Yoshihiro Minamiya

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. doi C-reactive protein 1059G>C genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    J Am Coll Surg 209:477-83. 2009
  2. doi Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients
    Yoshihiro Minamiya
    The Department of Chest Surgery, Akita University Hospital, Akita University Graduate School of Medicine, Hondo Akita, Japan
    Cancer Biomark 11:139-46. 2012
  3. doi The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Tumour Biol 31:673-9. 2010
  4. doi Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    The Division of Thoracic Surgery, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:533-9. 2010
  5. doi Transforming growth factor-β1 29T>C genetic polymorphism is associated with lymph node metastasis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:437-41. 2010
  6. doi Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl
    Yoshihiro Minamiya
    Department of Surgery, Akita University School of Medicine, Hondo, Japan
    Gen Thorac Cardiovasc Surg 57:657-9. 2009
  7. ncbi REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City, 010 8543 Japan
    Lung Cancer 60:98-104. 2008
  8. ncbi Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Tumour Biol 26:153-7. 2005
  9. doi Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 68:466-71. 2010
  10. ncbi Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Ann Thorac Surg 81:327-30. 2006

Collaborators

Detail Information

Publications88

  1. doi C-reactive protein 1059G>C genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    J Am Coll Surg 209:477-83. 2009
    ..The purpose of this study was to assess the association between CRP polymorphisms and acute-phase serum CRP levels after esophagectomy for thoracic esophageal cancer...
  2. doi Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients
    Yoshihiro Minamiya
    The Department of Chest Surgery, Akita University Hospital, Akita University Graduate School of Medicine, Hondo Akita, Japan
    Cancer Biomark 11:139-46. 2012
    ..Ratio of ZFHX3 mRNA in tumor against normal lung in low-ZFHX3 tumor was lower than in high-ZFHX3 tumor. In conclusion, suppression of ZFHX3 expression in tumor cells decreases the survival rate among patients with NSCLC...
  3. doi The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Tumour Biol 31:673-9. 2010
    ..76; 95% confidence interval, 1.003-3.16; p = 0.049) to be independent factors affecting 5-year overall survival. These findings suggest the CRP 1846T/T genotype is an independent predictor of a poor prognosis in patients with NSCLC...
  4. doi Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    The Division of Thoracic Surgery, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:533-9. 2010
    ..06; 95% CI, 1.07-7.55; P = 0.037) to be independent factors affecting the 5-DFS rate. Strong tumoral expression of HDAC3 is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung...
  5. doi Transforming growth factor-β1 29T>C genetic polymorphism is associated with lymph node metastasis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:437-41. 2010
    ..045) are factors associated with a significantly greater likelihood of developing lymph node metastasis. TGF-β1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung...
  6. doi Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl
    Yoshihiro Minamiya
    Department of Surgery, Akita University School of Medicine, Hondo, Japan
    Gen Thorac Cardiovasc Surg 57:657-9. 2009
    ..This approach could be especially useful for young female patients, given its cosmetic advantage...
  7. ncbi REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City, 010 8543 Japan
    Lung Cancer 60:98-104. 2008
    ..Although REG1A expression also has been observed in various tumors, the correlation between REG1A expression and the clinicopathological characteristics of non-small cell lung cancer (NSCLC) and patient prognosis has not been evaluated...
  8. ncbi Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Tumour Biol 26:153-7. 2005
    ..In the present study, therefore, we examined the role of MLCK in the metastasis of non-small cell lung cancer (NSCLC) in a clinical setting...
  9. doi Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 68:466-71. 2010
    ..037) to be independent factors affecting the 5-year disease-free survival rate. Conclusion: Higher levels of CXCR4 expression by tumor cells are an independent predictor of a better prognosis in patients with adenocarcinoma of the lung...
  10. ncbi Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Ann Thorac Surg 81:327-30. 2006
    ..The purpose of this study was to test the utility of a new, more sensitive, sterilizable magnetometer developed in our institute for in vivo sentinel lymph node mapping in patients with nonsmall cell lung cancer...
