Masaharu Akiyama

Summary

Country: Japan

Publications

  1. ncbi request reprint Functional disomy for Xq26.3-qter in a boy with an unbalanced t(X;21)(q26.3;p11.2) translocation
    M Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Am J Med Genet 99:111-4. 2001
  2. ncbi request reprint Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer Lett 178:187-97. 2002
  3. ncbi request reprint 11-year-old boy with sarcoidosis and generalized brawny induration of muscle
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Aoto Hospital, Aoto, Katsushika ku, Tokyo, Japan
    Pediatr Int 44:93-7. 2002
  4. doi request reprint Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells
    Masaharu Akiyama
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan Electronic address
    Cancer Lett 340:82-7. 2013
  5. doi request reprint Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines
    Yoko Mikami-Terao
    Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Exp Eye Res 89:200-8. 2009
  6. doi request reprint Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Cell Signal 23:1119-27. 2011
  7. ncbi request reprint Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation
    Takeshi Kawano
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    Int J Oncol 37:787-95. 2010
  8. ncbi request reprint Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells
    Yoko Mikami-Terao
    Department of Pediatrics and Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer Lett 261:226-34. 2008
  9. ncbi request reprint Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma
    Kentaro Yokoi
    Department of Pediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Childs Nerv Syst 23:237-42. 2007
  10. doi request reprint Leukemic cells with increased telomerase activity exhibit resistance to imatinib
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 49:1168-77. 2008

