Kenzo Hiroshima

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi Synchronous and metachronous lung carcinomas: molecular evidence for multicentricity
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
    Pathol Int 48:869-76. 1998
  2. ncbi Pulmonary large cell carcinoma with rhabdoid phenotype
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Ultrastruct Pathol 27:55-9. 2003
  3. ncbi Proliferative activity and apoptosis in thymic epithelial neoplasms
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 15:1326-32. 2002
  4. ncbi Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 95:1539-45. 2002
  5. ncbi Fatal infectious mononucleosis with evidence suggestive of the development of B cell lymphoma
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pathol Int 53:642-8. 2003
  6. ncbi Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Japan
    Ann Thorac Surg 73:1732-5. 2002
  7. ncbi Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1 8 1 Inohona, Chuo Ku, Chiba, 260 8670 Japan
    Cancer 92:1798-806. 2001
  8. ncbi Alpha-fetoprotein-producing lung carcinoma: report of three cases
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pathol Int 52:46-53. 2002
  9. ncbi Ultrastructural study of intranuclear inclusion bodies of pulmonary adenocarcinoma
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
    Ultrastruct Pathol 23:383-9. 1999
  10. ncbi Human pulmonary dirofilariasis: report of six cases
    K Hiroshima
    Division of Pathology, School of Medicine, Chiba University, Japan
    Tohoku J Exp Med 189:307-14. 1999

Collaborators

Detail Information

Publications94

  1. ncbi Synchronous and metachronous lung carcinomas: molecular evidence for multicentricity
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
    Pathol Int 48:869-76. 1998
    ....
  2. ncbi Pulmonary large cell carcinoma with rhabdoid phenotype
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Ultrastruct Pathol 27:55-9. 2003
    ..It is worthwhile detecting and recognizing the significance of these intracytoplasmic inclusions because of the poor prognosis of this tumor...
  3. ncbi Proliferative activity and apoptosis in thymic epithelial neoplasms
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 15:1326-32. 2002
    ..Bcl-2 and p53 protein expression may be useful markers in differentiating thymoma subtypes...
  4. ncbi Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 95:1539-45. 2002
    ..The objective of this study was to evaluate the degree of proliferative change and the amount of neovascularization in both normal and preneoplastic lesions in smokers who were at high risk for developing lung carcinoma...
  5. ncbi Fatal infectious mononucleosis with evidence suggestive of the development of B cell lymphoma
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pathol Int 53:642-8. 2003
    ..We suggest that EBVAHS develops into polyclonal and monoclonal lymphoproliferative disorder in a short period, and that EBVAHS is a preneoplastic condition that may result in B cell lymphoma...
  6. ncbi Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Japan
    Ann Thorac Surg 73:1732-5. 2002
    ..Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung...
  7. ncbi Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1 8 1 Inohona, Chuo Ku, Chiba, 260 8670 Japan
    Cancer 92:1798-806. 2001
    ..Whereas mature teratomas are benign tumors, immature teratomas are malignant. The purpose of this study was to find characteristics that could be used to distinguish between the growth and prognosis of the two teratoma types...
  8. ncbi Alpha-fetoprotein-producing lung carcinoma: report of three cases
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pathol Int 52:46-53. 2002
    ..05). The high proliferative activity, advanced stage at presentation, vascular endothelial growth factor expression and vascular invasion observed in these tumors may explain the poor prognosis of AFP-producing lung carcinomas...
  9. ncbi Ultrastructural study of intranuclear inclusion bodies of pulmonary adenocarcinoma
    K Hiroshima
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
    Ultrastruct Pathol 23:383-9. 1999
    ..HPV DNA was detected using PCR and type-specific probes in a case with type A inclusion bodies. This study suggests that intranuclear inclusion bodies in pulmonary adenocarcinoma are formed by several different mechanisms...
  10. ncbi Human pulmonary dirofilariasis: report of six cases
    K Hiroshima
    Division of Pathology, School of Medicine, Chiba University, Japan
    Tohoku J Exp Med 189:307-14. 1999
    ..Because the pulmonary dirofilariasis is difficult to be differentiated from primary or metastatic lung carcinoma, and the inflammation exists around the nodule, the nodule should be removed surgically...
