Tomohiko Ogawa

Summary

Affiliation: Asahi University School of Dentistry
Country: Japan

Publications

  1. ncbi request reprint Immunobiological activities of a chemically synthesized lipid A of Porphyromonas gingivalis
    T Ogawa
    Department of Microbiology, Asahi University, School of Dentistry, Gifu, Japan
    FEMS Immunol Med Microbiol 28:273-81. 2000
  2. pmc Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran
    T Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Clin Exp Immunol 143:103-9. 2006
  3. ncbi request reprint Oral immunoadjuvant activity of Lactobacillus casei subsp. casei in dextran-fed layer chickens
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Br J Nutr 95:430-4. 2006
  4. ncbi request reprint Detectable dioxins in human saliva and their effects on gingival epithelial cells
    T Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    J Dent Res 82:849-53. 2003
  5. ncbi request reprint A new synbiotic, Lactobacillus casei subsp. casei together with dextran, reduces murine and human allergic reaction
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Mizuho, Gifu, Japan
    FEMS Immunol Med Microbiol 46:400-9. 2006
  6. ncbi request reprint Chemical structure and immunobiological activity of Porphyromonas gingivalis lipid A
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Front Biosci 12:3795-812. 2007
  7. ncbi request reprint Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    FEMS Immunol Med Microbiol 36:1-7. 2003
  8. ncbi request reprint Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Eur J Immunol 32:2543-50. 2002
  9. ncbi request reprint Chemotaxis of oral treponemes toward sera and albumin of rabbit
    T Umemoto
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Microbiol Immunol 45:571-7. 2001
  10. ncbi request reprint Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    Int Immunol 14:1325-32. 2002