  11. ncbi Antithrombin III diminishes production of oxygen radical in endotoxin-infused rat lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Shock 21:139-43. 2004
    ..g., syndecan-4) on the neutrophil, thereby reducing neutrophil accumulation in the lung, which would in turn inhibit oxygen radical production in the lung...
  12. doi Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Department of Chest, Breast and Endoclinologic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Tumour Biol 32:197-202. 2011
    ..11 to 0.93; P = 0.034) to be independent factors affecting the 5-year disease-free survival rate. Greater expression of CCR6 by tumor cells is an independent predictor of a better prognosis in patients with adenocarcinoma of the lung...
  13. ncbi Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung
    Y Minamiya
    Second Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Am J Respir Cell Mol Biol 19:150-7. 1998
    ..These data indicate that the nonhypoxic ischemia without reperfusion alone causes radical production and increases MVP. Furthermore, PAF and ICAM-1 contribute to these reactions...
  14. ncbi Subpleural injection of tracer improves detection of mediastinal sentinel lymph nodes in non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Eur J Cardiothorac Surg 32:770-5. 2007
    ....
  15. doi Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    The Division of Thoracic Surgery, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 74:300-4. 2011
    ..We therefore investigated the relationship between HDAC1 expression by tumors and the clinicopathological characteristics of patients with adenocarcinoma of the lung...
  16. ncbi Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Surgery 146:931-8. 2009
    ..Our aim in this study was to assess whether cytokine polymorphisms were associated with infectious complications following esophagectomy in a Japanese population...
  17. doi REG1A expression status suggests chemosensitivity among advanced thoracic esophageal squamous cell carcinoma patients treated with esophagectomy followed by adjuvant chemotherapy
    Yusuke Sato
    Department of Surgery, Akita University Graduate School of Medicine, Akita, 010 8543, Japan
    Ann Surg Oncol 20:3044-51. 2013
    ....
  18. ncbi Preoperative mapping of lymphatic drainage from the tumor using ferumoxide-enhanced magnetic resonance imaging in clinical submucosal thoracic squamous cell esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Japan
    Surgery 141:736-47. 2007
    ..The aim of the present study was to evaluate the potential clinical utility of a new method of mapping lymphatic drainage from tumors using ferumoxide-enhanced magnetic resonance imaging (MRI)...
  19. ncbi Superior mediastinal and neck lymphatic mapping in mid- and lower-thoracic esophageal cancer as defined by ferumoxides-enhanced magnetic resonance imaging
    Hiroshi Imano
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Jpn J Thorac Cardiovasc Surg 52:445-50. 2004
    ....
  20. doi CRP genetic polymorphism is associated with lymph node metastasis in thoracic esophageal squamous cell cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Surg Oncol 16:2479-85. 2009
    ..The purpose of this study is to examine the association between inflammation-related genetic polymorphisms and lymph node metastasis...
  21. doi Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer
    Takashi Ono
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Interact Cardiovasc Thorac Surg 9:659-61. 2009
    ..Evaluation of micrometastases of all dissected lymph nodes may be substituted by evaluating micrometastases of SNs. We believe that further studies are warranted to determine the most useful clinical applications...
  22. ncbi A novel method for sentinel lymph node mapping using magnetite in patients with non-small cell lung cancer
    Taku Nakagawa
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    J Thorac Cardiovasc Surg 126:563-7. 2003
    ..The aim of the present study was to test the feasibility of this technique...
  23. doi Interleukin-2 -330T>G genetic polymorphism associates with prognosis following surgery for thoracic esophageal squamous cell cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 18:1995-2002. 2011
    ..We investigated the relationship between Th1/Th2 cytokine polymorphism and prognosis in patients with thoracic esophageal squamous cell cancer...
  24. ncbi Detection of pleural lymph flow using indocyanine green fluorescence imaging in non-small cell lung cancer surgery: a preliminary study
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 43:249-54. 2013
    ..This phenomenon is termed as "skip metastasis." This study investigated the subpleural lymphatic flow to the mediastinum using indocyanine green (ICG) with a near-infrared fluorescence imaging system...
