Masaomi Iyo

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc A preliminary study of individual cognitive behavior therapy for social anxiety disorder in Japanese clinical settings: a single-arm, uncontrolled trial
    Naoki Yoshinaga
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 6:74. 2013
  2. pmc Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series
    Kyoji Okita
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba, 260 8677, Japan
    Ann Gen Psychiatry 12:7. 2013
  3. pmc Treatment of refractory catatonic schizophrenia with low dose aripiprazole
    Tsuyoshi Sasaki
    Department of Child Psychiatry, Chiba University Hospital, Inohana 1 8 1, Chiba, 260 8670, Japan
    Ann Gen Psychiatry 11:12. 2012
  4. doi request reprint Optimal extent of dopamine D2 receptor occupancy by antipsychotics for treatment of dopamine supersensitivity psychosis and late-onset psychosis
    Masaomi Iyo
    Department of Psychiatry, Graduate School of Medicine, Division of Clinical Neuroscience, Center for Forensic Mental Health, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Clin Psychopharmacol 33:398-404. 2013
  5. pmc The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Behav Brain Funct 4:37. 2008
  6. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
  7. pmc Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    BMC Psychiatry 5:6. 2005
  8. pmc Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder
    Shigenori Tadokoro
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 10:26. 2011
  9. pmc Expert consensus on hospitalization for assessment: a survey in Japan for a new forensic mental health system
    Akihiro Shiina
    Department of Psychiatry, Chiba University Hospital, Chiba, Japan
    Ann Gen Psychiatry 10:11. 2011
  10. pmc Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
    Goro Fukami
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 9:37. 2010

Detail Information

Publications126 found, 100 shown here

  1. pmc A preliminary study of individual cognitive behavior therapy for social anxiety disorder in Japanese clinical settings: a single-arm, uncontrolled trial
    Naoki Yoshinaga
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 6:74. 2013
    ..We also examined the baseline predictors of outcomes associated with receiving CBT...
  2. pmc Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series
    Kyoji Okita
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba, 260 8677, Japan
    Ann Gen Psychiatry 12:7. 2013
    ..In addition, a 6-month follow-up showed maintenance of these effects. In this disorder, tandospirone may be an effective drug for long-term use with good patient compliance...
  3. pmc Treatment of refractory catatonic schizophrenia with low dose aripiprazole
    Tsuyoshi Sasaki
    Department of Child Psychiatry, Chiba University Hospital, Inohana 1 8 1, Chiba, 260 8670, Japan
    Ann Gen Psychiatry 11:12. 2012
    ..In this regard, our results suggest that aripiprazole has numerous advantages, especially in cases of stuporous catatonia and a defective general status...
  4. doi request reprint Optimal extent of dopamine D2 receptor occupancy by antipsychotics for treatment of dopamine supersensitivity psychosis and late-onset psychosis
    Masaomi Iyo
    Department of Psychiatry, Graduate School of Medicine, Division of Clinical Neuroscience, Center for Forensic Mental Health, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Clin Psychopharmacol 33:398-404. 2013
    ..We also attempted to develop a strategy for the prevention and treatment of patients with DSP or LOP by focusing on D2 density...
  5. pmc The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Behav Brain Funct 4:37. 2008
    ..abstract:..
  6. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
    ..We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis...
  7. pmc Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    BMC Psychiatry 5:6. 2005
    ..This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients...
  8. pmc Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder
    Shigenori Tadokoro
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 10:26. 2011
    ..abstract:..
  9. pmc Expert consensus on hospitalization for assessment: a survey in Japan for a new forensic mental health system
    Akihiro Shiina
    Department of Psychiatry, Chiba University Hospital, Chiba, Japan
    Ann Gen Psychiatry 10:11. 2011
    ..abstract:..
  10. pmc Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
    Goro Fukami
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 9:37. 2010
    ..The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects...
  11. pmc Serum glutamine, set-shifting ability and anorexia nervosa
    Michiko Nakazato
    Section of Eating Disorders, Institute of Psychiatry, King s College London, UK
    Ann Gen Psychiatry 9:29. 2010
    ....