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Immunobiological activities of a chemically synthesized lipid A of Porphyromonas gingivalis
    T Ogawa
    Department of Microbiology, Asahi University, School of Dentistry, Gifu, Japan
    FEMS Immunol Med Microbiol 28:273-81. 2000
    ..Thus, this study demonstrates that the chemical synthesis of lipid A, mimicking the natural lipid A portion of LPS from P. gingivalis, confirms its low endotoxic potency and immunobiological activity...
  2. pmc Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran
    T Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Clin Exp Immunol 143:103-9. 2006
    ..casei ssp. casei used as a probiotic together with the dextran, a specific substrate as a prebiotic, efficiently elicits murine and human NK cell activities...
  3. ncbi request reprint Oral immunoadjuvant activity of Lactobacillus casei subsp. casei in dextran-fed layer chickens
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Br J Nutr 95:430-4. 2006
    ..These results suggest that dietary supplementation of L. casei subsp. casei with dextran leads to immunomodulation of humoral immune responses...
  4. ncbi request reprint Detectable dioxins in human saliva and their effects on gingival epithelial cells
    T Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    J Dent Res 82:849-53. 2003
    ..These results suggest that dioxins in saliva may be a risk factor for periodontal diseases...
  5. ncbi request reprint A new synbiotic, Lactobacillus casei subsp. casei together with dextran, reduces murine and human allergic reaction
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Mizuho, Gifu, Japan
    FEMS Immunol Med Microbiol 46:400-9. 2006
    ..Thus, the oral administration of synbiotic L. casei subsp. casei together with dextran appears to be an effective supplement for the prevention and treatment of allergic reactions...
  6. ncbi request reprint Chemical structure and immunobiological activity of Porphyromonas gingivalis lipid A
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Front Biosci 12:3795-812. 2007
    ..Based on the history of studies of ligands acting on TLR4, Bacteroides species LPS findings were reviewed and are presented here. In particular, we investigated P. gingivalis LPS and its lipid A...
  7. ncbi request reprint Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    FEMS Immunol Med Microbiol 36:1-7. 2003
    ..pylori strain 206-1, has a low endotoxic potency and immunobiological activities, and is recognized by TLR4...
  8. ncbi request reprint Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Eur J Immunol 32:2543-50. 2002
    ..These results suggest that P. gingivalis fimbriae and these degraded peptides may play an important role in the inflamed gingival and periodontal tissues seen in the development and progression of periodontal diseases...
  9. ncbi request reprint Chemotaxis of oral treponemes toward sera and albumin of rabbit
    T Umemoto
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Microbiol Immunol 45:571-7. 2001
    ..Immunoelectron microscopy demonstrated that a 65 kDa rabbit albumin-binding polypeptide was located on the outer envelopes, suggesting that the rabbit albumin-binding polypeptide is responsible for chemotaxis toward rabbit serum...
  10. ncbi request reprint Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    Int Immunol 14:1325-32. 2002
    ..gingivalis lipid A molecule induces cell activation via a TLR4/MD2-MyD88-dependent pathway, and suggest the possibility that unknown bacterial components in P. gingivalis LPS and its lipid A may induce cell activation via TLR2...
  11. pmc Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4
    Riyoko Tamai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Immunology 110:66-72. 2003
    ..These findings suggest that monosaccharide lipid A analogues similar to disaccharide lipid As are capable of activating both murine and human cells through TLR4...
  12. ncbi request reprint Treponemal phospholipids inhibit innate immune responses induced by pathogen-associated molecular patterns
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    J Biol Chem 278:44205-13. 2003
    ..These results suggest that treponemal phospholipid interfere the function of LBP/CD14 and act as a modulator of innate immune responses...
  13. ncbi request reprint Treponemal glycoconjugate inhibits Toll-like receptor ligand-induced cell activation by blocking LPS-binding protein and CD14 functions
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Eur J Immunol 33:3196-204. 2003
    ..These results indicate that T. medium contains a glycoconjugate possessing an inhibitory effect on TLR-mediated cell activation through interaction with LBP and CD14...
  14. ncbi request reprint Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    J Immunol 179:7674-83. 2007
    ..These results suggest that sCD14 is able to discriminate the slight structural differences between these lipid As, which causes their distinct host cell activation activities...
  15. ncbi request reprint Protein-bound polysaccharide isolated from basidiomycetes inhibits endotoxin-induced activation by blocking lipopolysaccharide-binding protein and CD14 functions
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    FEMS Immunol Med Microbiol 43:91-8. 2005
    ..These findings indicate that PSK, which also has an ability to regulate LBP/CD14 functions, may be useful for clinical control of endotoxic sepsis...
  16. pmc Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Motosu gun, Gifu 501 0296, Japan
    Infect Immun 71:717-25. 2003
    ..1. These findings suggest that oral treponemes and their OMEs activate HGEC through TLR2...
  17. ncbi request reprint Chemical structure and immunobiological activity of lipid A from Serratia marcescens LPS
    Yutaka Makimura
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, Japan
    J Med Microbiol 56:1440-6. 2007
    ..These results indicate that S. marcescens possesses a penta-acylated lipid A, which is nearly identical to E. coli lipid A in regard to biological activities, while it also may be a crucial virulence factor of the bacterium...
  18. ncbi request reprint Possible requirement of intercellular adhesion molecule-1 for invasion of gingival epithelial cells by Treponema medium
    Riyoko Tamai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Can J Microbiol 53:1232-8. 2007
    ..These results suggest that ICAM-1 may be required for the invasion of T. medium into HGEC, and they indicate that the molecule plays a principal role in the primary stages of the development and progression of chronic periodontitis...
  19. ncbi request reprint Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Int Immunol 16:1431-7. 2004
    ..Pg-LP, as well as Ec-LPS, was potent in inducing IL-8 production in human gingival fibroblasts. From our results, we propose that Pg-LP is a powerful inflammatory factor of P. gingivalis...
  20. pmc Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Infect Immun 73:2157-63. 2005
    ..Taken together, these results clearly indicate that PG1828LP plays an essential role in inflammatory responses and may be a major virulence factor of P. gingivalis...
  21. ncbi request reprint Chemical structure and immunobiological activity of lipid A from Prevotella intermedia ATCC 25611 lipopolysaccharide
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, 501 0296, Gifu, Japan
    FEBS Lett 543:98-102. 2003
    ..Our results indicate that P. intermedia lipid A activates cells through a TLR4-dependent pathway similar to E. coli-type lipid A, even though these have structural differences...
  22. ncbi request reprint Toll-like receptor 2-mediated dendritic cell activation by a Porphyromonas gingivalis synthetic lipopeptide
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu 501 0296, Japan
    J Med Microbiol 56:459-65. 2007
    ..Taken together, these results indicate that the fatty acid residue at the glycerol position in the P. gingivalis lipopeptide plays a pivotal role in TLR2-mediated dendritic cell activation...
  23. ncbi request reprint Osteoclast differentiation by human osteoblastic cell line SaOS-2 primed with bacterial lipid A
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, 501 0296 Gifu, Japan
    FEMS Immunol Med Microbiol 38:71-9. 2003
    ..These findings suggest that the TLR signaling cascade in osteoblastic cells is involved in regulating the function of osteoclastogenesis...
  24. ncbi request reprint Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    FEMS Microbiol Lett 226:267-71. 2003
    ..Our results suggest that P. gingivalis fimbriae and T. denticola dentilisin are implicated in the coaggregation of these bacteria...
  25. ncbi request reprint Genetic variation of a fimbrial protein from Porphyromonas gingivalis and its distribution in patients with periodontal diseases
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Microbiol Res 160:257-63. 2005
    ..2%), type 2 (56.4%) and types 1 and 2 (5.4%). These findings strongly suggest that P. gingivalis organisms possessing Pg-II fim type 2 was principally detected in patients with periodontal diseases...
  26. pmc Requirement for intercellular adhesion molecule 1 and caveolae in invasion of human oral epithelial cells by Porphyromonas gingivalis
    Riyoko Tamai
    Department of Oral Microbiology, Asahi University School of Dentistry, Mizuho, Gifu, Japan
    Infect Immun 73:6290-8. 2005
    ..gingivalis into human oral epithelial cells, and these molecules appear to be associated with the primary stages of the development and progression of chronic periodontitis...
  27. ncbi request reprint [Chemical structure and immunobiological activity of Bacteroides species LPS based on study of Porphyromonas gingivalis LPS]
    Tomohiko Ogawa
    Department of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Nihon Saikingaku Zasshi 61:391-404. 2006
  28. ncbi request reprint Structural elucidation of polysaccharide part of glycoconjugate from Treponema medium ATCC 700293
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan Graduate School of Science, Osaka University, Osaka, Japan
    Eur J Biochem 270:2671-9. 2003
    ....
  29. pmc Detection and quantification of oral treponemes in subgingival plaque by real-time PCR
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    J Clin Microbiol 40:3334-40. 2002
    ..medium was also detected in deep pockets. On the other hand, T. vincentii was mainly found in shallow pockets. These results suggest that various oral treponemes are associated with the formation of each stage of periodontal disease...
  30. pmc Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6
    Tsugumi Okusawa
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Nishi 7, Kita 13, Kita kuSapporo 060 8586, Japan
    Infect Immun 72:1657-65. 2004
    ....
  31. ncbi request reprint Porphyromonas gingivalis lipopolysaccharides induce maturation of dendritic cells with CD14+CD16+ phenotype
    Sousuke Kanaya
    Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Eur J Immunol 34:1451-60. 2004
    ..These results suggested that Pg LPS triggers maturation of DC with unique characteristics, which exhibited weak immunostimulatory activity and may contribute to induction of chronic inflammation at the site of periodontal infection...