Mikihiro Fujiya

Summary

Affiliation: Asahikawa Medical College
Country: Japan

Publications

  1. pmc Traffic control of bacteria-derived molecules: a new system of host-bacterial crosstalk
    Hiroaki Konishi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
    Int J Cell Biol 2013:757148. 2013
  2. pmc Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway
    Shuichi Segawa
    Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, Yaizu, Japan
    PLoS ONE 6:e23278. 2011
  3. ncbi request reprint A therapeutic barium enema is a practical option to control bleeding from the appendix
    Youkou Konno
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    BMC Gastroenterol 13:152. 2013
  4. ncbi request reprint An invasive extragastrointestinal stromal tumor curably resected following imatinib treatment
    Momotaro Muto
    Internal Medicine, Engaru Kosei General Hospital, Engaru, Japan Email
    J Gastrointestin Liver Dis 22:329-32. 2013
  5. doi request reprint Endoscopic piecemeal resection is a practical option to cure colorectal tumors
    Mikihiro Fujiya
    Department of Medicine, Asahikawa Medical College, Hokkaidou, Japan
    Dig Endosc 21:S28-30. 2009
  6. doi request reprint Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer
    Jun Sakamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, 2 1 1 1, Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Cancer Epidemiol 34:194-9. 2010
  7. doi request reprint Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
    Yuhei Inaba
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Inflamm Bowel Dis 16:1488-95. 2010
  8. doi request reprint Autofluorescence imaging and the quantitative intensity of fluorescence for evaluating the dysplastic grade of colonic neoplasms
    Kentaro Moriichi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078 8510, Japan
    Int J Colorectal Dis 27:325-30. 2012
  9. pmc Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors
    Junpei Sasajima
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Cancer Res 70:6283-92. 2010
  10. ncbi request reprint Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection
    Kotaro Okamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1, Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Int J Colorectal Dis 27:1039-46. 2012

