Toru Kono

Summary

Affiliation: Asahikawa Medical College
Country: Japan

Publications

  1. ncbi request reprint Development and characterization of 1C6-203, a new monoclonal antibody specific to human thymidine phosphorylase
    T Kono
    Second Department of Surgery and Medicine, Kamakura, Kanagawa, Japan
    J Histochem Cytochem 49:131-8. 2001
  2. pmc Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine
    Toru Kono
    Center for Clinical and Biomedical Research, Sapporo Hisgashi Tokushukai Hospital, Hokkaido, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G428-36. 2013
  3. doi request reprint Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
    Life Sci 90:122-30. 2012
  4. doi request reprint Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido 078 8510, Japan
    J Crohns Colitis 4:161-70. 2010
  5. doi request reprint Preventive effect of goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study)
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Jpn J Clin Oncol 39:847-9. 2009
  6. doi request reprint A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's disease
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
    Dis Colon Rectum 54:586-92. 2011
  7. ncbi request reprint Phase II study of irinotecan, leucovorin, 5-fluorouracil and tegafur/uracil for metastatic colorectal cancer
    T Kono
    Second Department of Surgery, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    J Chemother 17:224-7. 2005
  8. doi request reprint Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, 2 1 Midorigaoka Higashi, Hokkaido 078 8510, Japan
    Exp Biol Med (Maywood) 236:1314-21. 2011
  9. doi request reprint Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
    J Surg Res 150:78-84. 2008
  10. ncbi request reprint Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system
    Toru Kono
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
    J Surg Res 117:329-38. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Development and characterization of 1C6-203, a new monoclonal antibody specific to human thymidine phosphorylase
    T Kono
    Second Department of Surgery and Medicine, Kamakura, Kanagawa, Japan
    J Histochem Cytochem 49:131-8. 2001
    ..Therefore, MAb 1C6-203 might be more suitable than MAb 654-1 for evaluating dThdPase expression in colorectal carcinoma...
  2. pmc Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine
    Toru Kono
    Center for Clinical and Biomedical Research, Sapporo Hisgashi Tokushukai Hospital, Hokkaido, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G428-36. 2013
    ..Epithelial TRPA1 appears to be a promising target for the development of novel strategies for the treatment of various gastrointestinal disorders...
  3. doi request reprint Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
    Life Sci 90:122-30. 2012
    ..This study examined the ability of polaprezinc, N-(3-aminopropionyl)-l-histidinato zinc, to prevent fibrosis in a rat model of thioacetamide (TAA)-induced hepatic fibrosis...
  4. doi request reprint Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido 078 8510, Japan
    J Crohns Colitis 4:161-70. 2010
    ..We investigated the therapeutic effects of daikenchuto (DKT), an extracted Japanese herbal medicine, on the regulation of endogenous ADM in the gastrointestinal tract in a CD mouse model...
  5. doi request reprint Preventive effect of goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study)
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Jpn J Clin Oncol 39:847-9. 2009
    ..Eighty patients are required in the study (40 patients per group)...
  6. doi request reprint A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's disease
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
    Dis Colon Rectum 54:586-92. 2011
    ..Recurrence of Crohn's disease usually occurs at anastomotic sites...
  7. ncbi request reprint Phase II study of irinotecan, leucovorin, 5-fluorouracil and tegafur/uracil for metastatic colorectal cancer
    T Kono
    Second Department of Surgery, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    J Chemother 17:224-7. 2005
    ..The median time to progression was 5.2 months, and the median survival time was 20.2 months. Considering the low toxicity and reasonable cost, this regimen deserves further investigation...
  8. doi request reprint Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, 2 1 Midorigaoka Higashi, Hokkaido 078 8510, Japan
    Exp Biol Med (Maywood) 236:1314-21. 2011
    ..We conclude that endogenous UTI is produced in the liver to suppress the production and activation of TGF-β and that administering exogenous UTI may be therapeutically beneficial for preventing liver fibrosis...
  9. doi request reprint Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
    J Surg Res 150:78-84. 2008
    ..CGRP is also the most powerful vasoactive substance. In the present study, we investigated whether DKT has any effect on the colonic blood flow in rats...
  10. ncbi request reprint Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system
    Toru Kono
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
    J Surg Res 117:329-38. 2004
    ..DAF-2 offers a sensitive indicator for visualizing production of NO with high spatial resolution. This new system may contribute to the study of the pathophysiological role of the nitrergic pathway in the gastrointestinal tract...
  11. ncbi request reprint Successful low-dose chemotherapy using vinblastine and methotrexate for the treatment of an ileoanal pouch mesenteric desmoid tumor: report of a case
    Toru Kono
    Second Department of Surgery, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Dis Colon Rectum 47:246-9. 2004
    ..This is a unique case highlighting the possibility of ileoanal pouch salvage by low-dose combination chemotherapy using vinblastine and methotrexate in a familial adenomatous polyposis patient with mesenteric desmoid tumor...
