H Ito

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells
    H Ito
    First Department of Surgery, School of Medicine, Chiba University, Japan
    Oncology 58:261-70. 2000
  2. ncbi request reprint Mechanism of cold ischemia-reperfusion-induced graft injury after orthotopic liver transplantation in rats
    H Shimizu
    First Department of Surgery, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260, Japan
    Hepatogastroenterology 48:216-9. 2001
  3. ncbi request reprint Postoperative radiation therapy for stage IB-IIB carcinoma of the cervix with poor prognostic factors
    T Uno
    Department of Radiology, Chiba University, School of Medicine, Japan
    Anticancer Res 20:2235-9. 2000
  4. ncbi request reprint Benefits and limits of hepatic resection for gastric metastases
    S Ambiru
    First Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan
    Am J Surg 181:279-83. 2001
  5. ncbi request reprint Radiotherapy for local progression in patients with hormone-refractory prostate cancer
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int J Urol 6:187-91. 1999
  6. ncbi request reprint Nonsurgical management of ruptured pseudoaneurysm in patients with hepatobiliary pancreatic diseases
    A Okuno
    First Department of Surgery, School of Medicine, Chiba University, Japan
    Am J Gastroenterol 96:1067-71. 2001
  7. ncbi request reprint Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma
    M Shiobara
    First Department of Surgery, School of Medicine, Chiba University, Japan
    J Gastroenterol Hepatol 16:338-44. 2001
  8. ncbi request reprint Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats
    H Shimizu
    First Department of Surgery, School of Medicine, Chiba University, Japan
    J Hepatol 34:683-9. 2001
  9. ncbi request reprint Incidence and characteristics of antiandrogen withdrawal syndrome in prostate cancer after treatment with chlormadinone acetate
    K Akakura
    Department of Urology, School of Medicine, Chiba University, Japan
    Eur Urol 33:567-71. 1998
  10. ncbi request reprint Prognosis of patients with T4 prostate carcinoma
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int J Urol 6:192-5. 1999

Detail Information

Publications77

  1. ncbi request reprint Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells
    H Ito
    First Department of Surgery, School of Medicine, Chiba University, Japan
    Oncology 58:261-70. 2000
    ..These actions indicate that hepatocellular carcinoma may possess a forceful autocrine mechanism enabling cells to survive and proliferate under cirrhotic conditions...
  2. ncbi request reprint Mechanism of cold ischemia-reperfusion-induced graft injury after orthotopic liver transplantation in rats
    H Shimizu
    First Department of Surgery, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260, Japan
    Hepatogastroenterology 48:216-9. 2001
    ..This phenomenon may subsequently cause ischemic damage to the hepatocyte, with eventual graft failure...
  3. ncbi request reprint Postoperative radiation therapy for stage IB-IIB carcinoma of the cervix with poor prognostic factors
    T Uno
    Department of Radiology, Chiba University, School of Medicine, Japan
    Anticancer Res 20:2235-9. 2000
    ..To investigate failure pattern and to evaluate the prognostic impact of lymph node metastasis in patients with cervical cancer treated with postoperative adjuvant pelvic irradiation...
  4. ncbi request reprint Benefits and limits of hepatic resection for gastric metastases
    S Ambiru
    First Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan
    Am J Surg 181:279-83. 2001
    ....
  5. ncbi request reprint Radiotherapy for local progression in patients with hormone-refractory prostate cancer
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int J Urol 6:187-91. 1999
    ..The aim of the present study was to investigate the effect of radiotherapy on the local progression of hormone-refractory prostate cancer...
  6. ncbi request reprint Nonsurgical management of ruptured pseudoaneurysm in patients with hepatobiliary pancreatic diseases
    A Okuno
    First Department of Surgery, School of Medicine, Chiba University, Japan
    Am J Gastroenterol 96:1067-71. 2001
    ..Early detection and immediate embolization might bring about a favorable outcome in patients with hepatobiliary pancreatic diseases who encounter rupture of pseudoaneurysms after surgical and interventional treatments...
  7. ncbi request reprint Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma
    M Shiobara
    First Department of Surgery, School of Medicine, Chiba University, Japan
    J Gastroenterol Hepatol 16:338-44. 2001
    ....