  12. ncbi request reprint Neuromechanism of developing methamphetamine psychosis: a neuroimaging study
    Masaomi Iyo
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann N Y Acad Sci 1025:288-95. 2004
    ..These findings suggest that long-term use of MAP causes abnormal cerebral blood flow patterns, reduction of brain dopamine transporter density, and metabolite alteration, which may be closely related to a susceptibility to MAP psychosis...
  13. doi request reprint Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:541-6. 2009
    ..We also found prepulse inhibition deficits reversed by clozapine and haloperidol in the Mdk(-/-) mice. Our results suggested that midkine deficiency may be related to neurochemical and behavioral dysfunctions in dopaminergic system...
  14. doi request reprint Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population
    Tomoko Tsunoka
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:639-44. 2010
    ....
  15. ncbi request reprint PROKR2 is associated with methamphetamine dependence in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1033-6. 2010
    ..In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients...
  16. doi request reprint Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neuropharmacology 58:452-6. 2010
    ..Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis...
  17. doi request reprint Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:70-82. 2008
    ..In conclusion, our results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese METH-use disorder...
  18. ncbi request reprint No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
    ..77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population...
  19. doi request reprint Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:86-94. 2009
    ....
  20. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  21. doi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors
    Hiroko Hagiwara
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Eur Neuropsychopharmacol 18:448-54. 2008
    ..Therefore, perospirone could be a potential therapy for the cognitive deficits observed in schizophrenic patients...
  22. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  23. doi request reprint Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 198:363-74. 2008
    ..However, differences in efficacy have also been reported, and further comparative pharmacological studies are still needed...
  24. ncbi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline
    Yuko Fujita
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:336-9. 2008
    ..This study was undertaken to determine whether the antibiotic drug minocycline could improve PCP-induced cognitive deficits in mice...
  25. doi request reprint Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors
    Shinsui Kunitachi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Brain Res 1279:189-96. 2009
    ..Therefore, it is likely that donepezil would be potential therapeutic drugs for the treatment of the cognitive deficits in schizophrenia...
  26. doi request reprint Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
    Shiho Arakawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Pharmacol Biochem Behav 100:601-6. 2012
    ..Taken together, minocycline may be a therapeutic drug for the treatment of depression...
  27. doi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  28. doi request reprint Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:63-9. 2008
    ..No significant association was found with schizophrenia. Our findings suggest that a common genetic variation in the GCLM gene might not contribute to the risk of METH-use disorder and schizophrenia in the Japanese population...
  29. ncbi request reprint Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population
    Nobuhisa Kanahara
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:233-8. 2009
    ..The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population...
  30. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  31. ncbi request reprint Deficits in auditory P50 inhibition in obsessive-compulsive disorder
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:288-96. 2008
    ..Our findings suggest that sensory gating deficits may be involved in the pathophysiology of OCD in a different way from clinical symptoms and executive attention dysfunction...
  32. doi request reprint Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: a possible role of alpha1-adrenoceptors
    Yuko Tanibuchi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur Neuropsychopharmacol 19:861-7. 2009
    ..Therefore, it is likely that antagonism at alpha(1)-adrenoceptors is involved in the mechanism underlying quetiapine's psychopharmacological action...
  33. ncbi request reprint Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neuropsychopharmacology 32:2004-10. 2007
    ..Therefore, it is possible that minocycline would be a potential therapeutic drug for schizophrenia...
  34. ncbi request reprint Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
    ..Our results do not support the view that serum BDNF levels are associated with schizophrenia...
  35. pmc Chronic treatment with aripiprazole prevents development of dopamine supersensitivity and potentially supersensitivity psychosis
    Shigenori Tadokoro
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Schizophr Bull 38:1012-20. 2012
    ..We investigated the chronic effects of aripiprazole (ARI) on dopamine sensitivity...
  36. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia: a preliminary study
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Psychopharmacol 32:593-601. 2012
    ..Nevertheless, a further study using a large sample size will be needed to confirm the secondary analyses findings...
  37. doi request reprint Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:83-8. 2008
    ..No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population...
  38. doi request reprint Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuroimage 49:2783-90. 2010
    ..These data suggest that specific metabolites of the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia...
  39. ncbi request reprint Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population
    Tomo Okochi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:903-5. 2009
    ..In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population...