  25. ncbi Hydrogen peroxide derived from intestine through the mesenteric lymph induces lung edema after surgical stress
    Masakatsu Nakamura
    Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Shock 21:160-4. 2004
    ..The H2O2 then enters the mesenteric lymph and travels to the lung, where it increases capillary permeability and thus induces edema...
  26. ncbi Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature
    Aki Ito
    Department of Surgery, Akita University, Hondo, Akita City, Japan
    Cancer Sci 100:558-64. 2009
    ..Thus, the combination of FMP-mediated, self-regulating hyperthermia with Hsp90 inhibition has important implications for the treatment of cancer...
  27. doi Status of involved lymph nodes and direction of metastatic lymphatic flow between submucosal and t2-4 thoracic squamous cell esophageal cancers
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Surg 33:512-7. 2009
    ....
  28. pmc Bronchioloalveolar invasion in non-small cell lung cancer is associated with expression of transforming growth factor-β1
    Kazuhiro Imai
    Department of Chest, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Surg Oncol 11:113. 2013
    ..We therefore analyzed the relationship between TGF-β1 expression and clinicopathological microinvasion in patients with small lung adenocarcinoma...
  29. ncbi Polymorphonuclear leukocytes are activated during atelectasis before lung reexpansion in rat
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Shock 30:81-6. 2008
    ..During atelectasis, PMNs accumulate in the lung, where they are primed for respiratory bursting. After pulmonary reexpansion, oxygen is supplied from the alveoli, and PMN respiratory bursting occurs...
  30. pmc Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, Japan
    J Exp Clin Cancer Res 31:3. 2012
    ..Moreover, although TGF-β1 has been shown to promote tumor progression, there is still no direct, in vivo evidence as to whether TGF-β1 is able to directly induce distant metastasis...
  31. doi Expression of the transient receptor potential channel c3 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Ann Surg Oncol 18:3377-83. 2011
    ..Therefore, we investigated the relationship between TRP expression and the prognosis of patients with adenocarcinoma of the lung...
  32. doi Accuracy of helical computed tomography for the identification of lymph node metastasis in resectable non-small cell lung cancer
    Kazuhiro Imai
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 38:1083-90. 2008
    ..New criteria for LNM were investigated because the resolution of hCT is better than that of conventional CT...
  33. ncbi Usefulness of circumference difference for estimating the likelihood of malignancy in small solitary pulmonary nodules on CT
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 58:348-54. 2007
    ..We measured the extent of ground-glass opacity (GGO) and our own original method of circumference difference (CD) as an additional approach in classifying SSPN revealed on CT, and evaluated the likelihood of malignancy...
  34. doi Tracheobronchial lesions following esophagectomy: erosions, ulcers, and fistulae, and the predictive value of lymph node-related factors
    Kiyotomi Maruyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 33:778-84. 2009
    ..In this study we assessed the causes and clinical features of these complications, paying particular attention to lymph node (LN)-related factors...
  35. doi Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells
    Shuetsu Usami
    Department of Biochemistry, Akita University Graduate School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 392:4-8. 2010
    ..The elevated IL-6 expression seen in REG Ialpha transfectants was silenced by small interfering RNA-mediated knockdown. These finding suggest that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology...
  36. ncbi Intraoperative detection of lymph node micrometastasis with flow cytometry in non-small cell lung cancer
    Manabu Ito
    Akita University School of Medicine, Division of Thoracic Surgery, Department of Surgery, Akita City, Japan
    J Thorac Cardiovasc Surg 130:753-8. 2005
    ..We sought to determine whether cytokeratin-positive cells can be detected as markers of lymph node metastasis by using flow cytometry within a time frame suitable for intraoperative decision making in non-small cell lung cancer...
  37. doi Outcomes of patients receiving additional esophagectomy after endoscopic resection for clinically mucosal, but pathologically submucosal, squamous cell carcinoma of the esophagus
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 43:638-42. 2013
    ....
  38. ncbi Surgical outcome of colon interposition by the posterior mediastinal route for thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Surg 83:1273-8. 2007
    ..Our aim was to review our experience with reconstruction by the posterior mediastinal route and assess the surgical outcomes...