  8. ncbi request reprint Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats
    H Shimizu
    First Department of Surgery, School of Medicine, Chiba University, Japan
    J Hepatol 34:683-9. 2001
    ..CONCLUSIONS: These data strongly suggest that VEGF secreted by proliferating hepatocytes may represent an important stimulator of SEC proliferation...
  9. ncbi request reprint Incidence and characteristics of antiandrogen withdrawal syndrome in prostate cancer after treatment with chlormadinone acetate
    K Akakura
    Department of Urology, School of Medicine, Chiba University, Japan
    Eur Urol 33:567-71. 1998
    ..This paper would like to contribute to this effort by describing the endocrine withdrawal phenomenon in patients treated with combinations of castration plus chlormadinone acetate, ethynylestradiol or estramustine phosphate...
  10. ncbi request reprint Prognosis of patients with T4 prostate carcinoma
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int J Urol 6:192-5. 1999
    ..The clinical course of patients with T4 prostate carcinoma was examined in order to consider whether there are alternative treatment options besides androgen ablation therapy...
  11. ncbi request reprint Multidrug resistance gene (MDR-1) expression as a useful prognostic factor in patients with human hepatocellular carcinoma after surgical resection
    A Kato
    First Department of Surgery, School of Medicine, Chiba University, Chuo-ku, Chiba, Japan
    J Surg Oncol 78:110-5. 2001
    ..CONCLUSION: This study suggested that the measurement of the MDR-1 mRNA levels in HCC and nontumorous liver tissue might be a useful prognostic factor after surgical resection in patients with HCC...
  12. ncbi request reprint An approach to intrapericardial inferior vena cava through the abdominal cavity, without median sternotomy, for total hepatic vascular exclusion
    M Miyazaki
    Department of General Surgery, School of Medicine, Chiba University, Inohana, Chuoh-ku, Chiba, 260-0856, Japan
    Hepatogastroenterology 48:1443-6. 2001
    ..We herein demonstrate an approach to the intrapericardial inferior vena cava through the abdominal cavity without median sternotomy...
  13. ncbi request reprint Pattern of progression and survival in hormonally treated metastatic prostate cancer
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int J Urol 6:240-4. 1999
    ..To further evaluate disease progression, the pattern of progression and survival in hormonally treated metastatic prostate cancer was examined...
  14. ncbi request reprint The impact of a 4 cm. cutoff point for stratification of T1N0M0 renal cell carcinoma after radical nephrectomy
    T Igarashi
    Department of Urology, Chiba University, School of Medicine, Japan
    J Urol 165:1103-6. 2001
    ..CONCLUSIONS: Tumor size is an important prognostic factor for patients with T1N0M0 renal cell carcinoma. A cutoff point of 4 cm. is practical for dividing the T1N0M0 classification into T1a and T1b subclasses...
  15. ncbi request reprint Transurethral holmium: YAG laser prostatectomy using a side-firing fiber for bladder outlet obstruction due to benign prostatic enlargement: urodynamic evaluation of surgical outcome
    T Yamanishi
    Department of Urology, Chiba University, School of Medicine, Dokkyo University, Medical School, Koshigaya Hospital, Koshigaya, Saitama, Japan
    Eur Urol 39:544-50. 2001
    ..To prospectively assess the efficacy of transurethral holmium (Ho):YAG laser prostatectomy using a side-firing fiber in patients with bladder outlet obstruction due to benign prostatic enlargement (BPE) from the standpoint of urodynamics...
  16. ncbi request reprint beta-estradiol 3-benzoate affects spermatogenesis in the adult mouse
    Y Toyama
    Department of Anatomy and Developmental Biology, School of Medicine, Chiba University, Chiba, Japan
    Mol Cell Endocrinol 178:161-8. 2001
    ..It is concluded that the chemical seems to affect round spermatids metabolically, but the morphological effect can be detected only from the spermatids older than step 6. The effects of the chemical on adult mice were reversible...
