K Mishima

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. ncbi Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Akita City, Japan
    Chronobiol Int 17:419-32. 2000
  2. ncbi The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample
    Kazuo Mishima
    Division of Neuropsychiatry, Department of Neuro and Locomotor Science, Akita University School of Medicine, Akita, Japan
    Am J Med Genet B Neuropsychiatr Genet 133:101-4. 2005
  3. ncbi Diminished melatonin secretion in the elderly caused by insufficient environmental illumination
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Akita City 010 8543, Japan
    J Clin Endocrinol Metab 86:129-34. 2001
  4. ncbi Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Chronobiol Int 15:647-54. 1998
  5. ncbi Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment
    M Okawa
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Sleep 14:478-85. 1991
  6. ncbi Vitamin B12 treatment for sleep-wake rhythm disorders
    M Okawa
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Sleep 13:15-23. 1990
  7. ncbi Hypnotic and hypothermic action of daytime-administered melatonin
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Psychopharmacology (Berl) 133:168-71. 1997
  8. ncbi Hypothermic action of exogenously administered melatonin is dose-dependent in humans
    K Satoh
    Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita-city, Akita, 010-8543, Japan
    Clin Neuropharmacol 24:334-40. 2001
  9. ncbi Total sleep deprivation induces an acute and transient increase in NK cell activity in healthy young volunteers
    Y Matsumoto
    Department of Neuropsychiatry, Akita University, School of Medicine, Japan
    Sleep 24:804-9. 2001
  10. pmc Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
    T Ebisawa
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Saitama 350 0495, Japan
    EMBO Rep 2:342-6. 2001

Collaborators

Detail Information

Publications10

  1. ncbi Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Akita City, Japan
    Chronobiol Int 17:419-32. 2000
    ..Future studies should address the most effective therapeutic design and the most suitable types of symptoms for treatment and investigate the use of these tools in preventive applications in persons in early stages of dementia...
  2. ncbi The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample
    Kazuo Mishima
    Division of Neuropsychiatry, Department of Neuro and Locomotor Science, Akita University School of Medicine, Akita, Japan
    Am J Med Genet B Neuropsychiatr Genet 133:101-4. 2005
    ..The present findings in a Japanese population sample, which should have a relatively low risk of population stratification effects, suggest the significance of the association of the 3111C/C allele of hClock with evening preference...
  3. ncbi Diminished melatonin secretion in the elderly caused by insufficient environmental illumination
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Akita City 010 8543, Japan
    J Clin Endocrinol Metab 86:129-34. 2001
    ..The present findings suggest that we need to pay attention to elderly individuals who suffer under conditions of poor environmental light resulting in disorganized circadian rhythms, including the sleep-wake cycle...
  4. ncbi Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Chronobiol Int 15:647-54. 1998
    ....
  5. ncbi Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment
    M Okawa
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Sleep 14:478-85. 1991
    ....
  6. ncbi Vitamin B12 treatment for sleep-wake rhythm disorders
    M Okawa
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Sleep 13:15-23. 1990
    ..After administration of VB12 at the daily doses of 1.5 mg, his sleep-wake rhythm disorder was improved. The good therapeutic effect lasted for more than 6 months while he was on the medication...
  7. ncbi Hypnotic and hypothermic action of daytime-administered melatonin
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Psychopharmacology (Berl) 133:168-71. 1997
    ....
  8. ncbi Hypothermic action of exogenously administered melatonin is dose-dependent in humans
    K Satoh
    Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita-city, Akita, 010-8543, Japan
    Clin Neuropharmacol 24:334-40. 2001
    ..Results suggest that the therapeutic effect of larger doses of ex-MLT should be tested on patients who benefit little from typically lower clinical doses of ex-MLT...
  9. ncbi Total sleep deprivation induces an acute and transient increase in NK cell activity in healthy young volunteers
    Y Matsumoto
    Department of Neuropsychiatry, Akita University, School of Medicine, Japan
    Sleep 24:804-9. 2001
    ..CONCLUSIONS: The present findings suggest that one night TSD induces an acute and transient increase in NK cell activity that is not influenced by the effects of circadian rhythm or the amount of physical exercise undertaken during TSD...
  10. pmc Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
    T Ebisawa
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Saitama 350 0495, Japan
    EMBO Rep 2:342-6. 2001
    ..037; odds ratio = 7.79; 95% CI 1.59-38.3) in our study population. Our results suggest that structural polymorphisms in the hPer3 gene may be implicated in the pathogenesis of DSPS...