Katsuhiro Ogawa

Summary

Affiliation: Asahikawa Medical College
Country: Japan

Publications

  1. pmc Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1
    Norikazu Hashimoto
    Department of Pathology, Section of Oncology, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    Int J Hepatol 2011:424356. 2011
  2. doi request reprint Molecular pathology of early stage chemically induced hepatocarcinogenesis
    Katsuhiro Ogawa
    Department of Pathology, Section of Oncology, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Pathol Int 59:605-22. 2009
  3. ncbi request reprint Gain of chromosomes 15 and 19 is frequent in both mouse hepatocellular carcinoma cell lines and primary tumors, but loss of chromosomes 4 and 12 is detected only in the cell lines
    K Ogawa
    Department of Pathology, Asahikawa Medical College, 4 5 3 11 Nishikagura, Asahikawa 078 8510, Japan
    Carcinogenesis 20:2083-8. 1999
  4. ncbi request reprint Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis
    Satoshi Honmo
    Department of Pathology, Asahikawa Medical College, East, Midorigaoka, Asahikawa, Japan
    Mol Carcinog 46:758-65. 2007
  5. ncbi request reprint Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis
    Hiroki Tanaka
    Department of Pathology, Asahikawa Medical College, Dohoku National Hospital, Asahikawa, Japan
    Cancer Res 66:11263-70. 2006
  6. ncbi request reprint Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation
    Keiko Asai
    Department of Pathology, Asahikawa Medical College, Midorigaoka, Asahikawa, Japan
    Liver Int 26:595-603. 2006
  7. ncbi request reprint Different growth capacity between infant and adult mouse hepatocytes in vitro correlates to the cyclin D1 level without relation to oxidative DNA damage
    Emi Imamura
    Department of Pathology, Asahikawa Medical College, 2 1 1 1 East Midorigaoka, Asahikawa 078 8510, Japan
    Liver Int 25:1036-43. 2005
  8. ncbi request reprint Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats
    Koji Imai
    Department of Pathology, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    Oncol Rep 17:55-60. 2007
  9. doi request reprint Effects of bone marrow and hepatocyte transplantation on liver injury
    Biao Zhang
    Department of Surgery, Asahikawa Medical College, Japan
    J Surg Res 157:71-80. 2009
  10. ncbi request reprint Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis
    Masahiro Yamamoto
    Department of Pathology, Asahikawa Medical College, Midorigaoka East, Asahikawa, Japan
    Mol Carcinog 45:901-13. 2006

