Mitsuko Furuya

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Pathophysiology of tumor neovascularization
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Vasc Health Risk Manag 1:277-90. 2005
  2. ncbi request reprint Expression of regulator of G protein signalling protein 5 (RGS5) in the tumour vasculature of human renal cell carcinoma
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Pathol 203:551-8. 2004
  3. ncbi request reprint Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
  4. ncbi request reprint Sonic Hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas
    Takashi Shida
    Departments of Molecular Pathology, General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Biol Ther 5:1530-8. 2006
  5. ncbi request reprint Maternal-fetal transmission of Toxoplasma gondii in interferon-gamma deficient pregnant mice
    Yuko Shiono
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Parasitol Int 56:141-8. 2007
  6. doi request reprint The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Mod Pathol 21:1363-70. 2008
  7. ncbi request reprint Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma
    Takahito Suyama
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer 103:258-67. 2005
  8. doi request reprint Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Chemother Pharmacol 65:889-93. 2010
  9. ncbi request reprint Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas
    Takashi Shida
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Clin Cancer Res 11:450-8. 2005
  10. ncbi request reprint CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity
    Masakazu Hasegawa
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Lab Invest 87:882-92. 2007

Collaborators

Detail Information

Publications27

  1. pmc Pathophysiology of tumor neovascularization
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Vasc Health Risk Manag 1:277-90. 2005
    ..In addition, recent topics such as contribution of the endothelial progenitor cells, tumor vasculogenic mimicry, markers for tumor-derived endothelial cells and pericytes, and angiogenic/angiostatic chemokines are summarized...
  2. ncbi request reprint Expression of regulator of G protein signalling protein 5 (RGS5) in the tumour vasculature of human renal cell carcinoma
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Pathol 203:551-8. 2004
    ..These findings suggest that RGS5 may be involved in G protein-mediated signalling in tumour vessels in human RCC...
  3. ncbi request reprint Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    ....
  4. ncbi request reprint Sonic Hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas
    Takashi Shida
    Departments of Molecular Pathology, General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Biol Ther 5:1530-8. 2006
    ..Blockade of Hh pathway using cyclopamine or its synthetic derivatives might open an effective therapeutic strategy to NECs, not only by suppressing tumor viability but also by altering tumor cell nature...
  5. ncbi request reprint Maternal-fetal transmission of Toxoplasma gondii in interferon-gamma deficient pregnant mice
    Yuko Shiono
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Parasitol Int 56:141-8. 2007
    ..gondii infection on intrauterine growth retardation of fetus in pregnant GKO mice...
  6. doi request reprint The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Mod Pathol 21:1363-70. 2008
    ....
  7. ncbi request reprint Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma
    Takahito Suyama
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer 103:258-67. 2005
    ..However, the expression of these chemokines in highly angiogenic tumors remains poorly understood. The authors examined expression of I-TAC, Mig, and their receptor, CXCR3, in tissue samples from patients with renal cell carcinoma (RCC)...
  8. doi request reprint Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
    Takashi Shida
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cancer Chemother Pharmacol 65:889-93. 2010
    ..The purpose of the present study was to determine the activation of mTOR in gastropancreatic neuroendocrine tumors, especially in poorly differentiated neuroendocrine carcinomas...
  9. ncbi request reprint Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas
    Takashi Shida
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    Clin Cancer Res 11:450-8. 2005
    ..There have been no biologically specific markers for this disease. In this study, distinctive up-regulation of human achaete-scute homologue 1 (hASH1) in gastrointestinal NECs was clarified...
  10. ncbi request reprint CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity
    Masakazu Hasegawa
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Lab Invest 87:882-92. 2007
    ..It is indicated that CD151 might contribute not only to cell stabilization by associating with adhesion complexes but also to cell migration by inducing integrins re-localization and MMPs production...
  11. ncbi request reprint Expression of liver-enriched nuclear factors and their isoforms in alpha-fetoprotein-producing gastric carcinoma cells
    Yana Supriatna
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Exp Mol Pathol 82:316-21. 2007
    ..Collecting these results, it was suggested that the contribution of LENFs, especially isoforms of C/EBP-beta, is possibly important in phenotypic regulation of AFP-GCs...
  12. ncbi request reprint Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor
    Koichiro Hirashiki
