M Shobo

Summary

Affiliation: Astellas Pharma Inc
Country: Japan

Publications

  1. doi request reprint Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake
    M Shobo
    Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    J Pharmacol Exp Ther 333:772-81. 2010
  2. doi request reprint Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone
    Miwako Shobo
    Pharmacology Research Labs, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Behav Brain Res 216:561-8. 2011
  3. doi request reprint Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats
    Miwako Shobo
    Pharmacology Research Labs, Astellas Pharma Inc, Miyukigaoka 21, Tsukuba, Ibaraki, Japan
    Life Sci 88:761-5. 2011

Detail Information

Publications3

  1. doi request reprint Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake
    M Shobo
    Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    J Pharmacol Exp Ther 333:772-81. 2010
    ..Given that norZTP is the major metabolite observed in humans, norZTP may contribute to the unique clinical profiles of its mother compound, ZTP...
  2. doi request reprint Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone
    Miwako Shobo
    Pharmacology Research Labs, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Behav Brain Res 216:561-8. 2011
    ..These animal models may provide useful experimental platforms for analysis of the mechanism of hyperphagia and evaluating the potential risk of novel antipsychotics to induce weight gain in humans...
  3. doi request reprint Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats
    Miwako Shobo
    Pharmacology Research Labs, Astellas Pharma Inc, Miyukigaoka 21, Tsukuba, Ibaraki, Japan
    Life Sci 88:761-5. 2011
    ..This study investigated the effect of chronic subcutaneous infusion of olanzapine in male rats via a recently developed electrical microinfusion pump...