionic conductance is identified, blocking or activating it may provide a new therapeutic option for a variety of neuromuscular diseases...
  15. ncbi request reprint Pharmacologic intervention in axonal excitability: in vivo assessment of nodal persistent sodium currents in human neuropathies
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Japan
    Curr Mol Pharmacol 1:61-7. 2008
    ..is of clinical relevance, because once a specific ionic conductance is identified, pharmacologic blocking or modulation could provide a new therapeutic option...
  16. ncbi request reprint Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome?
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Neurology 63:529-33. 2004
    ..C. jejuni-related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy [AIDP]) after C. jejuni infection...
  17. ncbi request reprint The effects of mexiletine on excitability properties of human median motor axons
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 116:284-9. 2005
    ..To investigate the effects of mexiletine, an analog of lidocaine, on excitability of human axons in vivo...
  18. doi request reprint Sympathetic sweat responses and skin vasomotor reflexes in carpal tunnel syndrome
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Clin Neurol Neurosurg 110:691-5. 2008
    ..To investigate cutaneous sympathetic functions in carpal tunnel syndrome (CTS) using sympathetic sweat responses (SSwRs) and skin vasomotor reflexes (SVmRs)...
  19. ncbi request reprint Latent addition in human motor and sensory axons: different site-dependent changes across the carpal tunnel related to persistent Na+ currents
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 117:810-4. 2006
    ..Positive sensory symptoms are prominent features in carpal tunnel syndrome, and a persistent Na+ current is a major determinant of axonal excitability...
  20. doi request reprint Thalidomide reduces serum VEGF levels and improves peripheral neuropathy in POEMS syndrome
    S Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 79:1255-7. 2008
    ....
  21. ncbi request reprint Guillain-barré syndrome
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Curr Neurol Neurosci Rep 7:57-62. 2007
    ..In contrast, target molecules in AIDP have not yet been identified. Meta-analyses show efficacy of plasmapheresis and immunoglobulin therapy, but not corticosteroids, in hastening recovery...
  22. ncbi request reprint Anti-MuSK-positive myasthenia gravis: neuromuscular transmission failure in facial and limb muscles
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Acta Neurol Scand 115:126-8. 2007
    ..These results suggest that when the diagnosis of anti-MuSK-positive MG is suspected, SFEMG should be performed in most prominently affected muscles...
  23. ncbi request reprint The effects of physiological fluctuation of serum potassium levels on excitability properties in healthy human motor axons
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 118:278-82. 2007
    ..We studied whether physiological fluctuation of serum potassium levels affects axonal excitability in normal human axons...
  24. doi request reprint Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Muscle Nerve 37:426-30. 2008
    ..Prominent muscle atrophy in APB and FDI, with relatively preserved ADM, appears to be specific to ALS. Dissociated hand muscle atrophy presumably reflects part of the pathophysiology and supports the diagnosis of ALS...
  25. doi request reprint Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome
    S Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Neurology 71:1691-5. 2008
    ..There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious treatment...
  26. doi request reprint Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: a Japanese-Italian collaborative study
    Yukari Sekiguchi
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 83:23-8. 2012
    ..Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries...
  27. ncbi request reprint Patterns and serial changes in electrodiagnostic abnormalities of axonal Guillain-Barré syndrome
    A Hiraga
    Department of Neurology, Chiba University Graduate School of Medicine, Japan
    Neurology 64:856-60. 2005
    ....
  28. pmc Abnormal muscle responses in hemifacial spasm: F waves or trigeminal reflexes?
    S Misawa
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 77:216-8. 2006
    ..The objective of this study was to investigate whether the afferent input of AMR is mediated by antidromic facial nerve stimulation or orthodromic trigeminal nerve stimulation...
  29. pmc Isolated absence of F waves and proximal axonal dysfunction in Guillain-Barré syndrome with antiganglioside antibodies
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 68:191-5. 2000
    ..Some patients with GBS show the absence of F waves as an isolated conduction abnormality, which has been interpreted as demyelination in the proximal nerve segments...
  30. pmc Recovery patterns and long term prognosis for axonal Guillain-Barré syndrome
    A Hiraga
    Department of Neurology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 76:719-22. 2005
    ..Little is known about the long term prognosis for patients the severe acute motor axonal neuropathy (AMAN) form of Guillain-Barré syndrome (GBS), unlike those with acute inflammatory demyelinating neuropathy (AIDP)...
