A Komatsuda

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. doi request reprint Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin γ1 CH 2 heavy chain and κ light chain: a new variant of monoclonal immunoglobulin deposition disease
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Pathol Int 63:63-7. 2013
  2. ncbi request reprint Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Intern Med 51:3273-6. 2012
  3. doi request reprint Distribution of glomerular IgG subclass deposits in patients with membranous nephropathy and anti-U1 ribonucleoprotein antibody
    Ayumi Omokawa
    Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Nephrol Dial Transplant 27:1937-41. 2012
  4. doi request reprint Serum procalcitonin levels in patients with myeloperoxidase-antineutrophil cytoplasmic antibodies-associated glomerulonephritis
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Am J Med Sci 343:136-40. 2012
  5. ncbi request reprint Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in northern Japan and review of the literature
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Ren Fail 28:223-7. 2006
  6. ncbi request reprint Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Tohoku J Exp Med 209:61-7. 2006
  7. ncbi request reprint Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Nephrol Dial Transplant 20:434-7. 2005
  8. ncbi request reprint Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, Akita, 010 8543, Japan
    Clin Rheumatol 27:395-7. 2008
  9. ncbi request reprint Amyloid A-type renal amyloidosis in a patient with sarcoidosis: report of a case and review of the literature
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Jaan
    Clin Nephrol 60:284-8. 2003
  10. ncbi request reprint Analysis of the NPHP genes in two Japanese patients with suspected sporadic juvenile or adolescent nephronophthisis
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 65:364-9. 2006

Collaborators

Detail Information

Publications83

  1. doi request reprint Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin γ1 CH 2 heavy chain and κ light chain: a new variant of monoclonal immunoglobulin deposition disease
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Pathol Int 63:63-7. 2013
    ....
  2. ncbi request reprint Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Intern Med 51:3273-6. 2012
    ..Therefore, we term the unusual form of glomerulonephritis observed in the present case "proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits."..
  3. doi request reprint Distribution of glomerular IgG subclass deposits in patients with membranous nephropathy and anti-U1 ribonucleoprotein antibody
    Ayumi Omokawa
    Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Nephrol Dial Transplant 27:1937-41. 2012
    ..However, there is no report focusing on the distribution of glomerular IgG subclass deposits in MN patients with anti-U1 ribonucleoprotein (RNP) antibody...
  4. doi request reprint Serum procalcitonin levels in patients with myeloperoxidase-antineutrophil cytoplasmic antibodies-associated glomerulonephritis
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
    Am J Med Sci 343:136-40. 2012
    ....
  5. ncbi request reprint Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in northern Japan and review of the literature
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Ren Fail 28:223-7. 2006
    ..However, it is still unclear whether there is a regional specific distribution of mutations in northern Japan. In this study, we analyzed mutations in the URAT1 gene of five Japanese patients with renal hypouricemia in northern Japan...
  6. ncbi request reprint Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Tohoku J Exp Med 209:61-7. 2006
    ..The present case report demonstrates that thiotepa can be employed as a conditioning regimen for auto-PBSCT in SSc patients with cardiac involvement in order to reduce cyclophosphamide-induced cardiotoxicity...
  7. ncbi request reprint Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Nephrol Dial Transplant 20:434-7. 2005
  8. ncbi request reprint Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, Akita, 010 8543, Japan
    Clin Rheumatol 27:395-7. 2008
    ..This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine...
  9. ncbi request reprint Amyloid A-type renal amyloidosis in a patient with sarcoidosis: report of a case and review of the literature
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Jaan
    Clin Nephrol 60:284-8. 2003
    ..Prognosis in these patients is extremely poor. AA-type amyloidosis should be considered as a rare renal complication in the setting of long-standing sarcoidosis...
  10. ncbi request reprint Analysis of the NPHP genes in two Japanese patients with suspected sporadic juvenile or adolescent nephronophthisis
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 65:364-9. 2006
    ..In this study, we analyzed mutations in the NPHP genes of 2 Japanese patients with suspected sporadic juvenile or adolescent NPHP without extrarenal involvement...
