N Hiki

Summary

Affiliation: Cancer Institute Hospital
Country: Japan

Publications

  1. doi request reprint Function-preserving gastrectomy for early gastric cancer
    Naoki Hiki
    Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan
    Ann Surg Oncol 20:2683-92. 2013
  2. doi request reprint A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Jpn J Clin Oncol 42:459-62. 2012
  3. doi request reprint Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Dig Endosc 24:79-86. 2012
  4. doi request reprint A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-menthol in upper gastrointestinal endoscopy
    N Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Clin Pharmacol Ther 90:221-8. 2011
  5. ncbi request reprint Manipulation of the small intestine as a cause of the increased inflammatory response after open compared with laparoscopic surgery
    N Hiki
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Br J Surg 93:195-204. 2006
  6. ncbi request reprint Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection
    N Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Surg Endosc 22:1729-35. 2008
  7. doi request reprint Increased fat content and body shape have little effect on the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for gastric cancer
    Naoki Hiki
    Gastroenterological Center, Department Gastroenterological Surgery, Cancer Institute Ariake Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake Koto ku, Tokyo, 135 8550, Japan
    J Gastrointest Surg 13:626-33. 2009
  8. ncbi request reprint Laparoscopy-assisted pylorus-preserving gastrectomy with quality controlled lymph node dissection in gastric cancer operation
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute, Ariake Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Am Coll Surg 203:162-9. 2006
  9. doi request reprint The benefits of standardizing the operative procedure for the assistant in laparoscopy-assisted gastrectomy for gastric cancer
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Tokyo, Japan
    Langenbecks Arch Surg 393:963-71. 2008
  10. ncbi request reprint Pylorus-preserving gastrectomy in gastric cancer surgery--open and laparoscopic approaches
    Naoki Hiki
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Langenbecks Arch Surg 390:442-7. 2005

Detail Information

Publications67

  1. doi request reprint Function-preserving gastrectomy for early gastric cancer
    Naoki Hiki
    Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan
    Ann Surg Oncol 20:2683-92. 2013
    ..Although many retrospective studies showed the functional benefit or oncological safety of function-preserving gastrectomy, further prospective studies using large case series are necessary. ..
  2. doi request reprint A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Jpn J Clin Oncol 42:459-62. 2012
    ....
  3. doi request reprint Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Dig Endosc 24:79-86. 2012
    ....
  4. doi request reprint A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-menthol in upper gastrointestinal endoscopy
    N Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Clin Pharmacol Ther 90:221-8. 2011
    ..The findings from this study provide new data on the safety and PK of NPO-11 and support further trials...
  5. ncbi request reprint Manipulation of the small intestine as a cause of the increased inflammatory response after open compared with laparoscopic surgery
    N Hiki
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Br J Surg 93:195-204. 2006
    ..The aim of this study was to assess manual handling of the gut in open procedures as the principal cause of the enhanced immune response...
  6. ncbi request reprint Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection
    N Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Surg Endosc 22:1729-35. 2008
    ..This study aimed to introduce a laparoscopic and endoscopic cooperative surgery (LECS) for gastric wedge resection that is applicable for submucosal tumor resection independent of tumor location and size...
  7. doi request reprint Increased fat content and body shape have little effect on the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for gastric cancer
    Naoki Hiki
    Gastroenterological Center, Department Gastroenterological Surgery, Cancer Institute Ariake Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake Koto ku, Tokyo, 135 8550, Japan
    J Gastrointest Surg 13:626-33. 2009
    ..The present study examined the effect of increasing fat content on surgical outcomes, including estimated blood loss and the number of lymph nodes retrieved during gastrectomy...
  8. ncbi request reprint Laparoscopy-assisted pylorus-preserving gastrectomy with quality controlled lymph node dissection in gastric cancer operation
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute, Ariake Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Am Coll Surg 203:162-9. 2006
    ..Pylorus-preserving gastrectomy (PPG) with extensive lymph node dissection is useful for treatment of early gastric cancer with preservation of function. This technique could be improved by using laparoscopy-assisted gastrectomy...
  9. doi request reprint The benefits of standardizing the operative procedure for the assistant in laparoscopy-assisted gastrectomy for gastric cancer
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Tokyo, Japan
    Langenbecks Arch Surg 393:963-71. 2008
    ..In addition to the proficiency of the operator, other factors could potentially be optimized to improve postoperative outcomes. The aim of this study was to evaluate a standardized operative procedure for assistants performing LADG...
