Takami Kakuda

Summary

Affiliation: Central Research Institute
Country: Japan

Publications

  1. doi Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction
    Takami Kakuda
    R and D Division, Itoen, Ltd, 21 Mekami, Makinohara, Shizuoka 421 0516, Japan
    Pharmacol Res 64:162-8. 2011
  2. ncbi Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors
    Takami Kakuda
    Central Research Institute, Itoen Ltd, 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    Biosci Biotechnol Biochem 66:2683-6. 2002
  3. doi Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain
    Takami Kakuda
    Central Research Institute, Itoen Ltd, Makinohara City, Shizuoka, Japan
    J Neurosci Res 86:1846-56. 2008
  4. doi Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats
    Makoto Kobayashi
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    J Agric Food Chem 57:7131-6. 2009
  5. ncbi Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterol-fed rats
    Makoto Kobayashi
    Central Research Institute, ITO EN, Ltd, Shizuoka, Japan
    Biosci Biotechnol Biochem 69:2455-8. 2005
  6. ncbi Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats
    Yuko Suzuki
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    Biosci Biotechnol Biochem 69:1288-91. 2005
  7. ncbi Analysis of tea catechins in human plasma by high-performance liquid chromatography with solid-phase extraction
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, 21 Mekami, Makinohara shi, Shizuoka 421 0516, Japan
    J Agric Food Chem 53:9885-9. 2005
  8. ncbi Effect of tea catechins on postprandial plasma lipid responses in human subjects
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    Br J Nutr 93:543-7. 2005
  9. ncbi Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers
    Tomonori Unno
    Central Research Institute, ITO EN Ltd 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    J Ethnopharmacol 93:391-5. 2004
  10. ncbi Urinary excretion of 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone, a ring-fission metabolite of (-)-epicatechin, in rats and its in vitro antioxidant activity
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    J Agric Food Chem 51:6893-8. 2003

