Research Topics
Genomes and GenesSpecies | Taiji NagaokaSummaryAffiliation: Asahikawa Medical College Country: Japan Publications
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Publications
Noninvasive evaluation of wall shear stress on retinal microcirculation in humansTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Midorigaoka Higashi, Asahikawa, Japan
Invest Ophthalmol Vis Sci 47:1113-9. 2006..To evaluate wall shear stress (WSS) on retinal microcirculation noninvasively...
Effect of systemic administration of simvastatin on retinal circulationTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
Arch Ophthalmol 124:665-70. 2006..To investigate the effect of systemic administration of simvastatin on the retinal circulation...
[Physiological mechanism for the regulation of ocular circulation]Taiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Japan
Nihon Ganka Gakkai Zasshi 110:872-8. 2006..Ocular warming increased RBF in the retinal artery and vein but decreased CBF in the foveal region. The CBF in the foveal region may contribute to maintaining a constant retinal temperature in response to ocular warming...
Retinal circulatory changes associated with interferon-induced retinopathy in patients with hepatitis CTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Invest Ophthalmol Vis Sci 48:368-75. 2007..To evaluate the effect of interferon (IFN) therapy on retinal microcirculation...
Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry studyTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Invest Ophthalmol Vis Sci 51:6729-34. 2010..To evaluate the differences in retinal circulation in eyes of patients with type 2 diabetes with no or early-stage diabetic retinopathy compared with control eyes...
Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosisTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Asahikawa 078 8510, Japan
Invest Ophthalmol Vis Sci 46:720-5. 2005..To examine the relation between intima-media thickness (IMT) in the common carotid artery, which is generally recognized as a marker of early atherosclerosis, and retinal circulatory parameters...
The effect of ocular warming on ocular circulation in healthy humansTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Arch Ophthalmol 122:1477-81. 2004..To examine the effect of ocular warming on retinal blood flow (RBF) and subfoveal choroidal blood flow (CBF) in humans...
Alteration of choroidal circulation in the foveal region in patients with type 2 diabetesT Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa, 078 8510, Japan
Br J Ophthalmol 88:1060-3. 2004..To investigate changes in choroidal blood flow (CBF) in the foveal region in patients with type 2 diabetes...
Effect of haemodialysis on retinal circulation in patients with end stage renal diseaseT Nagaoka
Department of Ophthalmology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa, 078 8510, Japan
Br J Ophthalmol 88:1026-9. 2004..To investigate the effect of haemodialysis on retinal circulation in patients with end stage renal disease (ESRD)...
C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide productionTaiji Nagaoka
Department of Ophthalmology, Scott and White Eye Institute, Temple, TX 76504, USA
Invest Ophthalmol Vis Sci 49:2053-60. 2008....
Retinal artery response to acute systemic blood pressure increase during cold pressor test in humansTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Invest Ophthalmol Vis Sci 43:1941-5. 2002..The purpose of this study was to investigate the response of the retinal arteriole to an acute increase in systemic blood pressure (BP)...
The effect of nitric oxide on retinal blood flow during hypoxia in catsTaiji Nagaoka
Departments of Ophthalmology and Physiology, Asahikawa Medical College, Asahikawa, Japan
Invest Ophthalmol Vis Sci 43:3037-44. 2002..To investigate how nitric oxide (NO) contributes to the regulation of retinal circulation during rest and hypoxia in cats...
Effect of aging on retinal circulation in normotensive healthy subjectsTaiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8502, Japan
Exp Eye Res 89:887-91. 2009..The UT is the only parameter that increased significantly in subjects with prehypertension compared with those without prehypertension, suggesting that the UT may indicate the effects of prehypertension on the retinal arterioles...
Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in catsNaohiro Izumi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Invest Ophthalmol Vis Sci 49:4595-603. 2008..To investigate whether nitric oxide (NO) regulates retinal circulation during and after induction of hyperoxia in cats...
Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factorsSeigo Nakabayashi
Department of Ophthalmology, Asahikawa Medical University, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
Exp Eye Res 103:63-70. 2012..It appears that the retinal endothelium, by releasing vasoactive substances, contributes to RBF regulation during acute severe elevation of systemic blood pressure...