  11. ncbi The evaluation of lymph node metastasis by endobronchial ultrasound-guided transbronchial needle aspiration: crucial for selection of surgical candidates with metastatic lung tumors
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 134:1485-90. 2007
    ....
  12. doi Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 17:878-88. 2010
    ..The aim of this study was to evaluate the molecular influence of chronic obstructive pulmonary diseases (COPD) on the pathogenesis of non-small cell lung cancer (NSCLC)...
  13. doi The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system
    Taiki Fujiwara
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Chest 138:641-7. 2010
    ....
  14. ncbi Prognostic implications of cell cycle-related proteins in primary resectable pathologic N2 nonsmall cell lung cancer
    Sherif Mohamed
    Department of Thoracic Surgery Graduate School of Medicine Chiba University, Chiba, Japan
    Cancer 109:2506-14. 2007
    ..For the current study, to select an appropriate therapeutic strategy for each patient, patients with N2 NSCLC were stratified into homogenous subgroups according to the expression profiles of cell cycle-related markers...
  15. doi Endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with non-small cell lung cancer in non-operable patients pursuing radiotherapy as a primary treatment
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Oncol 5:606-11. 2010
    ..The aim of this study was to evaluate the effectiveness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for lymph node staging in patients with non-small cell lung cancer before CIRT...
  16. ncbi Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Ann Thorac Surg 82:254-60. 2006
    ..We sought to identify poor prognostic factors preoperatively and to retrospectively evaluate preoperative clinical indications for surgery...
  17. doi Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation
    Lei Tian
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 113:1396-403. 2008
    ..The expression of prostaglandin E receptor 2 (PTGER2) affects the biologic behavior of various types of malignant tumors. Recently, transactivation of both PTGER2 and epidermal growth factor receptor (EGFR) has been reported in some tumors...
  18. ncbi Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis
    Mohamed Alaa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Oncol 34:805-12. 2009
    ..Synchronous alteration of p16INK4A and EP2 may accelerate progression of squamous cell carcinomas. These two alterations may differentially affect pathogenesis among subtypes of NSCLC...
  19. ncbi Biological features of bronchial squamous dysplasia followed up by autofluorescence bronchoscopy
    Hidehisa Hoshino
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 46:187-96. 2004
    ..Patients with dysplastic lesions with these characteristics should be carefully followed up...
  20. ncbi Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer
    Takaaki Sugimoto
    Department of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Oncol Rep 14:823-30. 2005
    ..The findings highlight the substantial roles of tumor stromal fibroblasts, interacting with soluble growth factors, in promoting the malignant propensity of the tumor...
  21. ncbi Ki-67 expression and prognosis for smokers with resected stage I non-small cell lung cancer
    Yukiko Haga
    Department of Basic Pathology and Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 75:1727-32; discussion 1732-3. 2003
    ..This study evaluates relationships between various clinicopathologic factors, including tumor proliferative activity and smoking status, and the patient's prognosis in stage I non-small cell lung cancer...
  22. doi Lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration in patients with small cell lung cancer
    Hironobu Wada
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 90:229-34. 2010
    ..The purpose of this study was to evaluate the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the evaluation of mediastinal and hilar lymph node metastasis in patients with SCLC...
  23. ncbi Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer
    Haruko Yamaji
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Immunol Immunother 53:786-92. 2004
    ..The presence of IL-6 and tumor-infiltrating lymphocytes (TILs) within tumor tissues was examined by immunohistochemical staining...
  24. ncbi Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Chest 132:597-602. 2007
    ..EBUS-TBNA enables the sampling of histologic cores, which can be used for genetic analysis...
  25. ncbi Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis
    Kenzo Hiroshima
    Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 19:1358-68. 2006
    ....
  26. ncbi Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Cancer 106:2200-7. 2006
    ..Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event...
  27. ncbi Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in non-small cell lung cancer
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 10:5361-6. 2004
    ..The aim of this study was to determine whether collagen XVIII expression is correlated with circulating serum endostatin and whether this has any prognostic value in patients with non-small cell lung cancer (NSCLC)...
