Masakazu Haneda

Summary

Affiliation: Asahikawa Medical College
Country: Japan

Publications

  1. ncbi request reprint Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy
    Masakazu Haneda
    Second Department of Medicine, Asahikawa Medical College, 1 1 1 Midorigaoka Higashi Nijyo, Asahikawa, Hokkaido 078 8510, Japan
    Diabetes Res Clin Pract 66:87-95. 2004
  2. ncbi request reprint [Glucose tolerance in renal failure]
    Atsuko Abiko
    Second Department of Internal Medicine, Asahikawa Medical College
    Nihon Rinsho 63:279-83. 2005
  3. ncbi request reprint An autopsy case of autoimmune pancreatitis
    Yohei Kitano
    Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    JOP 8:621-7. 2007
  4. pmc Successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    BMC Nephrol 5:18. 2004
  5. pmc Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism
    Yumi Takiyama
    Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan
    Diabetes 60:981-92. 2011
  6. doi request reprint Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity
    Kenji Takahashi
    Division of Metabolism and Biosystemic Sciences, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Pancreas 38:49-57. 2009
  7. doi request reprint Transient brain hyperperfusion detected with I-123 IMP SPECT in a patient with neuropsychiatric systemic lupus erythematosus
    Atsutaka Okizaki
    Departments of Radiology, Asahikawa Medical College, Asahikawa, Japan
    Clin Nucl Med 34:601-3. 2009
  8. ncbi request reprint Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells
    Yuichi Makino
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Tokyo, Japan
    J Biol Chem 282:14073-82. 2007
  9. ncbi request reprint Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes
    Fuminori Hirano
    Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Gastroenterol Hepatol 21:1807-13. 2006
  10. doi request reprint Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells
    Kazunari Miyauchi
    Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Diabetes Res Clin Pract 83:190-9. 2009

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy
    Masakazu Haneda
    Second Department of Medicine, Asahikawa Medical College, 1 1 1 Midorigaoka Higashi Nijyo, Asahikawa, Hokkaido 078 8510, Japan
    Diabetes Res Clin Pract 66:87-95. 2004
    ..In addition, candesartan cilexetil seems to be effective in subjects with both the II and DD genotypes of the ACE gene...
  2. ncbi request reprint [Glucose tolerance in renal failure]
    Atsuko Abiko
    Second Department of Internal Medicine, Asahikawa Medical College
    Nihon Rinsho 63:279-83. 2005
  3. ncbi request reprint An autopsy case of autoimmune pancreatitis
    Yohei Kitano
    Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    JOP 8:621-7. 2007
    ..Autoimmune pancreatitis is an increasingly recognized type of chronic pancreatitis, but little is known about the long-term outcome of the disease...
  4. pmc Successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    BMC Nephrol 5:18. 2004
    ..Prolonged parenteral administration of a bactericidal antimicrobial agent or combination of agents is usually recommended, however, the optimal therapy for infective endocarditis associated with renal injury is not adequately defined...
  5. pmc Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism
    Yumi Takiyama
    Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan
    Diabetes 60:981-92. 2011
    ..We assess here the effects of the biguanide, metformin, on the expression of HIF-1α in diabetic nephropathy using renal proximal tubular cells and type 2 diabetic rats...
  6. doi request reprint Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity
    Kenji Takahashi
    Division of Metabolism and Biosystemic Sciences, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Pancreas 38:49-57. 2009
    ..This study is intended to investigate the effect of CDX2 expression on cell proliferation and cyclin D1 expression in pancreatic cancer cells...
  7. doi request reprint Transient brain hyperperfusion detected with I-123 IMP SPECT in a patient with neuropsychiatric systemic lupus erythematosus
    Atsutaka Okizaki
    Departments of Radiology, Asahikawa Medical College, Asahikawa, Japan
    Clin Nucl Med 34:601-3. 2009
    ..Two months later, the hyperperfusion was disappeared. The hyperperfusion could be explained by inflammatory changes...