  31. ncbi request reprint Intravenous immunoglobulin therapy for Guillain-Barré syndrome with IgG anti-GM1 antibody
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 24:54-8. 2001
    ..4 of 14, P = 0.06). CMAP sum score at 6 months tended to be greater for the IVIg group (P = 0.07). For the IgG anti-GM1-positive subgroup of GBS patients, IVIg therapy may be a more efficacious treatment than plasmapheresis...
  32. pmc IgG anti-GQ1b positive acute ataxia without ophthalmoplegia
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    J Neurol Neurosurg Psychiatry 67:668-70. 1999
    ..The clinical presentation and laboratory results for this patient resemble those of Miller Fisher syndrome, except for the lack of ophthalmoplegia. This case may represent part of an IgG anti-GQ1b syndrome...
  33. pmc Hyperreflexia in Guillain-Barré syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    J Neurol Neurosurg Psychiatry 67:180-4. 1999
    ..It was reported that patients with AMAN in northern China often had hyperreflexia in the recovery phase...
  34. ncbi request reprint Haemophilus influenzae infection and Guillain-Barré syndrome
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Brain 123:2171-8. 2000
    ..influenzae in the Japanese population. A particular strain of non-typable H. influenzae has a ganglioside GM1-like structure and elicits axonal Guillain-Barré syndrome similar to C. jejuni-related Guillain-Barré syndrome...
  35. ncbi request reprint Aldose reductase inhibition alters nodal Na+ currents and nerve conduction in human diabetics
    S Misawa
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Neurology 66:1545-9. 2006
    ..In diabetic nerves, activation of the polyol pathway via an aldose reductase and the resulting impairment of the Na(+)-K(+) pump would lead to a decreased transaxonal Na+ gradient and thereby reduced nodal Na+ currents...
  36. pmc Patterns and severity of neuromuscular transmission failure in seronegative myasthenia gravis
    Y Nemoto
    Department of Neurology, Chiba University School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 76:714-8. 2005
    ..To investigate whether antibodies to muscle specific kinase (MuSK) and ryanodine receptor (RyR) are associated with particular features...
  37. ncbi request reprint Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Neurol Sci 168:121-6. 1999
    ..The patients with AMSAN had anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies, indicative that AMAN and AMSAN share a common immunological profile...
  38. doi request reprint POEMS syndrome with Guillan-Barre syndrome-like acute onset: a case report and review of neurological progression in 30 cases
    S Isose
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Neurol Neurosurg Psychiatry 82:678-80. 2011
    ..The early diagnosis and treatment could result in rapid improvement as shown in the present patient...
  39. ncbi request reprint Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a
    M Tatsumoto
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neuroimmunol 177:201-8. 2006
    ..A method to prepare GM1b was developed...
  40. ncbi request reprint Mechanisms of early and late recovery in acute motor axonal neuropathy
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 24:288-91. 2001
    ..The MUNE did not change significantly in this early recovery phase and increased slowly with time. The main mechanism for early recovery in AMAN may be collateral reinnervation, with nerve regeneration developing later...
  41. ncbi request reprint Differences in patterns of progression in demyelinating and axonal Guillain-Barré syndromes
    A Hiraga
    Department of Neurology, Chiba University School of Medicine, Japan
    Neurology 61:471-4. 2003
    ..Immune treatments are recommended for patients with Guillain-Barré syndrome (GBS) who cannot walk independently, but a considerable number of GBS patients are in the progressive phase at the first examination...
  42. ncbi request reprint Haemophilus influenzae has a GM1 ganglioside-like structure and elicits Guillain-Barré syndrome
    M Mori
    Department of Neurology, Chiba University School of Medicine, Japan
    Neurology 52:1282-4. 1999
    ..influenzae isolated from the patient. A particular strain of H. influenzae may have a GM1-like structure and may elicit an axonal Guillain-Barré syndrome...
  43. ncbi request reprint Anti-GM1 antibody IgG subclass: a clinical recovery predictor in Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Neurology 60:1514-8. 2003
    ..To determine whether the anti-GM1 antibody IgG subclass (IgG1 to 4) is associated with clinical profiles and patterns of recovery in Guillain-Barré syndrome (GBS)...
  44. ncbi request reprint Distal excitability changes in motor axons in amyotrophic lateral sclerosis
    Miho Nakata
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Clin Neurophysiol 117:1444-8. 2006
    ..This study tested the hypothesis that dysfunction of potassium channels is more pronounced in the more distal parts of axons...