  12. doi request reprint Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    J Gastroenterol 46:1187-96. 2011
    ..Therefore, we investigated the vasodilatory effect of TU-100 in a CD rat model...
  13. ncbi request reprint Adaptive cytoprotection against acetic acid induced colonic injury in rats
    T Kono
    Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
    Int J Colorectal Dis 16:384-90. 2001
    ..The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon...
  14. ncbi request reprint Protective effect of pretreatment with low-dose lipopolysaccharide on D-galactosamine-induced acute liver failure
    Toru Kono
    Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
    Int J Colorectal Dis 17:98-103. 2002
    ..The effect of low-dose lipopolysaccharide (LPS) induced nitric oxide (NO) on liver damage and survival in rats with acute liver failure caused by a lethal dose of D-galactosamine (D-gal) was studied...
  15. ncbi request reprint Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats
    Yoshiaki Ebisawa
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    J Surg Res 118:183-9. 2004
    ..The aims of this study were to investigate whether low-dose LPS (LLPS)-induced hepatic production of NO is beneficial and to clarify the origins of cytoprotective NO-producing cells in the liver during LPS tolerance...
  16. doi request reprint Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo
    Chisato Ishikawa
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Innate Immun 2:66-76. 2010
    ..05). This study demonstrated the multifunctional roles of the activation process in human defensin and the possibility of using antimicrobial peptides for the treatment of inflammatory bowel diseases in future applications...
  17. ncbi request reprint Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells
    Takahiro Ito
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan
    Tohoku J Exp Med 227:39-48. 2012
    ..Therefore, Paneth cells may play a role in the innate immunity associated with adaptive immune responses...
  18. ncbi request reprint Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase
    Kei Ohara
    Second Department of Surgery, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Int J Colorectal Dis 18:260-6. 2003
    ..This study investigated whether the CAP is preserved in the chronic inflamed colon...
  19. doi request reprint Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach
    Hiroki Tanabe
    Department of Internal Medicine, Division of Gastroenterology and Haematology Oncology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Helicobacter 13:370-9. 2008
    ..Detailed pathologic studies have shown that H. pylori settles on the surface of gastric mucosa, and that it is eliminated from metaplastic mucosa. However, its mechanism of natural protection is not well known...
  20. doi request reprint Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction
    Ryu Sato
    Division of Endoscopy, Asahikawa Medical College, Asahikawa, Japan
    Gastrointest Endosc 67:953-7. 2008
    ..The technical difficulties related to the insertion of a long intestinal tube into the jejunum under fluoroscopy present a considerable problem in patients with an intestinal obstruction...
  21. doi request reprint Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers
    Masaya Munekage
    Department of Surgery, Kochi Medical School, Kochi, Japan
    Drug Metab Dispos 41:1256-63. 2013
    ....
  22. pmc Infliximab extends the duration until the first surgery in patients with Crohn's disease
    Aki Sakatani
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Biomed Res Int 2013:879491. 2013
    ..We evaluated the effects of infliximab and other factors on extending the duration until the first surgery in CD patients on a long-term basis...
  23. doi request reprint The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen
    Masanori Nishioka
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    Int J Clin Oncol 16:322-7. 2011
    ..The aim of this study was to clarify the efficacy of GJG for peripheral neuropathy associated with oxaliplatin therapy...
  24. pmc Cetuximab-induced hypomagnesaemia aggravates peripheral sensory neurotoxicity caused by oxaliplatin
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
    J Gastrointest Oncol 1:97-101. 2010
    ..Therefore, when administering cetuximab after oxaliplatin therapy, we suggest serially evaluating serum magnesium levels and neurotoxicity...
  25. ncbi request reprint [Long-term survival of a patient with advanced colon cancer and para-aortic lymph node metastases treated with re-administration of high-dose molecular targeted agent bevacizumab]
    Yoshiaki Ebisawa
    Division of Gastroenterologic and General Surgery, Asahikawa Medical University
    Gan To Kagaku Ryoho 40:1401-4. 2013
    ..There was a possibility that long-term survival could be obtained by increasing the quantity of BV and re-administering it in second-line chemotherapy after PD in BV + FOLFOX first-line chemotherapy...
  26. pmc Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Evid Based Complement Alternat Med 2011:418481. 2011
    ..0%, 100%, 78.9%, and 91.7%, respectively. It was lowest in the group that received GJG alone. Concomitant administration of GJG reduced the neurotoxicity of oxaliplatin in patients that received chemotherapy for colorectal cancer...