  10. ncbi request reprint Pylorus-preserving gastrectomy in gastric cancer surgery--open and laparoscopic approaches
    Naoki Hiki
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Langenbecks Arch Surg 390:442-7. 2005
    ..The aim of this article is to describe procedures for PPG. The technique of laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) is also introduced because PPG is an ideal application for laparoscopic surgery...
  11. doi request reprint An effective duodenum bulb mobilization for extracorporeal Billroth I anastomosis of laparoscopic gastrectomy
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    J Gastrointest Surg 13:230-5. 2009
    ..The aim of this study was to evaluate the feasibility of circular-stapled B-I reconstruction for laparoscopy-assisted distal gastrectomy (LADG) with effective duodenal mobilization...
  12. doi request reprint An open-label, single-arm study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Gastroenterol 46:873-82. 2011
    ..The aim of the study reported here was to determine whether the anti-peristaltic effect of an L: -menthol preparation facilitates endoscopic examinations in a clinical setting...
  13. pmc Changes in endotoxin-binding proteins during major elective surgery: important role for soluble CD14 in regulation of biological activity of systemic endotoxin
    N Hiki
    Department of Surgery, The University of Tokyo, Tokyo, Japan
    Clin Diagn Lab Immunol 6:844-50. 1999
    ..This study demonstrated the role of sCD14 on the bioactivity of circulating endotoxin in a human model of endotoxemia after major abdominal surgery...
  14. doi request reprint Proximal margin length with transhiatal gastrectomy for Siewert type II and III adenocarcinomas of the oesophagogastric junction
    S Mine
    Department of Gastroenterological Surgery, Cancer Institute Hospital, 3 8 31, Ariake, Koto ku, Tokyo, 135 8550, Japan
    Br J Surg 100:1050-4. 2013
    ..This study investigated whether a shorter proximal margin might suffice in the context of total gastrectomy for Siewert type II and III tumours...
  15. doi request reprint Can immune-enhancing nutrients reduce postoperative complications in patients undergoing esophageal surgery?
    T Fukuda
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan
    Dis Esophagus 21:708-11. 2008
    ..These results suggest that preoperative administration of IEN in patients undergoing esophagectomy reduces infectious complications, mainly pneumonia, and shortens postoperative hospitalization...
  16. ncbi request reprint Learning curve of laparoscopy-assisted gastrectomy using a standardized surgical technique and an established educational system
    M Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan
    Scand J Surg 100:86-91. 2011
    ..The learning curve of a trainee for laparoscopy-assisted gastrectomy in a high volume center, in which an educational system and a standardized laparoscopic procedure are already established, remains unclear...
  17. pmc Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer
    X Jiang
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo 135 8550, Japan
    Br J Cancer 107:275-9. 2012
    ..The inflammation-based Glasgow prognostic score (GPS) has been shown to be a prognostic factor for a variety of tumours. This study investigates the significance of the modified GPS (mGPS) for the prognosis of patients with gastric cancer...
  18. doi request reprint Lymphadenectomy around the left renal vein in Siewert type II adenocarcinoma of the oesophagogastric junction
    S Mine
    Department of Gastroenterological Surgery, Cancer Institute Hospital, 3 8 31, Ariake, Koto ku, Tokyo, 135 8550, Japan
    Br J Surg 100:261-6. 2013
    ..The extent of lymphadenectomy in patients with Siewert type II adenocarcinoma of the oesophagogastric junction is controversial. The aim of this study was to investigate lymph node involvement around the left renal vein...
  19. doi request reprint Effect of individual fat areas on early surgical outcomes after open gastrectomy for gastric cancer
    M Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Br J Surg 96:496-500. 2009
    ..Body mass index (BMI) is widely accepted as an indicator of obesity, but does not necessarily reflect the distribution of fat. It is unclear how different types of fat may affect the operative procedure and outcome...
  20. doi request reprint Laparoscopy-assisted gastrectomy in patients with previous endoscopic resection for early gastric cancer
    X Jiang
    Department of Gastroenterological Surgery, Gastroenterological Centre, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Br J Surg 98:385-90. 2011
    ..Some patients undergoing endoscopic resection for early gastric cancer need further surgical treatment to achieve cure. However, the influence of endoscopic resection on subsequent laparoscopy-assisted gastrectomy (LAG) remains unclear...
