Kan Chiba

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi [Genetic marker of statin-induced rhabdomyolysis]
    Kan Chiba
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
    Yakugaku Zasshi 131:247-53. 2011
  2. doi Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Pharmacogenomics J 9:185-93. 2009
  3. pmc Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba shi, Chiba, Japan 260 8675
    Antimicrob Agents Chemother 54:3035-8. 2010
  4. ncbi Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 28:265-8. 2013
  5. ncbi Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8675, Japan
    Pharm Res 24:2327-32. 2007
  6. pmc ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system
    Minami Iikura
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Antimicrob Agents Chemother 56:1407-13. 2012
  7. ncbi Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers
    Sasitorn Aueviriyavit
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 22:391-8. 2007
  8. ncbi Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 27:478-85. 2012
  9. ncbi Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver
    Sachiyo Kawashima
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chiba 260 8675, Japan
    Drug Metab Dispos 34:1012-8. 2006
  10. ncbi Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver
    Norihiko Iwazaki
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 23:59-66. 2008

Collaborators

Detail Information

Publications38

  1. ncbi [Genetic marker of statin-induced rhabdomyolysis]
    Kan Chiba
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
    Yakugaku Zasshi 131:247-53. 2011
    ..These genetic factors may provide predisposition testing for statin-induced rhabdomyolysis...
  2. doi Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Pharmacogenomics J 9:185-93. 2009
    ..1628T>G (p.Leu543Trp) reduced the function of OATP1B1 probably due to decrease in turnover rate of one OATP1B1 molecule rather than impairment of protein sorting to the plasma membrane...
  3. pmc Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba shi, Chiba, Japan 260 8675
    Antimicrob Agents Chemother 54:3035-8. 2010
    ..We concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes...
  4. ncbi Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 28:265-8. 2013
    ....
  5. ncbi Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8675, Japan
    Pharm Res 24:2327-32. 2007
    ..The aim of the present study was to clarify the factors responsible for interindividual variability of organic anion transporting polypeptide (OATP, gene symbol SLCO) 1B1 mRNA expression level in the human liver...
  6. pmc ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system
    Minami Iikura
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Antimicrob Agents Chemother 56:1407-13. 2012
    ....
  7. ncbi Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers
    Sasitorn Aueviriyavit
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 22:391-8. 2007
    ..Further studies of other transcription factors are needed to clarify the factor(s) determining the interindividual variations in UGT1A1, UGT1A3 and UGT1A4 mRNA expression...
  8. ncbi Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 27:478-85. 2012
    ..The results suggest that FLC-4 cells cultured on micro-space cell culture plates are useful for studying drug metabolism and drug-induced hepatotoxicity...
  9. ncbi Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver
    Sachiyo Kawashima
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chiba 260 8675, Japan
    Drug Metab Dispos 34:1012-8. 2006
    ..Taken together, our results suggest that HNF4alpha is a factor responsible for the difference between the expression levels of CYP2C9 and CYP2C19 in the human liver...
  10. ncbi Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver
    Norihiko Iwazaki
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 23:59-66. 2008
    ..These results suggested that HNF4alpha transactivated the human PXR gene by binding to the DR1 element located at -88/-76 of the promoter and was involved in the expression of PXR in the human liver...
  11. doi Constitutive androstane/active receptor is a target of retinoic acid receptor in humans
    Kosuke Saito
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Biochem Pharmacol 80:129-35. 2010
    ..Although the physiological significance of RAR alpha-dependent up-regulation of CAR in the human liver remains to be clarified, retinoid metabolism may be regulated by the up-regulation of CAR...
  12. doi Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells
    Miki Nagai
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Biochem Biophys Res Commun 418:818-23. 2012
    ....
  13. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes
    Kosuke Saito
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Drug Metab Pharmacokinet 25:108-11. 2010
    ..Activated PPARalpha may increase functional CAR protein, which can induce the expression of CAR target genes such as CYP2B...
  14. ncbi Species differences in mechanism-based inactivation of CYP3A in humans, rats and mice
    Sasitorn Aueviriyavit
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Drug Metab Pharmacokinet 25:93-100. 2010
    ..Taken together, the results suggest that there are species differences in MBI of CYP3A in humans, rats and mice, which should be considered when rodents are used as in vivo models for MBI-mediated drug-drug interaction study...
  15. ncbi Characterization of ribavirin uptake systems in human hepatocytes
    Yukina Fukuchi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba shi, Chiba, Japan
    J Hepatol 52:486-92. 2010
    ..Furthermore, we aimed to address what causes the difference in uptake levels among human hepatocytes...
  16. ncbi Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis
    Eri Sano
    Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Comput Chem 31:2746-58. 2010
    ..This prediction will be helpful for advanced drug design because calculations forecast unexpected change in drug efficacy for individuals...
  17. ncbi Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Biochem Pharmacol 69:1287-97. 2005
    ..These findings, together with the findings described above, provide important information for the study of phramacokinetics and pharmacodynamics of ester-drugs as well as for the study of CESs...
