Kenji Hashimoto

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi Role of the mTOR signaling pathway in the rapid antidepressant action of ketamine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Expert Rev Neurother 11:33-6. 2011
  2. pmc Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism
    Chie Shimmura
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 4:6. 2013
  3. pmc Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial
    Yutaka Matsuoka
    Department of Psychiatry, National Disaster Medical Center, 3256 Midoricho, 190 0014, Tachikawa, Tokyo, Japan
    BMC Psychiatry 13:8. 2013
  4. doi Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, 260 8670, Japan
    Eur Arch Psychiatry Clin Neurosci 263:367-77. 2013
  5. ncbi [Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders]
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 48:118-25. 2013
  6. doi Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Prog Neurobiol 100:15-29. 2013
  7. ncbi Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases
    Tomihisa Niitsu
    1Research Center for Child Mental Development, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba, Japan
    Curr Pharm Des 18:875-83. 2012
  8. pmc Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder
    Shigenori Tadokoro
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 10:26. 2011
  9. pmc Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
    Goro Fukami
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 9:37. 2010
  10. pmc Fluvoxamine for aripiprazole-associated akathisia in patients with schizophrenia: a potential role of sigma-1 receptors
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 9:11. 2010

Detail Information

Publications112 found, 100 shown here

  1. ncbi Role of the mTOR signaling pathway in the rapid antidepressant action of ketamine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Expert Rev Neurother 11:33-6. 2011
    ..Here, these findings are put into context and their significance is discussed...
  2. pmc Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism
    Chie Shimmura
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 4:6. 2013
    ..We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism...
  3. pmc Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial
    Yutaka Matsuoka
    Department of Psychiatry, National Disaster Medical Center, 3256 Midoricho, 190 0014, Tachikawa, Tokyo, Japan
    BMC Psychiatry 13:8. 2013
    ..This paper describes the rationale and protocol of this trial...
  4. doi Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, 260 8670, Japan
    Eur Arch Psychiatry Clin Neurosci 263:367-77. 2013
    ..g., RO499819, RO4432717), and mGluR5 NAMs (e.g., AZD2066, RO4917523) are in progress. Future investigations should include effects on brain structure and activation to elucidate neural mechanisms underlying efficacy of these drugs. ..
  5. ncbi [Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders]
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 48:118-25. 2013
    ..In this article, we would like to discuss minocycline as a potential therapeutic drug for methamphetamine-related disorders...
  6. doi Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Prog Neurobiol 100:15-29. 2013
    ..Finally, the author will make a case for potent sigma-1 receptor agonists and TrkB agonists as new potential therapeutic drugs for depressive patients with CVD...
  7. ncbi Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases
    Tomihisa Niitsu
    1Research Center for Child Mental Development, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba, Japan
    Curr Pharm Des 18:875-83. 2012
    ..In this article, we review the recent findings on sigma-1 receptor agonists as potential therapeutic drugs for the treatment of cognitive impairment in schizophrenia and psychotic depression...
  8. pmc Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder
    Shigenori Tadokoro
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 10:26. 2011
    ..abstract:..
  9. pmc Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
    Goro Fukami
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 9:37. 2010
    ..The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects...
  10. pmc Fluvoxamine for aripiprazole-associated akathisia in patients with schizophrenia: a potential role of sigma-1 receptors
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 9:11. 2010
    ..CONCLUSION: Doctors may wish to consider fluvoxamine as an alternative approach in treating akathisia associated with antipsychotic drugs such as aripiprazole...
  11. pmc The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report
    Akira Kishimoto
    Yonago Medical Corporation, Yonago Clinic, Yonago, Tottori, Japan
    Ann Gen Psychiatry 9:23. 2010
    ..In several studies, monotherapy of SSRIs such as fluvoxamine has been shown to be effective in the treatment of psychotic major depression...
  12. pmc Sigma-1 receptor agonist fluvoxamine for delirium in intensive care units: report of five cases
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 9:18. 2010
    ..CONCLUSION: Doctors should consider fluvoxamine as an alternative approach to treating delirium in ICU patients in order to avoid the risk of side effects and increased mortality from antipsychotic drugs...