  11. ncbi request reprint Increased serum levels of S100A12 in patients with MPO-ANCA-associated glomerulonephritis
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 66:315-21. 2006
    ..In this study, we investigated serum levels of S100A 12 in patients with small-vessel vasculitis, myeloperoxidase anti-neutrophil cytoplasmic antibodies- (MPO-ANCA) associated pauci-immune glomerulonephritis...
  12. ncbi request reprint Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with active systemic lupus erythematosus
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Immunol 125:26-9. 2007
    ..These results indicate that increased expression of TRAIL mRNA in PBMC closely correlates with SLE activity and suggest an important role for TRAIL in the pathogenesis of SLE...
  13. doi request reprint Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Mod Rheumatol 18:315-8. 2008
    ..Cessation of infliximab therapy only led to dramatic regression of LPD. This case illustrates that EBV-associated LPDs can occur as part of infliximab adverse effects in patients with RA...
  14. pmc Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Exp Immunol 152:482-7. 2008
    ..These results suggest that up-regulated expression of TLR7 and TLR9 mRNAs together with increased expression of IFN-alpha mRNA in PBMCs may also contribute to the pathogenesis of human lupus...
  15. doi request reprint Cutaneous polyarteritis nodosa in a patient with Crohn's disease
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, and Department of Hematology, Municipal Akita General Hospital, 1 1 1 Hondo, Akita, 010 8543, Japan
    Mod Rheumatol 18:639-42. 2008
    ..She was diagnosed with cutaneous polyarteritis nodosa (PAN) associated with CD. Steroid therapy improved her symptoms. To our knowledge, this is the first Japanese case of cutaneous PAN associated with CD...
  16. doi request reprint IgA nephropathy associated with Castleman disease with cutaneous involvement
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Am J Med Sci 339:486-90. 2010
    ..To our knowledge, this is the first case of IgA nephropathy associated with multicentric CD with cutaneous involvement...
  17. doi request reprint Tubulointerstitial nephritis and renal tubular acidosis of different types are rare but important complications of primary biliary cirrhosis
    Atsushi Komatsuda
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Nephrol Dial Transplant 25:3575-9. 2010
    ..Although the clinical importance of this association has been suggested, information on its clinicopathological features and prognosis is limited...
  18. ncbi request reprint Analysis of mutations in alpha-actinin 4 and podocin genes of patients with chronic renal failure due to sporadic focal segmental glomerulosclerosis
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Ren Fail 25:87-93. 2003
    ..Other mutations were not found in ACTN4 and podocin genes. Our findings suggest that sporadic FSGS is a heterogeneous disease, since ACTN4 and podocin genes are not found in our patients with sporadic FSGS...
  19. ncbi request reprint Nephrotic syndrome in a patient with renal amyloidosis due to polyangiitis overlap syndrome
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Japan
    Nephrol Dial Transplant 17:669-71. 2002
  20. ncbi request reprint Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate
    A Komatsuda
    Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Am J Kidney Dis 32:E7. 1998
    ....
  21. ncbi request reprint Disappearance of nodular mesangial lesions in a patient with light chain nephropathy after long-term chemotherapy
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, and the Department of Internal Medicine, Yamamoto General Hospital, Akita, Japan
    Am J Kidney Dis 35:E9. 2000
    ..Although the prognosis of light chain nephropathy has been considered poor, long-term successful chemotherapy can clear light chain deposits and restore renal function...
  22. doi request reprint Monoclonal immunoglobulin deposition disease associated with membranous features
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita 010 8543, Japan
    Nephrol Dial Transplant 23:3888-94. 2008
    ..Information on clinicopathological features and prognosis in this entity is limited...
  23. ncbi request reprint Crescentic glomerulonephritis accompanied by myeloperoxidase-antineutrophil cytoplasmic antibodies in a patient having myelodysplastic syndrome with trisomy 7
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Hondo, Japan
    Am J Kidney Dis 31:336-40. 1998
    ..This is the first case of MPO-ANCA-related crescentic glomerulonephritis in a patient with myelodysplastic syndromes (MDS). A possible relationship between MPO-ANCA and MDS is discussed...