  18. ncbi Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells
    Tomoko Shiraishi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba shi, Japan
    Drug Metab Dispos 30:1201-5. 2002
    ....
  19. ncbi Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
    Drug Metab Pharmacokinet 29:211-4. 2014
    ..We believe that the present study will facilitate further pharmacogenomic and biochemical characterization of PNP as a key metabolic enzyme of ribavirin...
  20. doi Establishment of a new conditionally immortalized cell line from human brain microvascular endothelial cells: a promising tool for human blood-brain barrier studies
    Atsuko Kamiichi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8675, Japan
    Brain Res 1488:113-22. 2012
    ..It is also believed that the development of a specific culture method for HBMEC/ciβ will add significant value to the HBMEC/ciβ-based BBB model...
  21. ncbi Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat
    Kaoru Kobayashi
    Laboratory of Biochemical Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Biochem Pharmacol 63:889-96. 2002
    ..These results may provide useful information regarding catalytic probes of rat CYPs for studies using rat liver microsomal samples...
  22. ncbi Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 263 8522, Chiba, Japan
    Arch Biochem Biophys 416:101-9. 2003
    ..Furthermore, the biological characteristics of the expressed protein were identical with those of ACH M1 in many cases, suggesting that mCES2 encodes mouse liver ACH M1...
  23. ncbi Key structural features of ligands for activation of human pregnane X receptor
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Drug Metab Dispos 32:468-72. 2004
    ..These findings suggest that hydrophobicity of the ligand and adequate distance between the hydrogen-bond acceptor and the hydrophobic group are important for hPXR activation...
  24. ncbi Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
    Drug Metab Dispos 33:924-9. 2005
    ..HMG-CoA reductase inhibitors such as cerivastatin would be useful to study for elucidating molecular and cellular mechanisms of hCAR...
  25. ncbi Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Drug Metab Dispos 31:833-6. 2003
    ..However, it appears that sulfaphenazole can be used as a selective inhibitor for rat CYP2C6. In addition, furafylline may also be a relatively selective inhibitor for rat CYP1A2...
  26. doi Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Biopharm Drug Dispos 33:466-73. 2012
    ....
  27. ncbi Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo
    Nobuhito Mimura
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Life Sci 73:3201-12. 2003
    ..These findings suggest that CYP-catalyzed metabolism of MPA is mainly catalyzed by CYP3A1 and that MPA-induced hypercoagulation is predominantly caused by MPA itself in female rats...
  28. ncbi A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy
    Kaori Morimoto
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Drug Metab Pharmacokinet 19:453-5. 2004
    ..In this mutation (1628T>G), there is a substitution of Leu to Trp at position 543 in transmembrane-spanning domain 10 of OATP-C. However, the frequency of this mutation in the Japanese population appears to be very low (<1%)...
  29. pmc Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver
    Mari Hashimoto
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Lipid Res 54:2060-8. 2013
    ..Therefore, CYP3A enzymes appear to play roles in the synthesis of cholesterol and bile acid in vivo. ..
  30. ncbi Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells
    Ryotaro Saiki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chuo Ku, Chiba, Japan
    J Neurochem 127:652-9. 2013
    ..Furthermore, IL-6 decreased acrolein toxicity in several cell lines. ..
  31. ncbi Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation
    Tomoko Akutsu
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba shi, Chiba 260 8675, Japan
    Drug Metab Dispos 35:72-8. 2007
    ..In addition, large differences in the metabolic activities of CYP2D6 and those of CYP1A2, CYP2C9, and CYP2C19 could cause the individual differences in anti-allergic efficacy and the sedative effect of diphenhydramine...
  32. ncbi Functional analysis of GC Box and its CpG methylation in the regulation of CYP1A2 gene expression
    Atsushi Miyajima
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Pharmacokinet 24:269-76. 2009
    ..Genome-based approaches may be necessary for understanding this tissue-specific epigenetic mechanism...
  33. ncbi Pharmacogenetic roles of CYP2C19 and CYP2B6 in the metabolism of R- and S-mephobarbital in humans
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Pharmacogenetics 14:549-56. 2004
    ..Blood and urine samples were collected, and R-MPB, S-MPB and the metabolites, phenobarbital (PB) and 4'-hydroxy-MPB, were measured. Each subject was also genotyped for CYP2B6 gene...
  34. ncbi A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation
    Jun Morita
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Drug Metab Pharmacokinet 19:236-8. 2004
    ..A new allele having this SNP was designated as CYP2C19*16...
  35. ncbi Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Drug Metab Dispos 32:1170-7. 2004
    ..The present study has provided useful information for study of metabolism and disposition of ester-prodrugs as well as ester-drugs...
  36. ncbi Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells
    Yoshio Kameyama
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Pharmacogenet Genomics 15:513-22. 2005
    ....
  37. ncbi Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Arch Biochem Biophys 447:107-17. 2006
    ..These findings show that HNF-4alpha plays an important role in the regulation of mCES2 gene transcription...
  38. pmc Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter
    Tomomi Furihata
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Biochem J 384:101-10. 2004
    ..The results of the present study have provided some clues for understanding the molecular mechanisms regulating mCES2 gene expression, and should be useful for studies aimed at elucidation of physiological functions of mCES2...