  17. ncbi request reprint [Basic techniques in vascular surgery]
    M Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Nippon Geka Gakkai Zasshi 102:789-93. 2001
    ..Topical heparinization is easy and a useful method to prevent the production of thrombus. Systemic administration of anticoagulants is not always needed...
  18. ncbi request reprint Effect of combined treatment with radiation and low dose etoposide on cell survival
    N Shigematsu
    Department of Radiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 21:325-8. 2001
    ..To improve the radiotherapy results, we evaluated etoposide as an effective radiosensitizer by using cultured cell-lines...
  19. ncbi request reprint Changes in the composition of serum bile acid as a predictor of small bowel allograft rejection in rats
    K Miyagi
    First Department of Surgery, Ehime University School of Medicine, Japan
    Transplantation 71:565-9. 2001
    ..The ratio of secondary bile acids changed in relation to acute rejection after SBT, suggesting that they can be useful for early diagnosis of acute SBT allograft rejection...
  20. ncbi request reprint Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors
    T Hiwasa
    Department of Biochemistry, School of Medicine, Chiba University, Japan
    FEBS Lett 444:173-6. 1999
    ....
  21. ncbi request reprint Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing survival
    M Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8670, Japan
    Br J Surg 89:1525-31. 2002
    ..The results of surgical treatment for intrahepatic cholangiocarcinoma (ICC) and specific factors influencing survival are still unclear...
  22. ncbi request reprint Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis
    A Kitamura
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Oncology 61:205-11. 2001
    ..These results indicate that abnormal Fhit expression is a common event in the early stage of ESC development and may occur independently of p53 expression and apoptosis mechanisms...
  23. pmc Definitive chemoradiotherapy for patients with malignant stricture due to T3 or T4 squamous cell carcinoma of the oesophagus
    K Kaneko
    Second Department of Internal Medicine, Showa University School of Medicine, 1 5 8, Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Br J Cancer 88:18-24. 2003
    ..The efficacy and survival of patients treated with this regimen are related to the T factor...
  24. ncbi request reprint Neoadjuvant chemoradiotherapy followed by esophagectomy for initially resectable squamous cell carcinoma of the esophagus with multiple lymph node metastasis
    Yoshihiro Nabeya
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Dis Esophagus 18:388-97. 2005
    ..The prediction of response to CRT and the development of alternative treatment for hematogenous recurrence could achieve a further survival benefit of this trimodality treatment...
  25. ncbi request reprint Laparoscopic adrenalectomy for pheochromocytoma
    T Ichikawa
    Department of Urology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biomed Pharmacother 56:149s-153s. 2002
    ..We conclude that laparoscopic adrenalectomy for pheochromocytoma is equally effective and less invasive than open adrenalectomy and should be considered the therapy of choice even for pheochromocytoma...
  26. ncbi request reprint G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation
    T Kawata
    Department of Radiology, Graduate School of Medicine, Chiba, Japan
    Cytogenet Genome Res 104:211-5. 2004
    ....
  27. pmc Expression of angiogenic factors predicts response to chemoradiotherapy and prognosis of oesophageal squamous cell carcinoma
    H Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8677, Japan
    Br J Cancer 86:552-7. 2002
    ..0147). These results suggest that expression of angiogenic factors has predictive value for the treatment response and outcome of patients with oesophageal cancer...
  28. ncbi request reprint G2-chromosome aberrations induced by high-LET radiations
    T Kawata
    NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX, USA
    Adv Space Res 27:383-91. 2001
    ..It is concluded that the increased production of isochromatid-type breaks, induced by the densely ionizing track structure, is a signature of high-LET radiation exposure...
  29. ncbi request reprint Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis
    M Osaki
    First Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Japan
    Gastric Cancer 4:198-205. 2001
    ..CONCLUSIONS: Upregulation of FasL may correlate with the progression of gastric carcinoma. Apoptosis in gastric adenoma and carcinoma cells may occur via Fas-dependent and -independent pathways, but further clarification is needed...
  30. ncbi request reprint [Prospects for molecular research in urological oncology: bladder cancer]
    K Koshida
    Department of Urology, Kanazawa University School of Medicine
    Hinyokika Kiyo 47:815-8. 2001
    ..Anti-sense ORP150 may therefore have a potentially stronger antitumor effect because of its multitargeting capability as a molecular chaperone...
