Ken Nagata

Summary

Affiliation: Akita Research Institute of Brain and Blood Vessels
Country: Japan

Publications

  1. ncbi request reprint Misery perfusion with preserved vascular reactivity in Alzheimer's disease
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Ann N Y Acad Sci 826:272-81. 1997
  2. ncbi request reprint Clinical diagnosis of vascular dementia
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Sesnshu Kubota Machi Akita 010 0874, Japan
    J Neurol Sci 257:44-8. 2007
  3. ncbi request reprint Angiotensinogen gene polymorphism as a risk factor for ischemic stroke
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita, Japan 010 0874
    J Clin Neurosci 14:943-7. 2007
  4. ncbi request reprint Can PET data differentiate Alzheimer's disease from vascular dementia?
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Ann N Y Acad Sci 903:252-61. 2000
  5. ncbi request reprint Vascular and metabolic reserve in Alzheimer's disease
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, 010 0874, Akita, Japan
    Neurobiol Aging 21:301-7. 2000
  6. ncbi request reprint Hemodynamic aspects of Alzheimer's disease
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Ann N Y Acad Sci 977:391-402. 2002
  7. doi request reprint Cerebrovascular lesions in elderly Japanese patients with Alzheimer's disease
    Ken Nagata
    Department of Neurology, Research Institute for Brian and Blood Vessels, Japan
    J Neurol Sci 322:87-91. 2012
  8. ncbi request reprint Acute effects of cigarette smoking on global cerebral blood flow in overnight abstinent tobacco smokers
    Takao Shinohara
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Nicotine Tob Res 8:113-21. 2006
  9. ncbi request reprint Relationship between cerebral circulatory reserve and oxygen extraction fraction in patients with major cerebral artery occlusive disease: a positron emission tomography study
    Kenichiro Yata
    Department of Strokology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Stroke 37:534-6. 2006
  10. doi request reprint Analysis of cerebral perfusion and metabolism assessed with positron emission tomography before and after carotid artery stenting. Clinical article
    Shunji Matsubara
    Department of Strokology, Research Institute for Brain and Blood Vessels Akita, Akita, Japan
    J Neurosurg 111:28-36. 2009