  28. ncbi Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 13:6087-92. 2007
    ..Although the details of each cascade are understood, very little is known about their collective effects in non-small cell lung cancer (NSCLC)...
  29. ncbi Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma
    Kenzo Hiroshima
    Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 100:1190-8. 2004
    ..Therefore, the authors studied genetic alterations found in LCNEC and compared them with those of SCLC and classic large cell carcinoma (CLCC)...
  30. ncbi Preoperative pulmonary function as a prognostic factor for stage I non-small cell lung carcinoma
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 77:1896-902; discussion 1902-3. 2004
    ....
  31. ncbi Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Ann Surg Oncol 14:2636-42. 2007
    ..The aim of this study was to determine whether IL-12Rbeta2 methylation is a common feature in human lung cancer...
  32. ncbi Dramatic improvement of respiratory condition after lobectomy for localized bullous emphysema
    Hironobu Wada
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Cardiovasc Surg 10:293-6. 2004
    ..His dyspnea immediately disappeared and the respiratory function improved dramatically. We concluded that lobectomy could be considered as one of surgical options in case of complete lobar destruction in emphysema patients...
  33. ncbi Lymphangioleiomyomatosis with a giant bulla: report of a case
    Taiki Fujiwara
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 35:247-9. 2005
    ..She was commenced on progesterone, which improved her condition even further. This case report retrospectively follows the progression of her disease from the onset of symptoms 5 years before she was referred to us for treatment...
  34. ncbi Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    Oncol Rep 11:285-8. 2004
    ..It is possible to preoperatively differentiate LCNEC from CLCC by careful cytologic characterization...
  35. pmc Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels
    Shinya Okamoto
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    PLoS ONE 8:e60297. 2013
    ....
  36. doi Risk of acute exacerbation of interstitial pneumonia after pulmonary resection for lung cancer in patients with idiopathic pulmonary fibrosis based on preoperative high-resolution computed tomography
    Hidemi Suzuki
    Department of Thoracic Surgery, Chiba University, Chiba, Japan
    Surg Today 41:914-21. 2011
    ..In patients with lung cancer accompanied by idiopathic pulmonary fibrosis (IPF), acute exacerbation of the IPF often occurs after pulmonary resection; however, few studies have been done to identify its preexisting risk factors...
  37. ncbi Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 132:312-5. 2006
    ..However, if significant negative prognostic factors become evident in patients with pathologic stage Ia non-small cell lung carcinoma, patients with negative prognostic factors should have adjuvant treatment after surgery...
  38. ncbi Serum endostatin correlates with progression and prognosis of non-small cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, 260 8670, Chiba, Japan
    Lung Cancer 35:29-34. 2002
    ..Platelet count and serum endostatin level greater than the median were associated with poor prognosis. Our results suggested that platelet count and serum endostatin level may be useful markers for non-small cell lung cancer...
  39. doi Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis
    Di Wu
    Dept of Pathology, Tokyo Women s Medical University Yachiyo Medical Center, Owada shinden, Yachiyo, Chiba, Japan
    Am J Clin Pathol 139:39-46. 2013
    ..Methylation of p16 was observed in 7 (20.6%) of 34 informative cases. p16 FISH analysis can be a reliable test for distinguishing between sarcomatoid mesothelioma and fibrous pleuritis and a prognostic factor for MPM...
  40. doi LKB1 protein expression in neuroendocrine tumors of the lung
    Randa Mahmoud Sobhi Amin
    Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathol Int 58:84-8. 2008
    ..Although a few previous studies indicated rare genetic alterations of LKB1 in SCLC, further studies including analysis of other NE tumors and focusing on epigenetic abnormalities of LKB1 gene are warranted...
  41. ncbi Histological diagnosis of mediastinal lymph node metastases from renal cell carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respirology 12:302-3. 2007
    ..This current study reports a case of mediastinal lymph node metastases from renal cell carcinoma successfully diagnosed histologically by endobronchial ultrasound-guided transbronchial needle aspiration...
