Hidetoshi Morita

Summary

Affiliation: Azabu University
Country: Japan

Publications

  1. ncbi request reprint Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells
    Kaname Uno
    Research Project of Biofunctional Reactive Species, Yamagata Promotional Organization for Industrial Technology, Yamagata, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G1004-12. 2007
  2. pmc Comparative Genomic Analysis of Lactococcus garvieae Strains Isolated from Different Sources Reveals Candidate Virulence Genes
    Eiji Miyauchi
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8528, Japan
    Int J Microbiol 2012:728276. 2012
  3. pmc Genomic adaptation of the Lactobacillus casei group
    Hidehiro Toh
    Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 8:e75073. 2013
  4. doi request reprint Bifidobacterium kashiwanohense sp. nov., isolated from healthy infant faeces
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 61:2610-5. 2011
  5. doi request reprint Lactobacillus hayakitensis, L. equigenerosi and L. equi, predominant lactobacilli in the intestinal flora of healthy thoroughbreds
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    Anim Sci J 80:339-46. 2009
  6. doi request reprint Lactobacillus equicursoris sp. nov., isolated from the faeces of a thoroughbred racehorse
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 60:109-12. 2010
  7. pmc Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    DNA Res 15:151-61. 2008
  8. pmc Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum
    H Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    J Bacteriol 179:7812-5. 1997
  9. pmc Lactobacillus hayakitensis sp. nov., isolated from intestines of healthy thoroughbreds
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 57:2836-9. 2007
  10. ncbi request reprint Anti-microbial action against verotoxigenic Escherichia coli O157:H7 of nitric oxide derived from sodium nitrite
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    Biosci Biotechnol Biochem 68:1027-34. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells
    Kaname Uno
    Research Project of Biofunctional Reactive Species, Yamagata Promotional Organization for Industrial Technology, Yamagata, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G1004-12. 2007
    ..Induced TLR2 cooperated with TLR4 to amplify iNOS induction. This positive correlation may constitute a mechanism for stimulating the innate immune response against various bacterial pathogens, including H. pylori-LPS...
  2. pmc Comparative Genomic Analysis of Lactococcus garvieae Strains Isolated from Different Sources Reveals Candidate Virulence Genes
    Eiji Miyauchi
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8528, Japan
    Int J Microbiol 2012:728276. 2012
    ..garvieae. The discoveries revealed by the pangenomic analysis may provide significant insights into the biology of L. garvieae...
  3. pmc Genomic adaptation of the Lactobacillus casei group
    Hidehiro Toh
    Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 8:e75073. 2013
    ..casei group. In addition to previously fully sequenced L. rhamnosus and L. paracasei strains, the complete genome sequences of L. casei will provide valuable insights into the evolution of the L. casei group. ..
  4. doi request reprint Bifidobacterium kashiwanohense sp. nov., isolated from healthy infant faeces
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 61:2610-5. 2011
    ..nov. is proposed. The type strain is HM2-2(T) ( = JCM 15439(T) = DSM 21854(T))...
  5. doi request reprint Lactobacillus hayakitensis, L. equigenerosi and L. equi, predominant lactobacilli in the intestinal flora of healthy thoroughbreds
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    Anim Sci J 80:339-46. 2009
    ..hayakitensis, L. equigenerosi and L. equi are contained in all the samples, suggesting that these species are predominant lactobacilli in the intestinal flora of thoroughbreds...
  6. doi request reprint Lactobacillus equicursoris sp. nov., isolated from the faeces of a thoroughbred racehorse
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 60:109-12. 2010
    ..The results indicate that isolate DI70(T) indeed represents a novel species of the genus Lactobacillus, for which we propose the name Lactobacillus equicursoris sp. nov. The type strain is DI70(T) (=JCM 14600(T) =DSM 19284(T))...
  7. pmc Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    DNA Res 15:151-61. 2008
    ..Given that glycerol is shown to be naturally present in feces, the acquired ability to produce reuterin and cobalamin is an adaptive evolutionary response that likely contributes to the probiotic properties of L. reuteri...
  8. pmc Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum
    H Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    J Bacteriol 179:7812-5. 1997
    ..To our knowledge, this demonstrates for the first time the production of NO synthesized from the guanidino nitrogens of L-arginine by lactic acid bacteria. IFO 3956 may possess a bacterial NO synthase...