  31. ncbi request reprint Adjuvant pelvic irradiation in patients with pathologic T2b carcinoma of the uterine cervix
    Takashi Uno
    Department of Radiation Oncology, School of Medicine, Chiba University, Inohana 1 8 1, Chuou ku, Chiba City, Chiba 260 8670, Japan
    Int J Gynecol Cancer 12:187-91. 2002
    ..016). Results support previous evidence for chemoradiation in patients with pelvic lymph node metastasis. However, it appears that the role of systemic chemotherapy for node-negative pT2b patients is yet to be established...
  32. pmc Single nucleotide polymorphisms in DNA repair genes might be prognostic factors in muscle-invasive bladder cancer patients treated with chemoradiotherapy
    S Sakano
    Department of Urology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Br J Cancer 95:561-70. 2006
    ..04). The association was stronger in stage T3/T4 patients (P=0.0008). These results suggest that combined XPD and XRCC1 genotypes might be prognostic factors in muscle-invasive bladder cancer patients treated with CRT...
  33. ncbi request reprint Thymidine phosphorylase expression causes both the increase of intratumoral microvessels and decrease of apoptosis in human esophageal carcinomas
    E Okamoto
    First Department of Pathology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan
    Pathol Int 51:158-64. 2001
    ....
  34. ncbi request reprint Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy
    T Ito
    Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Gastroenterol 36:303-11. 2001
    ..CONCLUSION: Concurrent chemoradiotherapy is potentially curative for locally advanced esophageal carcinoma, but p53 genetic abnormality has no impact on prognosis...
  35. ncbi request reprint A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells
    S Kase
    Dept of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Exp Clin Cancer Res 23:301-7. 2004
    ..Moreover, TE-12 cells showed a decrease in the expression levels of cyclin B1 and an increase in p27Kip1. These findings suggest that NS398 inhibits cell growth and induces G2/M arrest in human SCC cells expressing COX-2...
  36. ncbi request reprint Concurrent daily cisplatin and extended-field radiation therapy for carcinoma of the cervix
    T Uno
    Departments of Radiology and Obstetrics and Gynecology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Gynecol Cancer 18:80-4. 2008
    ..A cumulative cisplatin dose of greater than 200 mg/m(2) during radiation therapy could be achieved by using daily cisplatin dose of 8 mg/m(2)...
  37. ncbi request reprint Stage IA non-Hodgkin's lymphoma of the Waldeyer's ring. Limited chemotherapy and radiation therapy versus radiation therapy alone
    M Uematsu
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    Acta Oncol 32:675-8. 1993
    ..Limited chemotherapy and radiation therapy seemed to be more beneficial than radiation therapy alone not only in relapse-free survival but also in quality of life after treatment...
  38. ncbi request reprint Concurrent chemoradiation for patients with squamous cell carcinoma of the cervical esophagus
    T Uno
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Dis Esophagus 20:12-8. 2007
    ..CCRT shows promise for cervical esophageal carcinoma. T-classification and initial local control had significant impact on survival...
  39. ncbi request reprint Hsp27 suppresses the formation of inclusion bodies induced by expression of R120G alpha B-crystallin, a cause of desmin-related myopathy
    H Ito
    Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya, Kasugai, Aichi 480 0392, Japan
    Cell Mol Life Sci 60:1217-23. 2003
    ..Moreover, co-expression resulted in reduced formation of inclusion bodies, suggesting that Hsp27 acts as a molecular chaperone for R120G alpha B-crystallin...
  40. ncbi request reprint Treatment and prognosis of patients with paraplegia or quadriplegia because of metastatic spinal cord compression in prostate cancer
    M Nagata
    Department of Urology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Prostate Cancer Prostatic Dis 6:169-73. 2003
    ..This should encourage an aggressive treatment approach. However, for patients with hormone-independent disease there seems to be no effective treatment and prognosis is poor...
  41. ncbi request reprint Chitosan application to X-ray irradiated wound in dogs
    H Ueno
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro 080 8555, Japan
    J Plast Reconstr Aesthet Surg 60:304-10. 2007
    ..The present results confirmed advanced granulation and capillary formation in wounds treated with chitosan, even after irradiation...