  40. doi request reprint High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Int J Neuropsychopharmacol 12:1127-31. 2009
    ..This study demonstrated that donepezil binds to sigma1 receptors in the living human brain at therapeutic doses. Therefore, sigma1 receptors may be implicated in the pharmacological mechanism of donepezil in the human brain...
  41. ncbi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 63:92-7. 2008
    ....
  42. ncbi request reprint Possible role of D-serine in the pathophysiology of Alzheimer's disease
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:385-8. 2004
    ..36, p=0.018) lower than that of controls. The present study suggests that the reduced activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine may play a role in the pathophysiology of AD...
  43. ncbi request reprint Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004
    ..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders...
  44. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  45. doi request reprint Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors
    Tamaki Ishima
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Department of Psychiatry, Chiba University School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1656-9. 2008
    ..These findings suggest that sigma-1 receptors and interaction with IP3 receptors may be involved in the pharmacological action of donepezil...
  46. ncbi request reprint Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1836-40. 2011
    ..Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia...
  47. ncbi request reprint Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Eur J Neurosci 24:2335-44. 2006
    ..These findings suggest that DR may alter the behaviours in BDNF(+/-) mice, and that the 5-HT system may be implicated in the beneficial effects of DR on these behaviours...
  48. ncbi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and D-serine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, Japan
    Eur Neuropsychopharmacol 18:414-21. 2008
    ....
  49. ncbi request reprint Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Neuropsychopharmacology 32:514-21. 2007
    ..Therefore, sigma-1 receptor agonists such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive deficits of schizophrenia...
  50. ncbi request reprint Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET
    Tetsuya Shiraishi
    Department of Medical Imaging, National Institute of Radiological Sciences, Graduate School of Medicine, Chiba University, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Neuropsychopharmacology 30:2154-61. 2005
    ..The IC(50) values (estimate+/-SE) were 42+/-9.0 (ng/ml; donepezil-1), 34+/-3.2 (donepezil-2), and 37+/-4.1 (combined data). The present method may be useful for in vivo evaluation of other AChE inhibitors and novel drugs...
  51. ncbi request reprint A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT
    Tsuneyoshi Ota
    Department of Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Ann Nucl Med 18:187-93. 2004
    ..MP4A ratio method showed 92% sensitivity and the IMP ratio method 69% sensitivity for the diagnosis of AD. These results encourage us to develop a new SPECT tracer similar to MP4A for the diagnosis of AD...
  52. ncbi request reprint Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine
    Goro Fukami
    Department of Psychiatry, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Brain Res 1016:90-5. 2004
    ....
  53. ncbi request reprint Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    J Psychiatr Res 41:49-56. 2007
    ..These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia...
  54. pmc [11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 3:e3231. 2008
    ..Here we report the novel PET radioligand [11C]CHIBA-1001 for in vivo imaging of alpha7 nAChRs in the non-human primate brain...
  55. ncbi request reprint An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
    Atsuko Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan
    Psychiatr Genet 16:133-8. 2006
    ..This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states...
  56. ncbi request reprint Characterization of [(3)H]CHIBA-1001 binding to alpha7 nicotinic acetylcholine receptors in the brain from rat, monkey, and human
    Yuko Tanibuchi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260 8670, Japan
    Brain Res 1348:200-8. 2010
    ..In summary, [(3)H]CHIBA-1001 would be a useful radioligand for alpha7 nAChRs in the brains of rodents, non-human primates, and humans...
  57. ncbi request reprint Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex
    Naoe Okamura
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Brain Res 992:114-9. 2003
    ..5 mg/kg, i.p.). These results suggest that LY379268 has a protective effect on the neurotoxicity in the rat retrosplenial cortex after administration of NMDA receptor antagonists such as dizocilpine...
  58. doi request reprint Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Drug Alcohol Depend 113:1-7. 2011
    ..The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis...
  59. ncbi request reprint Effectiveness of Information Technology Aided Relapse Prevention Programme in Schizophrenia excluding the effect of user adherence: a randomized controlled trial
    Hideki Komatsu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan Electronic address
    Schizophr Res 150:240-4. 2013
    ..However the effectiveness was influenced by user adherence to the protocol of the program, the exact effectiveness and the role of the ITAREPS have been partially uncertain...