Collaborators

Detail Information

Publications27

  1. pmc Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1
    Norikazu Hashimoto
    Department of Pathology, Section of Oncology, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    Int J Hepatol 2011:424356. 2011
    ..Thus, low responses to LN and resistance to hepatotoxins in DRH hepatocytes were linked to the Drh1 locus, while low proliferation in vitro and small nuclear size were not linked to the Drh1 locus...
  2. doi request reprint Molecular pathology of early stage chemically induced hepatocarcinogenesis
    Katsuhiro Ogawa
    Department of Pathology, Section of Oncology, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Pathol Int 59:605-22. 2009
    ....
  3. ncbi request reprint Gain of chromosomes 15 and 19 is frequent in both mouse hepatocellular carcinoma cell lines and primary tumors, but loss of chromosomes 4 and 12 is detected only in the cell lines
    K Ogawa
    Department of Pathology, Asahikawa Medical College, 4 5 3 11 Nishikagura, Asahikawa 078 8510, Japan
    Carcinogenesis 20:2083-8. 1999
    ..PCR analysis using polymorphic microsatellite DNA markers revealed that the loss of chromosome 12 as well as chromosome 4 was much more frequent for the C57BL/6J hepatocarcinogenesis-resistant rather than the susceptible C3H/HeJ strain...
  4. ncbi request reprint Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis
    Satoshi Honmo
    Department of Pathology, Asahikawa Medical College, East, Midorigaoka, Asahikawa, Japan
    Mol Carcinog 46:758-65. 2007
    ..The low activation of the stress-activated protein kinases may be linked to the resistance to cellular stress, which may underlie the hepatocarcinogenesis-resistance in DRH rats...
  5. ncbi request reprint Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis
    Hiroki Tanaka
    Department of Pathology, Asahikawa Medical College, Dohoku National Hospital, Asahikawa, Japan
    Cancer Res 66:11263-70. 2006
    ..These findings suggest that the reciprocal activation of PI3K/Akt signaling and HIF-1alpha may be important in the progression of hepatocarcinogenesis...
  6. ncbi request reprint Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation
    Keiko Asai
    Department of Pathology, Asahikawa Medical College, Midorigaoka, Asahikawa, Japan
    Liver Int 26:595-603. 2006
    ..Expression of neurotrophins (NTs) and their receptors is increased during hepatic regeneration, but their role is not well understood...
  7. ncbi request reprint Different growth capacity between infant and adult mouse hepatocytes in vitro correlates to the cyclin D1 level without relation to oxidative DNA damage
    Emi Imamura
    Department of Pathology, Asahikawa Medical College, 2 1 1 1 East Midorigaoka, Asahikawa 078 8510, Japan
    Liver Int 25:1036-43. 2005
    ..Proliferating capacity of hepatocytes is rapidly decreased during growth into maturity, but its exact reason(s) are not well known...
  8. ncbi request reprint Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats
    Koji Imai
    Department of Pathology, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    Oncol Rep 17:55-60. 2007
    ..The tissue environment of the DRH liver, therefore, is less effective for selective growth of preneoplastic hepatocytes during the carcinogen treatment, which is probably a major cause of the hepatocarcinogenesis-resistance in DRH rats...
  9. doi request reprint Effects of bone marrow and hepatocyte transplantation on liver injury
    Biao Zhang
    Department of Surgery, Asahikawa Medical College, Japan
    J Surg Res 157:71-80. 2009
    ..The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury...
  10. ncbi request reprint Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis
    Masahiro Yamamoto
    Department of Pathology, Asahikawa Medical College, Midorigaoka East, Asahikawa, Japan
    Mol Carcinog 45:901-13. 2006
    ..These observations indicate that the nuclear/cytoplasmic localization of cyclin D1 plays an important role in the proliferation/quiescence of neoplastic hepatocytes...
  11. doi request reprint Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine
    Masaaki Miyakoshi
    Department of Pathology, Section of Oncology, Asahikawa Medical University, Asahikawa, Japan
    Mol Carcinog 53:67-76. 2014
    ..Taken together, these data demonstrate that STAT3 activation, mainly through S727 phosphorylation, contributes to the DEN-induced hepatocarcinogenesis at the earliest stages...
  12. ncbi request reprint Hepatocytes derived from peripheral blood stem cells of granulocyte-colony stimulating factor treated F344 rats in analbuminemic rat livers
    Xiang Huiling
    Department of Surgery, Asahikawa Medical College, Midorigaoka Higashi, Asahikawa, Japan
    J Surg Res 122:75-82. 2004
    ..We investigated whether PB-SCs mobilized by treatment with granulocyte-colony stimulating factor (G-CSF) in normal rats can raise albumin-producing hepatocytes after transplantation within the liver of analbuminemic rats...
  13. ncbi request reprint F344 rat liver nonparenchymal cell transplantation can increase the number of albumin-positive hepatocytes in the liver following hematopoietic reconstitution in irradiated analbuminemic rats
    Yan Xia
    Department of Surgery, Asahikawa Medical College, Asahikawa, Japan
    Eur Surg Res 38:533-9. 2006
    ..The data indicate that BMCs derived from F344 LNPCs could increase the number Alb+ hepatocytes within the F344alb liver...