Collaborators

Detail Information

Publications45

  1. pmc Traffic control of bacteria-derived molecules: a new system of host-bacterial crosstalk
    Hiroaki Konishi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
    Int J Cell Biol 2013:757148. 2013
    ..The latter mechanism may contribute to the maintenance of intestinal homeostasis by improving the host damage induced by virulence factors and various disease states...
  2. pmc Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway
    Shuichi Segawa
    Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, Yaizu, Japan
    PLoS ONE 6:e23278. 2011
    ..This study, for the first time, demonstrated that poly P is the molecule responsible for maintaining intestinal barrier actions which are mediated through the intestinal integrin β1-p38 MAPK...
  3. ncbi request reprint A therapeutic barium enema is a practical option to control bleeding from the appendix
    Youkou Konno
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    BMC Gastroenterol 13:152. 2013
    ..We herein describe the first case of bleeding from the appendix, which was successively controlled by a therapeutic barium enema administered into the appendix...
  4. ncbi request reprint An invasive extragastrointestinal stromal tumor curably resected following imatinib treatment
    Momotaro Muto
    Internal Medicine, Engaru Kosei General Hospital, Engaru, Japan Email
    J Gastrointestin Liver Dis 22:329-32. 2013
    ..No recurrence was detected for 16 months after resection. In conclusion, preoperative treatment with imatinib followed by curable resection is a feasible option to cure invasive EGISTs. ..
  5. doi request reprint Endoscopic piecemeal resection is a practical option to cure colorectal tumors
    Mikihiro Fujiya
    Department of Medicine, Asahikawa Medical College, Hokkaidou, Japan
    Dig Endosc 21:S28-30. 2009
    ..Hood, 2-channel method and the combination of EMR and circumferential mucosal incision are regarded to be practical procedures on EPMR...
  6. doi request reprint Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer
    Jun Sakamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, 2 1 1 1, Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Cancer Epidemiol 34:194-9. 2010
    ..We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones...
  7. doi request reprint Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
    Yuhei Inaba
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Inflamm Bowel Dis 16:1488-95. 2010
    ....
  8. doi request reprint Autofluorescence imaging and the quantitative intensity of fluorescence for evaluating the dysplastic grade of colonic neoplasms
    Kentaro Moriichi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078 8510, Japan
    Int J Colorectal Dis 27:325-30. 2012
    ..This study investigated the efficacy of AFI in discriminating high-grade from low-grade adenoma...
  9. pmc Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors
    Junpei Sasajima
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Cancer Res 70:6283-92. 2010
    ..Together, our findings identify a novel alternate approach to regulate abnormal tumor vessels, offering the potential to improve the delivery and efficacy of anticancer drugs to hypoxic tumors...
  10. ncbi request reprint Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection
    Kotaro Okamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1, Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Int J Colorectal Dis 27:1039-46. 2012
    ..The purpose of this study is to determine the CSF effect on reducing intestinal inflammation...
  11. pmc Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells
    Kazumasa Nakamura
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    PLoS ONE 5:e8824. 2010
    ..Since Hh signaling plays a crucial role during embryonic and postnatal vasculogenesis, we speculated that Hh ligand may act on tumor vasculature specifically focusing on bone marrow (BM)-derived cells...
  12. doi request reprint Endosopic autofluorescence imaging is useful for the differential diagnosis of intestinal lymphomas resembling lymphoid hyperplasia
    Nobuhiro Ueno
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
    J Clin Gastroenterol 45:507-13. 2011
    ..A method for the differential diagnosis of intestinal lymphomas resembling lymphoid hyperplasia (LH) by endoscopy remains to be clearly established...
  13. doi request reprint Clinicopathologic implications of genetic instability in intestinal-type gastric cancer and intestinal metaplasia as a precancerous lesion: proof of field cancerization in the stomach
    Amen H Zaky
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Am J Clin Pathol 129:613-21. 2008
    ..Biologic detection of GIN in IM may be a surrogate marker for GC risk and for clinical evaluation of malignant potential. The condition is consistent with the hypothesis of field cancerization in the stomach...
  14. doi request reprint Reduction of E-cadherin by human defensin-5 in esophageal squamous cells
    Yoshiki Nomura
    Division of Gastroenterology and Hepatology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
    Biochem Biophys Res Commun 439:71-7. 2013
    ..In conclusion, E-cadherin expression in squamous cells was reduced by HD-5 using in vitro experiments. In gastro-esophageal junction, HD-5 produced from metaplastic Paneth cells may therefore accelerate the initiation of BE...
  15. doi request reprint Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo
    Chisato Ishikawa
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Innate Immun 2:66-76. 2010
    ..05). This study demonstrated the multifunctional roles of the activation process in human defensin and the possibility of using antimicrobial peptides for the treatment of inflammatory bowel diseases in future applications...
