Fumio Imazeki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Favorable prognosis of chronic hepatitis C after interferon therapy by long-term cohort study
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Hepatology 38:493-502. 2003
  2. ncbi request reprint Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ward, Japan
    Oncology 66:481-91. 2004
  3. doi request reprint Long-term follow-up of patients with hepatitis B e antigen negative chronic hepatitis B
    Dan Bekku
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 26:122-8. 2011
  4. ncbi request reprint Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma
    Yuichi Hirasawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncology 71:77-85. 2006
  5. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
    Kai Yu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Cancer Sci 98:1921-9. 2007
  6. ncbi request reprint Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba 260 8670, Japan
    J Hepatol 41:436-45. 2004
  7. ncbi request reprint Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Gastroenterol 42:560-6. 2007
  8. doi request reprint Interleukin-29 suppresses hepatitis A and C viral internal ribosomal entry site-mediated translation
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Viral Immunol 25:379-86. 2012
  9. doi request reprint Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    J Hepatol 52:72-8. 2010
  10. ncbi request reprint Phylogenetic analysis of hepatitis A virus in sera from patients with hepatitis A of various severities
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 29:838-45. 2009

Detail Information

Publications88

  1. ncbi request reprint Favorable prognosis of chronic hepatitis C after interferon therapy by long-term cohort study
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Hepatology 38:493-502. 2003
    ..In conclusion, the present data suggest that IFN therapy has a long-term clinical benefit for patients with chronic hepatitis C patients by reducing liver-related death, especially in patients with sustained virologic response...
  2. ncbi request reprint Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ward, Japan
    Oncology 66:481-91. 2004
    ..The effect of the HDAC inhibitor, trichostatin A (TSA), on hepatoma cells, however, has not been well studied. In this study, we examined cell viability and gene expression profile in hepatoma cell lines treated with TSA...
  3. doi request reprint Long-term follow-up of patients with hepatitis B e antigen negative chronic hepatitis B
    Dan Bekku
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 26:122-8. 2011
    ..We investigated the predictive factors for alanine aminotransferase (ALT) elevation, antiviral drug use, and hepatocellular carcinoma (HCC) occurrence in HBeAg-negative patients...
  4. ncbi request reprint Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma
    Yuichi Hirasawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncology 71:77-85. 2006
    ....
  5. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
    Kai Yu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Cancer Sci 98:1921-9. 2007
    ..8, and 1.4 times, respectively, in HepG2 cells. Substitutions and deletion of nucleotides of the HBV genome, especially the pre-S2 deletion and G1317A and T1341C/A/G mutations may be useful markers for predicting the development of HCC...
  6. ncbi request reprint Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba 260 8670, Japan
    J Hepatol 41:436-45. 2004
    ..Epigenetics is the key factor in the regulation of gene expression. We conducted cDNA microarray analysis to screen for genes induced by histone deacetylase (HDAC) inhibition and examined epigenetic alterations...
  7. ncbi request reprint Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Gastroenterol 42:560-6. 2007
    ..We therefore analyzed HAV 2B from many patients with various clinical disease severities...
  8. doi request reprint Interleukin-29 suppresses hepatitis A and C viral internal ribosomal entry site-mediated translation
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Viral Immunol 25:379-86. 2012
    ..Combining IL-29 with IFN-α or amantadine resulted in stronger inhibition of HAV IRES activity. Our findings demonstrated a novel antiviral effect of IFNs-λ against HAV and HCV through the suppression of IRES-mediated translation...
  9. doi request reprint Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    J Hepatol 52:72-8. 2010
    ..To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC)...
  10. ncbi request reprint Phylogenetic analysis of hepatitis A virus in sera from patients with hepatitis A of various severities
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 29:838-45. 2009
    ....
  11. ncbi request reprint Lower incidence of hepatic failure than hepatocellular carcinoma in Japanese patients with chronic hepatitis C
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:772-8. 2005
    ..We investigated the status in Japan in a retrospective cohort study...
  12. ncbi request reprint BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 23:1701-8. 2010
    ..In conclusion, our data suggest that silencing of BCL2L10 by aberrant methylation is a common feature in gastric cancer and its inactivation may be involved in the early steps of gastric carcinogenesis...