  45. ncbi request reprint Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromes
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Ann Neurol 52:180-7. 2002
    ..These results support the view that the predominantly distal targets of immune attack are different for AMAN and AIDP. Possible mechanisms for the reduced safety factor in AMAN are discussed...
  46. ncbi request reprint Trigeminal afferent input alters the excitability of facial motoneurons in hemifacial spasm
    K Ogawara
    Department of Neurology, Chiba University School of Medicine, Japan
    Neurology 62:1749-52. 2004
    ..To investigate whether skin or muscle afferent input via the trigeminal nerve alters the excitability of facial motoneurons in hemifacial spasm (HFS)...
  47. ncbi request reprint Single unit responses of human cutaneous mechanoreceptors to air-puff stimulation
    K Mizobuchi
    Department of Neurology, School of Medicine, Chiba University, Chiba, Japan
    Clin Neurophysiol 111:1577-81. 2000
    ..To investigate responsiveness of human cutaneous mechanoreceptor to selective tactile stimuli produced by brief air-puff stimulation...
  48. doi request reprint Clinical predictors of mechanical ventilation in Fisher/Guillain-Barré overlap syndrome
    K Funakoshi
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Neurol Neurosurg Psychiatry 80:60-4. 2009
    ..Some patients with Fisher syndrome (FS) developed subsequent descending tetraparesis (Fisher/Guillain-Barré overlapping syndrome: FS/GBS). The assumption is that such descending progression may frequently lead to respiratory failure...
  49. ncbi request reprint Threshold electrotonus in chronic inflammatory demyelinating polyneuropathy: correlation with clinical profiles
    Jia Ying Sung
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Muscle Nerve 29:28-37. 2004
    ..Threshold electrotonus can be used to detect demyelination at the tested sites and may provide new information about pathophysiology and distribution patterns of demyelination in CIDP...
  50. ncbi request reprint Is excitation-contraction coupling impaired in myasthenia gravis?
    Miho Nakata
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 118:1144-8. 2007
    ..To investigate whether excitation-contraction (E-C) coupling of muscle is impaired in patients with myasthenia gravis (MG)...
  51. ncbi request reprint The acute effects of glycemic control on axonal excitability in human diabetic nerves
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine
    Intern Med 41:360-5. 2002
    ..It is known that voluntary contraction or compression ischemia alters nerve Na+/K+ pump activity, and axonal excitability changes due to the pump activity can be estimated by threshold tracking...
  52. ncbi request reprint Increased nodal persistent Na+ currents in human neuropathy and motor neuron disease estimated by latent addition
    Noriko Tamura
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 117:2451-8. 2006
    ..In human motor axons, approximately 1.0% of total Na(+) channels are active at rest, termed "persistent" Na(+) channels, and the conductance can be non-invasively estimated by the technique of latent addition in vivo...
  53. doi request reprint Ultrasonographic detection of fasciculations markedly increases diagnostic sensitivity of ALS
    S Misawa
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Neurology 77:1532-7. 2011
    ..New diagnostic criteria for ALS, the Awaji algorithm, reintroduced fasciculations as evidence of acute denervation equivalent to that of fibrillations and positive sharp waves...
  54. ncbi request reprint The acute effects of glycemic control on axonal excitability in human diabetics
    Yukiko Kitano
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Ann Neurol 56:462-7. 2004
    ..Measurement of the excitability indices could provide new insights into the pathophysiology of human diabetic neuropathy...
  55. ncbi request reprint Strength-duration properties and glycemic control in human diabetic motor nerves
    Sonoko Misawa
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 116:254-8. 2005
    ..To investigate the influences of hyperglycemia on axonal excitability in human diabetic nerves. Hyperglycemia results in decreased Na+-K+ pump function, presumably leading to intra-axonal Na+ accumulation and thereby, reduced Na+ currents...
  56. doi request reprint Preserved autonomic function in patients with POEMS syndrome
    Y Fujinuma
    Department of Neurology, School of Medicine, Chiba University, Chiba, Japan
    J Neurol Sci 318:131-4. 2012
    ..We systematically performed autonomic testing on patients with polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) to determine whether autonomic function is preserved in such patients...
  57. ncbi request reprint Serum levels of tumor necrosis factor-alpha in chronic inflammatory demyelinating polyneuropathy
    S Misawa
    Department of Neurology, Chiba University School of Medicine, Japan
    Neurology 56:666-9. 2001
    ..CONCLUSION: Circulating TNFalpha increases during the active phase in a subgroup of CIDP patients and may play a role in the pathogenesis of demyelination and the breakdown of the blood-nerve barrier in CIDP...