  21. ncbi request reprint Laparoscopic esophagogastric circular stapled anastomosis: a modified technique to protect the esophagus
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Gastric Cancer 10:181-6. 2007
    ..This modified procedure of laparoscopic esophagogastric anastomosis after proximal gastrectomy for the resection of cancer is a simple, rapid, and atraumatic technique which reduces the risk of anastomotic insufficiency...
  22. doi request reprint Does age matter in the indication for laparoscopy-assisted gastrectomy?
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Gastrointest Surg 12:1502-7. 2008
    ..Laparoscopy-assisted gastrectomy (LAG) is being increasingly performed in Japan. However, the indication of LAG in elderly patients who usually have preoperative morbidities and reduced functional capacities still remains unclear...
  23. doi request reprint Celiac lymph nodes: distant or regional for thoracic esophageal carcinoma?
    Y Seto
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan
    Dis Esophagus 21:704-7. 2008
    ..Revision of the TNM classification to account for celiac node involvement in thoracic esophageal carcinoma, especially of the middle and lower portions, is needed...
  24. doi request reprint Laparoscopy-assisted distal gastrectomy with D2 lymph node dissection following standardization--a preliminary study
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    J Gastrointest Surg 13:1058-63. 2009
    ..Laparoscopy-assisted distal gastrectomy (LADG) with standard D2 dissection is a complex procedure usually performed only by experienced surgeons, and the feasibility of this procedure still remains unclear...
  25. doi request reprint Therapeutic value of lymph node dissection in advanced gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node dissection beneficial?
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Ann Surg Oncol 16:1241-6. 2009
    ..The therapeutic value of lymph node dissection in this area for AGC with macroscopic duodenum invasion remains unclear...
  26. doi request reprint Better prognosis of T2 gastric cancer with preoperative diagnosis of early gastric cancer
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Ann Surg Oncol 16:1514-9. 2009
    ..The aim of the present study was to clarify the clinicopathological characteristics and feasibility of limited lymph node dissection in patients with clinically early, but pathologically advanced, gastric cancer...
  27. doi request reprint Two rare cases of node-positive differentiated gastric cancer despite their infiltration to sm1, their small size, and lack of lymphatic invasion into the submucosal layer
    Hideki Nagano
    Department of Surgery, Cancer Institute Hospital of JFCR, Tokyo, Japan
    Gastric Cancer 11:53-7; discussion 57-8. 2008
    ..Curative surgery with lymph node dissection is thus required in patients with wide infiltration of the submucosal layer or lymphatic invasion in the muscularis mucosa...
  28. ncbi request reprint Survival benefits of pancreatoduodenectomy for gastric cancer: relationship to the number of lymph node metastases
    Souya Nunobe
    Department of Surgery, Cancer Institute Hospital, 10 6 Ariake 3 chome, Koto ku, Tokyo, 135 8550, Japan
    Langenbecks Arch Surg 393:157-62. 2008
    ..Pancreatoduodenectomy (PD) for advanced gastric cancer is rarely performed because of the high frequency of associated morbidity and mortality. The aim of this study was to determine the limited indication of PD for advanced gastric cancer...
  29. doi request reprint Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703)
    Hitoshi Katai
    National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Gastric Cancer 13:238-44. 2010
    ..We conducted a multi-institutional phase II trial to evaluate the safety of LADG with nodal dissection for clinical stage I gastric cancer patients...
  30. ncbi request reprint Pathophysiological relevance of the CD14 receptor in surgical patients: biological activity of endotoxin is regulated by the CD14 receptor
    N Hiki
    Department of Surgery, University of Tokyo, Tokyo, Japan
    J Endotoxin Res 7:461-6. 2001
    ..In this article, we outline: (i) the biological activity of circulating endotoxin; and (ii) the role of membrane and/or soluble CD14 regulating the bioactivity of circulating endotoxin in a human model of postoperative endotoxemia...
  31. ncbi request reprint A seasonal variation in the onset of postoperative adhesive small bowel obstruction is related to changes in the climate
    N Hiki
    Department of Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyou ku, Tokyo 113 8655, Japan
    Dig Liver Dis 36:125-9. 2004
    ..However, little is known about the influence of climate on the incidence of postoperative small bowel obstruction...