  42. doi The role of EBUS-TBNA for the diagnosis of sarcoidosis--comparisons with other bronchoscopic diagnostic modalities
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respir Med 103:1796-800. 2009
    ..To clarify the role of EBUS-TBNA for the diagnosis of sarcoidosis, we compared three diagnostic modalities: EBUS-TBNA, transbronchial lung biopsy (TBLB) and bronchoalveolar lavage fluid analysis (BAL)...
  43. doi Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 138:446-53. 2009
    ..In this study, we describe the clinical features of recurrent tumors of large-cell neuroendocrine carcinoma and discuss the role of adjuvant chemotherapy and management of recurrence in patients with large-cell neuroendocrine carcinoma...
  44. doi Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions
    Takahiro Nakajima
    Departments of Thoracic Surgery and daggerDiagnostic Pathology, Graduate School of Medicine, Chiba University, Japan
    J Thorac Oncol 3:985-8. 2008
    ..However, there have been no reports of the utility of EBUS-TBNA for the diagnosis of intrapulmonary tumors...
  45. ncbi Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 82:1802-7. 2006
    ..We performed a prospective analysis of adjuvant chemotherapy for patients with completely resected pulmonary LCNECs to assess the effect of adjuvant chemotherapy...
  46. ncbi Increased expression of collagen XVIII and its prognostic value in nonsmall cell lung carcinoma
    Hao Chang
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 100:1665-72. 2004
    ..The purpose of the current study was to evaluate whether the expression of collagen XVIII has additional prognostic value for survival in patients with nonsmall cell lung carcinoma (NSCLC)...
  47. ncbi A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Oncol Rep 14:919-23. 2005
    ..We conclude that the A4/A4 genotype of the 5'-flanking region of CYP2E1 was significantly more frequent in lung adenocarcinoma cases than in healthy controls and, therefore, may be involved in the development of lung adenocarcinoma...
  48. ncbi Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity
    Akira Iyoda
    Department of Thoracic Surgery, Chiba, Japan
    Ann Thorac Surg 77:1891-5; discussion 1895. 2004
    ....
  49. ncbi Double primary lung carcinoma consisting of large cell neuroendocrine carcinoma and squamous cell carcinoma: report of a case
    Yoshito Yamada
    Department of Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Thorac Cardiovasc Surg 11:397-400. 2005
    ..The patient had right supraclavicular lymph node metastases of LCNEC and died of multiple pulmonary metastases 10 months after the operation...
  50. doi In vivo microscopic imaging of the bronchial mucosa using an endo-cytoscopy system
    Kiyoshi Shibuya
    Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 72:184-90. 2011
    ..We investigated the capabilities of an endo-cytoscopy system (ECS) that enables microscopic imaging of the tracheobronchial tree during bronchoscopy, including normal bronchial epithelium, dysplastic mucosa and squamous cell carcinoma...
  51. ncbi Clinicopathological analysis of pulmonary sclerosing hemangioma
    Akira Iyoda
    Department of Thoracic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    Ann Thorac Surg 78:1928-31. 2004
    ..Sclerosing hemangiomas of the lung are uncommon tumors and are thought to be benign. However, the histogenesis and clinicopathological features of these tumors have not been elucidated...
  52. doi Narrow band imaging with high-resolution bronchovideoscopy: a new approach for visualizing angiogenesis in squamous cell carcinoma of the lung
    Kiyoshi Shibuya
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 69:194-202. 2010
    ..We investigated the ability of a high-resolution bronchovideoscopy system with narrow band imaging (NBI) to detect blood vessel structures in squamous cell carcinoma (SCC) of bronchi, as well as squamous dysplasia...
  53. ncbi A new thin-type bronchoscope improves diagnostic accuracy of peripheral pulmonary carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 10:387-9. 2003
    ..0001) at 90.0 and 0%, respectively. The new type of bronchoscope, XBF-4B40, is useful for peripheral pulmonary lesion diagnosis with diagnosis accuracy improvements in the right segment 1 or the left segment 1+2...
