K Miyazono

Summary

Affiliation: Cancer Institute Hospital
Country: Japan

Publications

  1. ncbi TGF-beta receptors and signal transduction
    K Miyazono
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Int J Hematol 65:97-104. 1997
  2. pmc Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway
    M Furuhashi
    Department of Biochemistry, The Japanese Foundation for Cancer Research JFCR Cancer Institute, Toshima ku, Tokyo 170 8455, Japan
    Mol Cell Biol 21:5132-41. 2001
  3. ncbi Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
    T Ebisawa
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 276:12477-80. 2001
  4. pmc Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation
    M Fujii
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research and Research for the Future Program, Tokyo, Japan
    Mol Biol Cell 10:3801-13. 1999
  5. pmc The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling
    A Hanyu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 170-8455, Japan
    J Cell Biol 155:1017-27. 2001
  6. ncbi TGF-beta signaling by Smad proteins
    K Miyazono
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, Japan
    Cytokine Growth Factor Rev 11:15-22. 2000
  7. pmc Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
    M Fukuchi
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Mol Biol Cell 12:1431-43. 2001
  8. pmc Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp
    H Inoue
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Tokyo 170 8455, Japan
    Mol Biol Cell 9:2145-56. 1998
  9. ncbi Schnurri interacts with Mad in a Dpp-dependent manner
    Y Udagawa
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Genes Cells 5:359-69. 2000
  10. ncbi Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter
    J Hanai
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 70 8455, Japan
    J Biol Chem 274:31577-82. 1999

Collaborators

Detail Information

Publications80

  1. ncbi TGF-beta receptors and signal transduction
    K Miyazono
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Int J Hematol 65:97-104. 1997
    ..TGF-beta receptors and Mad-related proteins have been found to act as tumor suppressor genes in various tumors, including colorectal cancers and T-cell lymphoma...
  2. pmc Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway
    M Furuhashi
    Department of Biochemistry, The Japanese Foundation for Cancer Research JFCR Cancer Institute, Toshima ku, Tokyo 170 8455, Japan
    Mol Cell Biol 21:5132-41. 2001
    ..Axin may thus function as an adapter of Smad3, facilitating its activation by TGF-beta receptors for efficient TGF-beta signaling...
  3. ncbi Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
    T Ebisawa
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 276:12477-80. 2001
    ..These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor...
  4. pmc Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation
    M Fujii
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research and Research for the Future Program, Tokyo, Japan
    Mol Biol Cell 10:3801-13. 1999
    ..Osteoblast differentiation induced by BMPs is thus mediated mainly via the Smad-signaling pathway, whereas chondrogenic differentiation may be transmitted by Smad-dependent and independent pathways...
  5. pmc The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling
    A Hanyu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 170-8455, Japan
    J Cell Biol 155:1017-27. 2001
    ..The N domain of Smad7 thus plays an important role in the specific inhibition of TGF-beta signaling...
  6. ncbi TGF-beta signaling by Smad proteins
    K Miyazono
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, Japan
    Cytokine Growth Factor Rev 11:15-22. 2000
    ..Through interaction with different transcription factors and transcriptional co-activators or co-repressors, Smads may exhibit specific effects in various cell types...
  7. pmc Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
    M Fukuchi
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Mol Biol Cell 12:1431-43. 2001
    ..Smad3 bound to ROC1-SCF(Fbw1a) is then exported from the nucleus to the cytoplasm for proteasomal degradation. TGF-beta/Smad3 signaling is thus irreversibly terminated by the ubiquitin-proteasome pathway...
  8. pmc Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp
    H Inoue
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Tokyo 170 8455, Japan
    Mol Biol Cell 9:2145-56. 1998
    ..We also show that Mad exists as a monomer in the absence of Tkv stimulation. Tkv induces homo-oligomerization of Mad, and Dad inhibits this step. Finally, we propose a model for Dpp signaling by Drosophila Smad proteins...
  9. ncbi Schnurri interacts with Mad in a Dpp-dependent manner
    Y Udagawa
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Genes Cells 5:359-69. 2000
    ..schnurri (shn) was identified as a candidate gene acting downstream of Dpp receptors, but its relevance to Mad has remained unknown...
  10. ncbi Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter
    J Hanai
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 70 8455, Japan
    J Biol Chem 274:31577-82. 1999
    ..PEBP2 may thus be a nuclear target of TGF-beta/BMP signaling...