  58. ncbi request reprint Properties of human skin mechanoreceptors in peripheral neuropathy
    K Mizobuchi
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 113:310-5. 2002
    ..The skin mechanoreceptor is a terminal organ of the primary sensory neuron, which is likely to be affected earlier and more severely than is the nerve trunk by peripheral neuropathies...
  59. doi request reprint Effects of age on excitability properties in human motor axons
    Jong Seok Bae
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Clin Neurophysiol 119:2282-6. 2008
    ..The aim of this study was to evaluate the effects of age and gender on excitability properties of human motor axons...
  60. ncbi request reprint Electrophysiological subtypes and prognosis of childhood Guillain-Barré syndrome in Japan
    Kasumi Nagasawa
    Department of Pediatrics, Chiba University School of Medicine, Chiba, Japan
    Muscle Nerve 33:766-70. 2006
    ..In Japanese childhood GBS, the proportion of AIDP and AMAN appears to be similar. Recovery is generally favorable in both subtypes, but some of the AMAN children experienced delayed recovery...
  61. ncbi request reprint Median-radial sensory nerve comparative studies in the detection of median neuropathy at the wrist in diabetic patients
    Megumi Imada
    Department of Clinical Laboratory, Graduate School of Medicine, Chiba University, 1 8 1 Inohama, Chiba, Japan
    Clin Neurophysiol 118:1405-9. 2007
    ..This study tested the utility of median-radial comparative studies (MRCS) in diabetic patients...
  62. ncbi request reprint The acute effects of glycemic control on nerve conduction in human diabetics
    Yuriko Kikkawa
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurophysiol 116:270-4. 2005
    ..To investigate acute changes in nerve conduction associated with glycemic control. In diabetes, nerve dysfunction can result from reversible metabolic factors associated with hyperglycemia, as well as structural changes...
  63. ncbi request reprint Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndrome
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Brain 126:2279-90. 2003
    ..A considerable number of BBE patients have associated axonal Guillain-Barré syndrome, indicative that the two disorders are closely related and form a continuous spectrum...
  64. ncbi request reprint Hyperreflexia in axonal Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    J Neurol Sci 199:89-92. 2002
    ..This case provides further evidence that patients with AMAN can develop increased motor neuron excitability, and possible mechanisms for the hyperreflexia are discussed...
  65. ncbi request reprint Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 26:283-7. 2002
    ..Multiple excitability measurements can be used as a tool to identify changes in membrane potential of human axons...
  66. ncbi request reprint Clinical features and prognosis of Miller Fisher syndrome
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Neurology 56:1104-6. 2001
    ..Patients with MFS usually had good recovery and no residual deficits...
  67. pmc Indicators of rapid clinical recovery in Guillain-Barré syndrome
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Neurol Neurosurg Psychiatry 70:560-2. 2001
    ..Among the axonal subgroup of patients with Guillain-Barré syndrome, preserved tendon reflexes, H influenzae infection, and the patient having received immunoglobulin treatment may be indicators of rapid recovery...
  68. pmc Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 72:37-42. 2002
    ....
  69. doi request reprint Spinal myoclonus in the periscapular muscles after mastectomy assessed by FDG-PET
    S Misawa
    Department of Neurology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Clin Neurol Neurosurg 112:527-9. 2010
    ..The new imaging tools, such as FDG-PET and ultrasonography, were useful to determine the therapeutic target muscle...
  70. ncbi request reprint Axonal Guillain-Barré syndrome associated with axonal Charcot-Marie-Tooth disease
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Sci 211:93-7. 2003
    ..The association may be coincidental, but a particular susceptibility to axonal damage of CMT2 cannot be excluded...
  71. ncbi request reprint Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment
    Kazuaki Kanai
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Brain 126:965-73. 2003
    ....
  72. ncbi request reprint Fisher syndrome or Bickerstaff brainstem encephalitis? Anti-GQ1b IgG antibody syndrome involving both the peripheral and central nervous systems
    Kazue Ogawara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 26:845-9. 2002
    ..These two conditions may represent a single autoimmune disease mediated by anti-GQ1b antibody, usually involving the peripheral and occasionally the central nervous systems...
  73. ncbi request reprint Excitability properties of human median axons measured at the motor point
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Muscle Nerve 29:227-33. 2004
    ..Motor point excitability testing may provide new insights into the pathophysiology of the nerve terminals in a variety of peripheral neuropathies and motor neuron disorders...
