Masahiro Takeyoshi

Summary

Affiliation: Chemicals Evaluation and Research Institute
Country: Japan

Publications

  1. ncbi request reprint Differences in responsiveness of mouse strain against p-benzoquinone as assessed by non-radioisotopic murine local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, Japan, Oita, Japan
    Exp Anim 53:171-3. 2004
  2. ncbi request reprint Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:129-34. 2005
  3. ncbi request reprint An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65
    David Basketter
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Altern Lab Anim 36:243-57. 2008
  4. ncbi request reprint Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 26:5-9. 2006
  5. ncbi request reprint Changes in serum alpha2u-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:176-8. 2005
  6. ncbi request reprint Skin sensitization potency of isoeugenol and its dimers evaluated by a non-radioisotopic modification of the local lymph node assay and guinea pig maximization test
    Masahiro Takeyoshi
    Health Effect Research Section, Chemicals Assessment Center, Chemicals Evaluation and Research Institute CERI Japan, 1600, Shimotakano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    J Appl Toxicol 28:530-4. 2008
  7. ncbi request reprint Assessment of the skin sensitization potency of eugenol and its dimers using a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 24:77-81. 2004
  8. ncbi request reprint Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita, 8770061, Japan
    Toxicology 191:259-63. 2003
  9. ncbi request reprint Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, 8770061, Oita, Japan
    Arch Toxicol 77:274-9. 2003
  10. ncbi request reprint Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    Reprod Toxicol 16:367-9. 2002

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Differences in responsiveness of mouse strain against p-benzoquinone as assessed by non-radioisotopic murine local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, Japan, Oita, Japan
    Exp Anim 53:171-3. 2004
    ..These results support the recommendation in the OECD test guideline 429 and the skin sensitization test guideline of US-EPA with regard to the selection of mouse strain for LLNA...
  2. ncbi request reprint Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:129-34. 2005
    ..Accordingly, this approach would be an effective modification of LLNA with regard to its experimental design. Moreover, this procedure can be applied also to the standard LLNA with radioisotopes and to other modifications of the LLNA...
  3. ncbi request reprint An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65
    David Basketter
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Altern Lab Anim 36:243-57. 2008
  4. ncbi request reprint Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 26:5-9. 2006
    ....
  5. ncbi request reprint Changes in serum alpha2u-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:176-8. 2005
    ....
  6. ncbi request reprint Skin sensitization potency of isoeugenol and its dimers evaluated by a non-radioisotopic modification of the local lymph node assay and guinea pig maximization test
    Masahiro Takeyoshi
    Health Effect Research Section, Chemicals Assessment Center, Chemicals Evaluation and Research Institute CERI Japan, 1600, Shimotakano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    J Appl Toxicol 28:530-4. 2008
    ..The data may also provide useful information for the structure-activity relationship (SAR) in skin sensitization...
  7. ncbi request reprint Assessment of the skin sensitization potency of eugenol and its dimers using a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 24:77-81. 2004
    ..These investigations provide support for the proposal that the non-radioisotopic LLNA may serve as an effective alternative to the GPMT where there is a need to avoid the use of radioisotopes...
  8. ncbi request reprint Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita, 8770061, Japan
    Toxicology 191:259-63. 2003
    ..The challenge is to develop strategies for further refinement of this approach...
  9. ncbi request reprint Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, 8770061, Oita, Japan
    Arch Toxicol 77:274-9. 2003
    ..This new type of reporter plasmid, ARE-AUG- Luc+, should be of value in endocrine research and in screening to identify endocrine-modulating chemicals...
  10. ncbi request reprint Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    Reprod Toxicol 16:367-9. 2002
    ....
  11. ncbi request reprint The efficacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, 8770061, Oita, Japan
    Toxicol Lett 126:91-8. 2002
    ..Particularly, the reporter gene assay may be a promising prescreening procedure, because it can be adopted in the high throughput screening process for thousands of chemicals and it requires no use of experimental animals...
  12. ncbi request reprint Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 183:93-115. 2003
    ..In the Hershberger assay, a clear androgen agonistic effect was detected in the androgen derivatives testosterone enanthate and methyltestosterone...
  13. ncbi request reprint Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 087 0061, Japan
    Toxicol Lett 142:119-31. 2003
    ....
  14. ncbi request reprint Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Chemicals Assessment Center, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Toxicology 176:101-12. 2002
    ..Although the alpha 2u-globulin level was reduced in this assay using BPA and EE, further studies are necessary before this assay becomes a useful method for detecting endocrine-mediated effects...
  15. ncbi request reprint Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, 877 0061, Oita, Japan
    Toxicology 170:21-30. 2002
    ..9202). These findings demonstrate that PC10 values are preferable to EC50 and PC50 values for predicting the estrogenic activities of chemicals...
  16. ncbi request reprint Comprehensive identification of cytochrome p450 isoforms from solubility-based fractionated rat liver microsomes
    Hidenori Yamanaka
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 1600, Shimo Takano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    Drug Metab Lett 1:281-6. 2007
    ..The combination of proteomic analysis and the solubility-based fractionation would provide powerful tool for the expression analysis of the superfamily proteins having great similarities between the amino acids sequences...
  17. ncbi request reprint Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells
    Naohiro Araki
    EcoScreen R and D Section, Endocrine Disrupting Chemical Analysis Center, Otsuka Life Science Initiative, Otsuka Pharmaceutical Co, Ltd, 224 18 Ebisuno Hiraishi, Kawauchi cho, Tokushima 771 0195, Japan
    Toxicol In Vitro 19:831-42. 2005
    ..These results suggest that AR-EcoScreen cell line has the potential to be used as a tool for the large scale tier 1 screening of chemicals for androgen receptor agonist and antagonist activity...
  18. ncbi request reprint Interlaboratory validation of the modified murine local lymph node assay based on adenosine triphosphate measurement
    Takashi Omori
    Kyoto University School of Public Health, Japan
    J Pharmacol Toxicol Methods 58:11-26. 2008
    ..Daicel Chemical Industries Ltd. has developed a modified LLNA based on the adenosine triphosphate (ATP) content (LLNA-DA). We conducted 2 interlaboratory validation studies to evaluate the reliability and relevance of LLNA-DA...
  19. ncbi request reprint Evaluation of a rapid in vitro androgen receptor transcriptional activation assay using AR-EcoScreen cells
    Naohiro Araki
    EcoScreen R and D Section, Endocrine Disrupting Chemical Analysis Center, Otsuka Life Science Initiative, Otsuka Pharmaceutical Co Ltd, 224 18 Ebisuno Hiraishi, Kawauchi cho, Tokushima 771 0195, Japan
    Toxicol In Vitro 19:335-52. 2005
    ..In summary, we concluded that AR-EcoScreen method was ready to proceed to the phase II prevalidation study to asses the inter-laboratory variability and transfer of the protocol...
  20. ncbi request reprint Development of a monoclonal antibody-based sandwich ELISA for detection of guinea pig interleukin-2
    Satoshi Adachi
    Department of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 68:1281-7. 2006
    ..Thus, a sandwich ELISA based on the two mAbs specific to different GPIL-2 epitopes was developed for detection of GPIL-2, which had a sensitivity threshold of about 0.3 ng/ml of GPIL-2...
  21. ncbi request reprint Gene expression changes induced by type IV allergy-inducible chemicals in dendritic cells
    Rie Tarama
    Department of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi, Japan
    J Vet Med Sci 70:673-80. 2008
    ..Thus, up-regulation of Sdc1 gene and down-regulation of SMO gene in DC2.4 cells may be diagnostic markers for the screening of type IV-allergenic chemicals...