  54. doi Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, orotate phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration: a
    Takahiro Nakajima
    Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Lung Cancer 12:293-7. 2011
    ....
  55. doi Pulmonary and systemic toxicity of bleomycin on severe combined immune deficiency mice
    Hiroshi Miyazawa
    Department of Respirology B2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Exp Lung Res 34:1-17. 2008
    ..Unsustainable inflammation in the lung might reduce BLM-induced lung injury in BLM-sensitive SCID mice...
  56. ncbi Preoperative cytodiagnosis of very small-sized peripheral-type primary lung cancer
    Masayuki Baba
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 37:277-80. 2002
    ..Therefore, cytodiagnosis is an effective and indispensable diagnostic method for determination of the optimal treatment approach, including approaches such as intentionally limited resection...
  57. doi Predictors of postoperative survival in patients with locally advanced non-small cell lung carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Surg Today 40:725-8. 2010
    ..This study analyzed the clinicopathological profile and surgical outcome of patients with locally advanced NSCLC to identify the predictors of survival...
  58. ncbi Epidermal growth factor receptor expression status in lung cancer correlates with its mutation
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 36:1127-34. 2005
    ..In conclusion, EGFR and HER2 overexpression is frequent in lung cancer, and EGFR overexpression correlates with the EGFR TK domain mutations...
  59. ncbi Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Chest 130:710-8. 2006
    ....
  60. ncbi Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Japan
    Surg Today 35:968-71. 2005
    ..A right upper lobectomy with SVC reconstruction was performed. The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type...
  61. doi E1B-55 kDa-defective adenoviruses activate p53 in mesothelioma and enhance cytotoxicity of anticancer agents
    Makako Yamanaka
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
    J Thorac Oncol 7:1850-7. 2012
    ..Genetic characterization of malignant mesothelioma shows a homozygous deletion of the INK4A/ARF locus, which results in inactivation of the p53 pathways...
  62. pmc A potential therapeutic strategy for malignant mesothelioma with gene medicine
    Yuji Tada
    Department of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biomed Res Int 2013:572609. 2013
    ....
  63. doi Risk of lung cancer in patients with preinvasive bronchial lesions followed by autofluorescence bronchoscopy and chest computed tomography
    Mohamed Alaa
    Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Lung Cancer 72:303-8. 2011
    ..To assess risk of lung cancer (LC) in patients with preinvasive bronchial lesions and to identify factors associated with higher risk...
  64. doi Chronic obstructive pulmonary disease and interstitial lung disease in patients with lung cancer
    Satoko Mizuno
    Department of Respirology, Graduaet School of Medicine, Chiba University, Chiba, Japan
    Respirology 14:377-83. 2009
    ....
  65. ncbi Histological diagnosis of spinal chondrosarcoma by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respirology 12:308-10. 2007
    ..A very rare case of spinal chondrosarcoma due to hereditary multiple exostoses successfully diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration and by immunohistochemistry with genetic analysis is reported...
  66. ncbi Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung
    Randa M S Amin
    Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Pathol Int 58:38-44. 2008
    ..These data imply that aberrant mTOR signaling may play a role in the development of SH, and its vascular nature may be due partially to high levels of VEGF caused by dysregulation of mTOR signaling...
  67. ncbi [Case of metachronous mucosa-associated lymphoid tissue (MALT) lymphoma originated from a distinct B-cell clone]
    Hidefumi Shimizu
    Department of Respirology, Graduate School of Medicine, Chiba University
    Nihon Kokyuki Gakkai Zasshi 46:759-63. 2008
    ..Lifelong observation of all patients treated for MALT lymphoma is required because of the high frequency of dissemination and recurrence...
  68. ncbi Effective detection of bronchial preinvasive lesions by a new autofluorescence imaging bronchovideoscope system
    Masako Chiyo
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 48:307-13. 2005
    ..0005). We conclude that AFI appears to represent a significant advance in distinguishing preinvasive and malignant lesions from bronchitis or hyperplasia under circumstances where LIFE would identify these all as abnormal lesions...
