M Kitagawa

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters
    M Kitagawa
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Mol Cell Biol 21:4337-46. 2001
  2. ncbi Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression
    T Tanaka
    Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 260, Japan
    J Biol Chem 273:26772-8. 1998
  3. ncbi Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
    A Hirai
    Second Department of Internal Medicine, Chiba University Medical School, Inohana cho, Chuou ku, Japan
    J Biol Chem 272:13-6. 1997
  4. ncbi Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
    Y Ishimi
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    J Biol Chem 275:16235-41. 2000
  5. ncbi Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 232:622-5. 1997
  6. ncbi Molecular cloning and characterization of a novel mitochondrial phosphoprotein, MIPP65, from rat liver
    M Kitagawa
    Faculty of Science, Kobe University, Kobe, 657, Japan
    Exp Cell Res 235:71-8. 1997
  7. ncbi Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
    B Xie
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 276:19512-23. 2001
  8. ncbi A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    C Li
    Genetics of Development and Diseases Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, 10 Center Drive, Bethesda, MD, USA
    Hum Mol Genet 8:35-44. 1999
  9. ncbi Stimulation of DNA polymerase alpha activity by cdk2-phosphorylated Rb protein
    M Takemura
    Laboratory of Cancer Cell Biology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan
    Biochem Biophys Res Commun 282:984-90. 2001
  10. ncbi Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    K Nakayama
    Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 19:2069-81. 2000