  24. ncbi request reprint Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Japan
    Pathol Int 49:513-8. 1999
    ..Our findings demonstrated that HSP73 and HSP90 chaperone proteins specifically accumulated within lysosomes of proximal tubular epithelial cells during the course of PDGA-induced acute lysosomal thesaurismosis...
  25. ncbi request reprint Renal amyloidosis associated with extracapillary glomerulonephritis and vasculitis in a patient with inflammatory bowel disease treated with infliximab
    T Hatakeyama
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Clin Nephrol 70:240-4. 2008
    ..Considering the temporal association of drug use with new onset of RPGN in our patient, we suggest a causal link between infliximab and RPGN due to extracapillary glomerulonephritis and vasculitis...
  26. ncbi request reprint Characteristics of proliferative glomerulo-nephritis with monoclonal IgG deposits associated with membranoproliferative features
    R Masai
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Clin Nephrol 72:46-54. 2009
    ..Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) associated with membranoproliferative features is an extremely rare entity. Information on clinicopathological features and prognosis in this entity is limited...
  27. ncbi request reprint GATA-3 is upregulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 71:608-16. 2009
    ..Interleukin-13 (IL-13: Th2 cytokine) has been implicated in the pathogenesis of MCNS, but Th1/Th2 regulators such as T-bet (Th1-specific transcription factor) and GATA-3 (Th2-specific transcription factor) have not been examined...
  28. ncbi request reprint A nonsense mutation (R220X) in the alpha-galactosidase A gene causes typical Fabry disease in both genders
    N Maki
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 61:185-90. 2004
    ..Chronic renal failure is an important cause of death in patients with Fabry disease. We report on patients with Fabry disease (a hemizygous male and his mother) due to a nonsense mutation (R220X) in the alpha-Gal A gene...
  29. ncbi request reprint Endocapillary proliferative glomerulonephritis in a patient with parvovirus B19 infection
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, and the Department of Internal Medicine, Senboku General Hospital, Akita
    Am J Kidney Dis 36:851-4. 2000
    ..These findings suggest that immune complex-type glomerulonephritis is caused by glomerular deposition of HPV antigen-antibody complexes in some patients with HPV infection...
  30. pmc Circulating antibodies against alpha-enolase in patients with primary membranous nephropathy (MN)
    H Wakui
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Exp Immunol 118:445-50. 1999
    ....
  31. ncbi request reprint Predominant tubulointerstitial nephritis in a patient with systemic lupus erythematosus: phenotype of infiltrating cells
    A Omokawa
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Nephrol 69:436-44. 2008
    ..The results suggest CD8-positive cytotoxic T cell-mediated tubular injury. Furthermore, immune complexes containing IgG4 might be one of etiologic factors...
  32. ncbi request reprint Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease
    R Masai
    Third Department of Internal Medicine, Akita University School of Medicine, Akita Kumiai General Hospital, Akita, Japan
    Clin Nephrol 71:9-20. 2009
    ..Although it has been considered that LHCDD is a variant of LCDD, information on clinicopathological features and prognosis in LHCDD is presently limited...
  33. ncbi request reprint Clinical application of the Personal Dialysis Capacity (PDC) test: serial analysis of peritoneal function in CAPD patients
    H Imai
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Kidney Int 54:546-53. 1998
    ..Peritoneal damage has been reported since the beginning of CAPD therapy...
  34. ncbi request reprint Successful treatment of post-MRSA infection glomerulonephritis with steroid therapy
    S Okuyama
    Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan
    Clin Nephrol 70:344-7. 2008
    ..MRSA infection did not recur. If the disease activity of post-MRSA infection glomerulonephritis persists after the disappearance of MRSA infection, the application of immunosuppressive therapy with steroids may be useful...
  35. ncbi request reprint Mammalian HSP60 is a major target for an immunosuppressant mizoribine
    H Itoh
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    J Biol Chem 274:35147-51. 1999
    ..On different types of mizoribine affinity columns, HSP60 or actin recognized the NH(2) group of mizoribine, and this group may be a functional group of the agent...