  8. ncbi request reprint Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells
    Yuichi Makino
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Tokyo, Japan
    J Biol Chem 282:14073-82. 2007
    ..Taken together, HIF-1 directly up-regulates IPAS gene expression through a mechanism distinct from RNA splicing, providing a further level of negative feedback gene regulation in adaptive responses to hypoxic/ischemic conditions...
  9. ncbi request reprint Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes
    Fuminori Hirano
    Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Gastroenterol Hepatol 21:1807-13. 2006
    ..However, whether bile acid induces inhibitors of apoptosis protein (IAPs) directly in human hepatocytes remains unknown. This study investigated effects of bile acids on cIAP-1, cIAP-2 and XIAP expression in hepatocytes...
  10. doi request reprint Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells
    Kazunari Miyauchi
    Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Diabetes Res Clin Pract 83:190-9. 2009
    ..In order to clarify the importance of Interleukin (IL)-18 in the development of diabetic nephropathy (DN), we evaluated the expressions of IL-18 in diabetic kidney...
  11. doi request reprint High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein
    Tsubasa Isoe
    Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Kidney Int 78:48-59. 2010
    ..Our results show that ChREBP and HIF-1alpha mediate gene regulation in mesangial cells. Further studies will be needed to find out whether these findings are relevant to the development of the diabetic nephropathy...
  12. ncbi request reprint A malignant nonfunctioning pancreatic endocrine tumor with a unique pattern of intraductal growth
    Mitsuhiro Inagaki
    Department of Surgery, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Hepatobiliary Pancreat Surg 14:318-23. 2007
    ..Both ERP and FDG-PET/CT were thus found to be useful for predicting the malignant potential of an NFPT in the preoperative diagnosis...
  13. ncbi request reprint [Mechanisms for the development and progression of diabetic nephropathy]
    Masakazu Haneda
    Second Department of Medicine, Asahikawa Medical College
    Nihon Rinsho 64:427-32. 2006
  14. doi request reprint Pioglitazone reduces urinary albumin excretion in renin-angiotensin system inhibitor-treated type 2 diabetic patients with hypertension and microalbuminuria: the APRIME study
    Akizuki Morikawa
    Department of Internal Medicine, Asahikawa Red Cross Hospital, Akebono 1 1, Asahikawa 070 8530, Japan
    Clin Exp Nephrol 15:848-53. 2011
    ..The aim of his study was to compare the efficacy of pioglitazone with metformin on the reduction of albuminuria in type 2 diabetic patients with hypertension and microalbuminuria treated with renin-angiotensin system inhibitors (RAS-Is)...
  15. ncbi request reprint [Diabetic nephropathy: diagnostic criteria and staging]
    Masakazu Haneda
    Second Department of Medicine, Asahikawa Medical College
    Nihon Rinsho 63:320-3. 2005
  16. ncbi request reprint Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
    Shiro Yokohama
    Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Hepatology 40:1222-5. 2004
    ..No side effect of treatment was noted at any time during the study. In conclusion, the present data raise the possibility that an angiotensin II receptor antagonist may be therapeutically efficacious for NASH...
  17. ncbi request reprint Effect of central thyrotropin-releasing hormone on pancreatic blood flow in rats
    Manabu Goto
    Second Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Regul Pept 121:57-63. 2004
    ..These results indicate that TRH acts in the central nervous system to stimulate pancreatic blood flow through vagal-cholinergic and nitric oxide-dependent pathways...
  18. ncbi request reprint Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct
    Mitsuhiro Inagaki
    Department of Surgery, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa, 078 8510, Japan
    J Hepatobiliary Pancreat Surg 14:518-21. 2007
    ....