  13. pmc Peginterferon Alfa-2a plus ribavirin in Japanese patients infected with hepatitis C virus genotype 2 who failed previous interferon therapy
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Int J Med Sci 10:43-9. 2013
    ..Attention should be paid to certain patients with unique features. Selection of patients according to their previous treatment could lead to optimal therapy in HCV genotype 2 treatment-experienced patients...
  14. doi request reprint Long-term cohort study of chronic hepatitis C according to interferon efficacy
    Daisuke Maruoka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 27:291-9. 2012
    ..We investigated the prognosis of patients with C-viral chronic liver disease (C-CLD) according to the efficacy of interferon (IFN) therapy in a long-term retrospective cohort study...
  15. ncbi request reprint Inhibition of subgenomic hepatitis C virus RNA replication in HeLa cells
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 54:32-5. 2007
    ..The aim of this study was to evaluate the effect of interferon or ribavirin treatment on subgenomic HCV RNA replication in 'non-hepatic' HeLa cells...
  16. ncbi request reprint Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 20:405-12. 2008
    ..Overexpression of NMES1 in ESCC cell lines increased cell motility. Down-regulation of NMES1 might play an important role in the cell motility of ESCC or be a potent marker of malignancy...
  17. ncbi request reprint Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 14:3768-76. 2008
    ..However, the mechanisms of Hh signaling activation in hepatocellular carcinoma (HCC) have not been fully elucidated. We analyzed the involvement of Hh-interacting protein (HHIP) gene, a negative regulator of Hh signaling, in HCC...
  18. ncbi request reprint Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-2'-deoxycytidine
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 106:2514-25. 2006
    ....
  19. ncbi request reprint Evaluation of clinical usefulness of second-generation HCV core antigen assay: comparison with COBAS AMPLICOR HCV MONITOR assay version 2.0
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:1136-41. 2005
    ..Hepatitis C virus (HCV) is an important etiologic agent for chronic liver diseases...
  20. ncbi request reprint Lamivudine treatment in a patient with hepatitis B virus reactivation after allogenic peripheral bone marrow transplantation
    Takaaki Imamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Leuk Lymphoma 46:915-7. 2005
    ..The administration of a nucleoside analog before transplantation should also be considered in the light of HBV genotypes and mutations, even if HBsAg was negative and the viral load was low before transplantation...
  21. doi request reprint Quantification of hepatitis C amino acid substitutions 70 and 91 in the core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Scand J Gastroenterol 44:872-7. 2009
    ..The purpose of this study was to establish real-time amplification refractory mutation system (ARMS) reverse transcription (RT)-polymerase chain reaction (PCR) assays for easy detection of these HCV mutations...
  22. pmc Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis B
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 9:27-32. 2012
    ..We compared the effects of lamivudine (LAM) with those of entecavir (ETV) treatments in acute exacerbation of chronic hepatitis B with 500 IU/L or higher alanine aminotransferase (ALT) levels...
  23. pmc Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 6:e28617. 2011
    ....
  24. ncbi request reprint Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Cancer 119:1616-22. 2006
    ..In particular, the suppression of BCL2L10, which could induce apoptosis and inhibit proliferation of cancer cells, might be one of the underlying mechanisms for gastric carcinogenesis...
  25. doi request reprint Hepatitis B virus e antigen downregulates cytokine production in human hepatoma cell lines
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Chiba, Japan
    Viral Immunol 23:467-76. 2010
    ..HBeAg might modify disease progression by inhibiting inflammatory cytokine and IFN gene expression, while simultaneously suppressing NF-κB-signaling- and IFNß-promoter activation...
  26. ncbi request reprint Identification and investigation of methylated genes in hepatoma
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba 260 8670, Japan
    Eur J Cancer 41:1185-94. 2005
    ..The results of MSP in hepatoma tissues suggested that some of these genes might be involved in the development or progression of hepatoma...
  27. ncbi request reprint Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma
    Motohisa Tada
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    J Hepatol 42:511-9. 2005
    ..In this study, we assessed the transcription and status of methylation of NQO1 gene in human hepatoma cells and primary human HCC tissues...
  28. pmc Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine
    Hidehiro Kamezaki
    Departments of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:567-74. 2013
    ..0% of ETV- and 94.1% of LAM-treated patients with viral breakthrough (P=0.047). Viral breakthrough associated with poor adherence could be a more important issue in the treatment with especially stronger NAs, such as ETV...
  29. pmc Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Viruses 4:1264-78. 2012
    ..Use of the combination of these two genotypes could lead to safe and effective treatment of chronic hepatitis C patients...