  14. ncbi request reprint Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components
    Yoshihiko Tokusashi
    Department of Pathology, Asahikawa Medical College, Asahikawa, Japan
    Int J Cancer 114:39-45. 2005
    ..NGF and its receptors are then thought to have a role in cellular interactions involving HCC cells, HSCs, arterial cells and nerve cells in HCC tissues...
  15. ncbi request reprint Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells
    T Uezono
    Department of Legal Medicine, Asahikawa Medical College, Japan
    J Neural Transm 108:943-53. 2001
    ..On the other hand, gamma-carbolines, Trp-P-1 and Trp-P-2, directly damaged DNA. Thus, the nitrogen atom at the gamma-position and/or an amino group in carboline structure would be required to induce the direct DNA cleavage...
  16. ncbi request reprint Colonization of albumin-producing hepatocytes derived from transplanted F344 rat bone marrow cells in the liver of congenic Nagase's analbuminemic rats
    Jun Arikura
    Department of Surgery, Asahikawa Medical College, 2 1 1 1, Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Hepatol 41:215-21. 2004
    ..We investigated whether bone marrow cells (BMCs) of normal rats can be transformed in albumin-producing hepatocytes in analbuminemic rat livers...
  17. ncbi request reprint Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis
    Junichi Gotoh
    Department of Pathology and Department of Surgery, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    Carcinogenesis 24:435-42. 2003
    ..These results indicate that, although beta-catenin and cyclin D1 activation are well correlated, the Akt/GSK3 beta and ras/ERK1/2 pathways may not play a major role in the beta-catenin/cyclin D1 activation...
  18. ncbi request reprint Fine mapping of smallest common regions of deletion on chromosome 12 in liver epithelial and hepatocellular carcinoma cell lines from B6C3F(1) and C3B6F(1) mice
    K Ishizaki
    Department of Pathology, School of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Int J Cancer 86:251-4. 2000
    ..Our results demonstrate that mouse chromosome 12 contains at least 2 independent suppressor loci and that loss of B6 genes may be more advantageous than C3H gene deletion for establishment of hepatic cell lines...
  19. ncbi request reprint Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kvlqt1 differentially methylated regions
    Tomoaki Ishizaki
    Department of Pathology, Asahikawa Medical College, 2 1 1 1 East, Midorigaoka, Asahikawa 078 8510, Japan
    J Biol Chem 278:6222-8. 2003
    ..These data indicate that Igf2 LOI in tumor cells is not necessarily linked to abnormal methylation at H19, Igf2, or Kvlqt1 loci...
  20. ncbi request reprint An autopsy case of autoimmune pancreatitis
    Yohei Kitano
    Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    JOP 8:621-7. 2007
    ..Autoimmune pancreatitis is an increasingly recognized type of chronic pancreatitis, but little is known about the long-term outcome of the disease...
  21. ncbi request reprint Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1)
    M Obata
    Department of Pathology, Asahikawa Medical College, Asahikawa, Japan
    Mol Carcinog 32:9-18. 2001
    ....
  22. ncbi request reprint Glutamate is not involved in the MPP+-induced dopamine overflow in the striatum of freely moving C57BL/6 mice
    T Uezono
    Department of Legal Medicine, Asahikawa Medical College, Japan
    J Neural Transm 108:899-908. 2001
    ..These results indicated that, at least in the striatum, neither glutamate release nor the NMDA antagonist, including (+)-MK-801, could regulate MPP+-evoked dopamine overflow...
  23. ncbi request reprint Most liver epithelial cell lines from C3B6F1 mice exhibit parentally-biased loss of heterozygosity at the Lci (Liver cell immortalization) locus on chromosome 4
    G H Lee
    Department of Pathology, Asahikawa Medical College, Japan
    Oncogene 11:2281-7. 1995
    ..We also observed a loss of heterozygosity on chromosomes 7, 14, or 17 in more than 50% of the cell lines...
  24. ncbi request reprint Carrier-mediated processes in blood--brain barrier penetration and neural uptake of paraquat
    K Shimizu
    Department of Legal Medicine, Asahikawa Medical College, Asahikawa 078-8510, Japan
    Brain Res 906:135-42. 2001
    ..These findings indicated that paraquat is possibly taken up into the brain by the neutral amino acid transport system, then transported into striatal, possibly neuronal, cells in a Na(+)-dependent manner...
  25. ncbi request reprint Prohibitin expression is decreased in the regenerating liver but not in chemically induced hepatic tumors in rats
    S Tanno
    Department of Pathology, Asahikawa Medical College
    Jpn J Cancer Res 88:1155-64. 1997
    ....
  26. ncbi request reprint Roles of the Pas1 and Par2 genes in determination of the unique, intermediate susceptibility of BALB/cByJ mice to urethane-induction of lung carcinogenesis: differential effects on tumor multiplicity, size and Kras2 mutations
    H Karasaki
    Department of Pathology, Asahikawa Medical College, Nishikagura, Japan
    Oncogene 15:1833-40. 1997
    ....
  27. ncbi request reprint Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes
    G H Lee
    Department of Pathology, Asahikawa Medical College, Nishikagura, Japan
    Cancer Res 57:590-3. 1997
    ..A locus on chromosome 6 designated Ots1 (ovarian teratoma susceptibility) was identified as the single major locus that increases the frequency of teratomas in a semidominant manner...