  39. ncbi Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node
    Manabu Ito
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 01 8543, Japan
    J Immunol 176:5637-43. 2006
    ..Taken together, these results suggest that tumor-derived TGFbeta-1 induces immunosuppression within SLNs before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes...
  40. ncbi Methylprednisolone inhibits low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused rat liver
    Satoru Motoyama
    Second Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Crit Care Med 31:1468-74. 2003
    ..To investigate the mechanism by which methylprednisolone protects the liver from hypoxia-induced injury...
  41. doi Use of CT to evaluate pleural invasion in non-small cell lung cancer: measurement of the ratio of the interface between tumor and neighboring structures to maximum tumor diameter
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery and Department of Integrated Medicine, Division of Radiology and Radiation Medicine, Akita University Graduate School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Radiology 267:619-26. 2013
    ..To develop a simple noninvasive technique for evaluating pleural invasion by using routine preoperative computed tomography (CT)...
  42. ncbi Interleukin-6 -634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Dig Surg 29:194-201. 2012
    ..We assessed the associations between IL-6 and IL-6 receptor (IL-6R) genetic polymorphisms, tumoral IL-6 expression and survival rates following surgery...
  43. doi Tumoral CRP expression in thoracic esophageal squamous cell cancers is associated with poor outcomes
    Toshinobu Nakatsu
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 42:652-8. 2012
    ..Cancer cells reportedly produce C-reactive protein (CRP) locally within tumors. The aim of this study was to determine whether tumoral CRP is associated with clinical outcome and recurrence in thoracic esophageal squamous cell cancer...
  44. doi REG1A expression is an independent factor predictive of poor prognosis in patients with breast cancer
    Yasuhiro Sasaki
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Ann Surg Oncol 15:3244-51. 2008
    ..Although REG1A expression has also been observed in various malignant tumors, the correlation between REG1A expression and the clinicopathological characteristics of breast cancer and patient prognosis has not been evaluated...
  45. ncbi Pleural dissemination of esophageal gastrointestinal stromal tumors after an eight-year interval following the primary surgery
    Kazuhiro Imai
    Department of Surgery, Akita University School of Medicine, Akita, 010 8543, Japan
    Gen Thorac Cardiovasc Surg 58:302-5. 2010
    ..The diagnosis was pleural dissemination of esophageal GISTs 8 years after primary surgery, making this the first report of pleural dissemination of esophageal GISTs after such a prolonged postsurgical interval...
  46. ncbi Expression of tissue factor mRNA and invasion of blood vessels by tumor cells in non-small cell lung cancer
    Yoshihiro Minamiya
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 34:1-5. 2004
    ..For example, by acting as an adhesion molecule enabling tissue invasion, TF may play a key role in the metastatic process and angiogenesis in non-small cell lung cancer (NSCLC)...
  47. doi C-reactive protein inhibits lymphangiogenesis and resultant lymph node metastasis of squamous cell carcinoma in mice
    Tomohiko Sasaki
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Surgery 154:1087-92. 2013
    ..We hypothesized that host CRP directly inhibits lymph node metastasis...
  48. doi Pathological finding of subclinical interstitial pneumonia as a predictor of postoperative acute respiratory distress syndrome after pulmonary resection
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, Hondo, Akita City 010 8543, Japan
    Eur J Cardiothorac Surg 39:190-4. 2011
    ..In this study, we evaluated IP on preoperative computed tomography (CT) and histopathological findings in patients who underwent thoracic surgery, and attempted to identify high-risk patients who might develop postoperative ARDS...
  49. ncbi New CT criteria for nodal staging in non-small cell lung cancer
    Satoshi Kudo
    Department of General Thoracic Surgery and Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Clin Imaging 38:448-53. 2014
    ..The purpose of our study was to develop a simple noninvasive technique for nodal staging using routine preoperative computed tomography (CT)...
  50. ncbi Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
    Shinogu Takashima
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Tumour Biol 35:4257-65. 2014
    ..Stronger expression of cyclin B2 mRNA in tumor cells is an independent predictor of a poor prognosis in patients with adenocarcinoma of lung. ..