Acute hyperglycemia-induced endothelial dysfunction in retinal arterioles in catsKenji Sogawa
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Invest Ophthalmol Vis Sci 51:2648-55. 2010..To investigate the effects of acute hyperglycemia on retinal microcirculation and endothelial function in cats and removal of superoxide to prevent retinal endothelial dysfunction from hyperglycemia...
Association between diabetic retinopathy and flow-mediated vasodilation in type 2 DMKenji Sogawa
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Curr Eye Res 37:446-51. 2012..Brachial artery flow-mediated vasodilation (FMD) is a marker of endothelial function associated with production of endogenous nitric oxide. Using FMD, we investigated the relationship between macrovascular function and DR...
Short-term effects of topical tafluprost on retinal blood flow in catsNaohiro Izumi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
J Ocul Pharmacol Ther 24:521-6. 2008..The aim of this study was to determine the short-term effects of topical tafluprost, a novel prostaglandin F(2) derivative, on feline retinal circulation...
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathwaysTaiji Nagaoka
Department of Ophthalmology, Scott and White Eye Institute, Temple, Texas 76504, USA
Invest Ophthalmol Vis Sci 48:825-32. 2007..In the current study, the direct effect and the underlying mechanism of the vasomotor action of simvastatin in retinal arterioles was studied...
Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channelsTaiji Nagaoka
Department of Ophthalmology, Scott and White Eye Institute, College of Medicine, Texas A and M Health Science Center, Temple, TX 76504, USA
Invest Ophthalmol Vis Sci 48:4232-9. 2007..In this study, the direct effect and the underlying mechanism of the vasomotor action of resveratrol were examined in retinal arterioles...
Role of nitric oxide in regulation of retinal blood flow during hypercapnia in catsEiichi Sato
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Invest Ophthalmol Vis Sci 44:4947-53. 2003..To investigate whether nitric oxide (NO) contributes to the regulation of retinal circulation during hypercapnia in cats...
Fenofibrate, an anti-dyslipidemia drug, elicits the dilation of isolated porcine retinal arterioles: role of nitric oxide and AMP-activated protein kinaseTsuneaki Omae
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Invest Ophthalmol Vis Sci 53:2880-6. 2012..In the current study, we examined the effect of the vasomotor action of fenofibrate on porcine retinal arterioles...
Macular hole formation in fellow eyes with a perifoveal posterior vitreous detachment of patients with a unilateral macular holeAtsushi Takahashi
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, 2 1 1 1 Midorigaoka Higashi, Hokkaido, Japan
Am J Ophthalmol 151:981-989.e4. 2011....
Relationship between choroidal thickness and choroidal circulation in healthy young subjectsKenji Sogawa
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Am J Ophthalmol 153:1129-32.e1. 2012..To investigate the relationship between the choroidal thickness and choroidal blood flow in healthy young subjects...
Functional and molecular characterization of the endothelin system in retinal arteriolesTravis W Hein
Department of Ophthalmology, Scott and White Eye Institute, Temple, Texas 76504, USA
Invest Ophthalmol Vis Sci 50:3329-36. 2009..The authors examined the roles of ET(A) and ET(B) receptors and of endothelin-converting enzyme (ECE)-1 in ET-1-induced vasomotor responses of single retinal arterioles...
Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patientsMotofumi Kawai
Department of Ophthalmology, Asahikawa Medical University, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
Jpn J Ophthalmol 56:458-63. 2012..Our aim was to evaluate the effects of topical carteolol on retinal arterial blood flow (RBF) in patients with primary open-angle glaucoma...
Idiopathic full-thickness macular holes and the vitreomacular interface: a high-resolution spectral-domain optical coherence tomography studyAtsushi Takahashi
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
Am J Ophthalmol 154:881-892.e2. 2012..To analyze the vitreomacular interface in idiopathic full-thickness macular holes (MHs) using spectral-domain optical coherence tomography...
Correlation between plasma pentosidine concentrations and retinal hemodynamics in patients with type 2 diabetesEiichi Sato
Department of Ophthalmology, Asahikawa Medical University, Japan
Am J Ophthalmol 153:903-909.e1. 2012..To investigate whether plasma pentosidine, a well-defined advanced glycation end product, is associated with retinal hemodynamic abnormalities in patients with type 2 diabetes...