  13. pmc Fluvoxamine monotherapy for psychotic depression: the potential role of sigma-1 receptors
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 8:26. 2009
    ..CONCLUSION: Doctors should consider fluvoxamine monotherapy as an alternative approach in treating psychotic depression because it avoids the risk of EPS from antipsychotic drugs...
  14. pmc Serum glutamine, set-shifting ability and anorexia nervosa
    Michiko Nakazato
    Section of Eating Disorders, Institute of Psychiatry, King s College London, UK
    Ann Gen Psychiatry 9:29. 2010
    ....
  15. pmc Sigma-1 receptor agonist fluvoxamine for postoperative delirium in older adults: report of three cases
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 9:28. 2010
    ..Drug treatment for postoperative delirium requires careful consideration of the balance between the effective management of symptoms and potential adverse effects...
  16. pmc Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia: report of five cases
    Tsutomu Furuse
    Department of Psychiatry, Asahikawa Red Cross Hospital, Asahikawa, Japan
    Ann Gen Psychiatry 9:17. 2010
    ..CONCLUSION: Doctors should consider that fluvoxamine may be an alternative approach in treating akathisia associated with atypical antipsychotic drugs...
  17. ncbi [Depression and BDNF]
    Kenji Hashimoto
    Nihon Yakurigaku Zasshi 127:201-4. 2006
  18. ncbi Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1529-31. 2006
    ..In this study, we studied whether serum levels of BDNF are altered in patients with autism...
  19. ncbi Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a positron emission tomography study in conscious monkeys
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba
    Biol Psychiatry 61:577-81. 2007
    ..However, there are currently no particular pharmacological treatments for the wide range of symptoms associated with METH abuse...
  20. pmc [11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 3:e3231. 2008
    ..Here we report the novel PET radioligand [11C]CHIBA-1001 for in vivo imaging of alpha7 nAChRs in the non-human primate brain...
  21. doi Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Psychiatry Clin Neurosci 64:341-57. 2010
    ..BDNF is initially synthesized as a precursor protein proBDNF, and then proBDNF is proteolytically cleaved to the mature BDNF. Finally, future perspectives on the use of proBDNF as a novel biomarker for mood disorders will be discussed...
  22. doi The role of glutamate on the action of antidepressants
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1558-68. 2011
    ..In this article, the author reviews the role of glutamate in the neuron-glia communication induced by potential antidepressants...
  23. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: role of alpha7 nicotinic receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur J Pharmacol 553:191-5. 2006
    ..These findings suggest that tropisetron could be a potential therapeutic drug for cognitive deficits in schizophrenic patients...
  24. pmc A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia
    Akihiro Shiina
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Ann Gen Psychiatry 9:27. 2010
    ..Therefore, it is of particular interest to investigate the effects of tropisetron on the cognitive deficits in patients with schizophrenia...
  25. ncbi BDNF variant linked to anxiety-related behaviors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Bioessays 29:116-9. 2007
    ..In the behavioral analysis, BDNF(Met/Met) mice show increased anxiety-related behaviors. This mini-review examines the impact of Met substitution of proBDNF on anxiety-related behaviors...
  26. ncbi Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Cent Nerv Syst Agents Med Chem 9:197-204. 2009
    ..In this article, the author would like to discuss the novel role of sigma-1 receptors in the active mechanisms of some SSRIs including fluvoxamine...
  27. ncbi Glycine transporter inhibitors as therapeutic agents for schizophrenia
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260 8670, Japan
    Recent Pat CNS Drug Discov 1:43-53. 2006
    ..In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction...
  28. doi Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  29. ncbi Can the sigma-1 receptor agonist fluvoxamine prevent schizophrenia?
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    CNS Neurol Disord Drug Targets 8:470-4. 2009
    ..g., fluvoxamine) with sigma-1 receptor agonism may reduce the risk of subsequent transition to schizophrenia...
  30. ncbi [Minocycline as a therapeutic drug for methamphetamine use disorders]
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:19-22. 2008
    ..In this review, we discuss minocycline as a new potential therapeutic drug for schizophrenia as well as psychosis associated with these abused drugs...
  31. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and D-serine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, Japan
    Eur Neuropsychopharmacol 18:414-21. 2008
    ....
  32. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 63:92-7. 2008
    ....
  33. ncbi Increased levels of glutamate in brains from patients with mood disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Biol Psychiatry 62:1310-6. 2007
    ....