  69. ncbi Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Oncol 33:113-9. 2008
    ..Analysis for CXCL12 may provide novel opportunities for prognosis and therapy of resected NSCLCs...
  70. ncbi Surgical treatment of a superior sulcus tumor in a patient with idiopathic thrombocytopenic purpura: report of a case
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Japan
    Surg Today 35:1078-80. 2005
    ..The patient remained in good condition for 20 months following the surgery; however, he eventually died due to bone metastases...
  71. ncbi Pulmonary artery leiomyosarcoma expressing Epstein-Barr virus in an immunocompetent individual
    Sana Yokoi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 81:1897-9. 2006
    ..We document a case of pulmonary artery leiomyosarcoma expressing Epstein-Barr virus DNA sequences in an immunocompetent patient 4 years after symptomatic Epstein-Barr virus infection...
  72. ncbi Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases
    Hidemi Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 35:243-6. 2005
    ..We also review 23 reported cases of endobronchial neurogenic tumors and discuss the efficacy of endoscopic treatments for endobronchial neurogenic tumors...
  73. ncbi A case of *-fetoprotein-producing pulmonary carcinoma with restricted expression of hepatocyte nuclear factor-4* in hepatoid foci: a case report with studies of previous cases
    Takashi Kishimoto
    Department of Molecular Pathology E3, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 39:1115-20. 2008
    ..These findings suggest that aberrant expression of HNF-4* is implicated in the emergence or maintenance of hepatoid foci in AFP-producing pulmonary carcinomas...
  74. ncbi Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Ann Thorac Surg 73:1049-54. 2002
    ..However, to date, the clinical relationship between these categories of neuroendocrine lung tumors has not been clearly defined...
  75. ncbi Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 84:702-7. 2007
    ....
  76. ncbi Rapid regression of stage IVb invasive thymoma under palliative corticosteroid administration
    Taiki Fujiwara
    Department of Chest Surgery, Matsudo City Hospital, Chiba, Japan
    Gen Thorac Cardiovasc Surg 55:180-3. 2007
    ..After 1 month of antipyretic therapy, whole-body eruption disappeared and we encountered rapid regression of the thymoma. Unfortunately she died of interstitial pneumonitis only 2 months after the regression...
  77. ncbi Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report
    Randa M S Amin
    Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Respirology 11:818-25. 2006
    ..05). Symptomatic patients and presence of pleural effusion were the independent predictors of survival in patients with PEH...
  78. ncbi A case of pulmonary adenocarcinoma accompanied by superior vena caval thrombosis in a patient with peutz-jeghers syndrome
    Satoshi Hirano
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Jpn J Clin Oncol 32:307-9. 2002
    ....
  79. ncbi Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine
    Koji Iwanaga
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Biochem Biophys Res Commun 325:1353-9. 2004
    ..These findings suggest that G-CSF prevents cardiac dysfunction and remodeling after MI in large animals...
  80. doi Improved survival in patients with breast rhabdoid tumors with multi-agent adjuvant chemotherapy combined with irradiation
    Yoshitaka Furuya
    Department of Surgery, Sodegaura Satsukidai Hospital, Sodegaura, Chiba, Japan
    Cancer Chemother Pharmacol 64:623-7. 2009
    ..Breast MRT is extremely rare; only three cases have been documented, with a mean prognosis of 7 months. Multi-agent chemotherapy with mastectomy and irradiation, as used in this case, may extend survival in breast MRT...
  81. ncbi Small cell carcinoma of the prostate expressing prostate-specific antigen and showing syndrome of inappropriate secretion of antidiuretic hormone: an autopsy case report
    Shigeo Kawai
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pathol Int 53:892-6. 2003
    ..This finding supports the hypothesis that SCC of the prostate originates from a multipotential stem cell of the prostatic epithelium...
  82. ncbi Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma
    Randa Mahmoud Sobhy Amin
    Department of Basic Pathology, Chiba University Graduate School of Medicine, Japan
    Pathol Int 55:649-54. 2005
    ....
