Affiliation: Astellas Pharma Inc
- Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptakeM Shobo
Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
J Pharmacol Exp Ther 333:772-81. 2010..Given that norZTP is the major metabolite observed in humans, norZTP may contribute to the unique clinical profiles of its mother compound, ZTP...
- Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidoneMiwako Shobo
Pharmacology Research Labs, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Behav Brain Res 216:561-8. 2011..These animal models may provide useful experimental platforms for analysis of the mechanism of hyperphagia and evaluating the potential risk of novel antipsychotics to induce weight gain in humans...
- Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male ratsMiwako Shobo
Pharmacology Research Labs, Astellas Pharma Inc, Miyukigaoka 21, Tsukuba, Ibaraki, Japan
Life Sci 88:761-5. 2011..This study investigated the effect of chronic subcutaneous infusion of olanzapine in male rats via a recently developed electrical microinfusion pump...