Affiliation: Central Research Laboratories
- Tatsumi Y, Yokoo M, Arika T, Yamaguchi H. In vivo fungicidal effect of KP-103 in a guinea pig model of interdigital tinea pedis determined by using a new method for removing the antimycotic carryover effect. Microbiol Immunol. 2002;46:433-9 pubmed....
- Tatsum Y, Yokoo M, Arika T, Yamaguchi H. KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs. Microbiol Immunol. 2002;46:425-32 pubmed..The effectiveness of KP-103 against dermatophytoses may be due to the favorable pharmacokinetic properties in the skin tissues, together with its potent antifungal activity...
- Tachibana H, Kumagai N, Tatsumi Y. Fungicidal Activity in the Presence of Keratin as an Important Factor Contributing to In Vivo Efficacy: A Comparison of Efinaconazole, Tavaborole, and Ciclopirox. J Fungi (Basel). 2017;3: pubmed publisher..This study suggests that not only fungistatic activity (MIC), but also fungicidal activity in the presence of keratin, is an important factor contributing to the in vivo efficacy of topical antifungal drugs against onychomycosis. ..
- Pollak R, Siu W, Tatsumi Y, Pillai R. Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success. J Fungi (Basel). 2015;1:107-114 pubmed publisher....