  19. ncbi request reprint Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan
    Yasunori Iwashima
    Department of Internal Medicine, Yoshida Hospital, 4 Nishi 4 1 2, Asahikawa 070 0054, Japan
    Diabetes Res Clin Pract 74:8-14. 2006
    ..020, 0.031 and 0.043). The present study thus revealed that candesartan effectively induced regression of LVH in type 2 diabetic patients with hypertension due to effects beyond reduction in BP...
  20. ncbi request reprint Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes Care 29:864-8. 2006
    ..We investigated the contribution of PKC-beta gene (PRKCB1) polymorphisms to diabetic kidney disease in a prospective observational follow-up study...
  21. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis
    Mitsugu Omata
    Biomedical Research Laboratories, Daiichi Asubio Pharma Co, Ltd, 1 1 1 Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8513, Japan
    J Am Soc Nephrol 17:674-85. 2006
    ..These findings suggest that Ac-SDKP treatment may be a novel and useful therapeutic strategy for the treatment of progressive renal diseases...
  22. ncbi request reprint Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 Okayama, Japan
    Diabetes Care 30:1577-8. 2007
  23. ncbi request reprint Olmesartan reducing incidence of endstage renal disease in diabetic nephropathy trial (ORIENT): rationale and study design
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:703-9. 2006
    ..0 mg/dl, the need for chronic dialysis, or renal transplantation) or death. The average follow-up period is 4 years and the study ends in 2009...
  24. pmc Estrogen and raloxifene, a selective estrogen receptor modulator, ameliorate renal damage in db/db mice
    Masami Chin
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Am J Pathol 166:1629-36. 2005
    ..Thus, our findings suggest that raloxifene, which lacks the harmful effects of estrogen, is useful for the treatment of diabetic nephropathy...
  25. doi request reprint Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATI
    Hirofumi Makino
    Department of Medicine and Clinical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hypertens Res 31:657-64. 2008
    ..Telmisartan is shown to be safe and well tolerated in these patients...
  26. ncbi request reprint [Diabetic nephropathy]
    Masakazu Haneda
    Third Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 60:260-9. 2002
  27. ncbi request reprint C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus
    Tetsuya Makiishi
    Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Am J Kidney Dis 42:943-51. 2003
    ..However, this association in Japanese patients with type 2 diabetes mellitus and its potential role as a clinical marker remain unclear...
  28. doi request reprint Impact of renin-angiotensin system inhibition on microalbuminuria in type 2 diabetes: a post hoc analysis of the Shiga Microalbuminuria Reduction Trial (SMART)
    Takashi Uzu
    Hypertens Res 31:1171-6. 2008
    ..Therefore, RAS inhibitors are first-line drugs for hypertensive patients with type 2 diabetes and microalbuminuria...
  29. ncbi request reprint APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetes Care 26:2416-20. 2003
    ..The aim of this study is to clarify the conflicting results of the epsilon2/epsilon3/epsilon4 APOE polymorphism as a risk factor on diabetic nephropathy by a cohort study...
  30. ncbi request reprint Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells
    Toshiki Nishio
    Third Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Eur J Pharmacol 437:113-22. 2002
    ..These results indicate that the agents, which activate cAMP/protein kinase-A axis, may work protectively against the injury from glomerular hypertension in mesangial cells...
  31. ncbi request reprint Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Hypertens 24:1627-32. 2006
    ....
  32. ncbi request reprint Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes
    Yoshimitsu Yamasaki
    Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Diabetes Care 29:2445-51. 2006
    ..However, the synergistic effects of SNPs have not been evaluated in detail...
  33. ncbi request reprint Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin
    Hideto Kojima
    Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Diabetes 51:1398-408. 2002
    ..In summary, our results indicated that immature intestinal stem cells can differentiate into insulin-producing cells given the ability to express the transcription factors Pdx-1 and Isl-1...
  34. ncbi request reprint Diabetic neuropathy and nerve regeneration
    Hitoshi Yasuda
    Division of Neurology, Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Prog Neurobiol 69:229-85. 2003
    ..For this purpose, especially clinically, skin biopsy, by which cutaneous nerve pathology including nerve regeneration can be morphometrically evaluated, might be a safe and useful examination...
