Tokiyoshi Ayabe

Summary

Affiliation: Asahikawa Medical College
Country: Japan

Publications

  1. ncbi request reprint The role of Paneth cells and their antimicrobial peptides in innate host defense
    Tokiyoshi Ayabe
    Department of Internal Medicine III, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Trends Microbiol 12:394-8. 2004
  2. doi request reprint Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
    Yuhei Inaba
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Inflamm Bowel Dis 16:1488-95. 2010
  3. ncbi request reprint Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats
    Yoshiaki Ebisawa
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    J Surg Res 118:183-9. 2004
  4. doi request reprint Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo
    Chisato Ishikawa
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Innate Immun 2:66-76. 2010
  5. doi request reprint Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach
    Hiroki Tanabe
    Department of Internal Medicine, Division of Gastroenterology and Haematology Oncology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Helicobacter 13:370-9. 2008
  6. ncbi request reprint Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis
    Mikihiro Fujiya
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    Gastrointest Endosc 56:535-42. 2002
  7. ncbi request reprint Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion
    Hiroki Tanabe
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Japan
    Biochem Biophys Res Commun 358:349-55. 2007
  8. ncbi request reprint Leukocytapheresis for treatment of IBD
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, 1 1 Midorigaoka, Higashi, Asahikawa 078 8510, Japan
    J Gastroenterol 38:51-4. 2003
  9. ncbi request reprint Reduction of syndecan-1 expression in differentiated type early gastric cancer and background mucosa with gastric cellular phenotype
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, 078 8510, Asahikawa, Japan
    J Gastroenterol 39:104-12. 2004
  10. ncbi request reprint Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD
    Fumika Orii
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Hokkaido 078 8510, Asahikawa, Japan
    Biochem Biophys Res Commun 296:1286-94. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The role of Paneth cells and their antimicrobial peptides in innate host defense
    Tokiyoshi Ayabe
    Department of Internal Medicine III, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Trends Microbiol 12:394-8. 2004
    ....
  2. doi request reprint Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
    Yuhei Inaba
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Inflamm Bowel Dis 16:1488-95. 2010
    ....
  3. ncbi request reprint Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats
    Yoshiaki Ebisawa
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    J Surg Res 118:183-9. 2004
    ..The aims of this study were to investigate whether low-dose LPS (LLPS)-induced hepatic production of NO is beneficial and to clarify the origins of cytoprotective NO-producing cells in the liver during LPS tolerance...
  4. doi request reprint Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo
    Chisato Ishikawa
    Division of Gastroenterology and Hematology Oncology, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Innate Immun 2:66-76. 2010
    ..05). This study demonstrated the multifunctional roles of the activation process in human defensin and the possibility of using antimicrobial peptides for the treatment of inflammatory bowel diseases in future applications...
  5. doi request reprint Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach
    Hiroki Tanabe
    Department of Internal Medicine, Division of Gastroenterology and Haematology Oncology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    Helicobacter 13:370-9. 2008
    ..Detailed pathologic studies have shown that H. pylori settles on the surface of gastric mucosa, and that it is eliminated from metaplastic mucosa. However, its mechanism of natural protection is not well known...
  6. ncbi request reprint Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis
    Mikihiro Fujiya
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    Gastrointest Endosc 56:535-42. 2002
    ..However, colonoscopic findings are inadequate for the prediction of relapse without histologic examination. In this study, the role of magnifying colonoscopy in ulcerative colitis was evaluated...
  7. ncbi request reprint Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion
    Hiroki Tanabe
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Japan
    Biochem Biophys Res Commun 358:349-55. 2007
    ..The HD-5 was sensitive to the trypsin treatment. These observations evidently predict that a defensin deficiency may be caused by a disulfide disorder in the disease...
  8. ncbi request reprint Leukocytapheresis for treatment of IBD
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, 1 1 Midorigaoka, Higashi, Asahikawa 078 8510, Japan
    J Gastroenterol 38:51-4. 2003
    ..Here, the current status of indications and mechanisms of action on UC are analyzed by reviewing the results of Japanese multicicenter trials, and the possible application for Crohn's disease is also discussed...
  9. ncbi request reprint Reduction of syndecan-1 expression in differentiated type early gastric cancer and background mucosa with gastric cellular phenotype
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, 078 8510, Asahikawa, Japan
    J Gastroenterol 39:104-12. 2004
    ..The purpose of this study was to elucidate the role and alterations of syndecan-1 expression in comparison with those of E-cadherin in different cellular phenotypes of differentiated-type gastric cancers (DGCs)...
  10. ncbi request reprint Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD
    Fumika Orii
    Third Department of Internal Medicine, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Hokkaido 078 8510, Asahikawa, Japan
    Biochem Biophys Res Commun 296:1286-94. 2002
    ..Through these analyses, it is indicated that the inflammatory cytokines altered the splicing condition of the primary transcript of hGR gene in IBD patients...
  11. ncbi request reprint Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system
    Toru Kono
    Department of Surgery II, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
    J Surg Res 117:329-38. 2004
    ..DAF-2 offers a sensitive indicator for visualizing production of NO with high spatial resolution. This new system may contribute to the study of the pathophysiological role of the nitrergic pathway in the gastrointestinal tract...
  12. ncbi request reprint Genetic and phenotypic polymorphisms of the A subunit of Coagulation factor XIII in Japanese population
    Masato Taniguchi
    Third Department of Internal Medicine, Asahikawa Medical College, Japan
    Biochem Genet 40:339-49. 2002
    ..6, 5.8 in the homozygote (AD) and the heterozygote (AD/BC), and a pl of 5.8 in the homozygote (BC). These polymorphisms affected isoelectric mobility, but did not affect protein levels, enzyme activities, or the molecular weight of FXIII...
  13. ncbi request reprint Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations
    Jiro Watari
    Third Department of Internal Medicine, Asahikawa Medical College, Japan
    Am J Gastroenterol 97:2109-15. 2002
    ..Furthermore, to clarify whether cell kinetic status affects the tumor development, proliferative indices, apoptotic indices, and K-ras codon 12 point mutations on biopsy specimens were investigated...
  14. ncbi request reprint Activation of Paneth cell alpha-defensins in mouse small intestine
    Tokiyoshi Ayabe
    Department of Pathology, College of Medicine, University of California, Irvine, California 92697 4800, USA
    J Biol Chem 277:5219-28. 2002
    ..MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen...
  15. ncbi request reprint Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel
    Tokiyoshi Ayabe
    Department of Pathology, College of Medicine, University of California, Irvine, California 92697 4800, USA
    J Biol Chem 277:3793-800. 2002
    ..These results demonstrate that mIKCa1 is modulator of Paneth cell alpha-defensin secretion and disclose an involvement in mucosal defense of the intestinal epithelium against ingested bacterial pathogens...
  16. pmc Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria
    Hiroki Tanabe
    Department of Pathology, School of Medicine, College of Health Sciences, University of California, Irvine, CA 92697 4800, USA
    Infect Immun 73:2312-20. 2005
    ..Thus, mouse Paneth cells respond equivalently to purified bacterial cell envelope glycolipids, regardless of functional Tlr4, the structural properties of glycolipid acyl chains, or their association with virulence in humans...