Research Topics
Species | Toru KonoSummaryAffiliation: Asahikawa Medical College Country: Japan Publications
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Detail Information
Publications
Development and characterization of 1C6-203, a new monoclonal antibody specific to human thymidine phosphorylaseT Kono
Second Department of Surgery and Medicine, Kamakura, Kanagawa, Japan
J Histochem Cytochem 49:131-8. 2001..Therefore, MAb 1C6-203 might be more suitable than MAb 654-1 for evaluating dThdPase expression in colorectal carcinoma...
Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestineToru Kono
Center for Clinical and Biomedical Research, Sapporo Hisgashi Tokushukai Hospital, 14 3 1 Higashi, N33, Higashi ku, Sapporo, Hokkaido 065 0033, Japan
Am J Physiol Gastrointest Liver Physiol 304:G428-36. 2013..Epithelial TRPA1 appears to be a promising target for the development of novel strategies for the treatment of various gastrointestinal disorders...
Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in ratsToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
Life Sci 90:122-30. 2012..This study examined the ability of polaprezinc, N-(3-aminopropionyl)-l-histidinato zinc, to prevent fibrosis in a rat model of thioacetamide (TAA)-induced hepatic fibrosis...- Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1Toru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
J Surg Res 150:78-84. 2008..CGRP is also the most powerful vasoactive substance. In the present study, we investigated whether DKT has any effect on the colonic blood flow in rats... - Preventive effect of goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study)Toru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Jpn J Clin Oncol 39:847-9. 2009..Eighty patients are required in the study (40 patients per group)... - Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse modelToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido 078 8510, Japan
J Crohns Colitis 4:161-70. 2010..We investigated the therapeutic effects of daikenchuto (DKT), an extracted Japanese herbal medicine, on the regulation of endogenous ADM in the gastrointestinal tract in a CD mouse model... - A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's diseaseToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
Dis Colon Rectum 54:586-92. 2011..Recurrence of Crohn's disease usually occurs at anastomotic sites... - Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat modelToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
J Gastroenterol 46:1187-96. 2011..Therefore, we investigated the vasodilatory effect of TU-100 in a CD rat model... - Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in miceToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, 2 1 Midorigaoka Higashi, Hokkaido 078 8510, Japan
Exp Biol Med (Maywood) 236:1314-21. 2011..We conclude that endogenous UTI is produced in the liver to suppress the production and activation of TGF-β and that administering exogenous UTI may be therapeutically beneficial for preventing liver fibrosis... - Phase II study of irinotecan, leucovorin, 5-fluorouracil and tegafur/uracil for metastatic colorectal cancerT Kono
Second Department of Surgery, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
J Chemother 17:224-7. 2005..The median time to progression was 5.2 months, and the median survival time was 20.2 months. Considering the low toxicity and reasonable cost, this regimen deserves further investigation... - Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging systemToru Kono
Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
J Surg Res 117:329-38. 2004..DAF-2 offers a sensitive indicator for visualizing production of NO with high spatial resolution. This new system may contribute to the study of the pathophysiological role of the nitrergic pathway in the gastrointestinal tract... - Protective effect of pretreatment with low-dose lipopolysaccharide on D-galactosamine-induced acute liver failureToru Kono
Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
Int J Colorectal Dis 17:98-103. 2002..The effect of low-dose lipopolysaccharide (LPS) induced nitric oxide (NO) on liver damage and survival in rats with acute liver failure caused by a lethal dose of D-galactosamine (D-gal) was studied... - Successful low-dose chemotherapy using vinblastine and methotrexate for the treatment of an ileoanal pouch mesenteric desmoid tumor: report of a caseToru Kono
Second Department of Surgery, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Dis Colon Rectum 47:246-9. 2004..This is a unique case highlighting the possibility of ileoanal pouch salvage by low-dose combination chemotherapy using vinblastine and methotrexate in a familial adenomatous polyposis patient with mesenteric desmoid tumor... - Adaptive cytoprotection against acetic acid induced colonic injury in ratsT Kono
Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
Int J Colorectal Dis 16:384-90. 2001..The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon... - Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in ratsYoshiaki Ebisawa
Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
J Surg Res 118:183-9. 2004..CONCLUSION: LLPS-induced NO in hepatocytes, but not in Kupffer cells, exhibits cytoprotective effects on HLPS-induced liver damage, suggesting that NO has a beneficial role in the induction of the early phase of LPS tolerance... - Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivoChisato Ishikawa
Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
J Innate Immun 2:66-76. 2010..05). This study demonstrated the multifunctional roles of the activation process in human defensin and the possibility of using antimicrobial peptides for the treatment of inflammatory bowel diseases in future applications... - Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cellsTakahiro Ito
Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan
Tohoku J Exp Med 227:39-48. 2012..Therefore, Paneth cells may play a role in the innate immunity associated with adaptive immune responses... - Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenaseKei Ohara
Second Department of Surgery, Asahikawa Medical College, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido 078-8510, Japan
Int J Colorectal Dis 18:260-6. 2003.... - Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomachHiroki Tanabe