  30. doi request reprint Evolution of hepatitis B genotype C viral quasi-species during hepatitis B e antigen seroconversion
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatol 54:19-25. 2011
    ..Although the evolution of viral quasi-species may be related to the pathological status of disease, little is known about this phenomenon in hepatitis B, particularly with respect to hepatitis B e antigen (HBeAg) seroconversion...
  31. doi request reprint Risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Kenichi Ito
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Scand J Gastroenterol 45:243-9. 2010
    ..To determine the risk factors for the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection...
  32. doi request reprint Response to peginterferon-alfa 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Dig Dis Sci 56:3335-42. 2011
    ..The current standard treatment for patients infected with hepatitis C virus (HCV) of genotype 2 is the combination of peginterferon (PEG-IFN) plus ribavirin (RBV) for 24 weeks...
  33. ncbi request reprint Body mass index in Japanese patients with autoimmune liver disease: overweight patients with primary biliary cirrhosis tend to be asymptomatic
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 54:1758-60. 2007
    ..The aim of this study was to investigate the effects of being overweight on autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) patients...
  34. doi request reprint Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma
    Yutaka Yonemitsu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 40:1304-11. 2009
    ..029) and BMI1 (P = .039) than in their negative counterparts, as determined by Kaplan-Meier analysis. These data indicate that EZH2 and BMI1 may cooperate in initiation and progression of hepatocellular carcinoma...
  35. ncbi request reprint Effect of lamivudine in HBeAg-positive chronic hepatitis B: discordant effect on HBeAg and HBV DNA according to pretreatment ALT level
    Tomoko Kurihara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou Ward, Chiba 260 8670, Japan
    World J Gastroenterol 11:3346-50. 2005
    ..To clarify differences in antiviral effect of the drug in patients with different ALT levels, we examined the changes in HBV markers in patients with high or low ALT levels with or without lamivudine treatment...
  36. ncbi request reprint Twenty-four weeks of interferon alpha-2b in combination with ribavirin for Japanese hepatitis C patients: sufficient treatment period for patients with genotype 2 but not for patients with genotype 1
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 26:520-8. 2006
    ....
  37. ncbi request reprint Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma
    Ryosuke Muroyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 45:805-12. 2006
    ..In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC...
  38. doi request reprint Clinical significance of endoscopic ultrasound for gastric submucosal tumors
    Sachio Hata
    Department of Medicine and Clinical Oncology K1, Graduate School of Medicine, Chiba University, Iohana 1 8 1, Chiba City, 260 8670 Japan
    Clin Res Hepatol Gastroenterol 37:207-12. 2013
    ..The aim of this study was to evaluate the natural course of gastrointestinal mesenchymal tumors (GIMTs) in the stomach...
  39. ncbi request reprint Occurrence of autoimmune hepatitis during the course of primary biliary cirrhosis: report of two cases
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Chiba, Japan
    Dig Dis Sci 51:45-6. 2006
  40. pmc Efficacy of lamivudine or entecavir against virological rebound after achieving HBV DNA negativity in chronic hepatitis B patients
    Tomoo Miyauchi
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260 8677, Japan
    Int J Med Sci 10:647-52. 2013
    ..In contrast, LAM could not inhibit HBV replication even if HBV negativity was achieved in the early phase. Attention should be paid to these features in clinical practice...
  41. ncbi request reprint Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma
    Kenichi Fukai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:1209-16. 2005
    ..The INK4 locus consisting of three genes involved in the regulation of cell cycle, p16INK4a, p15INK4b, and p14ARF is often disrupted in human neoplasms...
  42. doi request reprint Hepatitis B virus e antigen physically associates with receptor-interacting serine/threonine protein kinase 2 and regulates IL-6 gene expression
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Infect Dis 206:415-20. 2012
    ....
  43. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis in relation to HBeAg and anti-HBe
    Kaiyu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Med Virol 79:683-93. 2007
    ..This whole genome analysis of HBV chronic carriers suggested that the nucleotide substitutions and deletions in HBV were closely associated with the pathogenesis of chronic HBV infection...
  44. doi request reprint Occurrence of hepatocellular carcinoma was not a rare event during and immediately after antiviral treatment in Japanese HCV-positive patients
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Oncology 80:366-72. 2011
    ..Clinicians should regularly check for the possible development of HCC even in chronic hepatitis C patients under treatment...