  35. ncbi request reprint SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Biol Chem 282:151-8. 2007
    ..Our results suggest that up-regulation of SIRT1 deacetylase activity is a potentially useful therapeutic strategy for prevention of TGFbeta-related kidney disease through its effect on cell survival...
  36. ncbi request reprint [Management of blood glucose in diabetic patients undergoing dialysis therapy]
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 62:114-7. 2004
  37. ncbi request reprint N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells
    Keizo Kanasaki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Am Soc Nephrol 14:863-72. 2003
    ....
  38. ncbi request reprint Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes 56:1727-30. 2007
    ..The aim of this study is to investigate the clinical impact of reducing microalbuminuria in type 2 diabetic patients in an observational follow-up study...
  39. ncbi request reprint 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells
    Hirotaka Sawano
    Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Kidney Int 61:1957-67. 2002
    ..Therefore, we examined the effect of 15d-PGJ2 on COX-2 expression in cultured rat mesangial cells...
  40. ncbi request reprint [A study about normal values of urinary type IV collagen concentration--aim at constructing a diagnostic guideline for diabetic nephropathy]
    Hideto Sakai
    Nihon Jinzo Gakkai Shi 44:427-31. 2002
  41. ncbi request reprint [Chronic kidney diseases and other diseases: 3. Diabetes mellitus]
    Masakazu Haneda
    Nihon Naika Gakkai Zasshi 96:899-903. 2007
  42. ncbi request reprint [Present status and the future of diabetic nephropathy]
    Masakazu Haneda
    Nihon Jinzo Gakkai Shi 49:496-8. 2007
  43. ncbi request reprint Involvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells
    Kiho Takaya
    Department of Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Am J Physiol Renal Physiol 284:F1037-45. 2003
    ..In conclusion, these findings indicate that ERK signaling is involved in BSA-induced MCP-1 expression in mProx cells...
  44. ncbi request reprint Overview of glucose signaling in mesangial cells in diabetic nephropathy
    Masakazu Haneda
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    J Am Soc Nephrol 14:1374-82. 2003
  45. ncbi request reprint Progression of diabetic nephropathy
    Ryuichi Kikkawa
    Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Am J Kidney Dis 41:S19-21. 2003
    ....
  46. ncbi request reprint Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Free Radic Biol Med 40:2175-82. 2006
    ..Our results indicate that SIRT1 can prevent oxidative stress-induced apoptosis through p53 deacetylation in mesangial cells. Upregulation of SIRT1 may provide a new strategy for preventing kidney glomerular diseases...
  47. ncbi request reprint [Novel therapeutic strategy for diabetic nephropathy]
    Motohide Isono
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:464-8. 2005
  48. ncbi request reprint Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    J Am Soc Nephrol 14:S250-3. 2003
    ..In summary, oxidative stress by diabetes could play a crucial role in the development and progression of diabetic nephropathy, and antioxidant treatment could be a potential therapeutic procedure for diabetic nephropathy...
  49. ncbi request reprint Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Regul Pept 125:119-24. 2005
    ..These results indicate that the TRH analog acts in the central nervous system to protect against acute pancreatitis through vagal and nitric oxide-dependent pathways...
  50. ncbi request reprint Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus
    Shin Ichi Araki
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 14:2015-24. 2003
    ..It is concluded that DNA sequence differences in the promoter of PRKCB1 contribute to diabetic nephropathy susceptibility in type I diabetes mellitus...
  51. ncbi request reprint [Kidney and hypertension]
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 61:1124-9. 2003
    ..This review is an attempt to highlight a renal role on the development of hypertension, especially in diabetic nephropathy...