  42. ncbi request reprint Interleukin-1beta gene in esophageal, gastric and colorectal carcinomas
    H Ito
    Second Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 0064, Japan
    Oncol Rep 18:473-81. 2007
    ..Our results shows that IL-1B-511C/T and T carrier state may indicate less risk for gastric and colorectal carcinoma in the Japanese population...
  43. ncbi request reprint Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts
    H Tokuda
    Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu, Aichi 474 8511, Japan
    Eur J Endocrinol 149:239-45. 2003
    ..In the present study, we have investigated the involvement of SAPK/JNK in ET-1-induced HSP27 in MC3T3-E1 cells...
  44. pmc Study of p53 gene alteration as a biomarker to evaluate the malignant risk of Lugol-unstained lesion with non-dysplasia in the oesophagus
    K Kaneko
    Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Br J Cancer 96:492-8. 2007
    ..These findings suggest that some LULs-NDE may represent the earliest state of oesophageal squamous cell carcinoma in Japanese individuals...
  45. ncbi request reprint Fine needle aspiration cytology for soft tissue tumours of the hand
    Y Kitagawa
    Department of Orthopaedic Surgery, Division of Surgical Pathology, and Second Department of Pathology, Nippon Medical School, Tokyo, Japan
    J Hand Surg Br 28:582-5. 2003
    ..No complications were encountered. Fine needle aspiration cytology has a high degree of diagnostic accuracy and safety for soft tissue tumours of the hand...
  46. ncbi request reprint Detection and quantification of circulating tumor cells in patients with esophageal cancer by real-time polymerase chain reaction
    H Ito
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    J Exp Clin Cancer Res 23:455-64. 2004
    ..They also suggest that the identification of circulating tumor cells by the CEA mRNA assay is a reliable means of predicting early recurrence...
  47. ncbi request reprint The effect of cellular proliferative activity on recurrence and local tumour extent of localized giant cell tumour of tendon sheath
    Y Kitagawa
    Department of Orthopaedic Surgery, Pathology and Surgical Pathology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Hand Surg Br 29:604-7. 2004
    ..These results suggest that the proliferative activity of localized giant cell tumour of tendon sheath is not related to its high recurrence rate and local aggressiveness...
  48. ncbi request reprint MAP kinase phosphatase-1 is induced in abnormal fibers in inclusion body myositis
    S Nakano
    Department of Neurology, Kansai Medical University, Moriguchi City, Japan
    Neurology 61:322-6. 2003
    ..To investigate alterations in protein kinases and phosphatases that regulate the activity of mitogen activated protein kinase (MAPK) in sporadic inclusion body myositis (IBM)...
  49. pmc Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma
    A Toma
    Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo ku, Kyoto 602 8566, Japan
    Br J Cancer 93:131-6. 2005
    ..Mab A7 coupled to Ferumoxides is potentially suitable as a magnetic resonance contrast agent for detecting local recurrence of rectal carcinoma...
  50. pmc CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness
    M S Duxbury
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Br J Cancer 91:1384-90. 2004
    ..Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner. This pathway warrants further investigation as a target for therapy...
  51. ncbi request reprint Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38
    T Hiramitsu
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Rheumatology (Oxford) 45:824-32. 2006
    ..We investigated the role of intercellular adhesion molecule-1 (ICAM-1), another cell surface receptor for HA, and the intracellular signalling pathways in the actions of HA...
  52. ncbi request reprint SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
    T Inoue
    Department of Human Genome Science, Graduate School of Medical Science, Tottori University, Yonago, Tottori, Japan
    Oncogene 26:945-57. 2007
    ..Collectively, our results suggest that the further study of SIRT2 may thus provide new insights into the relationships among CIN, epigenetic regulation and tumorigenesis...
  53. ncbi request reprint High light inhibits chlorophyll biosynthesis at the level of 5-aminolevulinate synthesis during de-etiolation in cucumber (Cucumis sativus) cotyledons
    D Aarti
    Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan
    Photochem Photobiol 83:171-6. 2007
    ....