  45. ncbi request reprint Chronic graft-versus-host disease complicated by acute hepatitis B
    Tetsuhiro Chiba
    Department of Medicine, Graduate School of Medicine, Chiba University, Japan
    J Clin Gastroenterol 36:179-81. 2003
    ..On the other hand, the serum of the patient remained hepatitis B surface antigen positive for more than 1 year after the onset of the hepatitis, which suggested chronicity of HBV infection...
  46. ncbi request reprint Gene expression profiles in liver regeneration with oval cell induction
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 317:370-6. 2004
    ..They might be specifically activated in the induction of oval cells, and help to clarify the nature of stem cell stimulation that occurs during liver regeneration...
  47. doi request reprint Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 28:355-62. 2008
    ....
  48. ncbi request reprint Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: virological breakthrough is also dependent on adherence to medication
    Hidehiro Kamezaki
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Scand J Gastroenterol 46:1111-7. 2011
    ....
  49. doi request reprint Initial virological response and viral mutation with adefovir dipivoxil added to ongoing Lamivudine therapy in Lamivudine-resistant chronic hepatitis B
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba, 260 8670, Japan
    Dig Dis Sci 56:1207-14. 2011
    ..Initial virological response (IVR) has been reported to be an important factor in relation to the development of ADV-resistance...
  50. pmc Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha
    Lingli Yang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Virol J 7:212. 2010
    ..In conclusion, amantadine, in combination of IFN-alpha, might have a beneficial effect in some patients with acute hepatitis A...
  51. doi request reprint Assessment of hepatic fibrosis by analysis of the dynamic behaviour of microbubbles during contrast ultrasonography
    Hiroyuki Ishibashi
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Inohana, Chuou ku, Chiba, Japan
    Liver Int 30:1355-63. 2010
    ..The aim of this study was to determine the efficacy of contrast-enhanced ultrasound (US) with Sonazoid™ for the assessment of the grade of hepatic fibrosis...
  52. ncbi request reprint Serum osteopontin levels in patients with acute liver dysfunction
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine Chiba University, Japan
    Scand J Gastroenterol 41:102-10. 2006
    ..We demonstrated that the expression of osteopontin (OPN), a multifunctional cytokine, was up-regulated in mouse oval cell (a stem-cell progenitor) induction models...
  53. ncbi request reprint Fas polymorphisms influence susceptibility to autoimmune hepatitis
    Akira Hiraide
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    Am J Gastroenterol 100:1322-9. 2005
    ..Polymorphisms of the gene encoding Fas have been linked to a variety of autoimmune diseases. We hypothesized that Fas gene polymorphisms might be genetic markers for AIH and PBC...
  54. ncbi request reprint Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 101:1261-9. 2010
    ..Using high-density SNP arrays, we identified several novel and minute genomic alterations. LOH of four genes could be useful for prediction of lymph node metastasis and prognosis in early stage gastric cancers...
  55. ncbi request reprint Clinicopathological features in patients with hepatic graft-versus-host disease
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:1849-53. 2005
    ..The present study was intended to examine clinicopathological features in patients in which acute GVHD appeared to progress gradually into chronic GVHD...
  56. doi request reprint Efficacy of combination therapy of antiviral and immunosuppressive drugs for the treatment of severe acute exacerbation of chronic hepatitis B
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Gastroenterol 43:711-9. 2008
    ..In this study, we evaluated the efficacy of the early introduction of immunosuppressive therapy in combination with antiviral therapy in such patients...
  57. ncbi request reprint Prevalence of obesity in patients with acute hepatitis; is severe obesity a risk factor for fulminant hepatitis in Japan?
    Tatsuo Kanda
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:180-2. 2005
    ..The prevalence of obesity in acute convalescent hepatitis and fulminant hepatitis has not been reported. The aim of this study was to investigate whether obesity affected the disease severity in Japanese patients with acute hepatitis...
  58. ncbi request reprint Prolonged acute hepatitis A mimicking autoimmune hepatitis
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    World J Gastroenterol 11:3791-3. 2005
    ..We report a case with a prolonged course of hepatitis A, with alanine aminotransferase (ALT) higher than 500 IU/L for more than 2 mo...