  11. ncbi Intracellular signaling of the TGF-beta superfamily by Smad proteins
    M Kawabata
    Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research JFCR, Tokyo, Japan
    Ann N Y Acad Sci 886:73-82. 1999
    ..Thus, the missense mutation not only disrupts the function of the wild-type Smad but also creates a dominant-negative Smad, which could actively contribute to oncogenesis...
  12. ncbi Alpha-helix 2 in the amino-terminal mad homology 1 domain is responsible for specific DNA binding of Smad3
    K Kusanagi
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan
    J Biol Chem 276:28155-63. 2001
    ..Smad3 thus binds to DNA directly through the beta-hairpin loop, and H2 supports specific DNA binding of Smad3...
  13. ncbi c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads
    S Akiyoshi
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for Promotion of Science, 1 37 1, Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 274:35269-77. 1999
    ..c-Ski is thus a transcriptional co-repressor that links Smads to HDAC in TGF-beta signaling...
  14. ncbi ASK1 is essential for JNK/SAPK activation by TRAF2
    H Nishitoh
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Mol Cell 2:389-95. 1998
    ..In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF-dependent manner. Thus, ASK1 is a mediator of TRAF2-induced JNK activation...
  15. ncbi Growth/differentiation factor-5 induces angiogenesis in vivo
    H Yamashita
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Exp Cell Res 235:218-26. 1997
    ..These results suggest that GDF-5 is one of the molecules which induce angiogenesis in the bone formation process...
  16. ncbi E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins
    A Nishihara
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 274:28716-23. 1999
    ..We found that E1A interacts specifically with receptor-regulated Smads, suggesting a novel mechanism whereby E1A antagonizes TGF-beta signaling...
  17. ncbi Modulation of the functional binding sites for TGF-beta on the type II receptor leads to suppression of TGF-beta signaling
    T Shimanuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Oncogene 26:3311-20. 2007
    ..Our findings may thus provide useful information for designing therapeutic agents for various diseases induced by TGF-beta, including advanced cancers...
  18. pmc Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
    M Asada
    Department of Virology, The National Children s Medical Research Center, 3 35 31, Taishido, Setagaya Ku, Tokyo, 154, Japan
    EMBO J 18:1223-34. 1999
    ..Our findings highlight the different functional roles of p21(Cip1/WAF1), which are determined by its intracellular distribution and are dependent on the stage of differentiation...
  19. pmc TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
    K Horiguchi
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncogene 31:3190-201. 2012
    ..Therefore, δEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-β-induced EMT and the progression of breast cancers...
  20. pmc Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    M Saitoh
    Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    EMBO J 17:2596-606. 1998
    ..The evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine- and stress-induced apoptosis...
  21. ncbi Targets of transcriptional regulation by transforming growth factor-beta: expression profile analysis using oligonucleotide arrays
    S Akiyoshi
    Department of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research (JFCR, and Research for the Future Program, the Japan Society for the Promotion of Science, Toshima-ku, Tokyo 170-8455, Japan
    Jpn J Cancer Res 92:257-68. 2001
    ..Taken together, the results suggest that TGF-beta may suppress tumorigenesis through positive and negative regulation of transcription...
  22. ncbi Signal transduction of the TGF-beta superfamily by Smad proteins
    M Kawabata
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research JFCR, Toshima ku, Tokyo 170 8455, Japan
    J Biochem 125:9-16. 1999
    ..R-Smads interact with transcriptional coactivators, and have intrinsic transactivation activity. Elucidation of the functions of Smads will provide the framework for research on TGF-beta superfamily signaling...
  23. ncbi Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation
    T Ebisawa
    Department of Biochemistry, The Cancer Institute of JFCR, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima ku, Tokyo 170 8455, Japan
    J Cell Sci 112:3519-27. 1999
    ..These findings indicate that in the process of differentiation to osteoblasts, BMP-6 binds to ALK-2 as well as other type I receptors, and transduces signals mainly through Smad5 and possibly through Smad1...
  24. ncbi Interaction of Drosophila inhibitors of apoptosis with thick veins, a type I serine/threonine kinase receptor for decapentaplegic
    E Oeda
    Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research and Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 273:9353-6. 1998
    ..These data suggest that DIAP1 and DIAP2 may be involved, possibly as negative regulators, in the Dpp signaling pathway, which leads to cell apoptosis...