  51. ncbi Diagnostic imaging in the preoperative management of lung cancer
    Kazuhiro Imai
    Department of Chest and Endocrinological Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 44:1197-206. 2014
    ..However, thoracic surgeons should also be aware of the limitations of these techniques. ..
  52. ncbi [A case of survival--excellent response to chemotherapy in long-term postoperative recurrence of non-small cell lung cancer]
    Kazuhiro Imai
    Division of Thoracic Surgery, Dept of Surgery, Akita University School of Medicine
    Gan To Kagaku Ryoho 35:1415-7. 2008
    ..We conclude that oral administration of S-1 is useful as palliative chemotherapy without serious adverse events or worsening of quality of life. Patients like this case are thus able to continue chemotherapy for a long time...
  53. ncbi REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells
    Kaori Hayashi
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Cancer Sci 99:2491-5. 2008
    ....
  54. doi Acquired xanthine dehydrogenase expression shortens survival in patients with resected adenocarcinoma of lung
    Hayato Konno
    Division of Chest Surgery, Akita University Hospital, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 33:1727-32. 2012
    ..11-5.02; P = 0.026) were all independent factors affecting 5-year disease-free survival. In conclusion, high tumoral XDH expression is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung...
  55. doi Estimating the need for neck lymphadenectomy in submucosal esophageal cancer using superparamagnetic iron oxide-enhanced magnetic resonance imaging: clinical validation study
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Surg 36:83-9. 2012
    ....
  56. ncbi Pulmonary reexpansion causes xanthine oxidase-induced apoptosis in rat lung
    Satoshi Saito
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Japan
    Am J Physiol Lung Cell Mol Physiol 289:L400-6. 2005
    ....
  57. doi REG Ialpha is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients
    Kaori Hayashi
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan, 010 8543
    Ann Surg Oncol 15:1224-31. 2008
    ..A reliable marker of chemoradiosensitivity that would enable appropriate and individualized treatment of thoracic squamous cell esophageal cancer has long been sought. We investigated whether regenerating gene (REG) Ialpha is such a marker...
  58. ncbi Mediastinal neurofibroma originating from the left intrathoracic phrenic nerve: report of a case
    Hajime Saito
    Department of Surgery, Division of Thoracic Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 34:950-3. 2004
    ....
  59. ncbi Nafamostat mesilate attenuates radical formation in the rat lung infused with endotoxin
    Yoshihiro Minamiya
    Second Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Shock 18:255-60. 2002
    ..We conclude that NM attenuates plasma C3a formation, neutrophil adherence to pulmonary capillaries, and their production of oxygen radical in rats infused with endotoxin...
  60. doi IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells
    Kei Yoshino
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 404:1070-5. 2011
    ..IGFBP3 and BAG1 may thus be useful targets for improved and more individualized treatments for patients with esophageal squamous cell carcinoma...
  61. ncbi Malignant fibrous histiocytoma originating from the thymus
    Kazuhiro Imai
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, and Akita Kumiai General Hospital, 1 1 1 Hondo, Akita, 010 8543, Japan
    Gen Thorac Cardiovasc Surg 56:606-9. 2008
    ..Mediastinum MFH has been reported in 34 cases, but this appears to be a rare description of MFH originating from the thymus...
  62. doi Self-regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature
    Hajime Saito
    Department of Surgery, Akita University, 1 1 1 Hondo, Akita City 010 8543, Japan
    Cancer Sci 99:805-9. 2008
    ..A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control...
  63. ncbi A CRP genetic polymorphism associated with the tumoral expression of CRP in esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 43:339-40. 2013
    ..This finding suggests that tumoral CRP production controlled by CRP genetics significantly influences tumor behavior...
  64. ncbi [A case of complete resection of non-squamous non-small-cell lung cancer after induction chemotherapy using carboplatin, paclitaxel, and bevacizumab]
    Yasushi Kawaharada
    Dept of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, Japan
    Gan To Kagaku Ryoho 39:1533-7. 2012
    ..Induction chemotherapy with carboplatin, paclitaxel and bevacizumab may be useful for treatment of locally advanced lung cancer...