  16. doi request reprint Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function
    Nobuhiro Ueno
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Hokkaido, Japan
    Inflamm Bowel Dis 17:2235-50. 2011
    ....
  17. ncbi request reprint Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells
    Takahiro Ito
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan
    Tohoku J Exp Med 227:39-48. 2012
    ..Therefore, Paneth cells may play a role in the innate immunity associated with adaptive immune responses...
  18. doi request reprint Effects of Helicobacter pylori infection on genetic instability, the aberrant CpG island methylation status and the cellular phenotype in Barrett's esophagus in a Japanese population
    Kentaro Moriichi
    Department of Medicine, Division of Gastroenterology and Hematology Oncology, Asahikawa Medical College, Asahikawa, Japan
    Int J Cancer 124:1263-9. 2009
    ..H. pylori infection may therefore affect these molecular alterations associated with the pathogenesis of BE, to some degree, in the Japanese population...
  19. pmc Infliximab extends the duration until the first surgery in patients with Crohn's disease
    Aki Sakatani
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Biomed Res Int 2013:879491. 2013
    ..We evaluated the effects of infliximab and other factors on extending the duration until the first surgery in CD patients on a long-term basis...
  20. pmc Back-to-back comparison of auto-fluorescence imaging (AFI) versus high resolution white light colonoscopy for adenoma detection
    Kentaro Moriichi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    BMC Gastroenterol 12:75. 2012
    ..The aim of this study is to determine the efficacy of AFI in detecting colorectal adenoma...
  21. ncbi request reprint MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function
    Toshie Nata
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
    J Gene Med 15:249-60. 2013
    ..The precise role of microRNAs in inflammatory disease is not clear. The present study investigated the effect of microRNA (miR-146b) with respect to improving intestinal inflammation...
  22. ncbi request reprint Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis
    Mikihiro Fujiya
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    Gastrointest Endosc 56:535-42. 2002
    ..However, colonoscopic findings are inadequate for the prediction of relapse without histologic examination. In this study, the role of magnifying colonoscopy in ulcerative colitis was evaluated...
  23. ncbi request reprint Reduction of syndecan-1 expression in differentiated type early gastric cancer and background mucosa with gastric cellular phenotype
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, 078 8510, Asahikawa, Japan
    J Gastroenterol 39:104-12. 2004
    ..The purpose of this study was to elucidate the role and alterations of syndecan-1 expression in comparison with those of E-cadherin in different cellular phenotypes of differentiated-type gastric cancers (DGCs)...
  24. ncbi request reprint [A case report of ball valve syndrome caused by the gastrointestinal stromal tumor arising from the muscularis mucosae in gastric fornix]
    Chisato Ishikawa
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Japan
    Nihon Shokakibyo Gakkai Zasshi 105:1337-43. 2008
    ..The submucosal tumor was diagnosed histologically as gastrointestinal stromal tumor (GIST) arising from the muscularis mucosae. This is the first report that GIST arising from the muscularis mucosae in gastric fornix showed a BVS...
  25. doi request reprint Ex vivo activation of angiogenic property in human peripheral blood-derived monocytes by thrombopoietin
    Toru Kawamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2jo, 1chome, Midorigaoka Higashi, Asahikawa, Hokkaido, 078 8510, Japan
    Int J Hematol 98:417-29. 2013
    ....
  26. ncbi request reprint Spontaneous remission of primary diffuse large B-cell gastric lymphoma
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Gastroenterol 40:414-20. 2005
    ..pylori eradication is appropriate for consideration as an initial approach in standard therapy for stage I diffuse large B-cell gastric lymphoma...
  27. doi request reprint Interference of deferasirox with assays for serum iron and serum unsaturated iron binding capacity during iron chelating therapy
    Katsuya Ikuta
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
    Clin Chim Acta 412:2261-6. 2011
    ..We hypothesized that photometric assays for serum iron (sFe) and unsaturated iron binding capacity (UIBC) might be affected by DFX...
  28. doi request reprint Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction
    Ryu Sato
    Division of Endoscopy, Asahikawa Medical College, Asahikawa, Japan
    Gastrointest Endosc 67:953-7. 2008
    ..The technical difficulties related to the insertion of a long intestinal tube into the jejunum under fluoroscopy present a considerable problem in patients with an intestinal obstruction...
  29. doi request reprint Upregulation of iron regulatory hormone hepcidin by interferon α
    Kazuhiko Ichiki
    Division of Gastroenterology and Hematology Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
    J Gastroenterol Hepatol 29:387-94. 2014
    ..Iron dysregulation has been reported during treatment with IFN; however, it remains unclear whether IFN itself affects iron metabolism. We therefore determined the effect of IFN on iron metabolism...
  30. pmc Capsule endoscopy is a feasible procedure for identifying a Diphyllobothrium nihonkaiense infection and determining the indications for vermifuge treatment
    Yoshiki Nomura
    Department of Medicine, Division of Gastroenterology and Hematology Oncology, Asahikawa Medical College, Asahikawa, Japan
    BMJ Case Rep 2010:3023. 2010