Collaborators

Detail Information

Publications22

  1. doi Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction
    Takami Kakuda
    R and D Division, Itoen, Ltd, 21 Mekami, Makinohara, Shizuoka 421 0516, Japan
    Pharmacol Res 64:162-8. 2011
    ..5mgday(-1) of theanine) showed significantly lower decline in cognitive function compared with that of the placebo group. This result suggested that theanine might have improved a slight cognitive dysfunction in elderly persons...
  2. ncbi Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors
    Takami Kakuda
    Central Research Institute, Itoen Ltd, 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    Biosci Biotechnol Biochem 66:2683-6. 2002
    ..Theanine bound the three receptors, but its IC50 of theanine was 80- to 30,000-fold less than that of L-glutamic acid...
  3. doi Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain
    Takami Kakuda
    Central Research Institute, Itoen Ltd, Makinohara City, Shizuoka, Japan
    J Neurosci Res 86:1846-56. 2008
    ....
  4. doi Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats
    Makoto Kobayashi
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    J Agric Food Chem 57:7131-6. 2009
    ..These results suggest that BTP suppressed postprandial hypertriacylglycerolemia by reducing triacylglycerol absorption via the inhibition of pancreatic lipase activity...
  5. ncbi Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterol-fed rats
    Makoto Kobayashi
    Central Research Institute, ITO EN, Ltd, Shizuoka, Japan
    Biosci Biotechnol Biochem 69:2455-8. 2005
    ..There was no differential effect between the two catechin preparations...
  6. ncbi Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats
    Yuko Suzuki
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    Biosci Biotechnol Biochem 69:1288-91. 2005
    ..These results strongly suggest that catechins with a galloyl moiety would be promising agents for suppressing dietary fat absorption through the small intestine...
  7. ncbi Analysis of tea catechins in human plasma by high-performance liquid chromatography with solid-phase extraction
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, 21 Mekami, Makinohara shi, Shizuoka 421 0516, Japan
    J Agric Food Chem 53:9885-9. 2005
    ..The proposed method enables the rapid and accurate quantitation of plasma tea catechins and might prove useful for the evaluation of beneficial health effects of tea consumption...
  8. ncbi Effect of tea catechins on postprandial plasma lipid responses in human subjects
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, Shizuoka 421 0516, Japan
    Br J Nutr 93:543-7. 2005
    ..These results may provide evidence for one of the possible mechanisms involved in lowering the incidence of CVD, and may prove useful in further studies on the beneficial health effects of tea drinking...
  9. ncbi Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers
    Tomonori Unno
    Central Research Institute, ITO EN Ltd 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    J Ethnopharmacol 93:391-5. 2004
    ..These results may explain and support the dietary use of the aqueous extracts from Lagerstroemia speciosa leaves for the prevention and treatment of hyperuricemia...
  10. ncbi Urinary excretion of 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone, a ring-fission metabolite of (-)-epicatechin, in rats and its in vitro antioxidant activity
    Tomonori Unno
    Central Research Institute, ITO EN, Ltd, 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    J Agric Food Chem 51:6893-8. 2003
    ....
  11. ncbi Neuroprotective effects of the green tea components theanine and catechins
    Takami Kakuda
    Central Research Institute, Itoen, Ltd, Shuzuoka, Japan
    Biol Pharm Bull 25:1513-8. 2002
    ..Scavenging of *O(2)(-) was also exhibited by tea catechins. The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted...
  12. ncbi [Isolation and quantitative analysis of the alpha-amylase inhibitor in Lagerstroemia speciosa (L.) Pers. (Banaba)]
    Hirokazu Hosoyama
    Central Research Institute, ITO EN, Ltd, 21 Mekami, Sagara cho, Haibara gun, Shizuoka 421 0516, Japan
    Yakugaku Zasshi 123:599-605. 2003
    ..In addition, a strong linear correlation was observed between the whole valoneaic acid contents and total polyphenol contents. This analytical procedure is applicable to the chemical evaluation of Banaba...
  13. ncbi Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 69:1049-53. 2005
    ....
  14. ncbi Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Nutr 135:155-9. 2005
    ..Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease...
  15. ncbi Pigments in green tea leaves (Camellia sinensis) suppress transformation of the aryl hydrocarbon receptor induced by dioxin
    Itsuko Fukuda
    Laboratory of Food and Nutritional Chemistry, Faculty of Agriculture, Kobe University, Rokkodai cho, Nada Ku, Kobe, Hyogo 657 8501, Japan
    J Agric Food Chem 52:2499-506. 2004
    ..7 microM. Thus, these pigments of green tea leaves have the potential to protect from dioxin toxicity through the suppression of AhR transformation...
  16. ncbi Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Agric Food Chem 51:7303-7. 2003
    ..Compounds 7 and 8 were more effective to precipitate cholesterol than 3 and 4, respectively. These observations strongly suggest that heat-epimerized catechins may be more hypocholesterolemic than tea catechins...
  17. ncbi Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase
    Haruhito Tsuge
    Laboratory of Nutritional Biochemistry, Department of Food Science, Faculty of Agriculture, Gifu University, 1 1 Yanagido, Japan
    Biochim Biophys Acta 1620:47-53. 2003
    ....
  18. doi Effects of (-) -epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue
    Masaaki Tanaka
    Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nutrition 24:599-603. 2008
    ..However, in our daily lives, combined fatigue, which is the combination of physical and mental fatigue, is most often experienced. In this study, the effects of (-)-epigallocatechin gallate (EGCg) on combined fatigue were assessed...
  19. doi Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta
    Yusuke Ushida
    Faculty of Agriculture, Graduate School of Kyushu University, Higashi ku, Fukuoka 812 8581 Japan
    J Nutr Biochem 19:700-7. 2008
    ..In conclusion, tartary buckwheat was proven to regulate vascular tones and have latent acidic candidates except for rutin...
  20. ncbi Autonomic nervous responses according to preference for the odor of jasmine tea
    Naohiko Inoue
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Kyoto 606 8502, USA
    Biosci Biotechnol Biochem 67:1206-14. 2003
    ..These results suggest that the jasmine tea odor activated the parasympathetic nerve, whereas the higher-intensity odor activated the sympathetic nerve in those subjects who disliked the odor...
  21. ncbi Sedative effects of the jasmine tea odor and (R)-(-)-linalool, one of its major odor components, on autonomic nerve activity and mood states
    Kyoko Kuroda
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Japan
    Eur J Appl Physiol 95:107-14. 2005
    ..Thus, the low intensity of jasmine tea odor has sedative effects on both autonomic nerve activity and mood states, and (R)-(-)-linalool, one of its components, can mimic these effects...
  22. ncbi Identification of potent odorants in Chinese jasmine green tea scented with flowers of Jasminum sambac
    Yuriko Ito
    Laboratory of Food Chemistry, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    J Agric Food Chem 50:4878-84. 2002
    ..The omission of methyl anthranilate and the replacement of (R)-(-)-linalool by (S)-(+)-linalool led to great changes in the odor of the model. These two compounds were determined to be the key odorants of the jasmine tea flavor...