  32. doi request reprint Left-sided approach for suprapancreatic lymph node dissection in laparoscopy-assisted distal gastrectomy without duodenal transection
    Tetsu Fukunaga
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Gastric Cancer 12:106-12. 2009
    ..6%) and no mortality. The aim of the present study was to describe the surgical technique of our new approach for LADG with extended lymph node dissection and to evaluate the treatment outcomes achieved by this technique...
  33. ncbi request reprint Laparoscopic rectal resection for primary rectal cancer combined with open upper major abdominal surgery: initial experience
    Takashi Akiyoshi
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan
    Hepatogastroenterology 56:571-4. 2009
    ..Whether a laparoscopic approach for rectal cancer is safe and beneficial remains unknown when simultaneous open upper major abdominal surgery is planned...
  34. doi request reprint Increased risk of lymph node metastasis in mucosal gastric cancer with extra indication for endoscopic mucosal resection
    Kozo Yoshikawa
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Am Coll Surg 208:1045-50. 2009
    ..Laparoscopy-assisted gastrectomy is usually indicated for the surgical treatment of mucosal gastric cancer...
  35. ncbi request reprint Laparoscopy-assisted pylorus-preserving gastrectomy: preservation of vagus nerve and infrapyloric blood flow induces less stasis
    Souya Nunobe
    Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
    World J Surg 31:2335-40. 2007
    ..This study aimed to establish a stasis-less PPG procedure with preservation of the vagal nerve and blood flow to the pyloric cuff, and to apply the technique for laparoscopy-assisted PPG...
  36. ncbi request reprint Release of endotoxin-binding proteins during major elective surgery: role of soluble CD14 in phagocytic activation
    N Hiki
    Department of Surgery, University of Tokyo, Japan
    World J Surg 24:499-506. 2000
    ..The increased plasma level of sCD14 may be explained by the parallel-enhanced sCD14 PBMC production. Activated secretion of these endotoxin-binding proteins may play a role in regulating the biologic activity of circulating endotoxin...
  37. doi request reprint Benefit of mediastinal and para-aortic lymph-node dissection for advanced gastric cancer with esophageal invasion
    Souya Nunobe
    Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, Tokyo, Japan
    J Surg Oncol 97:392-5. 2008
    ..This study examined the significance of inferior mediastinal lymph-node (IM) and para-aortic lymph-node (PA) dissection for this type of cancer...
  38. doi request reprint Survival benefit of pylorus-preserving gastrectomy in early gastric cancer
    Naoki Hiki
    Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Am Coll Surg 209:297-301. 2009
    ..The aim of this study was to investigate longterm survival for patients having PPG with extensive lymph node dissection, except for the suprapyloric nodes, for early gastric cancer...
  39. doi request reprint Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter
    Yorimasa Yamamoto
    Department of Gastroenterology, Cancer Institute Hospital, Tokyo
    Dig Endosc 22:112-8. 2010
    ..The aim of the present study was to examine therapeutic outcomes of endoscopic submucosal dissection (ESD) of undifferentiated-type intramucosal gastric cancer and the problems of diagnosis...
  40. doi request reprint Investigation of the lymphatic stream of the stomach in gastric cancer with solitary lymph node metastasis
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    World J Surg 33:1235-9. 2009
    ..Understanding the lymphatic drainage route in gastric cancer is crucial for complete lymph node retrieval from sites susceptible to metastasis. However, the lymphatic stream of the stomach is complex and remains incompletely characterized...
  41. doi request reprint Endoscopic evaluation of reflux esophagitis after proximal gastrectomy: comparison between esophagogastric anastomosis and jejunal interposition
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    World J Surg 32:1473-7. 2008
    ..To date, only a few reports have compared the methods of reconstruction performed after proximal gastrectomy, and the method most likely to prevent postoperative reflux esophagitis remains undetermined...
  42. ncbi request reprint Nutritional comparisons between a pylorus-preserving gastrectomy with and without suprapyloric lymph node clearance: a preliminary report
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:2401-5. 2007
    ....
  43. doi request reprint Quality control and educational value of laparoscopy-assisted gastrectomy in a high-volume center
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Surg Endosc 23:289-95. 2009
    ..As this is a relatively new technique, a training system is important, however there has been little discussion about an educational system for teaching trainees to perform LAG and the ideal training system has not yet been established...
  44. ncbi request reprint Advanced gastric cancer with a duplicated hepatic artery: preoperative diagnostic value of multidetector-row computed tomography for surgical resection
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Gastric Cancer 10:191-5. 2007
    ..We consider that multidetector-row computed tomography is very useful for the diagnosis of vascular anomaly, preoperative staging and decision making on the appropriate surgical strategy...