  59. doi request reprint Inhibition of cell viability by human IFN-β is mediated by microRNA-431
    Takeshi Tanaka
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Int J Oncol 40:1470-6. 2012
    ..Based on these results, we propose that, in RSa cells, HuIFN-β-induced miR-431 expression may down-regulate IGF1R and IRS2 expression, and consequently inhibit cell proliferation by suppressing the MAPK pathway...
  60. pmc Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis
    Hiroyuki Ishibashi
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuou ku, Chiba 260 8670, Japan
    Eur Radiol 22:1083-90. 2012
    ..To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis...
  61. doi request reprint Quantification of hepatitis B surface antigen can help predict spontaneous hepatitis B surface antigen seroclearance
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Eur J Gastroenterol Hepatol 24:414-8. 2012
    ..The aim of this study was to investigate the clinical course of spontaneous HBsAg seroclearance and the factors predicting it...
  62. ncbi request reprint Acute-onset autoimmune hepatitis resembling acute hepatitis: a case report and review of reported cases
    Tatsuo Kanda
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan
    Hepatogastroenterology 52:1233-5. 2005
    ..This is the third such case report in the literature...
  63. ncbi request reprint Amantadine inhibits hepatitis A virus internal ribosomal entry site-mediated translation in human hepatoma cells
    Tatsuo Kanda
    Safety and Health Organization, Chiba University, 1 33 Yayoicho, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 331:621-9. 2005
    ..Immunoblot analysis revealed that amantadine had no effect on PKR and on IFN-regulatory factor-1 (IRF-1) expression. These findings demonstrated a novel antiviral effect of amantadine against HAV with or without HCV infection...
  64. pmc Analysis of 5' nontranslated region of hepatitis A viral RNA genotype I from South Korea: comparison with disease severities
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 5:e15139. 2010
    ..In conclusion, HAV 5'NTR subgenotype IA from Korea had relatively high homology to Japanese sequences previously reported from Japan, and this region would be considered one of the antiviral targets. Further studies will be needed...
  65. ncbi request reprint Enhanced sensitivity of human hepatoma cells to 5-fluorouracil by small interfering RNA targeting Bcl-2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    DNA Cell Biol 24:805-9. 2005
    ..5 +/- 0.86)%, respectively. The Bcl-2 siRNA prior to 5-FU treatment group showed the strongest effect of inducing apoptosis. In conclusion, the combination Bcl-2 siRNA and 5-FU might represent a new therapeutic option for HCC...
  66. doi request reprint Intragastric acidity during the first day following administration of low-dose proton pump inhibitors: a randomized crossover study
    Sachio Hata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Res Hepatol Gastroenterol 37:296-301. 2013
    ..The aim of this study is to investigate intragastric acidity during the first day following the administration of low-dose PPIs...
  67. doi request reprint Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Cancer Lett 312:33-42. 2011
    ..2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis...
  68. ncbi request reprint Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma
    Kenichi Fukai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer Res 63:8674-9. 2003
    ....
  69. ncbi request reprint Successful clearance of hepatitis B virus after allogeneic stem cell transplantation: beneficial combination of adoptive immunity transfer and lamivudine
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba, Japan
    Eur J Haematol 71:220-3. 2003
    ..We presume that the combination of adoptive immunity transfer by bone marrow transplantation (BMT) from an HBsAb-positive donor and antiviral drugs such as lamivudine is beneficial in clearing HBV in chronic carriers...
  70. ncbi request reprint Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chuo Ward, Chiba, Japan
    Eur J Gastroenterol Hepatol 16:225-8. 2004
    ..We presume that hepatic involvement of CAEBV should be considered as differential diagnosis in cases showing liver dysfunction with clinical and biochemical features observed in AIH...
  71. ncbi request reprint Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4
    Ryo Tamura
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan
    J Infect Dis 204:793-801. 2011
    ..The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS)...
  72. doi request reprint Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer
    Takeshi Tanaka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 26:1329-35. 2011
    ..Based on these results, we conclude that expression of hsa-miR-373 is down-regulated by aberrant methylation in colon cancer and that this miRNA may function by regulating expression of the oncogene RAB22A...
  73. ncbi request reprint Possible widespread presence of hepatitis A virus subgenotype IIIA in Japan: Recent trend of hepatitis A causing acute liver failure
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatol Res 42:248-53. 2012
    ..Conclusions:  Fujiwara et al. reported a frequency of HAV subgenotype IIIA of only 2.1% in Japan. We conclude that HAV subgenotype IIIA might be widespread in our country...