  34. ncbi Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:1056-8. 2007
    ..This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls...
  35. ncbi [Role of sigma-1 receptors in neural plasticity and in antipsychotic action]
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:123-7. 2010
    ..In this article, the author reviews the role of sigma-1 receptors in the neuronal plasticity and clinical implications of sigma-1 receptors in the treatment for neuropsychiatric diseases...
  36. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Neuropsychopharmacology 32:514-21. 2007
    ..Therefore, sigma-1 receptor agonists such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive deficits of schizophrenia...
  37. pmc A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 5:e15430. 2010
    ..Minocycline, a second-generation tetracycline antibiotic, has potential activity for the treatment of several neurodegenerative and psychiatric disorders. However, its mechanisms of action remain to be determined...
  38. pmc Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    BMC Psychiatry 5:6. 2005
    ..This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients...
  39. ncbi Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Ann N Y Acad Sci 1025:231-5. 2004
    ..Therefore, it is likely that NAC would be a suitable drug for treatment of neurotoxicity on dopaminergic nerve terminals related to chronic use of MAP in humans...
  40. ncbi Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropsychopharmacology 29:2018-23. 2004
    ..Therefore, it is likely that NAC would be a suitable drug for treatment of neurotoxicity in dopaminergic nerve terminals related to chronic use of MAP in humans...
  41. ncbi Critical role of brain-derived neurotrophic factor in mood disorders
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res Brain Res Rev 45:104-14. 2004
    ..New agents capable of enhancing BDNF levels may lead aid the development of novel therapeutic drugs for patients with mood disorders...
  42. ncbi Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:499-504. 2005
    ..In addition, a more complete understanding of the signal transduction pathway via the p75 neurotrophin receptor (p75NTR) and TrkB receptors would provide new perspectives for treating eating disorders...
  43. doi Emerging role of glutamate in the pathophysiology of major depressive disorder
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res Rev 61:105-23. 2009
    ....
  44. ncbi Increased levels of serum basic fibroblast growth factor in schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 120:211-8. 2003
    ....
  45. ncbi Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Japan
    Arch Gen Psychiatry 60:572-6. 2003
    ..The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls...
  46. doi Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 65:1103-6. 2009
    ....
  47. pmc Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol
    Kenji Hashimoto
    Division of Clinical Neuroscience, Center for Forensic Mental Health, Chiba University, Chiba, Japan
    PLoS ONE 6:e17431. 2011
    ..Therefore, agents that can increase the eEF1A1 protein may have therapeutic relevance in diverse conditions with altered neurite outgrowth...
  48. ncbi Glycine transporter-1: a new potential therapeutic target for schizophrenia
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Curr Pharm Des 17:112-20. 2011
    ..In this article, the author reviews the recent findings on the GlyT-1 as a potential therapeutic target of schizophrenia...
  49. ncbi No changes in serum epidermal growth factor levels in patients with schizophrenia
    Kenji Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Psychiatry Res 135:257-60. 2005
    ..Therefore, our results do not support the claim that EGF plays a role in the pathogenesis of schizophrenia, but they suggest that EGF may serve as a state marker, that is, as an index of symptom-linked deficits...
  50. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur J Pharmacol 519:114-7. 2005
    ..1 mg/kg). These findings suggest that PCP-induced cognitive deficits using the novel object recognition test may be a potential animal model of atypical antipsychotic activity...
  51. ncbi Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:767-9. 2005
    ..This study suggests that synthetic or metabolic pathways of D-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia...
  52. ncbi Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 183:13-9. 2005
    ..Similar to schizophrenic patients, DBA/2 mice spontaneously exhibit a deficit in inhibitory processing of the P20-N40 auditory evoked potential, which is thought to be a rodent analog of the human P50 auditory evoked potential...
  53. doi Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:541-6. 2009
    ..We also found prepulse inhibition deficits reversed by clozapine and haloperidol in the Mdk(-/-) mice. Our results suggested that midkine deficiency may be related to neurochemical and behavioral dysfunctions in dopaminergic system...
  54. doi Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 198:363-74. 2008
    ..However, differences in efficacy have also been reported, and further comparative pharmacological studies are still needed...
  55. ncbi No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:708-12. 2005
    ..77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population...
  56. doi Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:86-94. 2009
    ....