    ..Capsule endoscopy is a practical option to determine whether additional vermifuge treatment is required through the detection of the proglottids as well as a scolex or forefront of the parasite...
  31. pmc Cytokine regulation of OCTN2 expression and activity in small and large intestine
    Mikihiro Fujiya
    Department of Gastroenterology, Asahikawa Medical School, Asahikawa, Japan
    Inflamm Bowel Dis 17:907-16. 2011
    ..To explore its role further, we examined potential regulatory factors in human IBD and in experimental models of OCTN2 expression...
  32. ncbi request reprint Successful treatment of systemic Geotrichum capitatum infection by liposomal amphotericin-B, itraconazole, and voriconazole in a Japanese man
    Katsuya Ikuta
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Intern Med 49:2499-503. 2010
    ..G. capitatum was isolated from blood cultures, and also formed multiple nodular lesions in lung fields. The infection was successfully cured with a combination of amphotericin B, itraconazole, and voriconazole...
  33. doi request reprint Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma
    Hiroki Tanaka
    Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Japan
    Cancer Sci 103:767-74. 2012
    ..These results indicate that the iron-facilitating activity of LS081 inhibits HIF-1α expression through prolyl-hydroxylation of HIF-1α and might have a therapeutic effect in the treatment of hepatocellular carcinoma...
  34. doi request reprint Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13)
    Kazuya Sato
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Midorigaoka Higashi 2 jo 1 chome 1 1, Asahikawa, Hokkaido 078 8510, Japan
    Int J Hematol 93:311-8. 2011
    ..These findings suggest that loss of the ABCB7 gene may be a pathogenetic factor underlying mitochondrial iron accumulation in RARS patients with idicXq13...
  35. doi request reprint Improved quantification for non-transferrin-bound iron measurement using high-performance liquid chromatography by reducing iron contamination
    Katsunori Sasaki
    Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078 8510, Japan
    Mol Med Rep 4:913-8. 2011
    ....
  36. doi request reprint A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's disease
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Japan
    Dis Colon Rectum 54:586-92. 2011
    ..Recurrence of Crohn's disease usually occurs at anastomotic sites...
  37. pmc Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia
    Motohiro Shindo
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa 078 8510, Japan
    Case Report Hematol 2012:908196. 2012
    ..Here, we present a relapsed patient with APL in whom DIC was successfully and safely controlled by rTM during treatment with ATO...
  38. ncbi request reprint Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, Japan
    Am J Gastroenterol 97:2109-15. 2002
    ..Furthermore, to clarify whether cell kinetic status affects the tumor development, proliferative indices, apoptotic indices, and K-ras codon 12 point mutations on biopsy specimens were investigated...
  39. ncbi request reprint TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression
    Nobuhiro Ueno
    Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
    PLoS ONE 9:e97456. 2014
    ..The present studies demonstrate a new anti-inflammatory action of TU-100 that is microbe-independent and due to its ginger component. ..
  40. ncbi request reprint Effective control of relapsing disseminated intravascular coagulation in a patient with decompensated liver cirrhosis by recombinant soluble thrombomodulin
    Takumu Hasebe
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, Japan
    Intern Med 53:29-33. 2014
    ..This is the first report demonstrating that rhsTM can be administered safely and repeatedly to a patient with decompensated liver cirrhosis, and that it appears to be associated with a favorable outcome. ..
  41. doi request reprint Detection of soluble HFE associated with soluble transferrin receptor in human serum
    Kouhei Ohnishi
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1 1 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Int J Mol Med 27:435-9. 2011
    ..We also confirmed the existence of sHFE in this complex. This is the first report on the existence of sHFE in human serum...
  42. ncbi request reprint Atypical mucosa-associated lymphoid tissue lymphoma in the transverse colon associated with macroglobulinemia
    Katsuya Ikuta
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa
    Intern Med 49:677-82. 2010
    ..After chemotherapy and radiation, the lesions in the transverse colon improved and the patient has been in good condition without any evidence of recurrence for more than 1 year...
  43. ncbi request reprint Cell kinetics and genetic instabilities in differentiated type early gastric cancers with different mucin phenotype
    Naomi Shibata
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    Hum Pathol 34:32-40. 2003
    ..However, the molecular pathogenesis of each phenotypic cancer is not associated with microsatellite alterations...
  44. doi request reprint Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction
    Yanju Ma
    Department of Biochemistry, Asahikawa Medical University, Asahikawa, Japan
    Biochim Biophys Acta 1832:151-9. 2013
    ..These findings reveal that activation of FAK is necessary for maintaining and repairing epithelial barrier in Caco-2 cell monolayer via regulating TJ redistribution...
  45. doi request reprint Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
    Madoka Yamazaki
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Hokkaido 078 8510, Japan
    Cancer Sci 99:1131-8. 2008
    ..Targeting SHH would be a novel therapeutic approach that can inhibit not only proliferation of cancer cells but also EPC-mediated angiogenesis...