  36. ncbi request reprint Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Nephrol Dial Transplant 14:1385-90. 1999
    ..We have tested this hypothesis directly by transfection studies...
  37. pmc A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90
    H Itoh
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Biochem J 343:697-703. 1999
    ..The CDDP binding region of HSP90 is near the C-terminal which is quite different from the GA-binding site. Our results suggest that the chaperone activity of HSP90 may be inhibited by the binding of CDDP or GA by different mechanisms...
  38. ncbi request reprint Hemoperitoneum due to acute cytomegalovirus infection in a patient receiving peritoneal dialysis
    H Ohtani
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Japan
    Am J Kidney Dis 36:E33. 2000
    ..Acute and primary cytomegalovirus (CMV) infection induced hemoperitoneum in a patient who was receiving CAPD...
  39. ncbi request reprint A clinical analysis of 52 adult patients with hemophagocytic syndrome: the prognostic significance of the underlying diseases
    N Takahashi
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Int J Hematol 74:209-13. 2001
    ..The prognostic factors of adult HPS were found to be the underlying diseases, notably malignant lymphoma and infections, accompanied by the immunosuppressive state...
  40. ncbi request reprint Renal argininosuccinate synthetase: purification, immunohistochemical localization, and elastin-binding property
    H Wakui
    Third Department of Internal Medicine, Akita University School of Medicine, Japan
    Ren Physiol Biochem 15:1-9. 1992
    ..These results suggest that the elastin-binding property of a renal form of the enzyme may be related to a tissue-specific function in the kidney...
  41. ncbi request reprint Focal segmental glomerulosclerosis associated with polycythemia vera: report of a case and review of the literature
    S Okuyama
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Clin Nephrol 68:412-5. 2007
    ..Among them, three patients suffered from progressive azotemia. We suggest that steroid therapy with myelosuppressive agents can resolve the renal lesion in patients with PV...
  42. ncbi request reprint Extremely short small bowel induces focal tubulointerstitial fibrosis
    T Hebiguchi
    Department of Pediatric Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Pediatr Gastroenterol Nutr 32:586-92. 2001
    ..The experiment was designed to clarify whether massive small bowel resection (SBR) produces focal tubulointerstitial fibrosis in the kidney...
  43. ncbi request reprint Development of lupus nephritis in a patient with human T-cell lymphotropic virus type I-associated myelopathy
    Hideki Wakui
    Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Am J Kidney Dis 46:e25-9. 2005
    ..This is a rare case of a patient developing lupus nephritis during the long-term course of human T-cell lymphotropic virus type I-associated myelopathy...
  44. ncbi request reprint Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: preliminary study
    Shigeru Satoh
    Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Int J Urol 14:990-4. 2007
    ....
  45. ncbi request reprint Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide
    Akihiro Kigawa
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Clin Exp Nephrol 8:331-8. 2004
    ..The aim of this study was to identify endogenous molecules that interact with the actinin-4 R1-R4 domain...
  46. ncbi request reprint Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse
    Toshiyuki Haseyama
    Department of Hygiene, Akita University School of Medicine, Akita 010 8543, Japan
    Tohoku J Exp Med 198:233-44. 2002
    ..Similar degrees of diabetic glomerulosclerosis and glomerular IgA deposition were found in mice with C3H and B6 backgrounds. Akita mouse is a unique mouse model showing both mesangial sclerosis and IgA nephropathy...
  47. ncbi request reprint Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration
    Hideaki Itoh
    Department of Biochemistry, Akita University School of Medicine, Akita City, Japan
    Eur J Biochem 269:5931-8. 2002
    ..The cytoplasmic HSP60 is quickly imported into the mitochondria under severe conditions by cytoplasmic HSP70...
  48. ncbi request reprint Immune complex-type glomerulonephritis with unusual giant deposits in a patient with active rheumatoid arthritis
    Hiroshi Ohtani
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, 010 8543, Akita, Japan
    Clin Exp Nephrol 8:63-7. 2004
    ..This is the first report of immune complex-type glomerulonephritis with unusual giant deposits in a patient with RA in an active immunological state...