  45. doi request reprint Pancreatogram findings for carcinoma in situ (CIS) of the pancreas seen on endoscopic retrograde cholangiopancreatography and postoperative pancreatography of resected specimens: can CIS be diagnosed preoperatively?
    Makoto Seki
    Department of Surgery, Cancer Institute of the JFCR, Tokyo, Japan
    Pancreatology 8:142-52. 2008
    ..In addition, 7 of 79 invasive ductal carcinomata (IDC) of the pancreas were accompanied by CIS > or =2 cm long. A total of 11 patients were reviewed here for pancreatographic findings for CIS of the pancreas...
  46. ncbi request reprint Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model
    K Asai
    Department of Surgery, University of Tokyo, 3-28-6 Mejirodai Bunkyo-ku, Tokyo, Japan, 112-8688
    Shock 16:340-3. 2001
    ..In this PBMCs model of sepsis, only the supernatant IL-10 level was significantly lower in males. These ex vivo findings may partially explain the mechanism underlying the poorer outcome of male sepsis patients...
  47. doi request reprint Effects of reconstruction methods on a patient's quality of life after a proximal gastrectomy: subjective symptoms evaluation using questionnaire survey
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Langenbecks Arch Surg 394:637-41. 2009
    ..Esophagogastrostomy (EG) and jejunum interposition (JI) are often selected as reconstruction methods, although the more appropriate method of the two is unknown...
  48. doi request reprint Can superextended lymph node dissection be justified for gastric cancer with pathologically positive para-aortic lymph nodes?
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Ann Surg Oncol 17:2031-6. 2010
    ..However, the value of curative resection in patients with pathologically positive PALN is not determined yet...
  49. doi request reprint Laparoscopic surgery for synchronous gastric and colorectal cancer: a preliminary experience
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Langenbecks Arch Surg 395:207-10. 2010
    ..Increasingly, laparoscopy-assisted gastrectomy and laparoscopy-assisted colorectal surgery are being performed. However, simultaneous laparoscopic surgery for synchronous gastric and colorectal cancer is rare and its feasibility unknown...
  50. doi request reprint A clinicopathological study of gastric stump carcinoma following proximal gastrectomy
    Shigekazu Ohyama
    Department of Surgery, Cancer Institute Hospital of JFCR, 3 10 6 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Gastric Cancer 12:88-94. 2009
    ..We aimed to clarify the frequency and clinicopathological characteristics of gastric stump carcinoma following proximal gastrectomy...
  51. doi request reprint Better 5-year survival rate following curative gastrectomy in overweight patients
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Ann Surg Oncol 16:3245-51. 2009
    ..Although the adverse effects of higher body mass index (BMI) on early surgical outcomes are known, the relationship between BMI and long-term outcome is unclear...
  52. doi request reprint Previous laparotomy is not a contraindication to laparoscopy-assisted gastrectomy for early gastric cancer
    Souya Nunobe
    Department of Surgery, Cancer Institute Hospital, 10 6 Ariake 3 chome, Koto ku, Tokyo 135 8550, Japan
    World J Surg 32:1466-72. 2008
    ..The aim of the present study was to estimate whether LAG is contraindicated for the patient with a history of laparotomy (PSURG)...
  53. doi request reprint Twenty-two metachronous multiple signet-ring cell carcinomas treated with repeated gastrectomies and repeated endoscopic mucosal resections: report of a case
    Masanori Tokunaga
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Surg Today 39:430-3. 2009
    ..A thorough preoperative examination and regular postoperative follow-up are therefore essential for detecting multiple gastric cancers in their early stages...
  54. ncbi request reprint Quantitative detection of micrometastases in the lymph nodes of gastric cancer patients with real-time RT-PCR: a comparative study with immunohistochemistry
    Keisuke Kubota
    Department of Gastrointestinal Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 105:136-43. 2003
    ..These results indicate that duplex quantitative real-time RT-PCR is the most sensitive method for detecting micrometastases and useful for evaluating the prognostic significance of lymph node micrometastasis in gastric cancer patients...
  55. ncbi request reprint [Influence of primary disease factors on outcome after resection of colorectal liver metastases?]
    Junji Yamamoto
    Cancer Institute Hospital, Gatroenterological Division, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 107:109-15. 2006
    ..In conclusion, influence of primary disease factors should be considered for deciding the indication of hepatectomy for colorectal liver metastases, especially when patients have synchronous lesions...
  56. ncbi request reprint Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography
    Natsuyo Yamamoto
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 21:1394-8. 2006
    ..The purpose of the present paper was therefore to investigate peppermint as an antispasmodic for ERCP...
  57. ncbi request reprint Incidence of gastric cancer in the remnant stomach after proximal gastrectomy
    Souya Nunobe
    Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
    Hepatogastroenterology 55:1855-8. 2008
    ..Gastric cancer in the remnant stomach after proximal gastrectomy has not been studied in detail. The aim of this study was to clarify the incidence of this type of cancer...
  58. ncbi request reprint Helicobacter pylori-negative / API2-MALT1 translocation-negative low-grade MALT lymphoma
    Koji Nozaki
    Department of Gastrointestinal Surgery, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Gastric Cancer 9:229-34. 2006
    ....
  59. ncbi request reprint Utility of [13C] urea breath test for Helicobacter pylori detection in partial gastrectomy patients
    Keisuke Kubota
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
    Dig Dis Sci 48:2135-8. 2003
    ..In the present protocol [13C] UBT appears to be a reliable and convenient tool with the same accuracy rate as other routine tests in patients with a remnant stomach...
  60. ncbi request reprint Efficacy of triple therapy plus cetraxate for the Helicobacter pylori eradication in partial gastrectomy patients
    Keisuke Kubota
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
    Dig Dis Sci 50:842-6. 2005
    ..024) but not in LEFT (P = 0.058). Adverse events that occurred in each group were almost all mild ones. Cetraxate plus LAC for 1 week is a safe and effective regime for the eradication of H. pylori in patients after partial gastrectomy...
  61. ncbi request reprint Performance of outpatient regimen of S-1 in combination with fractional cisplatin for advanced or recurrent gastric cancers: a phase I study
    Shouji Shimoyama
    Department of Gastrointestinal Surgery, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Int J Clin Oncol 10:251-5. 2005
    ....
  62. doi request reprint Reduced risk of peristomal infection of direct percutaneous endoscopic gastrostomy in cancer patients: comparison with the pull percutaneous endoscopic gastrostomy procedure
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan
    J Am Coll Surg 207:737-44. 2008
    ..A novel extracorporeal PEG technique, Direct-PEG, has been developed to reduce the risk of peristomal infection and implantation...
  63. ncbi request reprint [Reconstruction after total gastrectomy]
    Toshiharu Yamaguchi
    Cancer Institute, Ariake Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 109:261-3. 2008
    ..The most common reconstructive procedure after laparoscopic total gastrectomy is the Roux-Y, although the anastomotic procedure remains controversial...
  64. ncbi request reprint Cut-and-screw insertion: a method for safe and speedy secondary trocar insertion in laparoscopic surgery
    Naoki Hiki
    Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Surg Technol Int 17:121-5. 2008
    ..Our procedure is simple, rapid, and safe. In this chapter, we describe the technique and present our initial clinical results...
  65. ncbi request reprint [Successful downstaging by a low-dose, fractional administration of irinotecan hydrochloride (CPT-11) in combination with cisplatin in peritoneal lavage cytology positive, 5-fluorouracil refractory advanced gastric cancer patients]
    Shouji Shimoyama
    Dept of Gastrointestinal Surgery, University of Tokyo
    Gan To Kagaku Ryoho 31:929-32. 2004
    ..This suggests that this combination could be an effective regimen for potentially disseminated, 5-FU resistant patients...
  66. ncbi request reprint The induction of super-resistance using synthetic lipopolysaccharide receptor agonist rescues fatal endotoxemia in rats without excessive immunosuppression
    Fumihiko Hatao
    Department of Metabolic Care and Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Shock 23:365-70. 2005
    ..These results indicate that pretreatment with ER can effectively induce endotoxin tolerance, with a consequent improvement in mortality without toxicity and without subsequent excessive immunosuppression...
  67. ncbi request reprint Effect of imatinib mesylate in a patient with a metastatic gastrointestinal stromal tumor with a c-kit mutation in exon 11
    Keisuke Kubota
    Department of Surgery, The International University of Health and Welfare Mita Hospital, Mita, Tokyo, Japan
    Dig Dis Sci 52:1725-9. 2007