  54. ncbi request reprint Clinical significance of pulmonary metastases in stage D2 prostate cancer patients
    H Nakamachi
    Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Prostate Cancer Prostatic Dis 5:159-63. 2002
    ..These data suggest that the presence of pulmonary metastasis has no ominous impact on clinical course and disease outcome even in patients with disseminated prostate cancer...
  55. ncbi request reprint Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts
    K Isaka
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Japan
    Placenta 24:53-64. 2003
    ..These suggests that the invasive ability of trophoblasts may be regulated by the enzyme activity of gelatinases, especially MMP-2...
  56. ncbi request reprint Clinical role of Tc-99m-MIBI scintigraphy in non-Hodgkin's lymphoma
    M Ohta
    Department of Radiology, School of Medicine, Chiba University, 1-8-2 Inohana Chuoku, Chiba City 260-8670, Japan
    Oncol Rep 8:841-5. 2001
    ..In this study, the number of patients was small and we could not reach definite conclusions. However, we think that MIBI scintigraphy is not valuable for predicting the chemotherapy outcome in patients with NHL...
  57. ncbi request reprint Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis
    T Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 37:1713-8. 2001
    ..This report is the first to describe a beneficial effect by an immunosuppressive agent in the treatment of acute viral myocarditis...
  58. ncbi request reprint Gastrointestinal stromal tumor of the stomach: report of a case
    H Shirai
    Department of Surgery, Tottori Seikyo Hospital, Japan
    Surg Today 31:346-9. 2001
    ..Nevertheless, careful and long-term follow-up is needed to monitor for signs of possible local recurrence or distant metastases...
  59. ncbi request reprint Identification of recurrent chromosomal rearrangements and the unique relationship between low-level amplification and translocation in glioblastoma
    H Kubota
    Department of Pathology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Genes Chromosomes Cancer 31:125-33. 2001
    ..These studies shed light on typical derivative chromosomes and the relationship between DNA amplification and chromosomal translocation in glioblastoma...
  60. ncbi request reprint Detection of structural aberrations of chromosome 17 in malignant gliomas by fluorescence in situ hybridization (FISH)
    T Kwak
    Department of Neurosurgery, Yamaguchi University School of Medicine, Japan
    Acta Oncol 34:27-30. 1995
    ....
  61. ncbi request reprint Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection
    H Yasuda
    Department of Neurosurgery, Yamaguchi University School of Medicine 1144, Kogushi Ube, Yamaguchi 755-8505, Japan
    Epilepsia 42:13-20. 2001
    ..CONCLUSIONS: The results suggest that remote seizure activity caused by the transneuronal spread of kainate-induced discharges may be related to NO derived from neuronal NOS...
  62. ncbi request reprint CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway
    H Ito
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Immunol 166:2970-81. 2001
    ..Exposure to donor bone marrow allows rapid tolerization of alloreactive CD4 cells when the CD40 pathway is blocked, leading to permanent marrow engraftment and intrathymic tolerization of T cells that develop subsequently...
  63. ncbi request reprint Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
    T Wekerle
    BMT Section, Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    J Immunol 166:2311-6. 2001
    ..Furthermore, these in vivo data demonstrate for the first time the significance of in vitro results indicating that proteins of the Bcl family can prevent Fas-mediated apoptosis under certain circumstances...
  64. ncbi request reprint Blastic natural killer cell lymphoma arising from the mediastinum with terminal deoxynucleotidyl transferase expression
    K Isobe
    Department of Radiology, Chiba University, School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan
    Pathol Int 51:55-9. 2001
    ..In situ hybridization for Epstein-Barr virus encoded small ribonucleic acid 1 was negative...
  65. ncbi request reprint Anti-alpha2 integrin antibody induces secretion and activation of 72-kDa progelatinase by human fibroblasts
    Y Ishibashi
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Japan
    IUBMB Life 51:25-31. 2001
    ....
  66. ncbi request reprint Major isoforms of starch branching enzymes in premature seeds of kidney bean (Phaseolus vulgaris L.)
    K Nozaki
    Department of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 65:1141-8. 2001
    ..Finally, though their N-terminal amino acid sequences were identical, their molecular masses and affinities for amylose differed; 80 kDa and 1.27 mM for KBE1 and 77 kDa and 0.74 mM for KBE2...