  60. ncbi request reprint No changes in serum epidermal growth factor levels in patients with schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 135:257-60. 2005
    ..Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits...
  61. ncbi request reprint Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Schizophr Res 76:67-72. 2005
    ..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia...
  62. ncbi request reprint Auditory-conditioned-fear-dependent c-Fos expression is altered in the emotion-related brain structures of Fyn-deficient mice
    Osamu Kubota
    Department of Anatomy and Developmental Biology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Brain Res Mol Brain Res 130:149-60. 2004
    ....
  63. ncbi request reprint Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Int J Neuropsychopharmacol 9:77-81. 2006
    ..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition...
  64. ncbi request reprint Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1529-31. 2006
    ..In this study, we studied whether serum levels of BDNF are altered in patients with autism...
  65. pmc Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder
    Taisuke Yoshida
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 7:e42676. 2012
    ..In this study, we examined whether serum levels of proBDNF, mature BDNF, and matrix metalloproteinase-9 (MMP-9), which converts proBDNF to mature BDNF, are altered in patients with MDD...
  66. doi request reprint Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine
    Hongxian Chen
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 222:37-45. 2012
    ..Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine whether SFN can attenuate behavioral and neuropathological changes associated with METH exposure...
  67. doi request reprint Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 65:1103-6. 2009
    ....
  68. ncbi request reprint Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Ann N Y Acad Sci 1025:231-5. 2004
    ..Therefore, it is likely that NAC would be a suitable drug for treatment of neurotoxicity on dopaminergic nerve terminals related to chronic use of MAP in humans...
  69. ncbi request reprint Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Psychiatry 54:70-5. 2003
    ....
  70. ncbi request reprint Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:767-9. 2005
    ..This study suggests that synthetic or metabolic pathways of D-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia...
  71. ncbi request reprint Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Neurosci Lett 363:81-3. 2004
    ..56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group...
  72. ncbi request reprint Increased levels of serum basic fibroblast growth factor in schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 120:211-8. 2003
    ....
  73. pmc Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    PLoS ONE 3:e1944. 2008
    ..In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in patients...
  74. ncbi request reprint Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia
    Kimiyoshi Ozawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 59:546-54. 2006
    ..Maternal viral infection is associated with increased risk for schizophrenia. It is hypothesized that the maternal immune response to viruses may influence fetal brain development and lead to schizophrenia...
  75. ncbi request reprint Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a positron emission tomography study in conscious monkeys
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba
    Biol Psychiatry 61:577-81. 2007
    ..However, there are currently no particular pharmacological treatments for the wide range of symptoms associated with METH abuse...
  76. ncbi request reprint The immunophilin ligand FK506 protects against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neuropharmacology 48:391-7. 2005
    ..These results suggest that FK506 shows protective effects on the MAP-induced neurotoxicity in the dopaminergic neurons of the mouse striatum...
  77. ncbi request reprint A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:895-8. 2009
    ..The symptoms of methamphetamine induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an association analysis of rs2234693 with Japanese methamphetamine induced psychosis patients...
  78. pmc Occupancy of α7 Nicotinic Acetylcholine Receptors in the Brain by Tropisetron: A Positron Emission Tomography Study Using [(11)C]CHIBA-1001 in Healthy Human Subjects
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Clin Psychopharmacol Neurosci 9:111-6. 2011
    ..In the present study, we evaluated the receptor occupancy in the human brain after a single oral administration of tropisetron and ondansetron using [(11)C]CHIBA-1001 and PET...
  79. doi request reprint Orbitofrontal cortex abnormality and deficit schizophrenia
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Schizophr Res 143:246-52. 2013
    ..These results demonstrated that at-rest hypofrontality was a common feature within the disease group and suggested that the OFC might play an important role in the development of severe negative symptoms in people with deficit syndrome...
  80. ncbi request reprint Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropsychobiology 52:68-70. 2005
    ..Glutathione peroxidase 1 (GPX1) plays a role in the antioxidant defense system...
  81. pmc Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Curr Neuropharmacol 9:129-32. 2011
    ..Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population...
  82. pmc Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
    Takenori Okumura
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Curr Neuropharmacol 9:155-9. 2011
    ..In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population...