  83. ncbi Malignant pleural mesothelioma: clinicopathology of 16 extrapleural pneumonectomy patients with special reference to early stage features
    Kenzo Hiroshima
    Department of Diagnostic Pathology, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Pathol Int 59:537-45. 2009
    ..Stage Ia mesothelioma (neoplasm limited to the parietal pleura) would not be observed in daily practice...
  84. ncbi Effects of repeated ozone exposure on pulmonary function and bronchial responsiveness in mice sensitized with ovalbumin
    Hidemitsu Funabashi
    Department of Public Health, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Toxicology 204:75-83. 2004
    ..Histopathologically, alveolar epithelial hyperplasia occurred in repeatedly exposed mice. These results indicated that respiratory allergy might be a risk factor, which aggravates the effects of repeated ozone exposure...
  85. doi Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Gen Thorac Cardiovasc Surg 56:354-6. 2008
    ..After 10 postoperative days, he had acute respiratory distress syndrome. He was given a corticosteroid and a neutrophil elastase inhibitor, which resulted in rapid improvement without lung dysfunction...
  86. ncbi Peripheral pulmonary diseases: evaluation with endobronchial US initial experience
    Shigenari Omori
    Department of Respirology B2, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Radiology 224:603-8. 2002
    ..Several different echoic patterns were found that may reflect changes due to pathologic alteration of lung parenchyma. This technique may have potential for evaluation and diagnosis of peripheral lung diseases...
  87. ncbi Cytological characteristics of pulmonary large cell neuroendocrine carcinoma
    Kenzo Hiroshima
    Committee on Pulmonary Cytology, The Japan Lung Cancer Society, Japan
    Lung Cancer 48:331-7. 2005
    ..In brush or curettage specimen, the LCNEC diagnosis may be possible if a sufficient number of tumor cells are obtained...
  88. ncbi Basaloid squamous-cell carcinoma of the lung in a young woman
    Hiroyasu Nagakawa
    Department of Respirology, Seirei Yokohama General Hospital, Yokohama, Japan
    Int J Clin Oncol 11:66-8. 2006
    ..This is the youngest patient with a case of basaloid squamous cell carcinoma of the lung ever reported...
  89. ncbi Systemic arterial supply to the left basal segment without the pulmonary artery: four consecutive cases
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Eur J Cardiothorac Surg 23:847-9. 2003
    ..We encountered four consecutive cases, which were treated successfully by three basalectomies and one lower lobectomy to preserve lung function...
  90. ncbi Cytological findings of pre-invasive bronchial lesions detected by light-induced fluorescence endoscopy in a lung cancer screening system
    Masayuki Baba
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Oncol Rep 17:579-83. 2007
    ..Sputum cytology is therefore a potential approach to diagnosing pre-invasive bronchial lesions...
  91. ncbi [A case of angiosarcoma of pelvis with pulmonary metastases which responded to paclitaxel]
    Yuji Tada
    Dept of Respirology, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 34:2275-7. 2007
    ..After eight weeks, the tumor recurred. Salvage chemotherapy of weekly administration of docetaxel yielded limited effects. The patient died of cancer one year after treatment initiation...
  92. ncbi Pulmonary toxicity by a cytotoxic agent, S-1
    Yuji Tada
    Respirology, Chiba University
    Intern Med 46:1243-6. 2007
    ..Both his symptoms and the radiographic findings were resolved dramatically after high-dose corticosteroid therapy. Clinicians should be aware that S-1 has the potential to cause lung injury when it is included in chemotherapy...
  93. ncbi Imprint cytologic features of pulmonary sclerosing hemangioma: comparison with well-differentiated papillary adenocarcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 96:146-9. 2002
    ..Moreover, there are few reports dealing with their cytologic features, and it is generally considered difficult to make accurate diagnoses of sclerosing hemangiomas that have a predominantly papillary pattern...
  94. ncbi Gene delivery to the lung by means of syngeneic fibroblasts: an experimental model
    Akira Suda
    Department of Respirology B2, Graduate School of Medicine, Chiba University, Japan
    Exp Lung Res 29:227-41. 2003
    ..This system may have potential relevance for certain experimental models requiring specific gene delivery to the lung...