Spontaneous outer retinal closure of stage 1B macular hole without vitreofoveal separationAtsushi Takahashi
Department of Ophthalmology, Asahikawa Medical College, 2 1 1 1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078 8510, Japan
Int Ophthalmol 30:731-4. 2010..This case demonstrates that spontaneous closure in the outer retina may develop in some cases of stage 1B macular holes without vitreofoveal separation...
Pulsatile ocular blood flow: changes associated with scleral buckling proceduresHarumasa Yokota
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Jpn J Ophthalmol 49:162-5. 2005..50 +/- 0.51 mmHg and 589.5 +/- 278.4 microl/min, respectively). CONCLUSIONS: These results indicate that the choroidal blood flow decreases after SB but returns to normal levels after 6 months...
Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channelsTsuneaki Omae
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Invest Ophthalmol Vis Sci 52:6749-56. 2011....
[The change of retinal arteriolar circulation in a case of branch retinal artery occlusion]Tsuneaki Omae
Department of Ophthalmology, Asahikawa Medical College, Japan
Nihon Ganka Gakkai Zasshi 113:800-7. 2009....
Influence of macular microcirculation and retinal thickness on visual acuity in patients with branch retinal vein occlusion and macular edemaHidetaka Noma
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Chiba, Japan
Jpn J Ophthalmol 54:430-4. 2010..To investigate perifoveal capillary blood flow velocity and retinal thickness at the central fovea in patients with branch retinal vein occlusion (BRVO) and macular edema and to assess their relation with visual acuity and visual prognosis...
Stage 1-A macular hole: a prospective spectral-domain optical coherence tomography studyAtsushi Takahashi
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Retina 31:127-47. 2011....
Role of prorenin in the pathogenesis of retinal neovascularizationHarumasa Yokota
Department of Ophthalmology, Asahikawa Medical College, Asahikawa 078 8510, Japan
Hokkaido Igaku Zasshi 83:159-65. 2008..To determine the role of prorenin in the pathogenesis of retinal neovascularization, we evaluated the inhibitory effect of the handle region peptide (HRP) on retinal neovascularization...
Impaired systemic vascular endothelial function in patients with branch retinal vein occlusionIchiro Tanano
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Curr Eye Res 38:114-8. 2013..Conclusions: The results suggested that BRVO is associated with generalized endothelial dysfunction and that impaired systemic endothelial function may be associated with BRVO...
Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetesHarumasa Yokota
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
J Renin Angiotensin Aldosterone Syst 12:290-4. 2011..However, there was no difference in the development of DR between high and low groups in females (p = 0.58). Serum prorenin levels in males with type 2 diabetes could be a new prognostic indicator of the development of DR...
Relation between plasma nitric oxide levels and diabetic retinopathyNaohiro Izumi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Jpn J Ophthalmol 50:465-8. 2006..05 in each case). CONCLUSION: The increased plasma NO levels in patients with type 2 diabetes indicate that NO may be associated with the pathogenesis of DR...
[Long-term clinical course and changes in the choroidal circulation in the foveal region in a case of juvenile retinitis pigmentosa with bilateral cystoid macular edema]Atsushi Takahashi
Department of Ophthalmology, Asahikawa Medical College, Hokkaido, Japan
Nihon Ganka Gakkai Zasshi 113:656-63. 2009....
[Evaluation of retinal circulation in patients with diabetic retinopathy]Taiji Nagaoka
Department of Ophthalmology, Asahikawa Medical College
Nippon Rinsho 63:220-5. 2005
Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrumentAkitoshi Yoshida
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Am J Ophthalmol 135:356-61. 2003....
Prorenin levels in retinopathy of prematurityHarumasa Yokota
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Am J Ophthalmol 143:531-3. 2007..To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP)...
[Pathogenesis of macular edema associated with branch retinal vein occlusion and strategy for treatment]Hidetaka Noma
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, 477 96 Owada Shinden, Yachiyo shi, Chiba ken 276 8524, Japan
Nihon Ganka Gakkai Zasshi 114:577-91. 2010..To manage macular edema associated with BRVO, it is important to control cytokine production with a combination of treatments...
Inhibitory effect of bucillamine on the increased leukocyte entrapment in the retinal microcirculation of diabetic ratsFumihiko Mori
Department of Ophthalmology, Hakodate Goryokaku Hospital, Hakodate, and Department of Ophthalmology, Asahikawa Medical College, Japan
Jpn J Ophthalmol 50:377-9. 2006..To evaluate quantitatively the effects of bucillamine on the entrapment of leukocytes in the retinal microcirculation of diabetic rats...