  52. ncbi request reprint [Increases in the incidence of diabetic nephropathy and its management]
    Masakazu Haneda
    Nihon Naika Gakkai Zasshi 93:1012-6. 2004
  53. ncbi request reprint Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells
    Baoliang Guo
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Diabetes 53:200-8. 2004
    ....
  54. ncbi request reprint Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms
    Nobue Tanaka
    Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Research, Yokohama, Kanagawa, Japan
    Diabetes 52:2848-53. 2003
    ....
  55. ncbi request reprint [Diabetic nephropathy--progress in its preclinical and clinical studies]
    Ryuichi Kikkawa
    Nihon Naika Gakkai Zasshi 92:1650-61. 2003
  56. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice
    Kazuyuki Shibuya
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetes 54:838-45. 2005
    ....
  57. ncbi request reprint [Diabetes mellitus]
    Masakazu Haneda
    Nihon Naika Gakkai Zasshi 94:881-5. 2005
  58. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators
    Keizo Kanasaki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Biochem Biophys Res Commun 342:758-65. 2006
    ..These results suggest that p53 is the key mediator of Ac-SDKP-induced inhibition of DNA synthesis through the up-regulation of cell cycle modulators, highlighting a potential effect of Ac-SDKP on various progressive renal diseases...
  59. ncbi request reprint [Estimation of glomerular filtration rate by inulin clearance: comparison with creatinine clearance]
    Yoshimasa Orita
    College of Nutrition Koshien University, Hyogo
    Nihon Jinzo Gakkai Shi 47:804-12. 2005
    ..Introduction of Cin into the clinical field is necessary to avoid this delay...
  60. ncbi request reprint [Revised criteria for the early diagnosis of diabetic nephropathy]
    Shigeki Inomat
    Japanese Society of Nephrology
    Nihon Jinzo Gakkai Shi 47:767-9. 2005
    ..4) Renal hypertrophy and elevated urinary type IV collagen may indicate the existence of diabetic renal disease. 5) Microalbuminuria originating in non-diabetic diseases should be excluded...
  61. ncbi request reprint Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes 54:2983-7. 2005
    ..Early detection of microalbuminuria and a multifactorial control may result in improved outcomes for diabetic nephropathy and cardiovascular events...
  62. ncbi request reprint MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells
    Baoliang Guo
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Kidney Int 68:972-84. 2005
    ..Because the sequence of the promoter region in rat PAI-1 gene differs from that in the human gene, we examined the mechanisms of TGF-beta-induced rat PAI-1 expression in rat mesangial cells...
  63. ncbi request reprint A case of type 2 diabetes with a large abscess of the gastric wall successfully treated with a glycemic control and systemic antibiotics
    Yasunori Iwashima
    Department of Internal Medicine, Yoshida Hospital, 4 Nishi 1 2, Asahikawa 070 0054, Japan
    Diabetes Res Clin Pract 69:299-304. 2005
    ..Thus, a tight glycemic control and awareness of this disease should be reemphasized, and this may improve the prognosis of this rare and fatal one, even a poorly-controlled diabetes...
  64. ncbi request reprint Prevalence and major risk factors of reduced flow volume in lower extremities with normal ankle-brachial index in Japanese patients with type 2 diabetes
    Eiji Suzuki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 26:1764-9. 2003
    ..To clarify the prevalence and major risk factors of reduced flow volume in lower extremities with normal ankle-brachial index (ABI) in Japanese patients with type 2 diabetes...
  65. pmc Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury
    Mikiko Takikita-Suzuki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Pathol 163:277-86. 2003
    ..These findings suggest that active Src participates in PDGF-B-dependent regeneration of tubular cells from acute ischemic injury...
  66. ncbi request reprint Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy
    Munehiro Kitada
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes 52:2603-14. 2003
    ..We now demonstrate that oxidative stress is primarily enhanced in the diabetic glomeruli due to a PKC-beta-dependent activation of NADPH oxidase resulting in ROS generation...