  74. ncbi request reprint Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage
    Kazuaki Kanai
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Brain 129:953-62. 2006
    ..These serial changes in axonal properties could provide insights into the pathophysiology of ALS, and implications for future therapeutic options...
  75. ncbi request reprint Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis
    Masakazu Onodera
    Department of Neurology, Chiba Rosai Hospital, Chiba, Japan
    J Neurol Sci 205:83-4. 2002
    ..This case suggests that an acute isolated bulbar palsy may be caused by a pathology relating to Guillain-Barré syndrome (GBS), in which anti-GT1a IgG antibody may have a role...
  76. ncbi request reprint Sensory nerve conduction in demyelinating and axonal Guillain-Barré syndromes
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Eur Neurol 51:196-8. 2004
    ..AMAN is very rarely associated with sensory nerve involvement. Abnormal sensory nerve conduction is supportive of AIDP and is more frequently found for the median and ulnar nerves than sural nerves...
  77. pmc Anti-high mobility group box 1 monoclonal antibody ameliorates experimental autoimmune encephalomyelitis
    A Uzawa
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Exp Immunol 172:37-43. 2013
    ..The novel aspect of this study is the demonstration that anti-HMGB1 ameliorates EAE. HMGB1 may be a novel therapeutic strategy for multiple sclerosis...
  78. doi request reprint Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity
    K Kanai
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Med Genet 46:671-9. 2009
    ..However, the reason why similar missense mutations in SCN1A result in different phenotypes has not yet been fully clarified...
  79. ncbi request reprint n-Hexane neuropathy caused by addictive inhalation: clinical and electrophysiological features
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Eur Neurol 41:163-7. 1999
    ..Conduction block, probably due to paranodal myelin retraction or ongoing wallerian degeneration, is very frequent and could be responsible for the clinical deficits, especially in the early phase of illness...
  80. ncbi request reprint Voltage-gated potassium channel antibody-associated encephalitis with basal ganglia lesions
    A Hiraga
    Department of Neurology, Chiba University Graduate School of Medicine, Japan
    Neurology 66:1780-1. 2006
  81. doi request reprint Differences in excitability properties of FDI and ADM motor axons
    Jong Seok Bae
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 39:350-4. 2009
    ..Even in the same nerve at the same sites, membrane properties of FDI and ADM motor axons differ significantly, and thus their axonal/neuronal responses to disease may also differ...
  82. ncbi request reprint Fine specificities of anti-LM1 IgG antibodies in Guillain-Barré syndrome
    Keiichiro Susuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, 321 0293, Tochigi, Japan
    J Neurol Sci 195:145-8. 2002
    ..In addition, whether monospecific anti-LM1 IgG antibody is associated with AIDP remains to be concluded. Larger studies are needed to verify whether monospecific anti-LM1 IgG antibody could be a marker of AIDP...
  83. doi request reprint Utility of trapezius EMG for diagnosis of amyotrophic lateral sclerosis
    Masahiro Sonoo
    Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan
    Muscle Nerve 39:63-70. 2009
    ..Tongue EMG added little utility over the clinical sign of tongue atrophy. Abnormal spontaneous activity in the trapezius would be more useful for the early diagnosis of ALS...
  84. ncbi request reprint Time course of axonal regeneration in acute motor axonal neuropathy
    Noriko Tamura
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 35:793-5. 2007
    ..Nerve terminal degeneration-regeneration presumably provides a mechanism for good recovery...
  85. doi request reprint Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain
    Sagiri Isose
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba, Japan
    Clin Neurophysiol 121:719-24. 2010
    ..To investigate changes in axonal persistent Na(+) currents in patients with neuropathic pain and the effects of mexiletine, an analogue of lidocaine, on axonal excitability properties...
  86. ncbi request reprint Axonal potassium conductance and glycemic control in human diabetic nerves
    Sonoko Misawa
    Department of Neurology, Chiba University School of Medicine, Japan
    Clin Neurophysiol 116:1181-7. 2005
    ..To investigate the effects of hyperglycemia on axonal excitability and potassium conductance in human diabetic nerves...
  87. ncbi request reprint Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
    Keiichiro Susuki
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Glia 55:746-57. 2007
    ..These results indicate that gangliosides are lipid raft components that contribute to stability and maintenance of neuron-glia interactions at paranodes...
