I Takahashi

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Distribution of acid sphingomyelinase in human various body fluids
    I Takahashi
    Department of Pediatrics, University School of Medicine, Akita, Japan
    Tohoku J Exp Med 192:61-6. 2000
  2. ncbi request reprint A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population
    Ikuko Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 208:255-9. 2006
  3. ncbi request reprint Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome
    T Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Clin Genet 60:447-51. 2001
  4. ncbi request reprint A molecular lesion in a Japanese patient with severe phenotype of 3-methylglutaconic aciduria type I
    Mika Matsumori
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 47:684-6. 2005
  5. ncbi request reprint Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese
    Tsutomu Takahashi
    Department of Pediatrics, Akita University School of Medicine, 1 1 1 Hondo, Akita shi, 010 8543, Akita, Japan
    Pediatr Nephrol 20:576-8. 2005
  6. ncbi request reprint Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis
    Tsutomu Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    J Pediatr Hematol Oncol 24:401-4. 2002
  7. ncbi request reprint Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation
    M Komatsu
    Department of Pediatrics, Akita University School of Medicine, Japan
    Biochim Biophys Acta 1533:47-54. 2001
  8. ncbi request reprint Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 43:256-8. 2001
  9. ncbi request reprint An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type II
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Clin Genet 61:222-5. 2002
  10. ncbi request reprint Thyroid dysgenesis caused by PAX8 mutation: the hypermutability with CpG dinucleotides at codon 31
    M Komatsu
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    J Pediatr 139:597-9. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Distribution of acid sphingomyelinase in human various body fluids
    I Takahashi
    Department of Pediatrics, University School of Medicine, Akita, Japan
    Tohoku J Exp Med 192:61-6. 2000
    ....
  2. ncbi request reprint A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population
    Ikuko Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 208:255-9. 2006
    ..However, c.188 A > G (Y63C) was not identified in 96 short individuals from the general population of 2,281 healthy adults. Thus, it is unlikely that PTPN11 is one of the genes underlying stature variations in the general population...
  3. ncbi request reprint Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome
    T Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Clin Genet 60:447-51. 2001
    ..386T>A (L129X) in a familial case of symphalangism, and a g.58delC (frameshift) in a family with multiple synostosis syndrome. Characteristic genotype-phenotype correlations have not been recognized from the mutations in the NOG gene...
  4. ncbi request reprint A molecular lesion in a Japanese patient with severe phenotype of 3-methylglutaconic aciduria type I
    Mika Matsumori
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 47:684-6. 2005
  5. ncbi request reprint Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese
    Tsutomu Takahashi
    Department of Pediatrics, Akita University School of Medicine, 1 1 1 Hondo, Akita shi, 010 8543, Akita, Japan
    Pediatr Nephrol 20:576-8. 2005
    ..In addition, we expect the prevalence of renal hypouricemia, 0.23%, from the analysis of serum urate levels in 1,730 Japanese children...
  6. ncbi request reprint Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis
    Tsutomu Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    J Pediatr Hematol Oncol 24:401-4. 2002
    ..The purpose of the current study was to investigate the serum level of S-SMase...
  7. ncbi request reprint Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation
    M Komatsu
    Department of Pediatrics, Akita University School of Medicine, Japan
    Biochim Biophys Acta 1533:47-54. 2001
    ..There were no differences by the degree of apoptosis between ASM-deficient lymphoblast cells and normal lymphoblast cells. These results are evidence that ASM plays one of the important roles in apoptosis induction by UV-C and H(2)O(2)...
  8. ncbi request reprint Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 43:256-8. 2001
    ..Recently, the absence of the Insl3 gene has been reported to result in bilateral cryptorchidism in male mice and it has been suggested that mutations of the INSL3 gene may cause cryptorchidism in humans...
  9. ncbi request reprint An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type II
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Clin Genet 61:222-5. 2002
    ..The present authors suggest that the first nucleotide of exon 3 is critical for the splicing of GH-1 mRNA...
  10. ncbi request reprint Thyroid dysgenesis caused by PAX8 mutation: the hypermutability with CpG dinucleotides at codon 31
    M Komatsu
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    J Pediatr 139:597-9. 2001
    ..Mutations at this codon have been independently reported in 2 cases (CGC to CA C). These transitions are considered typical CpG-consequence mutations and account for hypermutability at this position...
  11. ncbi request reprint Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenita
    T Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    J Pediatr 130:485-8. 1997
    ..We speculate that sometime between infancy and puberty this mutation in the DAX-1 gene leads to an inability to activate the reproductive axis from its childhood suppression; thus puberty will not develop in this infant...