  9. pmc Lactobacillus hayakitensis sp. nov., isolated from intestines of healthy thoroughbreds
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 57:2836-9. 2007
    ..salivarius and L. aviarius confirmed that KBL13(T) represents a novel species, for which the name Lactobacillus hayakitensis sp. nov. is proposed. The type strain is KBL13(T) (=JCM 14209(T)=DSM 18933(T))...
  10. ncbi request reprint Anti-microbial action against verotoxigenic Escherichia coli O157:H7 of nitric oxide derived from sodium nitrite
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    Biosci Biotechnol Biochem 68:1027-34. 2004
    ..These findings indicate that nitric oxide derived from sodium nitrite penetrated the cells and inactivated enzymes related to the respiratory chain...
  11. ncbi request reprint The formation of g=2.49-species of cytochrome P450 in the rat liver by PCB126 oral administration: identification of heme axial ligands by EPR spectroscopy
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara
    Biosci Biotechnol Biochem 70:2974-81. 2006
    ..These results indicated that g=2.49-species is a hemeprotein with cysteine thiolate at the 5th coordination site, and a nitrogenous ligand at the 6th site...
  12. ncbi request reprint Sharpea azabuensis gen. nov., sp. nov., a Gram-positive, strictly anaerobic bacterium isolated from the faeces of thoroughbred horses
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Int J Syst Evol Microbiol 58:2682-6. 2008
    ..nov., sp. nov. is proposed. The type strain of Sharpea azabuensis is ST18(T) (=JCM 14210(T) =DSM 18934(T))...
  13. doi request reprint Apoptosis caused by an inhibitor of NO production in the decidua of rat from mid-gestation
    Takehito Suzuki
    Graduate School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 229 8501, Japan
    Exp Biol Med (Maywood) 235:455-62. 2010
    ..5, suggesting that an NO peak in the decidua is essential to cell survival and the maintenance of uterine formation...
  14. pmc Complete genome sequence and comparative analysis of the fish pathogen Lactococcus garvieae
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan
    PLoS ONE 6:e23184. 2011
    ..The analysis also predicted other potential virulence factors such as haemolysin. The present study provides new insights into understanding of the virulence mechanisms of L. garvieae in fish...
  15. ncbi request reprint Gestational changes in production of NO and expression of NOS mRNA isoforms in the rat placenta
    Takehito Suzuki
    Graduate School of Veterinary Medicine, Azabu University, Japan
    J Vet Med Sci 71:495-8. 2009
    ..Thus, it appears that NO levels in the placenta are NOS II-dependent and differ at different gestational stages...
  16. ncbi request reprint Aqueous extracts of Rhizopus oryzae induced nitric oxide production in rat hepatocyte cell line RLN-10
    Takehito Suzuki
    Graduate School of Veterinary Medicine, Azabu University, Sagamihara 252 5201, Japan
    Biosci Biotechnol Biochem 77:1384-9. 2013
    ..Our data indicate that Aq-ROU induces NO production and potentially the production of superoxide, which may contribute to the broad range of physiological effects observed for Aq-ROU ingested by animals. ..
  17. ncbi request reprint Changes in nitric oxide production levels and expression of nitric oxide synthase isoforms in the rat uterus during pregnancy
    Takehito Suzuki
    Graduate School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan
    Biosci Biotechnol Biochem 73:2163-6. 2009
    ..Thus NOS-2-generated NO in the decidua contributed significantly to uterine NO levels...
  18. doi request reprint Complete sequence analysis of two cryptic plasmids from Bifidobacterium kashiwanohense JCM 15439 (type strain) isolated from healthy infant feces
    Muneaki Takahata
    School of Veterinary Medicine, Azabu University, Sagamihara BioBank Co, Ltd, Okayama
    Anim Sci J 85:158-63. 2014
    ..Our finding will provide new insights into safe recombinant plasmid constructions for humans. ..
  19. ncbi request reprint Nitric oxide induces vascular endothelial growth factor expression in the rat placenta in vivo and in vitro
    Hideaki Abe
    Graduate School of Veterinary Medicine, Azabu University, Fuchinobe, Chuo Ku, Sagamihara, Japan
    Biosci Biotechnol Biochem 77:971-6. 2013
    ..Our data indicate that NO induce VEGF expression in vivo and in vitro in the rat placenta, suggesting that peaked NO production was maintained by a reciprocal relationship between NO and VEGF via HIF-1α...