  25. ncbi Signal transduction by bone morphogenetic proteins
    M Kawabata
    Department of Biochemistry, The Cancer Institute, Tokyo, Japan
    Cytokine Growth Factor Rev 9:49-61. 1998
    ..In Drosophila melanogaster, Decapentaplegic (Dpp) is a homologue of mammalian BMPs. In this review, mechanism of action of Dpp will be discussed in comparison with that of BMPs...
  26. ncbi Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins
    K Miyazono
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, Japan Society for the Promotion of Science, Tokyo
    Bone 25:91-3. 1999
    ..Anti-Smads are induced by ligand stimulation, suggesting that they constitute a negative feedback loop in the signal transduction pathways of the TGF-beta superfamily...
  27. pmc Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons
    T Kanamoto
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    Mol Cell Biol 20:196-204. 2000
    ..Taken together, these results demonstrate that ASK1 is a crucial element of NGF withdrawal-induced activation of the Cdc42-c-Jun pathway and neuronal apoptosis...
  28. doi Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells
    S Ehata
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Oncogene 30:1693-705. 2011
    ..SP cells are thus responsible for the progression of diffuse-type gastric carcinoma, and TGF-β negatively contributes to maintain the CICs within the cancer...
  29. ncbi Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases
    M Saitoh
    Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research and Research for the Future Program, Tokyo
    Biochem Biophys Res Commun 253:470-6. 1998
    ..These findings suggest that p70(S6Kbeta) is an isoform of p70(S6K) with similar regulatory mechanisms...
  30. ncbi Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
    K Yagi
    Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Biol Chem 274:703-9. 1999
    ..These results suggest that exon 3 of Smad2 interferes with the direct DNA binding of Smad2, and modifies the function of Smad2 in transcription of certain target genes...
  31. ncbi BMP type II receptor is required for gastrulation and early development of mouse embryos
    H Beppu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
    Dev Biol 221:249-58. 2000
    ..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development...
  32. ncbi TGF-beta/SMAD signaling and its involvement in tumor progression
    K Miyazono
    Department of Biochemistry, The Center Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Biol Pharm Bull 23:1125-30. 2000
    ..Perturbation of the TGF-beta/SMAD signaling pathway may result in progression of tumors through resistance of the cells to the growth inhibition induced by TGF-beta...
  33. ncbi Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells
    N Fukuda
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Oncogene 25:3509-17. 2006
    ....
  34. doi Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway
    Y Katsuno
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan
    Oncogene 27:6322-33. 2008
    ..These results suggest that BMPs as well as TGF-beta promote invasion and bone metastasis of breast cancer...
  35. doi TGF-β-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20
    K C Kawabata
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncogene 32:2096-106. 2013
    ..Our findings suggest that the sensitivity of B-cell lymphoma cells to rituximab may be affected by TGF-β signaling...
  36. ncbi Positive and negative regulation of TGF-beta signaling
    K Miyazono
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, and Research for the Future Program, the Japan Society for the Promotion of Science, Toshima ku, Tokyo 170 8455, Japan
    J Cell Sci 113:1101-9. 2000
    ..Regulation of TGF-beta signaling might be tightly linked to tumor progression, since TGF-beta is a potent growth inhibitor in most cell types...
  37. ncbi Transforming growth factor-beta up-regulates CD40-engaged IL-12 production of mouse Langerhans cells
    Y Tada
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    Eur J Immunol 31:294-300. 2001
    ....
  38. ncbi Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1
    K Tobiume
    Department of Biochemistry, Japanese Foundation for Cancer Research, Tokyo
    Biochem Biophys Res Commun 239:905-10. 1997
    ....
  39. ncbi Smad6 inhibits signalling by the TGF-beta superfamily
    T Imamura
    Department of Biochemistry, The Cancer Institute, Tokyo, Japan
    Nature 389:622-6. 1997
    ..These data indicate that signals of the TGF-beta superfamily are regulated both positively and negatively by members of the SMAD family...
  40. ncbi Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
    H Yamashita
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:1995-2001. 1994
    ..These results revealed that endoglin is a phosphorylated protein which forms a heteromeric complex with signaling receptors for TGF-beta...
  41. pmc Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
    S Miura
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Aoba ku, Japan
    Mol Cell Biol 20:9346-55. 2000
    ..5. Mutant cells showed significantly decreased responses to stimulation with activin and TGF-beta. These findings suggest that the two FYVE domain proteins, Hgs and SARA, are prerequisites for receptor-mediated activation of Smad2...