  27. ncbi request reprint Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion
    Hiroki Tanabe
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Japan
    Biochem Biophys Res Commun 358:349-55. 2007
    ..The HD-5 was sensitive to the trypsin treatment. These observations evidently predict that a defensin deficiency may be caused by a disulfide disorder in the disease...
  28. ncbi request reprint Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in rats
    Yukiomi Nakade
    Second Department of Medicine and Surgery, Asahikawa Medical College, Asahikawa, Japan
    Eur J Pharmacol 460:135-8. 2003
    ..These results further establish a role of endogenous CRF in the brain in hepatic pathophysiological regulation...
  29. ncbi request reprint The role of Paneth cells and their antimicrobial peptides in innate host defense
    Tokiyoshi Ayabe
    Department of Internal Medicine III, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Trends Microbiol 12:394-8. 2004
    ....
  30. doi request reprint A rapid method to isolate soluble royal jelly proteins
    Reo Nozaki
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
    Food Chem 134:2332-7. 2012
    ..Our MRJP isolation method reduces the procedure time by using ultracentrifugation without dialysis to obtain SRJPs and produces layers containing MRJP1 oligomers, MRJP2 and MRJP3...
  31. ncbi request reprint [Effectiveness and motion mechanism of Taikencyuto in the perioperative period]
    Koutarou Maeda
    Department of Surgery, Fujita Health Univeristy, Sapporo, Japan
    Nihon Geka Gakkai Zasshi 114:232-5. 2013
    ..TJ-100 is considered to be useful for promoting intestinal motility and preventing ileus during the perioperative period. Further studies must be performed to confirm its usefulness in perioperative care...
  32. doi request reprint Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer
    Shougo Tamura
    Division of Health Sciences, Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan
    Proteomics 9:5534-43. 2009
    ..In conclusion, MRJP 1 oligomer is a heat-resistant protein comprising MRJP 1 monomer and Apisimin, and has cell proliferation activity. These findings will contribute to further studies analyzing the effects of MRJP 1 in humans...
  33. doi request reprint Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers
    Masaya Munekage
    Department of Surgery, Kochi Medical School, Nankoku, Kochi, Japan
    Drug Metab Dispos 39:1784-8. 2011
    ..023 ng/ml). The pharmacokinetics of HAS, HBS, 6S, and 10S, were linear within the range of 2.5 to 10 g/day of TJ-100. On the other hand, the kinetics of GRB1 and GRG1 were not proportional to dosage, and plateauing was observed...
  34. doi request reprint Localization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm of the pancreas
    Hidenori Karasaki
    Division of Gastroenterological and General Surgery, Department of Surgery, Asahikawa Medical University, Hokkaido, Japan
    Pancreas 40:588-94. 2011
    ..The aim of this study was to define the relevance of mural nodules (MNs) as a "direct" indicator of malignancy of intraductal papillary mucinous neoplasm (IPMN) of the pancreas...
  35. doi request reprint Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
    Madoka Yamazaki
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Hokkaido 078 8510, Japan
    Cancer Sci 99:1131-8. 2008
    ..Targeting SHH would be a novel therapeutic approach that can inhibit not only proliferation of cancer cells but also EPC-mediated angiogenesis...
  36. ncbi request reprint [A case of neurotoxicity reduced with goshajinkigan in modified FOLFOX6 chemotherapy for advanced colon cancer]
    Noriaki Mamiya
    Higashiasahikawa Hospital
    Gan To Kagaku Ryoho 34:1295-7. 2007
    ..The severities of neurotoxicity before and after administration of TJ 107 were grade 2 and 1,respectively. TJ 107 could reduce or prevent the neurotoxicity of L-OHP...
  37. ncbi request reprint Vitamin E therapy in patients with NASH
    Masashi Yoneda
    Hepatology 39:568; author reply 569-70. 2004
  38. ncbi request reprint Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Regul Pept 131:74-81. 2005
    ....
  39. ncbi request reprint Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Eur J Pharmacol 478:173-7. 2003
    ..These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in central TRH-induced hepatic cytoprotection...
  40. doi request reprint Role of alpha2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice
    Yuji Omiya
    Tsumura Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Eur J Pharmacol 592:62-6. 2008
    ..Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain...
  41. ncbi request reprint Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Peptides 26:1573-9. 2005
    ....
  42. ncbi request reprint [A case report of advanced cardiac cancer showing a complete response to TS-1 as neoadjuvant chemotherapy]
    Yasuhiro Yamamoto
    Dept of Surgery, Kobayashi Hospital
    Gan To Kagaku Ryoho 31:579-83. 2004
    ..In the future, TS-1 can be expected to display efficacy in neoadjuvant chemotherapy for patients with advanced gastric cancer who have poor prognoses...