M Yoshida

Summary

Affiliation: Banyu Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint Multiple viral strategies of HTLV-1 for dysregulation of cell growth control
    M Yoshida
    Banyu Tsukuba Research Institute, Tsukuba, Ibaraki 300 2611, Japan
    Annu Rev Immunol 19:475-96. 2001
  2. ncbi request reprint HTLV type 1 Tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity
    M Yoshida
    Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    AIDS Res Hum Retroviruses 16:1639-45. 2000
  3. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
  4. ncbi request reprint Inhibitory effects of uterine endometrial carcinogenesis in Donryu rats by tamoxifen
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Cancer Lett 134:43-51. 1998
  5. ncbi request reprint Developmental expression of sarcoglycan gene products in cultured myocytes
    S Noguchi
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Biochem Biophys Res Commun 262:88-93. 1999
  6. doi request reprint Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 18:1227-34. 2010
  7. doi request reprint Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: a longitudinal cohort study
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Osteoporos Int 24:459-66. 2013
  8. doi request reprint Taste preferences and body weight change in Japanese adults: the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 33:1191-7. 2009
  9. pmc Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome
    A Tanimura
    Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Japan
    J Virol 72:3958-64. 1998
  10. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Multiple viral strategies of HTLV-1 for dysregulation of cell growth control
    M Yoshida
    Banyu Tsukuba Research Institute, Tsukuba, Ibaraki 300 2611, Japan
    Annu Rev Immunol 19:475-96. 2001
    ..This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis...
  2. ncbi request reprint HTLV type 1 Tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity
    M Yoshida
    Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    AIDS Res Hum Retroviruses 16:1639-45. 2000
    ..These results suggested that Tax has a novel potential to affect various cellular processes, such as transcription and maintenance of genomic stability, in which DNA topoisomerase I is involved...
  3. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
    ..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...
  4. ncbi request reprint Inhibitory effects of uterine endometrial carcinogenesis in Donryu rats by tamoxifen
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Cancer Lett 134:43-51. 1998
    ..These results indicated that TAM acts as an anti-estrogen on the adult rat uterus, inhibiting the development of endometrial adenocarcinomas initiated by ENNG...
  5. ncbi request reprint Developmental expression of sarcoglycan gene products in cultured myocytes
    S Noguchi
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Biochem Biophys Res Commun 262:88-93. 1999
    ..The discrepancy between the expression of the mRNAs and proteins of the sarcoglycan subunits in proliferating cells may be ascribed to rapid degradation of the protein...
  6. doi request reprint Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 18:1227-34. 2010
    ..However, there is little information on the impact of this disease on quality of life (QOL) in Japanese men and women. The objective of the present study was to clarify the impact of radiographic and symptomatic knee OA on QOL in Japan...
  7. doi request reprint Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: a longitudinal cohort study
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Osteoporos Int 24:459-66. 2013
    ..7 years). Slower walking speed was a risk factor for falls in men and women. Knee pain was a risk factor for falls in women...
  8. doi request reprint Taste preferences and body weight change in Japanese adults: the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 33:1191-7. 2009
    ..Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan...
  9. pmc Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome
    A Tanimura
    Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Japan
    J Virol 72:3958-64. 1998
    ..Consequently, it is probable that the LTR can be regulated by two independent signals through hGli2 and CREB, since the LTR contains the 21-bp and TRE2S sequences in the vicinity...
  10. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009
    ..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...
  11. doi request reprint Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: the ROAD study
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 20:712-8. 2012
    ....
  12. ncbi request reprint Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice
    K Araishi
    Division of Cell Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Hum Mol Genet 8:1589-98. 1999
    ....
  13. pmc A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins
    A Tanimura
    Department of Cellular and Molecular Biology, University of Tokyo, Japan
    J Virol 67:5375-82. 1993
    ..These results suggest that binding of THP to TRE-2S may be involved in cooperation with one copy of the 21-bp enhancer in responding to Tax trans activation...
  14. doi request reprint Validity of self-reported cancer among a Japanese population: recent results from a population-based prospective study in Japan (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol 35:250-3. 2011
    ..Self-reported diagnoses of cancer do not provide sufficient accuracy for the detection and classification of incident cancers. Our findings may be extrapolated to other Japanese populations...
  15. doi request reprint Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study
    S Muraki
    22nd Century Medical and Research Center, University of Tokyo, Tokyo 113 8655, Japan
    Ann Rheum Dis 68:1401-6. 2009
    ..The prevalence of radiographic lumbar spondylosis was investigated in a large-scale population study and the association with low back pain was examined...
  16. doi request reprint High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Nutr 140:779-85. 2010
    ..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...
  17. ncbi request reprint Isolation and characterization of the gene encoding mouse tax-responsive element-binding protein (TREB) 5
    T Masaki
    Department of Physiology, Toho University School of Medicine, Tokyo, Japan
    DNA Res 7:187-93. 2000
    ..Promoter analysis of serial deletion mutants revealed that the -142 bp upstream region is the minimum sequence to promote mouse TREB5 gene expression and that the -1.0 kb upstream region is required for full promoter activity...
  18. ncbi request reprint The fourth component of the sarcoglycan complex
    M Yoshida
    Department of Cell Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    FEBS Lett 403:143-8. 1997
    ..Therefore, we concluded that the DAP is the fourth component of the sarcoglycan complex...
  19. doi request reprint Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men: a nested case-control study
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Sci 101:2652-7. 2010
    ..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...
  20. doi request reprint Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1718-29. 2011
    ..Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel...
  21. pmc Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein
    S Dan
    Department of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108, Japan
    J Virol 73:3258-63. 1999
    ..The effective sizes of the spacer suggest that TRE2S in the LTR would cooperate with the second and third copies of the 21-bp sequence and contribute to trans activation of the viral gene transcription...
  22. ncbi request reprint A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe
    T Usui
    Department of Biotechnology, University of Tokyo, Japan
    Gene 161:93-6. 1995
    ..It is therefore unlikely that the function of pmd1+ is involved in MDR conferred by sks1+. These results suggest that sks1+ is a functionally novel MDR gene...
  23. ncbi request reprint From dystrophinopathy to sarcoglycanopathy: evolution of a concept of muscular dystrophy
    E Ozawa
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Muscle Nerve 21:421-38. 1998
    ..In this review, the evolution of the concept of sarcoglycanopathy separate from that of dystrophinopathy is explained by comparing studies on these diseases...
  24. ncbi request reprint A novel HSP70 gene of Schizosaccharomyces pombe that confers K-252a resistance
    T Usui
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    Gene 189:43-7. 1997
    ..These results suggest that the sks2+ gene product plays a role in the cell cycle progression and is able to confer drug resistance in a multicopy state...
  25. ncbi request reprint Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export
    M Yoshida
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    Ann N Y Acad Sci 886:23-36. 1999
    ..Using LMB, we identified a novel NES in fission yeast transcription factor Pap1, the function of which is abolished by oxidative stress in a manner conserved in eukaryotes...
  26. pmc Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I
    Y Yamanashi
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 86:6538-42. 1989
    ....
  27. pmc A unique enhancer element for the trans activator (p40tax) of human T-cell leukemia virus type I that is distinct from cyclic AMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements
    J Fujisawa
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    J Virol 63:3234-9. 1989
    ..These findings indicate that tax function and its cascade can modulate activities of various enhancer sequences, which are probably regulated by distinct DNA-binding factors...
  28. ncbi request reprint [Leptomycin: a specific inhibitor of protein nuclear export]
    M Yoshida
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    Tanpakushitsu Kakusan Koso 44:1379-88. 1999
  29. ncbi request reprint Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Cancer Lett 141:99-107. 1999
    ..These results suggest that FLU hepatocarcinogenicity in mice is dependent on hepatotoxic damage and consequently increased cell proliferation. Oxidative damage to DNA may also be a crucial factor...
  30. ncbi request reprint Cell-line specific activation of SV40 transcriptional enhancer by p40tax of HTLV-1
    J Fujisawa
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    Jpn J Cancer Res 79:800-4. 1988
    ..Thus, apparent activation by p40tax depends on variable cellular components involved in transcriptional regulation...
  31. ncbi request reprint Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition
    M Yoshida
    Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 94:348-52. 2001
    ..Cyclin E, the other regulator of cdk2 activity, was not influenced by gnidimacrin. These results suggest that gnidimacrin exerts antitumor activity through suppression of cdc25A and inhibition of cdk2 activity...
  32. doi request reprint Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee: the ROAD study (OAC5914R2)
    S Muraki
    Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 19:840-6. 2011
    ....
  33. pmc Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins
    M Hidaka
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    EMBO J 7:519-23. 1988
    ..These observations demonstrate that rex is a positive post-transcriptional regulator for gag, pol and env protein expression, and acts at the same time as an indirect negative regulator of viral transcription...
  34. pmc Identification of a novel Sry-related gene and its germ cell-specific expression
    E Osaki
    Department of Cellular and Molecular Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 27:2503-10. 1999
    ..Mapping analyses revealed that the Sox30 gene is located on human chromosome 5 (5q33) and on mouse chromosome 11...
  35. ncbi request reprint Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation
    T Suzuki
    Department of Cellular and Molecular Biology, University of Tokyo, Japan
    Oncogene 10:1199-207. 1995
    ..These Tax effects counteract the negative feedback control of NF-kappa B by I kappa B-alpha and contribute to constitutive activation of NF-kappa B in Tax-transfected and HTLV-1-infected cells...
  36. pmc The magnitude of variation in temperature within a year has an effect on the seasonal variations of chickenpox incidence in Japan
    A Kokaze
    Department of Public Health, Kyorin University School of Medicine, Mitaka-shi, Tokyo, Japan
    Epidemiol Infect 126:269-77. 2001
    ..This is the first article focusing on the close relationship between the second peak of epidemic pattern of chickenpox incidence and the variation of temperature within a year...
  37. ncbi request reprint Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA
    T Fujimoto
    Department of Cellular and Molecular Biology, University of Tokyo
    J Biochem 115:298-303. 1994
    ..Their excess expression by transfection induced suppression of cAMP-mediated activation of transcription, suggesting their negative regulation of CRE-mediated transcription...
  38. ncbi request reprint Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain
    Y Sakamoto
    Department of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Japan
    Oncogene 15:2001-12. 1997
    ..This in turn results in a decrease in WT1 transcriptional repression. Our findings provide the first evidence that the function of WT1 can be modulated by its phosphorylation in vivo...
  39. pmc Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain
    T Yoshimura
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    EMBO J 9:2537-42. 1990
    ..These structural features and DNA binding properties suggest that TREB proteins are members of a CREB protein family and that some of them (i.e., TREB7 and TREB36) may be involved in p40tax-mediated trans-activation...
  40. ncbi request reprint [Mechanism of transcriptional activation by HTLV-1 Tax]
    J Fujisawa
    Department of Cellular and Molecular Biology, University of Tokyo, Japan
    Hum Cell 6:266-72. 1993
    ..Therefore, Tax seems to modulate the transcription by the interaction with multiple transcription factors in different modes of control...
  41. ncbi request reprint A uterine choriocarcinoma in a virgin Donryu rat
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Toxicol Pathol 25:644-6. 1997
    ..However, the animal exhibited a slight mammotropic status. The results thus suggest a choriocarcinoma nature for this uterine tumor and that the tumor cells secrete a weakly mammotrophic hormone...
  42. ncbi request reprint Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity
    S Matsuda
    Department of Oncology, University of Tokyo, Japan
    Oncogene 12:705-13. 1996
    ....
  43. ncbi request reprint Subcutaneous treatment of p-tert-octylphenol exerts estrogenic activity on the female reproductive tract in normal cycling rats of two different strains
    M Yoshida
    Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo, Japan
    Toxicol Lett 116:89-101. 2000
    ..Vaginal cytology may be the most sensitive endpoint for the detection of estrogenic activity of potential EDCs using adult cycling rats...
  44. ncbi request reprint HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity
    T Suzuki
    Department of Cellular and Molecular Biology, Institute of Medical Science, Tokyo, Japan
    Virology 270:291-8. 2000
    ..These results suggest that Tax has a novel potential to affect various cellular processes such as transcription and maintenance of genomic stability, in which DNA topoisomerase I is involved...
  45. ncbi request reprint [Clinical significance of sentinel node navigation surgery in the treatment of early gastric cancer]
    Y Kitagawa
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Nippon Geka Gakkai Zasshi 102:753-7. 2001
    ..Validation of the SN concept in gastric cancer in a multi-centric clinical trial is essential for clinical application of this procedure, including the establishment of a novel, minimally invasive approach for early-stage gastric cancer...
  46. doi request reprint Fish intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study
    Akiko Nanri
    Department of Epidemiology and Prevention, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan
    Am J Clin Nutr 94:884-91. 2011
    ..However, data from populations with high fish consumption are scarce...
  47. ncbi request reprint Effects of neonatal exposure to a high-dose p-tert-octylphenol on the male reproductive tract in rats
    M Yoshida
    Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, 101 0062, Tokyo, Japan
    Toxicol Lett 121:21-33. 2001
    ..Our results also indicate that more sensitive endpoints should be established to detect the effects of neonatal exposure to estrogens or estrogenic compounds on the male reproductive tract...
  48. ncbi request reprint Chiral discrimination of N-carbazole-carbonyl derivatives of alpha-amino acids with a short linear alkyl side chain by bovine serum albumin
    Y Abe
    Kyoritsu College of Pharmacy, Tokyo, Japan
    Chirality 12:565-7. 2000
    ....
  49. ncbi request reprint Age-specific prevalence of open-angle glaucoma and its relationship to refraction among more than 60,000 asymptomatic Japanese subjects
    M Yoshida
    Department of Public Health, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, 181 8611, Tokyo, Japan
    J Clin Epidemiol 54:1151-8. 2001
    ..Prevalence for children aged 6 to 14 of both sexes was approximately 0.5%. There were significant positive associations between the strength (diopter) of myopic refraction and OAG prevalence among all the examined subjects...
  50. ncbi request reprint Lack of nephrotoxic effects of the new quinolone antibacterial agent levofloxacin in rabbits
    F Inage
    Drug Safety Research Center, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Arzneimittelforschung 43:395-7. 1992
    ..Although reduced body weight gain was observed in the 120 mg/kg, DR-3355 induced no change in function and morphology of the kidneys at both doses...
  51. doi request reprint Phosphorylation of the MAPK pathway has an essential role in the acrosome reaction in miniature pig sperm
    N Kawano
    Misaki Marine Biological Station, Graduate School of Science, University of Tokyo, Koajiro, Misaki, Miura, Japan
    Reprod Domest Anim 45:263-8. 2010
    ..These results suggest that phosphorylation of MAPK pathway plays an important role in the AR in miniature pig sperm. Moreover, the SV fluid may have an inhibitory effect on the AR via the suppression of the MAPK pathway...
  52. ncbi request reprint Appearance of eosinophilic granule cells as pathological changes in the uteri of two aged virgin Donryu rats
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Toxicol Pathol 25:321-5. 1997
    ....
  53. ncbi request reprint In vitro and in vivo electron transfer to the triheme cytochrome subunit bound to the photosynthetic reaction center complex in the purple bacterium Rhodovulum sulfidophilum
    M Yoshida
    Department of Biology, Tokyo Metropolitan University, Tokyo, Japan
    Biochim Biophys Acta 1506:23-30. 2001
    ..Despite the unusual nature of the RC-bound cytochrome subunit, the cyclic electron transfer system in Rdv. sulfidophilum was shown to be similar to those in other purple bacteria...
  54. ncbi request reprint Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity
    H Fujii
    Department of Pathology II, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Res 60:114-20. 2000
    ..Because phenotypically divergent areas of the tumors share numerous genetic alterations, this divergence most likely occurs relatively late in the evolution of these tumors...
  55. ncbi request reprint Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma
    G Xia
    Department of Urology and Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer 91:1429-36. 2001
    ..CONCLUSIONS: These results suggest that endogenous VEGF can be up-regulated transcriptionally by EPAS1, and EPAS1 may be involved in the angiogenesis of RCC...
  56. ncbi request reprint Human EVI9, a homologue of the mouse myeloid leukemia gene, is expressed in the hematopoietic progenitors and down-regulated during myeloid differentiation of HL60 cells
    Y Saiki
    Department of Carcinogenesis, The Cancer Institute, Japan Science and Technology Corporation, Toshima ku, Tokyo, 170 8455, Japan
    Genomics 70:387-91. 2000
    ..These results indicate a distinct role for EVI9 in human hematopoietic cells and suggest that EVI9 may cause leukemia through inhibition of myeloid differentiation...
  57. doi request reprint Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study
    S Muraki
    22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan
    Osteoarthritis Cartilage 17:1137-43. 2009
    ....
  58. ncbi request reprint Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation
    A Masumi
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    Oncogene 25:5113-24. 2006
    ..We conclude that nucleolin is recruited to acetylated IRF-2, thereby contributing to gene regulation crucial for the control of cell growth...
  59. ncbi request reprint Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation
    N Yoshimizu
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Aliment Pharmacol Ther 20:95-101. 2004
    ..To demonstrate the antitumour effects of nobiletin (5,6,7,8,3',4'-hexamethoxyflavone), a citrus flavonoid extracted from Citrus depressa Hayata, on human gastric cancer cell lines TMK-1, MKN-45, MKN-74 and KATO-III...
  60. pmc Importance of fatty acid substituents of chemically synthesized lipid A-subunit analogs in the expression of immunopharmacological activity
    Y Kumazawa
    School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Infect Immun 56:149-55. 1988
    ..The importance of fatty acid substituents, including stereospecificity for the expression of immunopharmacological activities of 4-O-phosphono-D-glucosamine derivatives, was demonstrated...
  61. ncbi request reprint Role of two series of Ca2+ oscillations in activation of ascidian eggs
    M Yoshida
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, 3 1 1 Koyadai, Ibaragi, Tsukuba, 305 0074, Japan
    Dev Biol 203:122-33. 1998
    ..On the other hand, reinjection of IP3 after the first polar body extrusion led to emission of the second polar body. Thus, Series I and II of [Ca2+]i transients are likely to be required for metaphase-anaphase transition in meiosis...
  62. doi request reprint Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 32:1861-7. 2008
    ..Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan...
  63. ncbi request reprint An epidemic of parapoxvirus infection among cattle: isolation and antibody survey
    Y Kuroda
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 61:749-53. 1999
    ..The positive rate was more than 50% among cattle in the Kanto district. The positive rate increased with age. It was suggested that parapoxvirus infection might have already been prevalent among cattle in Japan...
  64. ncbi request reprint Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction
    M Kataoka
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Lett Appl Microbiol 42:471-6. 2006
    ..The ultimate aim is to elucidate the molecular mechanisms for glutamate overproduction by Corynebacterium glutamicum...
  65. ncbi request reprint Histone deacetylase as a new target for cancer chemotherapy
    M Yoshida
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    Cancer Chemother Pharmacol 48:S20-6. 2001
    ..These results suggest that CHAP31 is promising as a novel therapeutic agent for cancer treatment, and that CHAP may serve as a basis for new HDAC inhibitors and be useful for combinatorial synthesis and high-throughput screening...
  66. ncbi request reprint Sensitive and rapid diagnosis of human parvovirus B19 infection by loop-mediated isothermal amplification
    Y Yamada
    First Department of Dermatology, School of Medicine, and Sakura Hospital, Toho University, Tokyo, Japan
    Br J Dermatol 155:50-5. 2006
    ..The virological diagnosis of B19 infection is usually based on time-consuming serological tests and polymerase chain reaction (PCR)...