  74. doi request reprint Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Scand J Gastroenterol 46:955-61. 2011
    ..The purpose of the study was to establish methods for determining the SNP rs8099917 associated with IL28B, which might be useful for further research of the treatment of HCV...
  75. ncbi request reprint [Alternative measures for patients with chronic hepatitis C unresponsive to interferon therapy]
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University
    Nihon Rinsho 62:540-3. 2004
  76. ncbi request reprint Genetic analysis of hepatitis A virus protein 2C in sera from patients with fulminant and self-limited hepatitis A
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Hepatogastroenterology 54:871-7. 2007
    ....
  77. pmc Pegylated interferon-alfa-2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response
    Reiko Etoh
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Res Notes 4:316. 2011
    ..abstract:..
  78. pmc Factors Associated with Inadequate Tissue Yield in EUS-FNA for Gastric SMT
    Takuto Suzuki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chiba 260 8670, Japan
    ISRN Gastroenterol 2011:619128. 2011
    ..290-87.42) were the predictive factors for inadequate tissue yield in EUS-FNA. Conclusions. The factors associated with inadequate tissue yield in EUS-FNA were younger age and the location of lesion at lower third area in stomach...
  79. ncbi request reprint [Analysis of HCV core protein function using HCV core transgenic mice]
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University
    Nihon Rinsho 62:135-8. 2004
  80. ncbi request reprint Evaluation of the clinical usefulness of COBAS AMPLICOR HCV MONITOR assay (ver2.0): Comparison with AMPLICOR HCV MONITOR assay (ver1.0) and HCV core protein level
    Shigenobu Kawai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Med Virol 68:343-51. 2002
    ..0001) and serotype 2 (P < 0.05). Thus, both the COBAS v2.0 assay and the HCV core protein assay showed that the viral load was an indicator of virologically sustained response in serotype 2 and in serotype 1...
  81. ncbi request reprint Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
    Hajime Sumi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:19-26. 2003
    ....
  82. ncbi request reprint High sustained virologic response rate after interferon monotherapy in Japanese hepatitis C patients with a low HCV RNA titer and/or HCV genotype 2. A prospective study
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Intervirology 47:328-34. 2004
    ..To clarify whether interferon monotherapy is really effective in patients with the appropriate viral parameters, we prospectively examined these parameters and treated the patients with interferon monotherapy...
  83. ncbi request reprint Hepatic graft-versus-host disease resembling acute hepatitis: additional treatment with ursodeoxycholic acid
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Liver 22:514-7. 2002
    ..His liver function test completely returned to normal on day 260. We believe that it is worthwhile to administer UDCA as an additional treatment for not only common hepatic GVHD but also atypical cases presenting as acute hepatitis...
  84. doi request reprint Effect of signal intensity from the accumulated microbubbles in the liver for differentiation of idiopathic portal hypertension from liver cirrhosis
    Hitoshi Maruyama
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuou ku, Chiba 260 8670, Japan
    Radiology 252:587-94. 2009
    ..To examine the possibility of using contrast material-enhanced ultrasonography (US) to differentiate idiopathic portal hypertension (IPH) from cirrhosis...
  85. ncbi request reprint Hepatitis C virus core protein and hepatitis activity are associated through transactivation of interleukin-8
    Yujin Hoshida
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Infect Dis 192:266-75. 2005
    ..Expression vectors with the core region were transfected into Huh7 cells, and cytokine induction was evaluated by reporter assay...
  86. ncbi request reprint Antiviral therapy for cirrhotic hepatitis C: association with reduced hepatocellular carcinoma development and improved survival
    Yasushi Shiratori
    University of Tokyo, Japanese Red Cross Medical Center, Nippon University School of Medicine, and Tokyo Women s Medical College
    Ann Intern Med 142:105-14. 2005
    ..Although cirrhosis is a major risk factor for development of hepatocellular carcinoma, no definitive prospective analyses have assessed the long-term efficacy of antiviral therapy in cirrhotic patients...
  87. ncbi request reprint Corticosteroids and lamivudine combined to treat acute severe flare-up in a chronic hepatitis B and C patient
    Tatsuo Kanda
    J Gastroenterol Hepatol 19:238-9. 2004
  88. ncbi request reprint Hepatitis C infection with history of tuberculosis in Japan: no association with progression of liver fibrosis
    Tatsuo Kanda
    J Gastroenterol Hepatol 19:717-9. 2004