  88. ncbi request reprint The refractory period of transmission is impaired in axonal Guillain-Barré syndrome
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 28:683-9. 2003
    ..In addition to axonal degeneration, the critically but reversibly reduced safety factor is important in the pathophysiology of AMAN, and consistent with the rapid resolution of distal conduction block often seen in AMAN patients...
  89. doi request reprint The subthalamic activity and striatal monoamine are modulated by subthalamic stimulation
    T Yamamoto
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan Electronic address
    Neuroscience 259:43-52. 2014
    ..However, their direct relationship is unclear. We aimed to examine the correlation between the striatal monoamine and the STN beta activity induced by STN-DBS...
  90. pmc Serum matrix metalloproteinase-3 levels correlate with disease activity in relapsing-remitting multiple sclerosis
    T Kanesaka
    Department of Neurology, Chiba University School of Medicine, 1 8 1, Inohana, Chuo Ku, Chiba, 260 8670 Japan
    J Neurol Neurosurg Psychiatry 77:185-8. 2006
    ..This study examined whether serum matrix metalloproteinase-3 (MMP-3) levels correlate with disease activity in MS...
  91. ncbi request reprint Autonomic function in demyelinating and axonal subtypes of Guillain-Barré syndrome
    M Asahina
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Acta Neurol Scand 105:44-50. 2002
    ....
  92. doi request reprint Different responses to interferon beta-1b treatment in patients with neuromyelitis optica and multiple sclerosis
    A Uzawa
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Eur J Neurol 17:672-6. 2010
    ..Although the benefit of treatment for relapsing-remitting multiple sclerosis (MS) is firmly established, whether interferon beta-1b (IFNB-1b) therapy is efficacious for neuromyelitis optica (NMO) has been debated...
  93. doi request reprint The ipsilateral cortico-spinal tract is activated after hemiparetic stroke
    S Misawa
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Eur J Neurol 15:706-11. 2008
    ..We investigated whether the ipsilateral tract is activated in hemiparetic stroke...
  94. doi request reprint Biphasic effect of apomorphine, an anti-parkinsonian drug, on bladder function in rats
    T Uchiyama
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Neuroscience 162:1333-8. 2009
    ....
  95. ncbi request reprint Superficial radial sensory nerve potentials in immune-mediated and diabetic neuropathies
    Noriko Tamura
    Department of Neurology, Chiba University School of Medicine, Inohana, Japan
    Clin Neurophysiol 116:2330-3. 2005
    ..To investigate whether radial SNAP and its amplitude ratio to median or sural SNAP provide additional particular patterns of sensory nerve involvement...
  96. doi request reprint Neuropathic pain is associated with increased nodal persistent Na(+) currents in human diabetic neuropathy
    Sonoko Misawa
    Department of Neurology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Peripher Nerv Syst 14:279-84. 2009
    ..Our findings support the view that altered Na(+) channels could be responsible for neuropathic pain/paresthesia in diabetic neuropathy...
  97. doi request reprint Spectral analysis of heart rate variability in patients with Machado-Joseph disease
    Masato Asahina
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Auton Neurosci 154:99-101. 2010
    ..Tachycardia is a clinical feature of Machado-Joseph disease (MJD), and it may be attributable to cardiac autonomic dysfunction. We investigated heart rate variability in MJD patients to reveal heart rate dysregulation in MJD...
  98. ncbi request reprint Fisher syndrome
    Masahiro Mori
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Curr Treat Options Neurol 13:71-8. 2011
    ..To evaluate the efficacy of immunotherapies used to treat Fisher syndrome, large prospective studies are required...
  99. ncbi request reprint Treatment and outcome of myasthenia gravis: retrospective multi-center analysis of 470 Japanese patients, 1999-2000
    Naoki Kawaguchi
    Department of Neurology, Chiba University, 1 8 1 Inohna, Chuo, 260 8670, Japan
    J Neurol Sci 224:43-7. 2004
    ..More effective or intensive treatments are required to improve the prognosis...
  100. ncbi request reprint [Amyotrophic lateral sclerosis--electrophysiologic aspects of its pathophysiology and new therapeutic options]
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chuou ku, Chiba, Japan
    Brain Nerve 62:885-91. 2010
    ..The altered axonal properties in patients with ALS may provide new insights into the pathophysiology of ALS and have implications for the development of ion channel modulators as therapeutic options for patients with ALS...
  101. doi request reprint Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6
    Akiyuki Uzawa
    Department of Neurology, Graduate School of Medicine, Chiba University, Japan
    Mult Scler 16:1443-52. 2010
    ..Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking...