Masanori Baba

Summary

Country: Japan

Publications

  1. pmc Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 51:707-15. 2007
  2. pmc Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 82:3843-52. 2008
  3. ncbi request reprint Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Pharmacol 68:1363-70. 2004
  4. doi request reprint Modulation of innate and adaptive immunity by biodegradable nanoparticles
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Immunol Lett 125:46-52. 2009
  5. pmc Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 81:10009-16. 2007
  6. pmc Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(gamma-glutamic acid) nanoparticles
    Takayuki Hamasaki
    Division of Antiviral Chemotherapy, Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Clin Vaccine Immunol 17:748-56. 2010
  7. pmc TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:4584-91. 2005
  8. ncbi request reprint Poly(gamma-glutamic acid) nanoparticles as an efficient antigen delivery and adjuvant system: potential for an AIDS vaccine
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 80:11-9. 2008
  9. ncbi request reprint Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
  10. ncbi request reprint Induction of dendritic cell-mediated immune responses against HIV-1 by antigen-capturing nanospheres in mice
    Masaki Kawamura
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 76:7-15. 2005

Collaborators

Detail Information

Publications82

  1. pmc Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 51:707-15. 2007
    ..Several amino acid changes not only in the V3 region but also in other Env regions seemed to be required for R5 HIV-1 to acquire complete resistance to TAK-652...
  2. pmc Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 82:3843-52. 2008
    ..Since CD70 expression is strictly restricted in normal tissues, such as highly activated T and B cells, CD70 appears to be a potential target for effective antibody therapy against ATL...
  3. ncbi request reprint Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Pharmacol 68:1363-70. 2004
    ..Furthermore, the BCRP-specific inhibitor fumitremorgin C completely restored the reduction of AZT in MT-4/BCRP cells. These results indicate that, like BCRP(R482M), BCRP(WT) also plays an important role in cellular resistance to NRTIs...
  4. doi request reprint Modulation of innate and adaptive immunity by biodegradable nanoparticles
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Immunol Lett 125:46-52. 2009
    ..Thus, gamma-PGA NPs have great potential as an efficient antigen carrier and strong adjuvant to DCs...
  5. pmc Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 81:10009-16. 2007
    ..Thus, gamma-PGA NPs carrying various HIV-1 antigens may have great potential as a novel priming and/or boosting tool in current vaccination regimens for the induction of cellular immune responses...
  6. pmc Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(gamma-glutamic acid) nanoparticles
    Takayuki Hamasaki
    Division of Antiviral Chemotherapy, Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Clin Vaccine Immunol 17:748-56. 2010
    ..Thus, gamma-PGA NPs may be an attractive candidate to be developed further as a vaccine adjuvant...
  7. pmc TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:4584-91. 2005
    ..The compound displayed favorable pharmacokinetics, and its plasma concentration was 7.2 ng/ml (9.1 nM) even 24 h after the administration of 25 mg. Thus, TAK-652 is a promising candidate as a novel entry inhibitor of HIV-1...
  8. ncbi request reprint Poly(gamma-glutamic acid) nanoparticles as an efficient antigen delivery and adjuvant system: potential for an AIDS vaccine
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 80:11-9. 2008
    ..Thus, gamma-PGA nanoparticles encapsulating various antigens may have great potential as novel and efficient protein-based vaccines against infectious diseases, including HIV-1 infection...
  9. ncbi request reprint Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
    ..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases...
  10. ncbi request reprint Induction of dendritic cell-mediated immune responses against HIV-1 by antigen-capturing nanospheres in mice
    Masaki Kawamura
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 76:7-15. 2005
    ..These results suggest that the use of HIV-1-NS may provide a novel and promising approach for the induction of humoral and cellular immune responses to HIV-1...
  11. doi request reprint Inhibition of porcine endogenous retrovirus (PERV) replication by HIV-1 gene expression inhibitors
    Minyi Shi
    Frontier Science Research Center, Kagoshima University, Kagoshima, Japan
    Antiviral Res 83:201-4. 2009
    ..Thus, retroviral gene expression inhibitors may be able to reduce the risk of PERV transmission...
  12. doi request reprint Inhibitory effect of cepharanthine on dendritic cell activation and function
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Int Immunopharmacol 11:1932-8. 2011
    ..These results suggest that CEP may have great potential as an immunoregulatory agent against various autoimmune diseases and allergy...
  13. pmc Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist
    Katsunori Takashima
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:3474-82. 2005
    ..At a dose of 5 mg/kg of body weight, TAK-220 showed oral bioavailabilities of 9.5 and 28.9% in rats and monkeys, respectively. Thus, TAK-220 is a promising candidate for the treatment of HIV-1 infection...
  14. ncbi request reprint Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 18:201-11. 2007
    ..These results suggest that JTK-101 exerts its anti-HIV-1 activity through the inhibition of known or unknown Tat cofactors, presumably CDK9/cyclin T1...
  15. doi request reprint Comparative activity of biodegradable nanoparticles with aluminum adjuvants: antigen uptake by dendritic cells and induction of immune response in mice
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 0544, Japan
    Immunol Lett 140:36-43. 2011
    ..Thus, γ-PGA NPs may have great potential as an effective vaccine carrier and adjuvant for clinical use...
  16. doi request reprint Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 379:600-4. 2009
    ..Strong antibody production was observed by s.c. immunization, yet no antibody was identified by intranasal immunization. Thus, gamma-PGA NPs are a safe and efficient antigen carrier with unique immunological properties...
  17. pmc Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro
    Takao Nitanda
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:3355-60. 2005
    ..Since 4'-Ed4T has increased anti-HIV-1 activity, decreased cytotoxicity, and a different resistance profile, it should be considered for further development as a new member of NRTIs...
  18. ncbi request reprint The role of breast cancer resistance protein (BCRP/ABCG2) in cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 16:213-6. 2005
    ..Thus, BCRP is considered to be a cellular factor that modulates the anti-HIV-1 activity of NRTIs...
  19. pmc Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates
    Minyi Shi
    Frontier Science Research Center, Kagoshima University, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 51:2600-4. 2007
    ..Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine...
  20. ncbi request reprint Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse
    Katsuaki Sato
    Department of Immunology and Medical Zoology, School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, 890 8520, Kagoshima, Japan
    Immunity 18:367-79. 2003
    ..Thus, the use of rDCs may be therapeutically useful for the treatment of acute GVHD and leukemia relapse in allogeneic BMT...
  21. ncbi request reprint Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative
    Masaaki Toyama
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Anticancer Res 32:2639-45. 2012
    ..Thus, TMNAA may have potential as a therapeutic agent against ATL either alone or in combination with cepharanthine, which is clinically used as an anti-inflammatory drug in Japan...
  22. doi request reprint Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives
    Mohammed T A Salim
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 415:714-9. 2011
    ....
  23. ncbi request reprint Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
    Xin Wang
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 63:65-72. 2003
    ..An analysis for intracellular metabolism of AZT suggests that the resistance is attributed to the increase of ATP-dependent efflux of its metabolites, presumably AZT 5'-monophosphate, in MT-4/DOX 500 cells...
  24. pmc Novel reporter T-cell line highly susceptible to both CCR5- and CXCR4-using human immunodeficiency virus type 1 and its application to drug susceptibility tests
    Hiroshi Miyake
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, USA
    J Clin Microbiol 41:2515-21. 2003
    ..Thus, MOCHA cells are an extremely useful tool for detection of R5 and X4 HIV-1 replication and drug susceptibility tests...
  25. doi request reprint Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives
    Mohammed T A Salim
    Center for Chronic Viral Diseases, Sakuragaoka, Kagoshima University, Japan
    Antiviral Res 88:263-8. 2010
    ..Although SK3M4M5M was highly active against BVDV, the compound proved inactive against hepatitis C virus (HCV) in HCV RNA replicon cells...
  26. pmc Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction
    Takayuki Hamasaki
    Division of Antiviral Chemotherapy Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Antimicrob Agents Chemother 57:1323-31. 2013
    ..Thus, a series of compounds described herein are novel inhibitors of HIV-1 transcription through inhibition of CycT1/Tat interaction...
  27. ncbi request reprint Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity
    Kengo Tsuneyoshi
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Lett 244:239-46. 2006
    ..These results suggest that AZT enhances the cytotoxic effect of 5'-DFUR on U937 cells by upregulating TP activity in addition to its inhibition of thymidine kinase (TK) activity and reduction of intracellular dTTP pools...
  28. ncbi request reprint Selective inhibition of HTLV-1-infected cell proliferation by a novel tetramethylnaphthalene derivative
    Takayuki Hamasaki
    Division of Antiviral Chemotherapy, Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Anticancer Res 31:2241-7. 2011
    ..These results indicate that TMNAA exerts selective inhibition of HTLV-1-infected cells through a novel mechanism, presumably modulating cell cycle regulatory proteins associated with the G0/G1 phase...
  29. ncbi request reprint HIV-1-infected macrophages induce astrogliosis by SDF-1alpha and matrix metalloproteinases
    Mika Okamoto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Biochem Biophys Res Commun 336:1214-20. 2005
    ..These results indicate that the activated and HIV-1-infected macrophages can indirectly induce astrocyte proliferation through up-regulating SDF-1alpha and MMP production, which implies a mechanism of astrogliosis in HAD...
  30. ncbi request reprint Recent status of HIV-1 gene expression inhibitors
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Antiviral Res 71:301-6. 2006
    ....
  31. doi request reprint Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives
    Mohammed T A Salim
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 20:193-200. 2010
    ..Among them, some diphenylmethane derivatives were found to be selective inhibitors of BVDV...
  32. doi request reprint The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Biomaterials 32:5206-12. 2011
    ..These results suggest that γ-PGA NPs have not only an antigen-carrying capacity but also a potent adjuvant function of eliciting adaptive immune responses to the carrying antigen through recognition of the first-line host-sensor system...
  33. ncbi request reprint [Recent progress in anti-HIM-1 research]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Uirusu 54:59-66. 2004
    ..Furthermore, clinical trials with CCR 5 (coreceptor of HIV-1) antagonists are in progress, and inhibitors of integrase, HIV-1 gene expression, and virion assembly have been identified...
  34. ncbi request reprint Long-term culture of HIV-1-infected cells with the transcription inhibitor K-37
    Kazunobu Yamataka
    Division of Human Retroviruses, Center for Chronic Viral Diseases Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Antiviral Res 56:85-92. 2002
    ..Furthermore, both M(1) and U(1) had a G to T nucleotide mutation at position -215 in the second nuclear factor of activated T-cells-binding domain (-215 to -203) of the HIV-1 long terminal repeat...
  35. pmc High-sensitivity analysis of naturally occurring sugar chains, using a novel fluorescent linker molecule
    Masaki Sato
    Department of Nanostructure and Advanced Materials, Kagoshima University, Kohrimoto, Japan
    J Biochem 146:33-41. 2009
    ..Immobilization of the FLC onto gold-coated chips, and their subsequent SPR analyses were successively accomplished, as had been performed previously using non-fluorescent ligand conjugates...
  36. doi request reprint Effective induction of cell death on adult T-cell leukaemia cells by HLA-DRbeta-specific small antibody fragment isolated from human antibody phage library
    Satoshi Muraoka
    Department of Bioengineering, Faculty of Engineering, Kagoshima University, Korimoto 1 21 40, Kagoshima, Kagoshima 890 0065, Japan
    J Biochem 145:799-810. 2009
    ..This is the first report elucidating that diabody specific to HLA-DR is effective to induce the cell death in T-cell malignancy especially adult T-cell leukaemic cell line...
  37. ncbi request reprint Inhibition of the tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinolone derivative k-37
    Xin Wang
    Division of Human Retroviruses, Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 61:1359-65. 2002
    ..These results suggest that the inhibition occurred at the level of HTLV-I LTR-driven Tax expression...
  38. doi request reprint Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560
    Mika Okamoto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 20:47-54. 2009
    ..A number of compounds were examined for their inhibitory effect on bovine viral diarrhoea virus (BVDV) replication in cell cultures and found that some cyclooxygenase (COX) inhibitors had antiviral activity against the virus...
  39. ncbi request reprint Inhibitors of HIV-1 gene expression and transcription
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Curr Top Med Chem 4:871-82. 2004
    ..In addition, various compounds have been identified as inhibitors of HIV-1 gene expression and transcription, yet their precise mechanisms are still unknown...
  40. ncbi request reprint Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof
    Mika Okamoto
    Faculty of Medicine, Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Virol Methods 108:195-203. 2003
    ..These results indicate that this system seems to be a useful tool for the evaluation of compounds against HIV-1-induced neural cell death...
  41. ncbi request reprint [Advances in antiviral chemotherapy]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Uirusu 55:69-75. 2005
    ..Thus, it seems still mandatory to continue the search for more effective and less toxic compounds against various viral infections...
  42. pmc Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives
    Paula Ordonez
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antimicrob Agents Chemother 56:2581-9. 2012
    ..Further studies are required to determine the precise role of each mutation in the acquisition of HIV-1 resistance...
  43. ncbi request reprint Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A
    Masahiko Mitsuo
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Oncol Res 14:39-48. 2003
    ....
  44. ncbi request reprint [The history and progress of antiviral research]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University
    Nihon Rinsho 70:553-7. 2012
    ..Currently, highly potent and selective inhibitors are also available in clinic for the treatment of influenza virus and hepatitis virus B and C infections...
  45. doi request reprint Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells
    Mika Okamoto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Hum Gene Ther Methods 24:94-103. 2013
    ..Thus, the Tat-dependent MazF expression system has great potential for inhibition of HIV-1 replication in vivo without apparent toxicity and may be able to avoid the emergence of resistant strains...
  46. ncbi request reprint SJ-3366 Sam Jin Pharmaceutical
    Masanori Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Curr Opin Investig Drugs 3:1146-8. 2002
    ..As of June 1998, Sam Jin had been awarded a patent for SJ-3366 in South Africa, with applications pending in 22 other countries [302450]...
  47. ncbi request reprint Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells
    Katsuaki Sato
    Department of Immunology and Medical Zoology, Division of Human Retroviruses, Center for Chronic Viral Diseases, School of Medicine, Kagoshima University, Kagoshima City, Kagoshima, Japan
    Blood 101:3581-9. 2003
    ..Thus, the modulation of T cell-mediated immunity by regulatory DCs provides a novel therapeutic approach for immunopathogenic diseases...
  48. ncbi request reprint IgG responses to intranasal immunization with cholera-toxin-immobilized polymeric nanospheres in mice
    Tatsuo Kaneko
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1 21 40 Korimoto, Kagoshima 890 0065, Japan
    J Biomater Sci Polym Ed 15:661-9. 2004
    ..Thus, polymeric NS may be an effective substrate to covalently immobilize antigen on their surface, steadily inducing a high level of IgG production in response to the intranasal administration...
  49. ncbi request reprint Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice
    Masaki Kawamura
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    J Med Virol 66:291-8. 2002
    ..Thus, HIV-NS may have great potential as a prophylactic HIV-1 vaccine and should be examined further for its efficacy in non-human primates...
  50. doi request reprint Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    J Med Chem 51:1885-93. 2008
    ..It is noteworthy that 36 and 37 were also inhibitory against replication of HIV variant resistant to 3TC (HIV-1 M184V), being as potent as against HIV-1 IIIB...
  51. ncbi request reprint [Basic approaches to anti-HIV resistance]
    Masanori Baba
    Center for Chronic Viral Research, Faculty of Medicine, Kagoshima University
    Nihon Rinsho 60:763-8. 2002
    ..Furthermore, molecular mechanisms of the resistance induced by some RTIs and PIs have been well understood. Novel inhibitors effective against the resistant mutants have recently been discovered and are under clinical trials...
  52. ncbi request reprint Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety
    Masaki Seto
    Medicinal Chemistry Research Laboratries, Pharmaceutical Research Division, Takeda Chemical Industries Ltd Osaka, Japan
    Chem Pharm Bull (Tokyo) 52:818-29. 2004
    ..In particular, compound (S)-5s showed the most potent CCR5 antagonistic activity (IC(50)=7.2 nM) and inhibitory effect (IC(50)=5.4 nM) in the fusion assay, together with good pharmacokinetic properties in rats...
  53. ncbi request reprint Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides
    Naoyuki Masuda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Bioorg Med Chem 12:6171-82. 2004
    ..These results confirm the important role of the substituents at these positions and the thiazolidenebenzenesulfonamide motif as a valuable lead series for the next generation NNRTIs...
  54. ncbi request reprint Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 23:647-54. 2004
    ..Evaluation of the anti-HIV activity of 9 showed that this compound is much less potent than the recently reported 2',3'-didehydro-3'-deoxy-4'-(ethynyl)thymidine (1)...
  55. ncbi request reprint CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Chemical Industries Ltd, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Chem Pharm Bull (Tokyo) 52:63-73. 2004
    ..038 microM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC(50) values of 0.44, 0.19, and 0.49 microM, respectively...
  56. ncbi request reprint CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 2 17 85, Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 12:2295-306. 2004
    ....
  57. ncbi request reprint Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety
    Masaki Seto
    Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 13:363-86. 2005
    ..In addition, we established the synthesis of (S)-4r and (S)-4w by asymmetric oxidation with titanium-(S)-(-)-1,1'-bi-2-naphthol complex...
  58. ncbi request reprint CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Pharmaceutical Co Ltd, 2 17 85, Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 13:397-416. 2005
    ..The selected compound 11f showed excellent antiviral activity against CCR5-using HIV-1 replication in human peripheral blood mononuclear cells (EC50=0.59 nM) and an acceptable pharmacokinetic profile in dogs...
  59. ncbi request reprint 4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants
    Hiromichi Tanaka
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Antivir Chem Chemother 16:217-21. 2005
    ..The study of 4'-Ed4T against various drug-resistant HIV-1 mutants has disclosed its unique activity profile...
  60. ncbi request reprint Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines, a structural analog of C-5 and/or C-6 substituted pyrimidine acyclonucleoside
    Takanori Miyashita
    Biochemical Division, Yamasa Corporation, Chiba, Japan
    Chem Pharm Bull (Tokyo) 51:630-4. 2003
    ..Among the derivatives, compounds 6, 7, and 8 bearing an alkoxymethyl moiety at the N-1 position exhibited modest inhibitory activity towards the cytotopathic effect of HIV-1...
  61. ncbi request reprint Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety
    Masaki Seto
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    J Med Chem 49:2037-48. 2006
    ..The synthesis and biological activity of the 1-benzazocine compound (S)-(-)-5b and its related derivatives are described...
  62. ncbi request reprint Orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety
    Masaki Seto
    Medicinal Chemistry Research Laboratries, Pharmaceutical Research Division, Takeda Chemical Industries Ltd, Osaka, Japan
    Chem Pharm Bull (Tokyo) 52:577-90. 2004
    ..7 nM) and inhibitory effect (IC(50)=1.2 nM) on membrane fusion, together with good pharmacokinetic properties in rats. The synthesis of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives and their biological activity are described...
  63. ncbi request reprint Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice
    Takami Akagi
    Japan Immunoresearch Laboratories, Takasaki, Gunma, Japan
    J Med Virol 69:163-72. 2003
    ..Intranasal immunization with HIV-NS should be further pursued for its potential as an HIV-1 prophylactic vaccine...
  64. pmc Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate
    Guangwei Yang
    Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 52:2035-42. 2008
    ..The structural basis for the higher binding affinity of 4'-Ed4TTP than of d4TTP could be the additional binding of the 4'-ethynyl group in a preformed hydrophobic pocket by A114, Y115, M184, F160, and part of D185...
  65. doi request reprint Pharmacogenetics of hormone replacement therapy for climacteric symptoms
    Chikari Takeo
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 374:604-8. 2008
    ..30, 95% CI 0.14-0.65, P=0.002) gene decreased HRT. rs2228480 in ERalpha gene also increased HRT. Tailored decisions can be expected on the future use of HRT referring genetic polymorphisms of individuals...
  66. ncbi request reprint Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Bioorg Med Chem Lett 13:3775-7. 2003
    ..The compounds were assayed for their ability to inhibit the replication of HIV in cell culture. The 4'-ethynyl analogue (15) was found to be more potent and less toxic than the parent compound stavudine...
  67. pmc Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity
    Ginger E Dutschman
    Department of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Antimicrob Agents Chemother 48:1640-6. 2004
    ..Since 4'-ethynyl D4T has increased anti-HIV activity and decreased toxicity and interacts favorably with other currently used anti-HIV drugs, it should be considered for further development as an anti-HIV drug...
  68. ncbi request reprint Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques
    Ariko Miyake
    Laboratory of Primate Model, Experimental Research Center for Infectious Disease, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Med Virol 73:368-77. 2004
    ..The rapid antibody responses having neutralizing activity might contribute to the clearance of the challenge virus. Thus, SHIV-NS-immunized macaques exhibited partial protection to vaginal and systemic challenges with SHIV KU-2...
  69. ncbi request reprint Synthesis and antiviral activities of 1'-carbon-substituted 4'-thiothymidines
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Bioorg Med Chem 12:5309-16. 2004
    ..Among the deprotected 1'-branched 4'-thiothymidines (20-25), the 1'-methyl analogue 20 showed the most potent anti-HSV-1 activity, but it was much less active than the parent compound 4'-thiothymidine...
  70. ncbi request reprint Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives
    Naoyuki Masuda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Bioorg Med Chem 13:949-61. 2005
    ..Compound 11g (YM-215389), a combination of 2-hydroxyphenyl and 4-chloro-5-isopropylthiazole moieties, proved to be the most active against both K103N and Y181C RTs with IC50 values of 0.043 and 0.013 microM, respectively...
  71. ncbi request reprint Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Biochem Biophys Res Commun 329:205-10. 2005
    ..0001), with an odds ratio (OR) of 2.53 (95%CI:1.62-4.12). Diplotype analysis also showed a significant association of the diplotypes with the haplotype 2 (OR:2.59, 95%CI:1.48-4.54, p = 0.0013)...
  72. ncbi request reprint Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C
    Naoya Kato
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 42:846-53. 2005
    ..In conclusion, these SNPs and haplotypes located in the SCBY14, CRHR2, and GFRA1 genes will be used as markers to identify a subgroup of Japanese patients with chronic HCV infection who are at high risk of developing HCC...
  73. ncbi request reprint A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 24:343-7. 2005
    ..Evaluation of their ability to inhibit the replication of HIV in cell culture showed that 4'-ethynyl-d4T (19) is more potent and less toxic than the parent compound d4T...
  74. ncbi request reprint AIDS vaccine: Intranasal immunization using inactivated HIV-1-capturing core-corona type polymeric nanospheres
    Takami Akagi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan
    J Control Release 109:49-61. 2005
    ..These results suggest that HIV-NS provides an efficient vaccine delivery system for the induction of a mucosal immune response and the development of a mucosal vaccine...
  75. ncbi request reprint Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa ku, Osaka 532 8686, Japan
    J Med Chem 49:2784-93. 2006
    ..1 nM, EC(90) = 13 nM) and exhibited a good pharmacokinetic profile in monkeys (BA = 29%). This compound has been chosen as a clinical candidate for further development...
  76. ncbi request reprint Association of nephrin gene polymorphisms with type 2 diabetes in a Japanese population: The Funagata study
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Care 29:1117-9. 2006
  77. ncbi request reprint Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT
    Guangwei Yang
    Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Antiviral Res 73:185-91. 2007
    ..4'-Ed4TTP showed much less inhibitory effects toward major host DNA polymerases. Overall, our results suggest that 4'-Ed4TTP is the active form for anti-HIV-1 activity via its inhibitory effect against RT...
  78. ncbi request reprint Synthesis and anti-human immunodeficiency virus activity of 4'-branched (+/-)-4'-thiostavudines
    Hiroki Kumamoto
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Med Chem 49:7861-7. 2006
    ..6 and 0.74 microM, respectively. The activity of 29 was comparable to that of stavudine, but 29 was not as active as 4. Optical resolution of 29 was briefly examined...
  79. ncbi request reprint [Development of vaccine adjuvants using polymeric nanoparticles and their potential applications for anti-HIV vaccine]
    Takami Akagi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita City, Japan
    Yakugaku Zasshi 127:307-17. 2007
    ..These HIV-1-capturing nanospheres and protein-loaded gamma-PGA nanoparticles have shown unique potential as vaccine carriers...
  80. pmc Comparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs
    Chih Hung Hsu
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 51:1687-93. 2007
    ..Qualitatively, the metabolism of 4'-ethynyl D4T is more similar to that of AZT than to that of its progenitor, D4T...
  81. pmc Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, SHM B226, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 51:3870-9. 2007
    ..4'-Ed4T is a promising antiviral candidate for HIV type 1 chemotherapy...
  82. ncbi request reprint Fusion of mature dendritic cells and human T-lymphotropic virus type I infected T cells: its efficiency as an antigen-presenting cell
    Satoshi Shimokubo
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, 189 0002, Japan
    Virology 301:13-20. 2002
    ..The results suggest that fusion DC-T cells produce functionally competent Ag-presenting cells and may be a likely candidate for immunotherapeutic use...