  57. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline
    Yuko Fujita
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:336-9. 2008
    ..This study was undertaken to determine whether the antibiotic drug minocycline could improve PCP-induced cognitive deficits in mice...
  58. doi Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors
    Shinsui Kunitachi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Brain Res 1279:189-96. 2009
    ..Therefore, it is likely that donepezil would be potential therapeutic drugs for the treatment of the cognitive deficits in schizophrenia...
  59. ncbi Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females
    Eiji Shimizu
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:99-103. 2006
    ..Taking into account the effects of multiple comparisons, this result should be interpreted with caution, and needs confirmation in a larger sample...
  60. ncbi A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  61. ncbi Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  62. doi Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
    Shiho Arakawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Pharmacol Biochem Behav 100:601-6. 2012
    ..Taken together, minocycline may be a therapeutic drug for the treatment of depression...
  63. doi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors
    Hiroko Hagiwara
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Eur Neuropsychopharmacol 18:448-54. 2008
    ..Therefore, perospirone could be a potential therapy for the cognitive deficits observed in schizophrenic patients...
  64. doi Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction
    Daisuke Ishii
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:183-8. 2010
    ..These results suggested contextual fear conditioning could enhance acoustic PPI, and that contextual fear extinction could decrease freezing behaviors, but not acoustic PPI...
  65. doi Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors
    Tamaki Ishima
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Department of Psychiatry, Chiba University School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1656-9. 2008
    ..These findings suggest that sigma-1 receptors and interaction with IP3 receptors may be involved in the pharmacological action of donepezil...
  66. ncbi Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Schizophr Res 76:67-72. 2005
    ..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia...
  67. doi Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population
    Nobuhisa Kanahara
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:233-8. 2009
    ..The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population...
  68. doi Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: a possible role of alpha1-adrenoceptors
    Yuko Tanibuchi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur Neuropsychopharmacol 19:861-7. 2009
    ..Therefore, it is likely that antagonism at alpha(1)-adrenoceptors is involved in the mechanism underlying quetiapine's psychopharmacological action...
  69. ncbi Deficits in auditory P50 inhibition in obsessive-compulsive disorder
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:288-96. 2008
    ..Our findings suggest that sensory gating deficits may be involved in the pathophysiology of OCD in a different way from clinical symptoms and executive attention dysfunction...
  70. ncbi Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  71. ncbi Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion
    Hideo Matsuzaki
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Neurosci 25:3376-84. 2007
    ..These results indicate that reelin signaling plays a pivotal role in the dopaminergic system in adult mice, especially in postsynaptic levels...
  72. ncbi Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Psychiatry 54:70-5. 2003
    ....
  73. ncbi Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neuropsychopharmacology 32:2004-10. 2007
    ..Therefore, it is possible that minocycline would be a potential therapeutic drug for schizophrenia...
  74. ncbi Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Eur J Neurosci 24:2335-44. 2006
    ..These findings suggest that DR may alter the behaviours in BDNF(+/-) mice, and that the 5-HT system may be implicated in the beneficial effects of DR on these behaviours...
  75. ncbi Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Schizophr Res 98:148-56. 2008
    ..Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia...
  76. ncbi Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex
    Naoe Okamura
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Brain Res 992:114-9. 2003
    ..5 mg/kg, i.p.). These results suggest that LY379268 has a protective effect on the neurotoxicity in the rat retrosplenial cortex after administration of NMDA receptor antagonists such as dizocilpine...
  77. ncbi Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy
    Keisuke Kobayashi
    Department of Psychiatry K2, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:658-63. 2005
    ..These results suggested that BDNF might contribute to therapeutic response of panic disorder. A potential link between an increased risk of secondary depression and BDNF remains to be investigated in the future...
  78. doi Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuroimage 49:2783-90. 2010
    ..These data suggest that specific metabolites of the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia...
  79. doi Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:491-8. 2009
    ..Our findings also suggest that the prefrontal hemodynamic response assessed by noninvasive and less demanding NIRS is a useful intermediate phenotype for translational research in schizophrenia...
  80. ncbi Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol
    Satoshi Yanahashi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Brain Res 1011:84-93. 2004
    ..g., CP-101,606) might be useful drugs for the treatment of extrapyramidal side effects (EPS) associated with the chronic use of typical antipsychotics such as haloperidol...
  81. ncbi Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004
    ..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders...