  20. ncbi request reprint Nitric oxide production and its contribution to hepatocyte proliferation in normal juvenile rats
    Naoto Inukai
    Graduate School of Veterinary Medicine, Azabu University, Kanagawa, Japan
    J Vet Med Sci 72:861-7. 2010
    ..Thus, this study provides a novel insight into the contribution of NO to hepatic growth and liver maturation in juveniles...
  21. pmc Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103
    Hidetoshi Morita
    School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    J Bacteriol 191:7630-1. 2009
    ..L. rhamnosus ATCC 53103, isolated from a healthy human intestinal flora, is one of the most widely used and well-documented probiotics. Here, we report the finished and annotated genome sequence of this organism...
  22. pmc Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult
    Kenshiro Oshima
    Kitasato Institute for Life Sciences, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    DNA Res 15:375-86. 2008
    ..coli in human gut habitat...
  23. ncbi request reprint Effect of D-alanine in teichoic acid from the Streptococcus thermophilus cell wall on the barrier-protection of intestinal epithelial cells
    Eiji Miyauchi
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    Biosci Biotechnol Biochem 76:283-8. 2012
    ..Taken together, D-Ala in TA played an important role in the barrier-protecting effect of S. thermophilus in the intestinal epithelium, and these beneficial effects could be enhanced by exogenous L-Ala...
  24. pmc Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules
    Eiji Miyauchi
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences IMS RCAI, Yokohama, Kanagawa, Japan
    PLoS ONE 8:e79735. 2013
    ..Collectively, these data indicate that JCM 1222(T) negatively regulate epithelial costimulatory molecules, and this effect might be attributed, at least in part, to suppression of IL-17A in DSS-induced colitis. ..
  25. pmc Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells
    Tasuku Ogita
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8528, Japan
    J Biomed Biotechnol 2011:378417. 2011
    ..The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease...
  26. ncbi request reprint Expression of nitric oxide synthase isoforms and detection of nitric oxide in rat placenta
    Tatsuya Takizawa
    Laboratory of Developmental Biotechnology, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Am J Physiol Cell Physiol 282:C762-7. 2002
    ..01, n = 4 or 5). These results suggest that NOS II is the predominant producer of NO in the placenta and that NOS II-generated NO plays significant roles in the maintenance of placental functions immediately before birth...
  27. doi request reprint Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ
    Tasuku Ogita
    Graduate School of Biosphere Science, Hiroshima University, Higashi Ηiroshima, Japan
    Int J Mol Med 28:817-22. 2011
    ..Therefore, modulation of Th1/Th17 balance would be one of the mechanisms under which S. thermophilus ST28 exerts an anti-inflammatory effect...
  28. ncbi request reprint Molecular profiling of Lactobacillus, Streptococcus, and Bifidobacterium species in feces of active racehorses
    Akihito Endo
    NODAI Culture Collection Center, Tokyo University of Agriculture, Setagaya, Tokyo, Japan
    J Gen Appl Microbiol 53:191-200. 2007
    ..Repeated tests of the feces from the same horse over 3 months showed that the diversity and composition of lactic acid bacteria and bifidobacteria in the feces was basically stable throughout the test period...
  29. doi request reprint Lactobacillus equigenerosi sp. nov., a coccoid species isolated from faeces of thoroughbred racehorses
    Akihito Endo
    NODAI Culture Collection Center, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya, Tokyo 156 8502, Japan
    Int J Syst Evol Microbiol 58:914-8. 2008
    ..Thus, the isolates represent an atypical novel species of the genus Lactobacillus, for which the name Lactobacillus equigenerosi sp. nov. is proposed. The type strain is NRIC 0697T (=JCM 14505T =DSM 18793T)...
  30. pmc Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
    Ken Kurokawa
    Laboratory of Comparative Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    DNA Res 14:169-81. 2007
    ..In addition, we discovered a conjugative transposon family explosively amplified in human gut microbiomes, which strongly suggests that the intestine is a 'hot spot' for horizontal gene transfer between microbes...
  31. ncbi request reprint Paenibacillus macerans possesses two types of 16S rDNA copies in a genome with a length difference of twelve base pairs
    Yoshikatsu Hamasaki
    Central Research Institute, Marudai Food Co, Ltd, Takatsuki, Osaka, Japan
    Biosci Biotechnol Biochem 69:1995-8. 2005
    ..Both types of 16S rRNA were expressed in each strain, and it was predicted that the polymorphism at this position is located in helix H10, based on a comparison with the E. coli 16S rRNA secondary structure model...