Research Topics
Species | I TakahashiSummaryAffiliation: Akita University School of Medicine Country: Japan Publications
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Detail Information
Publications
Distribution of acid sphingomyelinase in human various body fluidsI Takahashi
Department of Pediatrics, University School of Medicine, Akita, Japan
Tohoku J Exp Med 192:61-6. 2000....- A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general populationIkuko Takahashi
Department of Pediatrics, Akita University School of Medicine, Japan
Tohoku J Exp Med 208:255-9. 2006..However, c.188 A > G (Y63C) was not identified in 96 short individuals from the general population of 2,281 healthy adults. Thus, it is unlikely that PTPN11 is one of the genes underlying stature variations in the general population... - Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndromeT Takahashi
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
Clin Genet 60:447-51. 2001..386T>A (L129X) in a familial case of symphalangism, and a g.58delC (frameshift) in a family with multiple synostosis syndrome. Characteristic genotype-phenotype correlations have not been recognized from the mutations in the NOG gene... - A molecular lesion in a Japanese patient with severe phenotype of 3-methylglutaconic aciduria type IMika Matsumori
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
Pediatr Int 47:684-6. 2005 - Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in JapaneseTsutomu Takahashi
Department of Pediatrics, Akita University School of Medicine, 1 1 1 Hondo, Akita shi, 010 8543, Akita, Japan
Pediatr Nephrol 20:576-8. 2005..In addition, we expect the prevalence of renal hypouricemia, 0.23%, from the analysis of serum urate levels in 1,730 Japanese children... - Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosisTsutomu Takahashi
Department of Pediatrics, Akita University School of Medicine, Japan
J Pediatr Hematol Oncol 24:401-4. 2002..The purpose of the current study was to investigate the serum level of S-SMase... - Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activationM Komatsu
Department of Pediatrics, Akita University School of Medicine, Japan
Biochim Biophys Acta 1533:47-54. 2001..There were no differences by the degree of apoptosis between ASM-deficient lymphoblast cells and normal lymphoblast cells. These results are evidence that ASM plays one of the important roles in apoptosis induction by UV-C and H(2)O(2)... - Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese populationI Takahashi
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
Pediatr Int 43:256-8. 2001..Recently, the absence of the Insl3 gene has been reported to result in bilateral cryptorchidism in male mice and it has been suggested that mutations of the INSL3 gene may cause cryptorchidism in humans... - An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type III Takahashi
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
Clin Genet 61:222-5. 2002..The present authors suggest that the first nucleotide of exon 3 is critical for the splicing of GH-1 mRNA... - Thyroid dysgenesis caused by PAX8 mutation: the hypermutability with CpG dinucleotides at codon 31M Komatsu
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
J Pediatr 139:597-9. 2001..Mutations at this codon have been independently reported in 2 cases (CGC to CA C). These transitions are considered typical CpG-consequence mutations and account for hypermutability at this position... - Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenitaT Takahashi
Department of Pediatrics, Akita University School of Medicine, Japan
J Pediatr 130:485-8. 1997..We speculate that sometime between infancy and puberty this mutation in the DAX-1 gene leads to an inability to activate the reproductive axis from its childhood suppression; thus puberty will not develop in this infant... - An SEDL gene mutation in a Japanese kindred of X-linked spondyloepiphyseal dysplasia tardaT Takahashi
Clin Genet 61:319-20. 2002 - Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movementH Kanzaki
Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
J Dent Res 83:920-5. 2004..Local OPG gene transfer significantly diminished tooth movement. In this study, we report that OPG gene transfer to periodontal tissue inhibited RANKL-mediated osteoclastogenesis and inhibited experimental tooth movement... - Osteoclastogenic activity during mandibular distraction osteogenesisL C Wang
Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 950-8575, Japan
J Dent Res 84:1010-5. 2005..It was concluded that osteoclastogenic and osteoclastic activities are stimulated at distraction sites during the early consolidation period... - Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movementH Kanzaki
Department of Oral Health and Development Sciences, Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai 980 8575, Japan
Gene Ther 13:678-85. 2006..Local RANKL gene transfer might be a useful tool not only for shortening orthodontic treatment, but also for moving ankylosed teeth where teeth, fuse to the surrounding bone... - Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cellsM-N Kweon
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565, Japan
Gut 50:299-306. 2002..Our results contrast with those from studies in some colitis models in which CD45RB(low) T cells appeared to prevent colitis through secretion of immunosuppressive cytokines... - Midazolam for continuous sedation in Japanese patients in the critical care setting: phase II studyK Tsutsumi
Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Japan
J Int Med Res 29:335-41. 2001..In conclusion, midazolam infusion achieved successful sedation in this critical care setting. The optimum dose differed among the patients, however, and was influenced by the presence of complications... - An Alu-linked repetitive sequence corresponding to 280 amino acids is expressed in a novel bovine protein, but not in its human homologueT Nobukuni
Mitsubishi Kasei Institute of Life Sciences, Tokyo 194
J Biol Chem 272:2801-7. 1997..These results show that bovine BCNT is a unique molecule and suggest that an analysis of the relationship between bovine bcnt and its human homologue may help further the understanding of gene organization and evolution... - Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomesI Takahashi
National Institute of Infectious Diseases, Tokyo 162 8640, Japan
Gene 211:387-94. 1998.... - Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient miceH Iijima
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
J Exp Med 190:607-15. 1999.... - Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursorsK Oritani
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
Nat Med 6:659-66. 2000..However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons... - Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophagesT Yokota
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
Blood 96:1723-32. 2000..Blood. 2000;96:1723-1732).. - Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient miceD Kishi
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
J Immunol 165:5891-9. 2000..These findings suggest that the ED-induced alteration of intestinal microenvironments such as the enteric flora prevented the development of IBD in TCR alpha(-/-) mice via the immunologic quiescence of CD4(+), betabeta T cells... - Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1S Iwashita
Mitsubishi Kasei Institute of Life Sciences, 194 8511, Tokyo, Japan
Gene 268:59-66. 2001..These results suggest that a truncated bovine RTE-1 was inserted into the intron upstream of an IR unit of an ancestor bcnt gene and that a duplication of a relatively long region that includes IR occurred in the bovine genome... - Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)M Yura
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
J Autoimmun 17:17-25. 2001..These results clearly show that MOG-specific CD4+ T cells preferentially invade into the CNS and mediate the development of EAE by producing Th1-biased cytokines... - A new IFN-like cytokine, limitin, modulates the immune response without influencing thymocyte developmentI Takahashi
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
J Immunol 167:3156-63. 2001.... - gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responsesK Fujihashi
Department of Oral Biology, University of Alabama at Birmingham, Medical Center 35294, USA
J Exp Med 183:1929-35. 1996..The selective reduction of IgA responses to ingested antigens in the absence of gamma/delta T cells suggests a specialized role for gamma/delta cells in mucosal immunity... - Effects of rugby sevens matches on human neutrophil-related non-specific immunityI Takahashi
Department of Social Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Aomori, Japan
Br J Sports Med 41:13-8. 2007..To evaluate the influences of the accumulative effect of two consecutive rugby sevens matches (Sevens) on aspects of human neutrophil-related non-specific immunity...