  83. pmc No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis
    Tomoko Tsunoka
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Curr Neuropharmacol 9:160-2. 2011
    ..To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls)...
  84. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  85. pmc Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Curr Neuropharmacol 9:133-6. 2011
    ..Our findings suggest that PROK2 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population...
  86. doi request reprint Possible involvement of brain-derived neurotrophic factor in eating disorders
    Michiko Nakazato
    Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
    IUBMB Life 64:355-61. 2012
    ..In the previous studies, serum BDNF levels in subjects with EDs are reduced significantly compared with healthy controls, hence, we proposed that levels of serum BDNF would be a useful diagnostic indicator for EDs...
  87. ncbi request reprint High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 62:878-83. 2007
    ..The present study was undertaken to examine whether fluvoxamine binds to sigma-1 receptors in living human brain...
  88. ncbi request reprint An open trial of outpatient group therapy for bulimic disorders: combination program of cognitive behavioral therapy with assertive training and self-esteem enhancement
    Akihiro Shiina
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Psychiatry Clin Neurosci 59:690-6. 2005
    ..06) were predictors of dropout from the CGCBT program. Our CGCBT program is a promising first-line treatment for bulimic outpatients. Lower age and the presence of comorbidity had effects on dropout rates...
  89. ncbi request reprint Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 183:13-9. 2005
    ..Similar to schizophrenic patients, DBA/2 mice spontaneously exhibit a deficit in inhibitory processing of the P20-N40 auditory evoked potential, which is thought to be a rodent analog of the human P50 auditory evoked potential...
  90. doi request reprint Impaired P50 suppression in fear extinction in obsessive-compulsive disorder
    Makoto Nanbu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:317-22. 2010
    ..The S2/S1 ratio in the extinction phase was significantly higher in the OCD patient group than in the healthy control group. In conclusion, our data suggested that P50 sensory gating in fear extinction was impaired in patients with OCD...
  91. doi request reprint Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Hippocampus 21:1105-13. 2011
    ..These results suggest that ALLO exerts antidepressant-like effects in the CA3 region of hippocampus through the GABA system and in the central region of amygdala, dependently on the activation of the glutamatergic mechanisms...
  92. pmc A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia
    Akihiro Shiina
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Ann Gen Psychiatry 9:27. 2010
    ..Therefore, it is of particular interest to investigate the effects of tropisetron on the cognitive deficits in patients with schizophrenia...
  93. ncbi request reprint Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:499-504. 2005
    ..In addition, a more complete understanding of the signal transduction pathway via the p75 neurotrophin receptor (p75NTR) and TrkB receptors would provide new perspectives for treating eating disorders...
  94. doi request reprint A case of methamphetamine use disorder treated with the antibiotic drug minocycline
    Yuko Tanibuchi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Gen Hosp Psychiatry 32:559.e1-3. 2010
    ....
  95. ncbi request reprint Combined intoxication with methylone and 5-MeO-MIPT
    Eiji Shimizu
    Department of Integrative Neurophysiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:288-91. 2007
    ..This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs...
  96. ncbi request reprint Increased levels of glutamate in brains from patients with mood disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Biol Psychiatry 62:1310-6. 2007
    ....
  97. ncbi request reprint Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol
    Satoshi Yanahashi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res 1011:84-93. 2004
    ..g., CP-101,606) might be useful drugs for the treatment of extrapyramidal side effects (EPS) associated with the chronic use of typical antipsychotics such as haloperidol...
  98. ncbi request reprint [Glutamate hypothesis of schizophrenia and targets for new antipsychotic drugs]
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 22:3-13. 2002
    ..Moreover, the glycine site of the NMDA receptor, metabotropic glutamate receptor, AMPA receptor, and antioxidant glutathione as novel potential targets for the treatment of schizophrenia are discussed...
  99. ncbi request reprint Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 124:61-3. 2004
    ..Our findings suggest that BDNF 196 A/G polymorphism might be associated with personality traits in female, but not male, healthy subjects...
  100. ncbi request reprint Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 54:485-90. 2003
    ....
  101. ncbi request reprint No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba, 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1117-21. 2006
    ..2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5)...