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Functional disomy for Xq26.3-qter in a boy with an unbalanced t(X;21)(q26.3;p11.2) translocation
    M Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Am J Med Genet 99:111-4. 2001
    ..2). This is the first description of pure functional disomy for Xq26-qter due to an unbalanced X-autosome translocation...
  2. ncbi request reprint Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer Lett 178:187-97. 2002
    ..These findings suggest that overexpression of telomerase by transfecting hTERT confers telomere-elongation and resistance to double-stranded DNA break inducing agents...
  3. ncbi request reprint 11-year-old boy with sarcoidosis and generalized brawny induration of muscle
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Aoto Hospital, Aoto, Katsushika ku, Tokyo, Japan
    Pediatr Int 44:93-7. 2002
  4. doi request reprint Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells
    Masaharu Akiyama
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan Electronic address
    Cancer Lett 340:82-7. 2013
    ..Our results suggest that differential activation of Akt and PP2A may be responsible for telomerase regulation...
  5. doi request reprint Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines
    Yoko Mikami-Terao
    Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Exp Eye Res 89:200-8. 2009
    ..This study provides insight into the molecular mechanism of the antitumor effects of TMPyP4. G-quadruplex structure may be a potential therapeutic target in retinoblastoma...
  6. doi request reprint Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Cell Signal 23:1119-27. 2011
    ..Together, these findings indicate a novel mechanism that contributes toward multidrug resistance involving STAT5 as a sensor for cytotoxic drugs in CML patients...
  7. ncbi request reprint Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation
    Takeshi Kawano
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    Int J Oncol 37:787-95. 2010
    ..These results suggest that acetylation of p53 by HDAC inhibitors is a promising new therapeutic target in refractory retinoblastoma...
  8. ncbi request reprint Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells
    Yoko Mikami-Terao
    Department of Pediatrics and Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer Lett 261:226-34. 2008
    ..These findings may provide a rationale for the development of guanine-quadruplex-interactive agents as novel antileukemic therapies...
  9. ncbi request reprint Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma
    Kentaro Yokoi
    Department of Pediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Childs Nerv Syst 23:237-42. 2007
    ..Cadherins are Ca(2+)-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently been reported...
  10. doi request reprint Leukemic cells with increased telomerase activity exhibit resistance to imatinib
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 49:1168-77. 2008
    ....
  11. doi request reprint Erythropoietin activates telomerase through transcriptional and posttranscriptional regulation in human erythroleukemic JAS-REN-A cells
    Masaharu Akiyama
    Department of Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Leuk Res 35:416-8. 2011
    ..These results suggest that EPO activates telomerase in JAS-REN-A cells through dual regulation: hTERT gene transcription by Janus tyrosine kinase 2/STAT5/c-Myc and hTERT protein phosphorylation by phosphatidylinositol 3'-kinase/AKT...
  12. doi request reprint Effects of prednisolone on specifically expressed genes in pediatric acute B-lymphoblastic leukemia
    Masaharu Akiyama
    Department of Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Pediatr Hematol Oncol 30:313-6. 2008
    ....
  13. ncbi request reprint Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Blood Cancer 46:506-11. 2006
    ..The results might offer the potential to define the molecular mechanism underlying ATRA-induced granulocytic differentiation in patients with APL, and provide clues to identify novel molecular therapeutic targets...
  14. doi request reprint Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4-year-old girl
    Masayoshi Yamaoka
    Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan
    Head Neck 35:E386-90. 2013
    ..Planning multidisciplinary treatment for head and neck ESFT is challenging...
  15. doi request reprint Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells
    Osamu Yamada
    Department of Hematology, Medical Research Institute, Tokyo Women s Medical University, Tokyo, Japan
    Histochem Cell Biol 134:555-63. 2010
    ....
  16. ncbi request reprint Lymphocytic hypophysitis with central diabetes insipidus and subsequent hypopituitarism masking a suprasellar germinoma in a 13-year-old girl
    Yoko Mikami-Terao
    Department of Pediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Childs Nerv Syst 22:1338-43. 2006
    ..Despite prednisolone therapy, 1 year later an enlarged, irregular cystic mass lesion had developed; in the pituitary stalk and inferior hypothalamus, a endoscopic biopsy revealed germinoma...
  17. doi request reprint Atypical clinical features of children with central nervous system tumor: Delayed diagnosis and switch in handedness
    Kentaro Yokoi
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Int 58:923-6. 2016
    ..Pediatricians should carefully examine such patients who present with some suggestive symptoms of CNS tumor, even when they are unusual, in order to make a timely and appropriate diagnosis. ..
  18. doi request reprint Somatic mosaic mutations of IDH1 and NPM1 associated with cup-like acute myeloid leukemia in a patient with Maffucci syndrome
    Masaharu Akiyama
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Int J Hematol 102:723-8. 2015
    ..However, further studies are needed to identify additional molecular events in AML but not in hemangioma. ..
  19. ncbi request reprint Segregation of megakaryocytic or erythroid cells from a megakaryocytic leukemia cell line (JAS-R) by adhesion during culture
    Hisashi Yamada
    Department of Molecular Genetics, Institute of DNA Medicine, The Jikei University, School of Medicine, 3 25 8 Nishi shinbashi, Tokyo, Japan
    Leuk Res 31:1537-43. 2007
    ..These findings indicate that adhesion via integrins is related to the phenotypic shift of JAS-R cells between megakaryocytic and erythroid lineages...
  20. doi request reprint Differences in CTG triplet repeat expansion in leukemic cells and normal lymphocytes from a 14-year-old female with congenital myotonic dystrophy
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Blood Cancer 51:563-5. 2008
    ....
  21. doi request reprint Multistep regulation of telomerase during differentiation of HL60 cells
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Leukoc Biol 83:1240-8. 2008
    ..These results indicate that telomerase activity is regulated by at least two mechanisms during granulocytic and monocytic differentiation, with one mechanism being transcriptional and the other being post-translational...
  22. doi request reprint JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Mol Cancer Ther 11:1112-21. 2012
    ..These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL...
  23. ncbi request reprint Severe aplastic anaemia complicating Sjögren syndrome in a 2-year-old girl
    Masaharu Akiyama
    Department of Paediatrics, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, 105 8461 Tokyo, Japan
    Eur J Pediatr 164:700-2. 2005
  24. doi request reprint Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production
    Masaharu Akiyama
    Departments of Pediatrics Pathology Division of Pediatric Surgery Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University School of Medicine Department of Pathology, National Center for Child Health and Development Departments of Pediatric Hematology and Oncology Research Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Pediatr Hematol Oncol 37:554-9. 2015