  42. ncbi Smad-mediated transcription is required for transforming growth factor-beta 1-induced p57(Kip2) proteolysis in osteoblastic cells
    S Nishimori
    Department of Molecular Oncology, and the Department of Tumor Biochemistry, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan
    J Biol Chem 276:10700-5. 2001
    ..These results indicate that accelerated degradation of p57(Kip2) by TGF-beta1/Smad signaling is mediated through a newly synthesized factor(s) that modifies p57(Kip2) or the ubiquitin-proteasome pathway...
  43. ncbi Negative regulation of BMP/Smad signaling by Tob in osteoblasts
    Y Yoshida
    Department of Oncology, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cell 103:1085-97. 2000
    ..The results indicate that Tob negatively regulates osteoblast proliferation and differentiation by suppressing the activity of the receptor-regulated Smad proteins...
  44. ncbi A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation
    M Kondo
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Death Differ 11:1092-101. 2004
    ....
  45. ncbi Focal adhesion kinase activity is required for bone morphogenetic protein--Smad1 signaling and osteoblastic differentiation in murine MC3T3-E1 cells
    Y Tamura
    Department of Medicine, University of Tokyo School of Medicine, Japan
    J Bone Miner Res 16:1772-9. 2001
    ..These observations suggest that FAK activity is essential for BMP-Smad signaling to stimulate osteoblastic differentiation...
  46. ncbi Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A
    J Esparza-Lopez
    , , UNAM Apartado Postal 70-246, , 04510,
    J Biol Chem 276:14588-96. 2001
    ..All together, the present results suggest that betaglycan ectodomain is endowed with two bona fide independent ligand binding domains that can perform specialized functions as co-receptors of distinct members of the TGF-beta superfamily...
  47. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  48. pmc BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
    K Nakashima
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Proc Natl Acad Sci U S A 98:5868-73. 2001
    ....
  49. ncbi Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha
    M Kawabata
    Vanderbilt Cancer Center, Nashville, Tennessee 37232 6838, USA
    J Biol Chem 270:29628-31. 1995
    ..These results suggest that FT alpha may be one of the substrates of the activated T beta R-I kinase...
  50. ncbi Transforming growth factor-beta/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells
    H Kanai
    Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Circ Res 88:30-6. 2001
    ..These data indicate that CARP is a downstream target of TGF-beta/Smad signaling in VSMCs and suggest a role of CARP in mediation of the inhibitory effects of TGF-beta on the proliferation of VSMCs...
  51. ncbi Activation of the p21(CIP1/WAF1) promoter by bone morphogenetic protein-2 in mouse B lineage cells
    K Yamato
    Section of Molecular Cellular Oncology and Microbiology, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
    Oncogene 20:4383-92. 2001
    ..These results suggested that BMP-2 might activate p21(CIP1/WAF1) transcription by inducing a binding of Smad4 and Smad1 to the 29-b region in HS-72 cells...
  52. ncbi Cross-talk between IL-6 and TGF-beta signaling in hepatoma cells
    T Yamamoto
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    FEBS Lett 492:247-53. 2001
    ..These results demonstrate a molecular mechanism of a cross-talk between STAT3 and TGF-beta signaling pathways in hepatocytes...
  53. ncbi Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
    Y Saijoh
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 5:35-47. 2000
    ..These results suggest that the asymmetric expression of lefty2 and nodal is induced by a left side-specific TGF beta-related factor, which is most likely Nodal itself...
  54. ncbi Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
    P ten Dijke
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Uppsala, S 751 24, Sweden
    Curr Opin Cell Biol 8:139-45. 1996
    ..Recent genetic analyses of Drosophila also indicate a strict requirement for both type I and type II receptors in decapentaplegic signaling in vivo...
  55. pmc Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours
    N Yamada
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Br J Cancer 73:624-9. 1996
    ..These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma...
  56. ncbi Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta
    M Saitoh
    Department of Oral Pathology, Tokyo Medical and Dental University, Japan
    J Biol Chem 271:2769-75. 1996
    ..These observations indicate that serine 172 and threonine 176 of T beta R-I are dispensable for extracellular matrix protein production but essential to the growth inhibition by TGF-beta...
  57. ncbi Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix
    A Olofsson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 270:31294-7. 1995
    ..These results suggest that the different splice forms of LTBP-1 mediate different localization patterns of the latent TGF-beta complexes in vivo...
  58. ncbi Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
    P Franzen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Cell 75:681-92. 1993
    ..These results suggest that signal transduction by TGF beta involves the formation of a heteromeric complex of two different serine/threonine kinase receptors...