Collaborators

Detail Information

Publications43

  1. ncbi A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters
    M Kitagawa
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Mol Cell Biol 21:4337-46. 2001
    ..These results indicate that Mam is an essential component of the transcriptional apparatus of Notch signaling...
  2. ncbi Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression
    T Tanaka
    Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 260, Japan
    J Biol Chem 273:26772-8. 1998
    ..These data indicate that geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E expression, Cdk2 activation, and G1/S transition in rat astrocytes...
  3. ncbi Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
    A Hirai
    Second Department of Internal Medicine, Chiba University Medical School, Inohana cho, Chuou ku, Japan
    J Biol Chem 272:13-6. 1997
    ....
  4. ncbi Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
    Y Ishimi
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    J Biol Chem 275:16235-41. 2000
    ..These results raise the possibility that the inactivation of Mcm4,6,7 helicase activity by Cdk2 is a part of the system for regulating DNA replication...
  5. ncbi Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 232:622-5. 1997
    ..PF was also resistant against the selective inhibitor of cdk2, butyrolactone I. These findings suggest that tumor cell proliferation and tumor progression can be promoted by the activation of a molecule(s) downstream of cdk2...
  6. ncbi Molecular cloning and characterization of a novel mitochondrial phosphoprotein, MIPP65, from rat liver
    M Kitagawa
    Faculty of Science, Kobe University, Kobe, 657, Japan
    Exp Cell Res 235:71-8. 1997
    ..These results suggest that MIPP65 is a novel mitochondrial phosphoprotein that is a candidate substrate for PKN...
  7. ncbi Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
    B Xie
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 276:19512-23. 2001
    ..Thus, our results have demonstrated, for the first time, a critical signaling pathway from integrin/FAK to Stat1 that reduces cell adhesion and promotes cell migration...
  8. ncbi A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    C Li
    Genetics of Development and Diseases Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, 10 Center Drive, Bethesda, MD, USA
    Hum Mol Genet 8:35-44. 1999
    ....
  9. ncbi Stimulation of DNA polymerase alpha activity by cdk2-phosphorylated Rb protein
    M Takemura
    Laboratory of Cancer Cell Biology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan
    Biochem Biophys Res Commun 282:984-90. 2001
    ....
  10. ncbi Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    K Nakayama
    Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 19:2069-81. 2000
    ....
  11. ncbi pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells
    Y Watanabe
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Brain Res 842:342-50. 1999
    ..These observations suggest that Cdk2 and Cdk4 may phosphorylate different sites of pRb in vivo and that the two sites of pRb examined here are newly phosphorylated during RA-induced neuronal differentiation in P19 cells...
  12. ncbi Molecular genetic identification of a candidate receptor gene for sweet taste
    M Kitagawa
    Bio oriented Technology Research Advancement Institution, 1 40 2 Nisshin cho, Oomiya, Saitama, 331 0044, Japan
    Biochem Biophys Res Commun 283:236-42. 2001
    ..Our results indicate that T1R3 may serve as the receptor for sweet perception in mice...
  13. ncbi Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
    S Hatakeyama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 96:3859-63. 1999
    ..Skp1/Cullin/F-box protein FWD1 might play a critical role in transcriptional regulation of NF-kappaB through control of IkappaB protein stability...
  14. ncbi Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    W C Su
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Nature 386:288-92. 1997
    ..Thus, abnormal STAT activation and p21(WAF1/CIP1) expression by the TDII mutant receptor may be responsible for this FGFR3-related bone disease...
  15. ncbi The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
    M Kitagawa
    Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Tsukuba, Japan
    EMBO J 15:7060-9. 1996
    ..Furthermore, we found that pRB phosphorylated at Ser780 cannot bind to E2F-1 in vivo. Our data show that cyclin D1-Cdk4 and cyclin A/E Cdk2 phosphorylate different sites of pRB in vivo...
  16. ncbi Phosphorylation of E2F-1 by cyclin A-cdk2
    M Kitagawa
    Banyu Tsukuba Research Institute, Merck Research Laboratories, Japan
    Oncogene 10:229-36. 1995
    ..These results suggest that E2F-1 is phosphorylated by cyclin A-cdk2 in the S phase in vivo as well as in vitro and that its phosphorylation by cyclin A-cdk2 may modulate its activity...
  17. ncbi Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function
    M Kitagawa
    Department of Clinical Research, Okura National Hospital, Okura, Tokyo, 157 8535, Japan
    Biochem Biophys Res Commun 271:358-63. 2000
    ..The zipper model, however, needs further improvement to fully account for the present results...
  18. ncbi Down-regulation of p27Kip1 expression is required for development and function of T cells
    T Tsukiyama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Fukuoka, Japan
    J Immunol 166:304-12. 2001
    ..These results suggest that down-regulation of p27(Kip1) expression is required for the development, proliferation, and immunoresponsiveness of T cells...
  19. ncbi Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation
    T Nishida
    School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 276:39060-6. 2001
    ..Kishida, S., Fukui, A., Hinoi, T., Michiue, T., Asashima, M., and Kikuchi, A. (2000) J. Biol. Chem. 275, 37030-37037). The involvement of its enzyme activities in the Wnt signaling pathway remains to be elucidated...
  20. ncbi Overexpression of cdk4/cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support
    K Katayama
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    FEBS Lett 509:382-8. 2001
    ..These results suggest that upregulation of cdk4 kinase activity is a primary and critical mediator of apoptosis in PC12 cells under physiological conditions...
  21. ncbi E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
    M Kitagawa
    Helen Diller Family Comprehensive Cancer Center and Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Oncogene 27:5303-14. 2008
    ..Furthermore, our results suggest that tumor cells, including Rb mutated cells, which harbor wild-type p53 and high E2F transcriptional activity, could be a good target for Mdm2 antagonist therapy...
  22. ncbi Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30)
    Y Mada
    Department of Oral Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Periodontol 77:2051-8. 2006
    ....
  23. ncbi Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury
    H Fukasawa
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Kidney Int 69:1733-40. 2006
    ..Our results suggest that the reduction of SnoN/Ski proteins resulting from increased ubiquitin-dependent degradation is involved in the progression of tubulointerstitial fibrosis...
  24. ncbi A gene therapy model for retrovirus-induced disease with a viral env gene: expression-dependent resistance in immunosuppressed hosts
    M Kitagawa
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, Japan
    Leukemia 15:1779-84. 2001
    ..These chimeras also resisted FLV-induced leukemogenesis, indicating that receptor interference-based gene therapy could become a therapeutic basis for immunodeficiency virus-induced diseases in vivo...
  25. ncbi Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine
    K Mochizuki
    School of Food and Nutritional Sciences, The University of Shizuoka, Japan
    Arch Biochem Biophys 389:41-8. 2001
    ..These results suggest that the transcriptions of CRBPII, L-FABP, and the other PPAR-dependent genes in the small intestine may be coordinately regulated by the disproportional expression of PPARalpha and PPARdelta...
  26. ncbi Expression of IAP family proteins in colon cancers from patients with different age groups
    T Endo
    Department of Pathology and Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Immunol Immunother 53:770-6. 2004
    ..These results suggest that the expression of IAP family proteins, especially survivin, is associated with the age-related biological characteristics of colon cancer...
  27. ncbi DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line
    K Tahara
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan
    Cell Death Differ 10:496-507. 2003
    ..The cell death was not suppressed by exogenous His-PTD-Bcl-x(L) at all, suggesting involvement of a Bcl-x(L)-resistant pathway for cytochrome c release...
  28. ncbi Progression of esophageal carcinoma by loss of EGF-STAT1 pathway
    G Watanabe
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan
    Cancer J 7:132-9. 2001
    ..This loss appears to cause a significantly more malignant clinical course. These findings may point out a critical step in the progression of esophageal cancer and could lead to the development of useful clinical applications...
  29. ncbi Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE
    M Kitagawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    FEBS Lett 479:57-62. 2000
    ..These results suggest that LIS1 functions in nuclear migration by interacting with multiple intracellular proteins in mammals...
  30. ncbi Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene
    T Kawakami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    FEBS Lett 358:225-9. 1995
    ..These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation...
  31. ncbi Involvement of the IRF-1 transcription factor in antiviral responses to interferons
    T Kimura
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 264:1921-4. 1994
    ..Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state...
  32. ncbi Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 259:971-4. 1993
    ..This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors...
  33. ncbi Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3
    H Sago
    Doheny Eye Institute, Los Angeles, CA 90033, USA
    Genomics 29:631-40. 1995
    ..These results indicate the structural and possibly functional diversity of the protocadherin family and suggest a distinctive biological role for Pcdh3...
  34. ncbi PKN associates and phosphorylates the head-rod domain of neurofilament protein
    H Mukai
    Department of Biology, Faculty of Science, Kobe University, Japan
    J Biol Chem 271:9816-22. 1996
    ..The identification and characterization of the novel interaction with PKN may contribute toward the elucidation of mechanisms regulating the function of neurofilament...
  35. ncbi Translocation of PKN from the cytosol to the nucleus induced by stresses
    H Mukai
    Department of Biology, Faculty of Science, Kobe University, Japan
    Proc Natl Acad Sci U S A 93:10195-9. 1996
    ..These results raise the possibility that there is a pathway mediating stress signals from the cytosol to the nucleus through PKN...
  36. ncbi Expression of ClpB, an analog of the ATP-dependent protease regulatory subunit in Escherichia coli, is controlled by a heat shock sigma factor (sigma 32)
    M Kitagawa
    Institute for Virus Research, Kyoto University, Japan
    J Bacteriol 173:4247-53. 1991
    ..coli...
  37. ncbi Interaction of PKN with alpha-actinin
    H Mukai
    Radioisotope Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 272:4740-6. 1997
    ..We therefore propose that PKN is linked to the cytoskeletal network via a direct association between PKN and alpha-actinin...
  38. ncbi Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo
    T Tatsuta
    Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 862 0976, Japan
    Mol Microbiol 30:583-93. 1998
    ..In addition, CbpA, an analogue of DnaJ, was demonstrated to have overlapping functions with DnaJ in both the activity and the stability control of sigma32...
  39. ncbi Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene
    Y N Harada
    The Genome Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba 263, Osaka 565, Japan
    Mol Cell Biol 19:2366-72. 1999
    ..Our in vitro studies showed that primary embryonic fibroblasts isolated from the xpg-deficient mice underwent premature senescence and exhibited the early onset of immortalization and accumulation of p53...
  40. ncbi Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
    T Matsuyama
    Amgen Institute, University of Toronto, Ontario, Canada
    Cell 75:83-97. 1993
    ..IRF-2-deficient mice exhibited bone marrow suppression of hematopoiesis and B lymphopoiesis and mortality following lymphocytic choriomeningitis virus infection...
  41. ncbi Second transmembrane segment of FtsH plays a role in its proteolytic activity and homo-oligomerization
    S Makino
    Department of Biotechnology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo
    FEBS Lett 460:554-8. 1999
    ..Therefore, the second transmembrane segment, which neighbors the C-terminal cytoplasmic region of the FtsH, participates in not only its membrane-anchoring, but also its protease activity and homo-oligomerization...
  42. ncbi An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
    M Kitagawa
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 18:2401-10. 1999
    ..SCFFWD1 may be critical for tumor development and suppression through regulation of beta-catenin protein stability...
  43. ncbi The gene coding for lipoprotein signal peptidase (lspA) and that for isoleucyl-tRNA synthetase (ileS) constitute a cotranscriptional unit in Escherichia coli
    H Yamada
    FEBS Lett 171:245-8. 1984
    ..The gene order of dnaJ - rpsT - ileS - lspA - dapB around 0.5 min on the E. coli chromosome map was also determined...