Detail Information

Publications38

  1. ncbi request reprint Misery perfusion with preserved vascular reactivity in Alzheimer's disease
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Ann N Y Acad Sci 826:272-81. 1997
    ..The results may suggest a vascular involvement, possibly at the capillary level, that might cause a relative misery perfusion syndrome accompanied by preserved vascular reactivity in AD...
  2. ncbi request reprint Clinical diagnosis of vascular dementia
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Sesnshu Kubota Machi Akita 010 0874, Japan
    J Neurol Sci 257:44-8. 2007
    ..There is a limitation in the diagnosis based on the strict dichotomy between AD and VaD, and the concept of "AD with CVD" or "mixed dementia" should be included in the clinical diagnosis of VaD...
  3. ncbi request reprint Angiotensinogen gene polymorphism as a risk factor for ischemic stroke
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita, Japan 010 0874
    J Clin Neurosci 14:943-7. 2007
    ..031 and 0.026, respectively). Synergistic effects of the AGT gene polymorphism and clinical risks were not observed. In conclusion, AGT M allele may present a risk of lacunar infarctions in Japanese men, independent of hypertension...
  4. ncbi request reprint Can PET data differentiate Alzheimer's disease from vascular dementia?
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Ann N Y Acad Sci 903:252-61. 2000
    ..Thus, PET provides important functional information in discriminating AD from VaD by comparing the patterns of hypoperfusion and/or hypometabolism, and in the understanding of the underlying hemodynamic pathophysiology...
  5. ncbi request reprint Vascular and metabolic reserve in Alzheimer's disease
    K Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, 010 0874, Akita, Japan
    Neurobiol Aging 21:301-7. 2000
    ..The increase of OEF and preserved VTT and VR seen in AD patients indicate the possible participation of vascular factors in the pathogenesis of AD perhaps at the capillary level...
  6. ncbi request reprint Hemodynamic aspects of Alzheimer's disease
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Ann N Y Acad Sci 977:391-402. 2002
    ..Thus, from the hemodynamic point of view, the preservation of vascular reserve may be a distinct difference between AD and VaD. Furthermore, this indicates a hemodynamic integrity of the vasculature in the level of arterioles in AD...
  7. doi request reprint Cerebrovascular lesions in elderly Japanese patients with Alzheimer's disease
    Ken Nagata
    Department of Neurology, Research Institute for Brian and Blood Vessels, Japan
    J Neurol Sci 322:87-91. 2012
    ..The present study was conducted to elucidate the relationship between the CVLs and vascular risk factors (VRFs) in elderly Japanese patients with AD...
  8. ncbi request reprint Acute effects of cigarette smoking on global cerebral blood flow in overnight abstinent tobacco smokers
    Takao Shinohara
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Nicotine Tob Res 8:113-21. 2006
    ..These individual differences result in important bimodal effects of smoking on the brains of different young adult tobacco smokers...
  9. ncbi request reprint Relationship between cerebral circulatory reserve and oxygen extraction fraction in patients with major cerebral artery occlusive disease: a positron emission tomography study
    Kenichiro Yata
    Department of Strokology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Stroke 37:534-6. 2006
    ..The present study examined the relationship between circulatory and metabolic reserve in patients with hemodynamic impairment...
  10. doi request reprint Analysis of cerebral perfusion and metabolism assessed with positron emission tomography before and after carotid artery stenting. Clinical article
    Shunji Matsubara
    Department of Strokology, Research Institute for Brain and Blood Vessels Akita, Akita, Japan
    J Neurosurg 111:28-36. 2009
    ..The authors analyzed cerebral perfusion and metabolism in patients with internal carotid artery stenosis before and after carotid artery stenting (CAS)...
  11. doi request reprint Exogenous l-DOPA induce no dopamine immuno-reactivity in striatal astroglias and microglias of adult rats with extensive nigro-striatal dopaminergic denervation
    Tetsuya Maeda
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Neurosci Lett 433:255-8. 2008
    ..These findings suggest that the proliferation of glial cells in the striatum is the response to the loss of dopaminergic terminals but the glial cells do not compensate for the lost dopaminergic terminals...
  12. doi request reprint The impact of inflammation on the pathogenesis and prognosis of ischemic stroke
    Taizen Nakase
    Division of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan
    J Neurol Sci 271:104-9. 2008
    ..In conclusion, IL-6 may predict not only the severity of the stroke lesions but also the outcome of patients. TNFalpha may suggest the small arterial lesions...
  13. ncbi request reprint Long-term angiotensin-converting enzyme inhibitor perindopril therapy improves cerebral perfusion reserve in patients with previous minor stroke
    Jun Hatazawa
    Department of Radiology, Research Institute of Brain and Blood Vessels, Akita, Japan
    Stroke 35:2117-22. 2004
    ..Angiotensin-converting enzyme (ACE) inhibitor-based therapy reduces the recurrence of stroke. The present study assessed the effects of long-term ACE inhibitor therapy on cerebral circulation in patients with previous minor stroke...
  14. pmc Ischemia alters the expression of connexins in the aged human brain
    Taizen Nakase
    Department of Stroke Science, Research Institute for Brain and Blood Vessels Akita, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    J Biomed Biotechnol 2009:147946. 2009
    ..Therefore, Cx32, Cx43, and Cx45 may respond differently to ischemic insult in terms of neuroprotection...
  15. ncbi request reprint [Subjects in the acute thrombolytic therapy by intravenous administration of rt-PA]
    Akifumi Suzuki
    Department of Strokology, Research Institute for Brain and Blood Vessels Akita, 6 10 Senshu kubotamachi, Akita shi, Akita 010 0874, Japan
    No To Shinkei 58:931-6. 2006
  16. pmc High prevalence of gastroesophageal reflux disease in Parkinson's disease: a questionnaire-based study
    Tetsuya Maeda
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Parkinsons Dis 2013:742128. 2013
    ..Because clinical symptoms of GERD are usually treatable, the management can improve the patient's quality of life. Increased attention should be given to detect GERD in PD...
  17. doi request reprint Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: an open-label trial
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Phytomedicine 19:524-8. 2012
    ..There was no adverse effect during the treatment period. The present results suggest that yokukansan is beneficial for the treatment of BPSD in VaD patients...
  18. doi request reprint Research and development of a portable device to quantify muscle tone in patients with Parkinsons disease
    David Wright