  59. ncbi Characterization of type I receptors for transforming growth factor-beta and activin
    P ten Dijke
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Science 264:101-4. 1994
    ....
  60. ncbi Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
    P ten Dijke
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:16985-8. 1994
    ..These results suggest that ALK-3 and ALK-6 are type I receptors for OP-1 and BMP-4; in addition, ALK-2 is a type I receptor shared by activin and OP-1, but not by BMP-4...
  61. ncbi Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein
    A Moren
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:32469-78. 1994
    ..The LTBP-2 gene was assigned to chromosome 14q24. These results indicate that different forms of latent TGF-beta complexes occur and suggest that the different associated proteins may function to target the complexes to specific sites...
  62. ncbi Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains
    H Ichijo
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    J Biol Chem 268:14505-13. 1993
    ..On the other hand, ficolin-beta was mainly expressed in skeletal muscle. The in vivo functions of ficolin will be discussed...
  63. ncbi Localization of transforming growth factor-beta type I and type II receptors in mouse development
    S Iseki
    Department of Oral Pathology, Tokushima University School of Dentistry, Japan
    Exp Cell Res 219:339-47. 1995
    ....
  64. pmc Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein
    S L Dallas
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7877, USA
    J Cell Biol 131:539-49. 1995
    ....
  65. ncbi A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner
    M Kato
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 270:12373-9. 1995
    ....
  66. pmc Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses
    S Souchelnytskyi
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    EMBO J 15:6231-40. 1996
    ..Mutations of Ser165 changed the phosphorylation pattern of TbetaR-I. These observations suggest that TGF-beta receptor signaling specificity is modulated by phosphorylation of Ser165 of TbetaR-I...
  67. pmc Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart
    Y Nakajima
    Department of Anatomy, Saitama Medical School, Japan
    J Cell Biol 136:193-204. 1997
    ..These results suggest that LTBP-1 exists as an extracellular fibrillar structure and plays a role in the storage of TGF beta as a large latent TGF beta complex...
  68. pmc Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    A Nakao
    Department of Medicine II, Chiba University, School of Medicine, Chiba 260 0856, Japan
    J Clin Invest 104:5-11. 1999
    ..These data indicated that gene transfer of Smad7 (but not Smad6) prevented bleomycin-induced lung fibrosis, suggesting that Smad7 may have applicability in the treatment of pulmonary fibrosis...
  69. ncbi Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals
    P Das
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854 8020, USA
    Genes Cells 4:123-34. 1999
    ....
  70. ncbi Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins
    Y Yanagi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0034, Japan
    J Biol Chem 274:12971-4. 1999
    ....
  71. ncbi Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
    K Nakashima
    Department of Molecular Cell Biology, Cell Fate Modulation Research Unit, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Science 284:479-82. 1999
    ..The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors...
  72. ncbi Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
    J Yanagisawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Science 283:1317-21. 1999
    ..Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways...
  73. ncbi Immunolocalization of latent transforming growth factor-beta binding protein-1 (LTBP1) during mouse development: possible roles in epithelial and mesenchymal cytodifferentiation
    Y Nakajima
    Department of Anatomy, Saitama Medical School, 38 Morohongo, Moroyama cho, Iruma gun, Saitama, 350 0495, Japan
    Cell Tissue Res 295:257-67. 1999
    ....
  74. ncbi HNPCC associated with germline mutation in the TGF-beta type II receptor gene
    S L Lu
    Nat Genet 19:17-8. 1998
  75. ncbi Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway
    S Takenoshita
    First Department of Surgery, Gunma University School of Medicine, Japan
    Genomics 48:1-11. 1998
    ..These data will be valuable for studying the MADH2 function in both normal cells and cancer cells...
  76. ncbi Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors
    E Roijer
    Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Mamm Genome 9:266-8. 1998
  77. ncbi TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    Nature 390:465-71. 1997
    ..Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs...
  78. pmc TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
    A Nakao
    Ludwig Institute for Cancer Research, Box 595, S 751 24 Uppsala, Sweden
    EMBO J 16:5353-62. 1997
    ..These data suggest that TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction...
  79. pmc Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160
    A Olofsson
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 751 24 Uppsala, Sweden
    Biochem J 324:427-34. 1997
    ....
  80. ncbi Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors
    A Moren
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Biochem Biophys Res Commun 189:356-62. 1992
    ..In addition, two portions with 29 and 52 amino acids in the extracellular domain were found to be substantially similar with human endoglin...