  65. ncbi The current status of sentinel lymph node mapping in non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Cardiovasc Surg 11:67-72. 2005
    ..For all of these reasons, we think that SLN mapping will be useful in the treatment of NSCLC, and that further development aimed at making SLN mapping a practical surgical procedure is warranted...
  66. pmc Esophagotracheal fistula caused by gastroesophageal reflux 9 years after esophagectomy
    Kiyotomi Maruyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Gastroenterol 13:801-3. 2007
    ..It was successfully treated with transposition of a pedicled pectoralis major muscle flap...
  67. ncbi Methylprednisolone-induced expression of mitochondrial heat shock protein 60 protects mitochondrial membrane potential in the hypoxic rat liver
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Shock 22:234-9. 2004
    ..This raises the possibility that one way in which methylprednisolone protects the mitochondrial membrane potential under hypoxic conditions is to induce expression of mitochondrial hsp 60...
  68. ncbi [A novel method for sentinel lymph node mapping using magnetite]
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita, Japan
    Nihon Geka Gakkai Zasshi 104:759-61. 2003
    ..To detect sentinel lymph nodes in vivo, the magnetometer should be sterilized and the sensitivity of the magnetometer should be higher than that we used. Therefore now we are developing a more sensitive and sterilizable magnetometer...
  69. ncbi Effect of antithrombin III on neutrophil deformability
    Hajime Saito
    Division of Thoracic Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    J Leukoc Biol 78:777-84. 2005
    ..These findings suggested that AT inhibits the increase in neutrophil stiffness seen during inflammatory processes by inhibiting actin polymerization via a heparin-independent pathway...
  70. doi Resection of a giant, invasive malignant solitary fibrous tumor of pleura
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Gen Thorac Cardiovasc Surg 60:859-62. 2012
    ..SFTPs have malignant potential, as 20-30 % of resected SFTPs reportedly contain malignant components. Careful long-term clinical follow-up is therefore required for all cases of SFTP...
  71. doi Postoperative bronchial stump fistula after lobectomy: response to occlusion with polyglycolic acid mesh and fibrin glue via bronchoscopy
    Kazuhiro Imai
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Gen Thorac Cardiovasc Surg 59:771-4. 2011
    ..Air leakage was stopped, and the patient did not develop empyema. Particularly for patients in poor general condition, our noninvasive technique seems to serve as a therapy of first choice...
  72. ncbi Soluble and cell-associated forms of some yet to be identified factor in transfused blood which promotes solid tumor growth in mice
    Manabu Okuyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 34:673-7. 2004
    ..The aim of the present study was to determine whether the transfusion of a soluble or insoluble factor present in stored blood can induce immunomodulation, which would thereby promote solid tumor growth...
  73. ncbi Giant cell tumor of the sternum
    Kazuhiro Imai
    Department of Surgery, Division of Thoracic Surgery, Akita University School of Medicine, Japan
    Jpn J Thorac Cardiovasc Surg 54:405-8. 2006
    ..5 x 4.5 x 2.5cm, and the histopathological examination confirmed GCT. Radical wide resection of primary sternum tumors and reconstruction with an appropriately rigid prosthetic material are necessary to minimize local recurrence...
  74. ncbi VEGF121 promotes lymphangiogenesis in the sentinel lymph nodes of non-small cell lung carcinoma patients
    Hideki Kawai
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Lung Cancer 59:41-7. 2008
    ..Our aim was to further investigate the capacity of VEGFs to induce lymphangiogenesis within SLNs and to assess their role in SLN metastasis in non-small cell lung carcinoma (NSCLC)...
  75. ncbi Indication for preoperative localization of small peripheral pulmonary nodules in thoracoscopic surgery
    Hajime Saito
    Second Department of Surgery and Radiology, Akita University School of Medicine, Akita City, Japan
    J Thorac Cardiovasc Surg 124:1198-202. 2002
    ..The purpose of this study was to determine indications for preoperative hookwire marking in thoracoscopic resection of small peripheral pulmonary nodules...