  67. ncbi request reprint Identification of a novel human ankyrin-repeated protein homologous to CARP
    M Moriyama
    Department of Molecular Biology, Tottori University, 86 Nishimachi, Yonago City, Tottori 683 8503, Japan
    Biochem Biophys Res Commun 285:715-23. 2001
    ..Interestingly, Arpp expression was detectable in bilateral ventricles, but undetectable in bilateral atria and large vessels, suggesting that Arpp may play a specific function in cardiac ventricles as well as skeletal muscles...
  68. pmc Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
    H Andachi
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 87:441-5. 2002
    ..These results suggested that reduced Fragile histidine triad expression might be correlated with mismatch repair expression, but not with p53 expression...
  69. ncbi request reprint Laparoscopic adrenalectomy: comparison of transperitoneal and retroperitoneal approaches
    Y Naya
    Department of Urology, Yokohama Rosai Hospital, Yokohama, Japan
    BJU Int 90:199-204. 2002
    ..To compare the effectiveness and efficiency of transperitoneal anterior laparoscopic adrenalectomy with that of retroperitoneal posterior laparoscopic adrenalectomy...
  70. ncbi request reprint Prognostic significance of changes in prostate-specific antigen in patients with metastasis prostate cancer after endocrine treatment
    Y Furuya
    Department of Urology, School of Medicine, Chiba University, Japan
    Int Urol Nephrol 32:659-63. 2001
    ..In metastatic prostate cancer patients treated with androgen withdrawal, serial measurement of PSA could distinguish nonfavorable responders early in the course of treatment and assist in monitoring for disease progression...
  71. ncbi request reprint [A case of esophageal carcinoma with multiple liver metastases successfully treated with nedaplatin (NDP) and 5-fluorouracil (5-FU) combined with radiotherapy]
    K Kaneko
    Second Dept. of Internal Medicine, Showa University School of Medicine
    Gan To Kagaku Ryoho 28:831-4. 2001
    ..In conclusion, concurrent chemoradiotherapy including NDP is effective and safe for patients with esophageal carcinoma accompanied by multiple liver metastasis. This nonsurgical approach may be an option for standard care in such cases...
  72. ncbi request reprint Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa
    I Kodani
    First Department of Pathology, Faculty of Medicine, Tottori University, Tottori, Japan
    Pathobiology 69:150-8. 2001
    ..We examined cell cycle and cell death biomarker trends with the normal-dysplasia-carcinoma sequence of the oral epithelia analyzing the pathological significance of a new biomarker, minichromosome maintenance 2 (MCM2)...
  73. ncbi request reprint Pretreatment serum level of testosterone as a prognostic factor in Japanese men with hormonally treated stage D2 prostate cancer
    T Imamoto
    Department of Urology, Graduate School of Medicine, Chiba University, Japan
    Endocr J 48:573-8. 2001
    ..However, a higher T level was also associated with stage progression of this disease...
  74. ncbi request reprint Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene
    R Ishida
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    J Hum Genet 46:557-9. 2001
    ..These results may prove to be useful as genetic markers for population-based disease-association studies in osteoporosis...
  75. ncbi request reprint Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines
    N Sekita
    Department of Urology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
    Jpn J Cancer Res 92:947-51. 2001
    ..From these results, it is suggested that epigenetic change is not the main mechanism of KAI1 down-regulation, though there remains a possibility that methylation in a more upstream region might be associated with this regulation...
  76. ncbi request reprint The role of epigenetic modifications in retinoic acid receptor beta2 gene expression in human prostate cancers
    T Nakayama
    Second Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1049-57. 2001
    ..These data suggest that the RARbeta2 gene may be one of the frequently silenced genes by epigenetic modifications in PCa...
  77. pmc Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kr├╝ppel-like factor, a novel zinc finger repressor
    S Uchida
    Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Cell Biol 20:7319-31. 2000
    ..These results suggest that a novel set of zinc finger proteins may help regulate the strict tissue- and nephron segment-specific expression of the CLC-K1 and CLC-K2 channel genes through their GA cis element...