Effects of shear stress on the gene expressions of endothelial nitric oxide synthase, endothelin-1, and thrombomodulin in human retinal microvascular endothelial cellsAkihiro Ishibazawa
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Invest Ophthalmol Vis Sci 52:8496-504. 2011..Physiological shear stress is higher in the retinal microcirculatory network than in other organs. The effects of laminar shear stress on gene expression in human retinal microvascular endothelial cells (HRMECs) was investigated...
Foveal anatomic changes in a progressing stage 1 macular hole documented by spectral-domain optical coherence tomographyAtsushi Takahashi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Ophthalmology 117:806-10. 2010..To report the case of a stage 1 macular hole and the sequential intrafoveal changes with spectral-domain optical coherence tomography (SD-OCT)...
Effect of timolol and UF-021 (a prostaglandin-related compound) on pulsatile ocular blood flow in normal volunteersN Kitaya
Department of Ophthalmology, Asahikawa Medical College, Japan
Ophthalmic Res 29:139-44. 1997..Our results suggest that in normal subjects timolol decreases POBF in both the treated and the untreated eyes, whereas UF-021 has no action on either IOP or POBF...
Features of abnormal choroidal circulation in central serous chorioretinopathyN Kitaya
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Br J Ophthalmol 87:709-12. 2003..To evaluate abnormalities in the choroidal circulation in cases of central serous chorioretinopathy (CSC)...
Serum prorenin levels and diabetic retinopathy in type 2 diabetes: new method to measure serum level of prorenin using antibody activating direct kinetic assayH Yokota
Department of Ophthalmology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa, 078 8510 Japan
Br J Ophthalmol 89:871-3. 2005..To investigate the serum levels of prorenin and its correlation with the severity of diabetic retinopathy (DR)...
Choroidal blood flow in the foveal region in eyes with rhegmatogenous retinal detachment and scleral buckling proceduresR Sugawara
Department of Ophthalmology, Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, Japan
Br J Ophthalmol 90:1363-5. 2006..CONCLUSIONS: The results suggest that ChBF in the foveal region transiently decreases after scleral buckling and recovers to the baseline level within 12 weeks in patients with a retinal detachment and no macular involvement...
Effect of panretinal photocoagulation on choroidal circulation in the foveal region in patients with severe diabetic retinopathyA Takahashi
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Br J Ophthalmol 92:1369-73. 2008..To study alterations in choroidal blood flow (CBF) in the foveal region after panretinal photocoagulation (PRP) in patients with severe proliferative diabetic retinopathy...
Central corneal thickness measurements with Fourier-domain optical coherence tomography versus ultrasonic pachymetry and rotating Scheimpflug cameraAkihiro Ishibazawa
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
Cornea 30:615-9. 2011..To compare the accuracy and repeatability of Fourier-domain optical coherence tomography (FD-OCT) with ultrasonic pachymetry (USP) and a rotating Scheimpflug camera for measuring the central corneal thickness (CCT)...
Macular microcirculation and macular oedema in branch retinal vein occlusionH Noma
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Yachiyo, Chiba 276 8524, Japan
Br J Ophthalmol 93:630-3. 2009..The relationship between the blood-flow velocity in the perifoveal capillaries and macular oedema was investigated in patients with branch retinal vein occlusion (BRVO)...
Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic ratsR Sugawara
Department of Ophthalmology, Asahikawa Medical College, Midorogaoka Higashi 2-1. Asahikawa 078-8510, Japan
Curr Eye Res 29:11-6. 2004..The current study suggests a role for peroxynitrite production and for PARP activation in the pathogenesis of retinal microvascular leukostasis in early diabetes...
Inhibitory effect of losartan, an AT1 angiotensin II receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic ratsF Mori
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
Br J Ophthalmol 86:1172-4. 2002..The effectiveness of losartan for the treatment of leucocyte entrapment in the retinal microcirculation of diabetic rats was evaluated quantitatively...
Pulsatile ocular blood flow is unaffected in type 2 diabetes mellitusFumihiko Mori
Jpn J Ophthalmol 47:621-2. 2003
Dysfunction of active transport of blood-retinal barrier in patients with clinically significant macular edema in type 2 diabetesFumihiko Mori
Diabetes Care 25:1248-9. 2002