    Akita Research Institute for Brain and Blood Vessels, Akita, Japan
    Conf Proc IEEE Eng Med Biol Soc 2008:2825-7. 2008
    ..In conclusion, the results clearly differentiate between normal and parkinsonian cases and to some extent severity. Quantification of disease severity might be possible given a broader range and greater number of patients...
  19. ncbi request reprint Amplified expression of uncoupling proteins in human brain ischemic lesions
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Neuropathology 27:442-7. 2007
    ..In conclusion, brains may respond to neuroprotection through the increased expression of UCP2 and UCP5 under ischemic conditions. Moreover, UCP5 may respond to repetitive ischemic stresses or have a long-term effect...
  20. ncbi request reprint [An epilepsy case presenting temporal aphonia and prosodic deficit with left hemiparesis]
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita
    Rinsho Shinkeigaku 46:718-21. 2006
    ..The symptoms observed and the findings obtained may indicate that the deficiency of the affective prosody may be caused by the dysfunction of the medial surface of the non-dominant frontal lobe in this case...
  21. ncbi request reprint Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia
    Taizen Nakase
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Sensyu Kubota Machi, Akita 010 0874, Japan
    Glia 54:369-75. 2006
    ..These findings suggested that the brain may generate neuronal protection by increasing the levels of Cx43 and amplifying the astrocytic gap junctional intercellular communication under hypoxic condition...
  22. ncbi request reprint [Glucose metabolism in the brain]
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels
    Nihon Rinsho 60:314-23. 2002
  23. ncbi request reprint [Update on stroke epidemiology]
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Brain Nerve 65:857-70. 2013
    ..These findings suggest a participation of cerebrovascular lesions in the development and evolution of dementia, especially in the elderly population...
  24. doi request reprint The relationship between visuospatial ability and cognitive function in patients with right-hemisphere infarction
    Haruhisa Kato
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    J Neurol Sci 322:129-31. 2012
    ..The relationship between visuospatial ability and cognitive function is still controversial among the patients with right-hemisphere damage...
  25. ncbi request reprint [A case of vertebral artery dissection with recurrent brain embolism]
    Taizen Nakase
    Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan
    No To Shinkei 58:239-43. 2006
    ..Surgical treatments should be taken into consideration at the early stage, especially for the cases presenting fragile dissecting lesions. Further study need to decide the effective treatment of the vertebral artery dissection...
  26. ncbi request reprint [Cigarette smoking and neurological disease]
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    No To Shinkei 56:205-23. 2004
  27. ncbi request reprint Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis
    Hirotsugu Kado
    Department of Radiology, Akita Research Institute for Brain and Blood Vessels, 6 10 Kubotamachi, Sensyu, Akita 010 0874, Japan
    Radiology 238:248-55. 2006
    ..To prospectively assess the usefulness of magnetic resonance (MR) spectroscopy data acquired before the initiation of medical therapy in predicting prognosis in patients with depressive psychosis...
  28. doi request reprint Dabigatran and factor Xa inhibitors for stroke prevention in patients with nonvalvular atrial fibrillation
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:165-73. 2012
    ..We also discuss precautions for the use of dabigatran and future perspectives with a view to reducing the risk of stroke with new oral anticoagulants, including factor Xa inhibitors in AF patients...
  29. ncbi request reprint Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA
    Tetsuya Maeda
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Brain Res 1046:230-3. 2005
    ..These findings suggest that striatal serotonergic hyperinnervation can compensate for the lost function of dopaminergic neurons...
  30. ncbi request reprint [Ximelagatran]
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita
    Nihon Rinsho 64:630-6. 2006
  31. ncbi request reprint The anterior portion of the bilateral temporal lobes participates in music perception: a positron emission tomography study
    Masayuki Satoh
    Department of Neurology, Mie University School of Medicine, Mie, Japan
    AJNR Am J Neuroradiol 24:1843-8. 2003
    ..We investigated the role of the anterior portion of the temporal lobes in the perception of music in nonmusicians by use of positron emission tomography (PET)...
  32. ncbi request reprint Activated brain regions in musicians during an ensemble: a PET study
    M Satoh
    Department of Neurology, Japanese Red Cross Medical Center, 4-1-22, Hiroo, Shibuya-ku, Tokyo 150-8935, Japan
    Brain Res Cogn Brain Res 12:101-8. 2001
    ..Further studies are necessary to clarify the difference in music processing between musicians and nonmusicians...
  33. ncbi request reprint Positron-emission tomography of brain regions activated by recognition of familiar music
    M Satoh
    Department of Neurology, Mie University School of Medicine, Mie, Japan
    AJNR Am J Neuroradiol 27:1101-6. 2006
    ..We used positron-emission tomography (PET) to study changes in regional cerebral blood flow (rCBF) that occur during listening to familiar music...
  34. ncbi request reprint [Study on dopamine D2 binding capacity in vascular parkinsonism]
    H Terashi
    Department of Neurology, Research Institute for Brain and Blood Vessels, Third Department of Internal Medicine, Tokyo Medical University
    Rinsho Shinkeigaku 41:659-64. 2001
    ..This may indicate that striatal dopamine D2 receptor function is not primarily associated with the development of the parkinsonism in VP...
  35. pmc Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions...
  36. ncbi request reprint Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury
    Ritsuko Ikeda
    Department of Immunology, St Marianna University School of Medicine, 2 16 1, Sugao, Kawasaki, Kanagawa 216 8511, Japan
    Neurobiol Dis 20:38-48. 2005
    ..This is the first demonstration that neural cells derived from nonhuman primate ES cells have the ability to restore motor function in an animal model of brain injury...
  37. doi request reprint Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: a prospective, multicenter, observational study
    Kazunori Toyoda
    Cerebrovascular Division, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan toyoda hsp ncvc go jp
    Stroke 39:1740-5. 2008
    ....
  38. doi request reprint Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study
    Kazuaki Shimamoto
    Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 31:469-78. 2008
    ..BP was controlled below 140/90 mmHg in a half of the very elderly hypertensive patients in this study, and these patients also had a lower incidence of CV events...