  76. ncbi Clinical presentation of pulmonary edema following esophagectomy on chest radiograph
    Hideki Ota
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Hepatogastroenterology 50:1403-6. 2003
    ..To determine whether the clinical presentation of pulmonary edema following esophagectomy can be objectively determined by changes in X-ray density in the lung field on chest radiography...
  77. ncbi Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation
    Hajime Saito
    Second Department of Surgery, Akita University School of Medicine, Akita City, Japan
    J Leukoc Biol 72:829-36. 2002
    ..These data suggest that endothelial Rho and Rho kinase regulate transendothelial neutrophil migration by modulating the cytoskeletal events that mediate such migration...
  78. ncbi Hydrogen peroxide-dependent declines in Bcl-2 induces apoptosis in hypoxic liver
    Satoru Motoyama
    The Second Department of Surgery, Akita University School of Medicine 1 1 1 Hondo, 010 8543, Akita City, Japan
    J Surg Res 110:211-6. 2003
    ....
  79. ncbi Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer
    Hideki Kawai
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita, Japan
    Clin Cancer Res 11:5084-9. 2005
    ..Our goal was to investigate ER expression in non-small cell lung cancer (NSCLC) and to assess whether their expression correlates with prognosis...
  80. ncbi [Current status and new applications of sentinel lymph node mapping in non-small cell lung cancer]
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita, Japan
    Nihon Geka Gakkai Zasshi 110:82-5. 2009
    ..We expect SLN mapping to become a common clinical practice in the treatment of NSCLC in the near future..
  81. ncbi Nocturnal hypoxemia after lobectomy for lung cancer
    Hideki Kawai
    Department of Thoracic Surgery, Nakadori General Hospital, Akita, Japan
    Ann Thorac Surg 79:1162-6. 2005
    ..This study also compared the postoperative course of nocturnal oxygen saturation after standard lobectomy with posterolateral thoracotomy and lobectomy with video-assisted thoracic surgery...
  82. ncbi Hydrogen peroxide derived from hepatocytes induces sinusoidal endothelial cell apoptosis in perfused hypoxic rat liver
    S Motoyama
    Second Department of Surgery, Akita University School of Medicine, Japan
    Gastroenterology 114:153-63. 1998
    ..Evidence is accumulating that hypoxic liver injury involves not only necrosis but also apoptosis. Reactive oxygen species can cause apoptosis. This study examined the hypothesis that H2O2 induces apoptosis in hypoxic rat liver...
  83. ncbi Estimation of pulmonary oxygen consumption in the early postoperative period after thoracic surgery
    H Saito
    Department of Surgery, Division of Thoracic Surgery, Akita University School of Medicine, Hondo, Akita City, 010 8543, Japan
    Anaesthesia 62:648-53. 2007
    ..These findings suggest that the difference in oxygen consumption may be useful for estimating the extent of lung injury and for predicting pulmonary complications in the postoperative period...
  84. doi Preventive wrapping of the fragile tracheobronchial wall using a flap of latissimus dorsi muscle during esophagectomy after chemoradiotherapy
    Y Sato
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Eur Surg Res 41:279-83. 2008
    ..This scleroid layer must be removed with the tumor, thereby weakening the wall...
  85. doi In situ replacement of the thoracic aorta using an equine pericardial roll graft for an aortobronchial fistula due to aortic rupture
    Hiroshi Yamamoto
    Department of Cardiovascular Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Gen Thorac Cardiovasc Surg 57:413-7. 2009
    ..The equine pericardium can be an option of alternative graft materials for in situ replacement of the thoracic aorta in patients with an aortobronchial fistula due to aortic rupture...
  86. ncbi Benefit of sentinel lymph node mapping in non-small cell lung cancer
    Yoshihiro Minamiya
    Ann Thorac Cardiovasc Surg 12:381-2. 2006
  87. ncbi [A case of long-term remission with salvage surgeries for chemotherapy-resistant germ cell tumor of testis]
    Takamitsu Inoue
    Department of Urology, Akita University School of Medicine
    Nihon Hinyokika Gakkai Zasshi 93:715-8. 2002
    ..Our experience illustrates that the salvage surgery even under high serum marker levels may provide a beneficial outcome for selected cases of chemotherapy-resistant germ cell tumors...