    Department of Molecular Pathology E3, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chiba 260 8670, Japan
    Exp Mol Pathol 78:247-56. 2005
    ..These results indicate that C/EBP-beta plays a role in the production of plasma proteins of yolk sac tumors...
  13. doi request reprint FLCN gene-mutated renal cell neoplasms: mother and daughter cases with a novel germline mutation
    Yoji Nagashima
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Int J Urol 19:468-70. 2012
    ..332_349del/p.H111_Q116del), predicting an alteration of the amino acid sequence of "HPSHPQ" replaced by a single amino acid, "L". This is a novel germline mutation of the FCLN gene that has not been previously reported...
  14. doi request reprint Impaired placental neovascularization in mice with pregnancy-associated hypertension
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Lab Invest 88:416-29. 2008
    ..Collective data suggest that the impairments of fetoplacental neovascularization and uteroplacental remodeling contribute to the development of complications in PAH...
  15. ncbi request reprint Involvement of p38alpha in kainate-induced seizure and neuronal cell damage
    Kana Namiki
    Department of Biochemistry and Molecular Pharmacology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Recept Signal Transduct Res 27:99-111. 2007
    ..These results suggest that p38alpha signaling pathway plays an important role in epileptic seizure and excitotoxicity...
  16. pmc Birt-Hogg-Dube syndrome: clinicopathological features of the lung
    Mitsuko Furuya
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Clin Pathol 66:178-86. 2013
    ..This review discusses the clinical and pathological features of lungs of patients with BHD, focusing on the diagnostic pathology and possible mechanisms of cyst formation...
  17. doi request reprint Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families
    Mitsuko Furuya
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Surg Pathol 36:589-600. 2012
    ..We propose a new insight, namely, that the BHD syndrome-associated pulmonary cyst may be considered a hamartoma-like cystic alveolar formation associated with deranged mTOR signaling...
  18. ncbi request reprint Tumor-derived interleukin (IL)-6 induced anti-tumor effect in immune-compromised hosts
    Hiroshi Ishiguro
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Cancer Immunol Immunother 54:1191-9. 2005
    ..Natural killer (NK) activity was augmented in the spleen of mIL-6H-inoculated scid mice. This study indicated a possible vaccination effect with tumor-derived IL-6 in immune-compromised hosts...
  19. ncbi request reprint Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Res 65:2617-25. 2005
    ..Down-regulated CD9 may attenuate the expression of several integrins and rearrange junctional and cytoskeletal molecules that might contribute to dissemination of ovarian carcinomas...
  20. pmc Identification of miR-30d as a novel prognostic maker of prostate cancer
    Naohito Kobayashi
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    Oncotarget 3:1455-71. 2012
    ..0057). Taken together, miR-30d appears to be a novel independent prognostic marker of PCa progression that allows clinicians to identify patients who need more intensive treatments...
  21. pmc Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cancer Biol Ther 13:671-80. 2012
    ..Suppression of CXCL4 in cancer lesions is likely to be attributable to TAMs in part...
  22. ncbi request reprint Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells
    Yuji Matsuo
    Departments of Biochemistry and Molecular Pharmacology, Respirology, and Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Biol Chem 281:36767-75. 2006
    ....
  23. doi request reprint Metastasis of malignant struma ovarii to the lumbar spine
    Masaomi Yamashita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
    J Clin Neurosci 17:269-72. 2010
    ..Metastasis may occur when a patient has had prior surgery to remove this rare tumour...
  24. doi request reprint Lung cysts in Birt-Hogg-Dubé syndrome: histopathological characteristics and aberrant sequence repeats
    Shunsuke Koga
    Department of Pathology, Chiba University Hospital, Chiba, Japan
    Pathol Int 59:720-8. 2009
    ..Haploinsufficiency of folliculin may cause deranged alveolar development, leading to the aberrant cystic alveolar formation. The unique mutation patterns of abnormal sequence repeats in patients with BHD syndrome are also reviewed...
  25. ncbi request reprint Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70
    Hao Fang
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int Immunol 18:1487-97. 2006
    ..Treatment with PAF receptor antagonist rescued WT mice from the anaphylactic reaction. These data demonstrated the involvement of IFN-gamma-dependent PAF activation in T.g.HSP70-induced anaphylactic reaction...
  26. ncbi request reprint Expression of matrix metalloproteinase in the fluids of renal cystic lesions
    Hiroshi Harada
    Division of Pathophysiological Science, Department of Pathology Pathophysiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Urol 168:19-22. 2002
    ..We analyzed the expression of matrix metalloproteinase (MMP) in the fluids of benign and malignant renal cystic lesions to clarify matriolytic activities in the cyst...
  27. ncbi request reprint Cancer neovascularization and proinflammatory microenvironments
    Mitsuko Furuya
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Curr Cancer Drug Targets 8:253-65. 2008
    ....