  82. doi Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine
    Hiroko Hagiwara
    Chiba University Center for Forensic Mental Health, Inohana, Japan
    Brain Res 1301:189-96. 2009
    ..In the future, however, another Sp1 inhibitors with fewer side effects might be more appropriate...
  83. ncbi [Glutamate hypothesis of schizophrenia and targets for new antipsychotic drugs]
    Kenji Hashimoto
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chiba, 260 8670 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 22:3-13. 2002
    ..Moreover, the glycine site of the NMDA receptor, metabotropic glutamate receptor, AMPA receptor, and antioxidant glutathione as novel potential targets for the treatment of schizophrenia are discussed...
  84. pmc Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    PLoS ONE 3:e1944. 2008
    ..In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in patients...
  85. ncbi Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 124:61-3. 2004
    ..Our findings suggest that BDNF 196 A/G polymorphism might be associated with personality traits in female, but not male, healthy subjects...
  86. ncbi Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropsychobiology 52:68-70. 2005
    ..Glutathione peroxidase 1 (GPX1) plays a role in the antioxidant defense system...
  87. ncbi Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine
    Goro Fukami
    Department of Psychiatry, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Brain Res 1016:90-5. 2004
    ....
  88. ncbi Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 54:485-90. 2003
    ....
  89. ncbi Alterations in serum amino acid concentrations in male and female schizophrenic patients
    Masayuki Tomiya
    Division of Bio Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Shizuoka 422 8526, Japan
    Clin Chim Acta 380:186-90. 2007
    ..in schizophrenic patients, we examined the alterations in serum amino acids concentrations in male and female patients separately...
  90. ncbi High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 62:878-83. 2007
    ..The present study was undertaken to examine whether fluvoxamine binds to sigma-1 receptors in living human brain...
  91. pmc Irradiation in adulthood as a new model of schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e2283. 2008
    ..Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia...
  92. ncbi Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1381-93. 2006
    ..Therefore, minocycline could be considered as a useful drug for the treatment of several symptoms associated with METH abuse in humans...
  93. ncbi α7 nicotinic acetylcholine receptor as a potential therapeutic target for schizophrenia
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Curr Pharm Des 17:121-9. 2011
    ..In this article, we review recent topics on α7 nAChR agonists and α7 nAChR allosteric modulators as therapeutic drugs for schizophrenia...
  94. ncbi Recent topics on pharmacotherapy for amphetamine-type stimulants abuse and dependence
    Hongxian Chen
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Japan
    Curr Drug Abuse Rev 3:222-38. 2010
    ..In this article, we review recent reports on potential pharmacotherapies (naltrexone, minocycline, antioxidants, immunotherapy, and dopaminergic, serotonergic, cholinergic, and GABAergic agents) for the treatment of ATS abusers...
  95. ncbi Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Neurosci Lett 351:111-4. 2003
    ..Our results do not support the view that serum BDNF levels are associated with schizophrenia...
  96. ncbi Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans
    Eiji Shimizu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Neurosci Lett 363:81-3. 2004
    ..56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group...
  97. ncbi No changes in serum ghrelin levels in female patients with bulimia nervosa
    Michiko Nakazato
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba City, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:1181-4. 2004
    ..Our study suggests that serum ghrelin levels in the patients with BN were indistinguishable from normal controls. Therefore, it is unlikely that ghrelin plays a role in the pathophysiology of BN...
  98. ncbi Combined intoxication with methylone and 5-MeO-MIPT
    Eiji Shimizu
    Department of Integrative Neurophysiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuouku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:288-91. 2007
    ..This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs...
  99. ncbi Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits
    Eiji Shimizu
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    J Psychiatr Res 41:49-56. 2007
    ..These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia...
  100. ncbi Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia
    Kimiyoshi Ozawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Biol Psychiatry 59:546-54. 2006
    ..Maternal viral infection is associated with increased risk for schizophrenia. It is hypothesized that the maternal immune response to viruses may influence fetal brain development and lead to schizophrenia...
  101. ncbi Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia
    Eiji Shimizu
    Department of Integrative Neurophysiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:571-3. 2007
    ..Using maintenance ECT, she was able to live in the custody of her parents after 7-years hospitalization. This case report suggests that continuation and maintenance ECT benefits patients with serious cases of refractory schizophrenia...