  12. ncbi request reprint An SEDL gene mutation in a Japanese kindred of X-linked spondyloepiphyseal dysplasia tarda
    T Takahashi
    Clin Genet 61:319-20. 2002
  13. ncbi request reprint Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement
    H Kanzaki
    Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Dent Res 83:920-5. 2004
    ..Local OPG gene transfer significantly diminished tooth movement. In this study, we report that OPG gene transfer to periodontal tissue inhibited RANKL-mediated osteoclastogenesis and inhibited experimental tooth movement...
  14. ncbi request reprint Osteoclastogenic activity during mandibular distraction osteogenesis
    L C Wang
    Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 950 8575, Japan
    J Dent Res 84:1010-5. 2005
    ..It was concluded that osteoclastogenic and osteoclastic activities are stimulated at distraction sites during the early consolidation period...
  15. ncbi request reprint Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement
    H Kanzaki
    Department of Oral Health and Development Sciences, Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai 980 8575, Japan
    Gene Ther 13:678-85. 2006
    ..Local RANKL gene transfer might be a useful tool not only for shortening orthodontic treatment, but also for moving ankylosed teeth where teeth, fuse to the surrounding bone...
  16. pmc Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells
    M N Kweon
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565, Japan
    Gut 50:299-306. 2002
    ....
  17. ncbi request reprint Midazolam for continuous sedation in Japanese patients in the critical care setting: phase II study
    K Tsutsumi
    Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Japan
    J Int Med Res 29:335-41. 2001
    ..In conclusion, midazolam infusion achieved successful sedation in this critical care setting. The optimum dose differed among the patients, however, and was influenced by the presence of complications...
  18. ncbi request reprint An Alu-linked repetitive sequence corresponding to 280 amino acids is expressed in a novel bovine protein, but not in its human homologue
    T Nobukuni
    Mitsubishi Kasei Institute of Life Sciences, Tokyo 194
    J Biol Chem 272:2801-7. 1997
    ..These results show that bovine BCNT is a unique molecule and suggest that an analysis of the relationship between bovine bcnt and its human homologue may help further the understanding of gene organization and evolution...
  19. ncbi request reprint Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomes
    I Takahashi
    National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Gene 211:387-94. 1998
    ....
  20. pmc Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice
    H Iijima
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
    J Exp Med 190:607-15. 1999
    ....
  21. ncbi request reprint Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors
    K Oritani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Nat Med 6:659-66. 2000
    ..However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons...
  22. ncbi request reprint Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    T Yokota
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Blood 96:1723-32. 2000
    ..Blood. 2000;96:1723-1732)..
  23. ncbi request reprint Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice
    D Kishi
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 165:5891-9. 2000
    ..These findings suggest that the ED-induced alteration of intestinal microenvironments such as the enteric flora prevented the development of IBD in TCR alpha(-/-) mice via the immunologic quiescence of CD4(+), betabeta T cells...
  24. ncbi request reprint Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1
    S Iwashita
    Mitsubishi Kasei Institute of Life Sciences, 194 8511, Tokyo, Japan
    Gene 268:59-66. 2001
    ..These results suggest that a truncated bovine RTE-1 was inserted into the intron upstream of an IR unit of an ancestor bcnt gene and that a duplication of a relatively long region that includes IR occurred in the bovine genome...
  25. ncbi request reprint Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)
    M Yura
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Autoimmun 17:17-25. 2001
    ..These results clearly show that MOG-specific CD4+ T cells preferentially invade into the CNS and mediate the development of EAE by producing Th1-biased cytokines...
  26. ncbi request reprint A new IFN-like cytokine, limitin, modulates the immune response without influencing thymocyte development
    I Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Immunol 167:3156-63. 2001
    ....
  27. pmc gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses
    K Fujihashi
    Department of Oral Biology, University of Alabama at Birmingham, Medical Center 35294, USA
    J Exp Med 183:1929-35. 1996
    ..The selective reduction of IgA responses to ingested antigens in the absence of gamma/delta T cells suggests a specialized role for gamma/delta cells in mucosal immunity...
  28. pmc Effects of rugby sevens matches on human neutrophil-related non-specific immunity
    I Takahashi
    Department of Social Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Aomori, Japan
    Br J Sports Med 41:13-8. 2007
    ..To evaluate the influences of the accumulative effect of two consecutive rugby sevens matches (Sevens) on aspects of human neutrophil-related non-specific immunity...