Department of Internal Medicine, Division of Gastroenterology and Haematology Oncology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
Helicobacter 13:370-9. 2008..Detailed pathologic studies have shown that H. pylori settles on the surface of gastric mucosa, and that it is eliminated from metaplastic mucosa. However, its mechanism of natural protection is not well known... - Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstructionRyu Sato
Division of Endoscopy, Asahikawa Medical College, Asahikawa, Japan
Gastrointest Endosc 67:953-7. 2008..The technical difficulties related to the insertion of a long intestinal tube into the jejunum under fluoroscopy present a considerable problem in patients with an intestinal obstruction... - The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimenMasanori Nishioka
Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
Int J Clin Oncol 16:322-7. 2011..The aim of this study was to clarify the efficacy of GJG for peripheral neuropathy associated with oxaliplatin therapy... - Cetuximab-induced hypomagnesaemia aggravates peripheral sensory neurotoxicity caused by oxaliplatinToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
J Gastrointest Oncol 1:97-101. 2010..Therefore, when administering cetuximab after oxaliplatin therapy, we suggest serially evaluating serum magnesium levels and neurotoxicity... - Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancerToru Kono
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
Evid Based Complement Alternat Med 2011:418481. 2011..0%, 100%, 78.9%, and 91.7%, respectively. It was lowest in the group that received GJG alone. Concomitant administration of GJG reduced the neurotoxicity of oxaliplatin in patients that received chemotherapy for colorectal cancer... - Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestionHiroki Tanabe
Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Japan
Biochem Biophys Res Commun 358:349-55. 2007..The HD-5 was sensitive to the trypsin treatment. These observations evidently predict that a defensin deficiency may be caused by a disulfide disorder in the disease... - Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in ratsYukiomi Nakade
Second Department of Medicine and Surgery, Asahikawa Medical College, Asahikawa, Japan
Eur J Pharmacol 460:135-8. 2003..These results further establish a role of endogenous CRF in the brain in hepatic pathophysiological regulation... - The role of Paneth cells and their antimicrobial peptides in innate host defenseTokiyoshi Ayabe
Department of Internal Medicine III, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
Trends Microbiol 12:394-8. 2004.... - A rapid method to isolate soluble royal jelly proteinsReo Nozaki
Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan Japan Royal Jelly Research Laboratories, Japan Royal Jelly and Co, Miyagi, Japan
Food Chem 134:2332-7. 2012..Our MRJP isolation method reduces the procedure time by using ultracentrifugation without dialysis to obtain SRJPs and produces layers containing MRJP1 oligomers, MRJP2 and MRJP3... - Molecular characteristics and physiological functions of major royal jelly protein 1 oligomerShougo Tamura
Division of Health Sciences, Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan
Proteomics 9:5534-43. 2009..In conclusion, MRJP 1 oligomer is a heat-resistant protein comprising MRJP 1 monomer and Apisimin, and has cell proliferation activity. These findings will contribute to further studies analyzing the effects of MRJP 1 in humans... - Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteersMasaya Munekage
Department of Surgery, Kochi Medical School, Nankoku, Kochi, Japan
Drug Metab Dispos 39:1784-8. 2011..023 ng/ml). The pharmacokinetics of HAS, HBS, 6S, and 10S, were linear within the range of 2.5 to 10 g/day of TJ-100. On the other hand, the kinetics of GRB1 and GRG1 were not proportional to dosage, and plateauing was observed... - Localization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm of the pancreasHidenori Karasaki
Division of Gastroenterological and General Surgery, Department of Surgery, Asahikawa Medical University, Hokkaido, Japan
Pancreas 40:588-94. 2011..The aim of this study was to define the relevance of mural nodules (MNs) as a "direct" indicator of malignancy of intraductal papillary mucinous neoplasm (IPMN) of the pancreas... - Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cellsMadoka Yamazaki
Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Hokkaido 078 8510, Japan
Cancer Sci 99:1131-8. 2008..Targeting SHH would be a novel therapeutic approach that can inhibit not only proliferation of cancer cells but also EPC-mediated angiogenesis... - [A case of neurotoxicity reduced with goshajinkigan in modified FOLFOX6 chemotherapy for advanced colon cancer]Noriaki Mamiya
Higashiasahikawa Hospital
Gan To Kagaku Ryoho 34:1295-7. 2007..The severities of neurotoxicity before and after administration of TJ 107 were grade 2 and 1,respectively. TJ 107 could reduce or prevent the neurotoxicity of L-OHP... - Vitamin E therapy in patients with NASHMasashi Yoneda
Hepatology 39:568; author reply 569-70. 2004 - Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in ratsMasashi Yoneda
Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
Regul Pept 131:74-81. 2005.... - Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in ratsMasashi Yoneda
Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
Peptides 26:1573-9. 2005.... - Role of alpha2-adrenoceptors in enhancement of antinociceptive effect in diabetic miceYuji Omiya
Tsumura Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
Eur J Pharmacol 592:62-6. 2008..Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain... - Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotectionMasashi Yoneda
Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
Eur J Pharmacol 478:173-7. 2003..These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in central TRH-induced hepatic cytoprotection... - [A case report of advanced cardiac cancer showing a complete response to TS-1 as neoadjuvant chemotherapy]Yasuhiro Yamamoto
Dept. of Surgery, Kobayashi Hospital
Gan To Kagaku Ryoho 31:579-83. 2004..In the future, TS-1 can be expected to display efficacy in neoadjuvant chemotherapy for patients with advanced gastric cancer who have poor prognoses...