    ..Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. ..
  25. doi request reprint Familial cases with MYH9 disorders caused by MYH9 S96L mutation
    Shizuko Murayama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Int 55:102-4. 2013
    ..The possibility of MYH9 disorders including Epstein syndrome should be assessed in cases of thrombocytopenia through the careful examination of hematological features...
  26. ncbi request reprint Successful treatment of Diamond-Blackfan anemia with metoclopramide
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Am J Hematol 78:295-8. 2005
    ..Metoclopramide therapy should be considered in patients with refractory DBA before treatment-related complications develop...
  27. ncbi request reprint TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Biochem Biophys Res Commun 316:528-32. 2004
    ..These studies suggest that activation and nuclear translocation of telomerase are regulated by PI3K/Akt/NF-kappaB signaling pathways in PBL...
  28. doi request reprint Phosphoglycerate kinase deficiency due to a novel mutation (c. 1180A>G) manifesting as chronic hemolytic anemia in a Japanese boy
    Masato Tamai
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Int J Hematol 100:393-7. 2014
    ..At 3 years of age the patient has transfusion-dependent hemolytic anemia but no evidence of neuromuscular disease or developmental delay. Long-term follow-up will be needed to identify possible future clinical manifestations. ..
  29. ncbi request reprint RNA expression analysis of a congenital intracranial teratoma
    Kentaro Yokoi
    Department of Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Blood Cancer 44:516-20. 2005
    ..The data from the microarray analysis offer not only the potential to help define disease pathogenesis but may also provide clues to identify potential molecular therapeutic targets...
  30. ncbi request reprint Hemoglobin Hammersmith [beta 42(CD1) Phe --> Ser] causing severe hemolytic anemia in a Japanese girl
    Masaharu Akiyama
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Pediatr Blood Cancer 47:839-41. 2006
    ..DNA sequence analysis of the polymerase chain reaction-amplified beta-globin gene revealed a point mutation (T --> C) in the second nucleotide of the 42nd codon of the beta-globin chain (beta 42(CD1) Phe --> Ser)...
  31. ncbi request reprint Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect
    Takeshi Kawano
    Department of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 24:2705-12. 2004
    ..To explore the effective use of ST1571, we studied the combination treatment with histone deacetylase inhibitor (depsipeptide, FK228)...
  32. ncbi request reprint [Diagnosis of mild hemophilia A made by massive intraabdominal bleeding in a 13-year-old boy]
    Yoko Terao
    Department of Pediatrics, Jikei University School of Medicine, Japan
    Rinsho Ketsueki 53:765-9. 2012
    ..However, bleeding episodes in mild hemophilia may result in excessive, sometimes life-threatening hemorrhage and require early diagnosis and replacement treatment with adequate amounts of factor VIII, as in severe hemophilia...
  33. doi request reprint Effect of donor chimerism to reduce the level of glycosaminoglycans following bone marrow transplantation in a murine model of mucopolysaccharidosis type II
    Kentaro Yokoi
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8461, Japan
    J Inherit Metab Dis 38:333-40. 2015
    ....
  34. ncbi request reprint Novel drug delivery system using thermoreversible gelation polymer for malignant glioma
    Takao Arai
    Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan
    J Neurooncol 77:9-15. 2006
    ..60-70%, respectively). This is to the best of our knowledge the first report of TGP as a novel drug delivery system, and further we provide evidence that TGP exhibits potential for use as a novel DDS for malignant glioma...
  35. doi request reprint A study investigating the need and impact of pediatric palliative care education on undergraduate medical students in Japan
    Yoko Kato
    Department of Pediatrics, Daisan Hospital, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    J Palliat Med 14:560-2. 2011
    ..Education for medical students is crucial to providing pediatric palliative care (PPC). However, few comprehensive curricula of PPC exist in Japan...
  36. ncbi request reprint Telomerase inhibitors as anticancer therapy
    Masaharu Akiyama
    Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Curr Med Chem Anticancer Agents 2:567-75. 2002
    ..In this review, we will discuss the basic biology of telomeres and telomerase as a platform for the development of treatments based upon inhibition of telomerase activity...
  37. ncbi request reprint Overexpression of telomerase confers a survival advantage through suppression of TRF1 gene expression while maintaining differentiation characteristics in K562 cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Japan
    Cell Transplant 12:365-77. 2003
    ..These data suggest that ectopic expression of hTERT by normal hematopoietic stem cells may confer a survival advantage without changing their innate biological characteristics...
  38. ncbi request reprint Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma
    Masood A Shammas
    Boston VA Health Care System, West Roxbury, MA, USA
    Mol Cancer Ther 2:825-33. 2003
    ..The aim of this study was to test the efficacy of telomerase inhibitor (TMPyP4 [tetra(N-methyl-4-pyridyl)-porphyrin chloride]; a G-quadruplex-intercalating porphyrin) as a potential therapeutic agent for multiple myeloma...
  39. ncbi request reprint Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells
    Masaharu Akiyama
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 63:6187-94. 2003
    ....
  40. ncbi request reprint Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    Teru Hideshima
    Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 101:1530-4. 2003
    ..Inhibition of JNK activity abrogates PS-341-induced MM cell death. These studies identify molecular targets of PS-341 and provide the rationale for the development of second-generation, more targeted therapies...
  41. ncbi request reprint Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
    Masaharu Akiyama
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Res 63:18-21. 2003
    ..These studies suggest that NF-kappaB p65 plays a pivotal role in regulating telomerase by modulating its nuclear translocation...
  42. ncbi request reprint Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma
    Teru Hideshima
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 63:8428-36. 2003
    ..Our data therefore demonstrate for the first time that inhibiting LPAAT-beta induces cytotoxicity in MM cells in the bone marrow milieu, providing the framework for clinical trials of these novel agents in MM...
  43. ncbi request reprint Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    Constantine S Mitsiades
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Cell 5:221-30. 2004
    ....
  44. pmc Antimyeloma activity of heat shock protein-90 inhibition
    Constantine S Mitsiades
    Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston MA 02115, USA
    Blood 107:1092-100. 2006
    ....
  45. ncbi request reprint Cytokines modulate telomerase activity in a human multiple myeloma cell line
    Masaharu Akiyama
    Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Res 62:3876-82. 2002
    ..These studies therefore demonstrate that telomerase activity is associated with cell growth, survival, and drug resistance in MM cells...
  46. ncbi request reprint Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment
    Toshiaki Hayashi
    The Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cancer Ther 1:851-60. 2002
    ..These studies provide the rationale for clinical trials of As2O3, either alone or together with dexamethasone, to overcome classical drug resistance and improve outcome in patients with MM...