  49. doi request reprint CYP3A5 *1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal transplant recipients
    Shigeru Satoh
    Division of Renal Replacement Therapeutic Science, Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Eur J Clin Pharmacol 65:473-81. 2009
    ....
  50. doi request reprint Simultaneous herpes simplex virus esophagitis and lupus enteritis in a patient with systemic lupus erythematosus
    Hideki Wakui
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Mod Rheumatol 20:98-101. 2010
    ..Treatment with acyclovir followed by high-dose intravenous steroids improved her symptoms. To our knowledge, this is the first case of simultaneous HSV esophagitis and lupus enteritis...
  51. ncbi request reprint Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy
    Hiroshi Ohtani
    The Third Department of Internal Medicine, Akita University School of Medicine, Hondo, Japan
    Nephrol Dial Transplant 19:574-9. 2004
    ....
  52. doi request reprint Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL?
    Yoshihiro Kameoka
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Int J Hematol 89:533-7. 2009
    ..All 4 patients treated with intensive chemotherapy responded well to the treatment as our patient. We suggest that kidney-limited IVLBCL might be a distinct variant of IVLBCL...
  53. ncbi request reprint Nodular mesangial lesions, marked mesangiolysis, and fingerprint deposits of unknown origin in a patient with nephrotic syndrome: a unique combination of glomerular lesions
    Hiroshi Ohtani
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Clin Exp Nephrol 10:140-5. 2006
    ..To our knowledge, such a unique combination of glomerular lesions has not been described previously in the literature...
  54. ncbi request reprint Influence of pretransplant dialysis modality on the change of lymphocyte subset populations and acute rejection rates after renal transplantation
    Shigeru Satoh
    Department of Urology, Akita School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Int J Urol 11:825-30. 2004
    ..We investigated whether the pretransplant dialysis modality correlated with the lymphocyte subset populations and the incidence of AR after renal transplantation...
  55. ncbi request reprint Renal alpha-actinin-4: purification and puromycin aminonucleoside-binding property
    Hiroyuki Goto
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Nephron Exp Nephrol 93:e27-35. 2003
    ..Moreover, our findings indicate that the central rod domain of actinin-4 has a high affinity to PAN. In the PAN nephrosis animal model, actinin-4 might be a target protein from PAN nephrotoxicity...
  56. ncbi request reprint Enhanced urinary adiponectin excretion in IgA-nephropathy patients with proteinuria
    Takashi Shimotomai
    Division of Endocrinology, Diabetes and Geriatric Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Ren Fail 27:323-8. 2005
    ..However, clinical implication of urinary adiponectin excretion in healthy control remains to be elucidated...
  57. doi request reprint Simultaneous determination of warfarin and 7-hydroxywarfarin enantiomers by high-performance liquid chromatography with ultraviolet detection
    Masatomo Miura
    Department of Pharmacy, Akita University Hospital, Akita, Japan
    Ther Drug Monit 33:108-14. 2011
    ..24 to 0.75 and from 1.83 to 19.02, respectively, whereas these ratios in a CYP2C9*3/*3 patient were 1.12 and 17.02, respectively...
  58. ncbi request reprint Clinical applications of CD34+ cell-selected peripheral blood stem cells
    Y Kawabata
    Department of Internal Medicine III, Akita University School of Medicine, Akita, Japan
    Ther Apher Dial 7:298-304. 2003
    ..We describe here clinical applications of CD34+ cell-selected PBSC for a variety of diseases, with special emphasis on the efficacy as well as drawbacks of this novel technique...
  59. doi request reprint The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease
    Wataru Kitagawa
    Department of Internal Medicine, Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Nephrol Dial Transplant 23:3126-9. 2008
    ..We aimed to clarify the relationship between HLA-DRB1(*)1501 and anti-glomerular basement membrane (GBM) antibody-mediated disease in Japanese patients...
  60. ncbi request reprint Interaction of alpha-actinin-4 with class I PxxP motif-containing OK/SW-CL.16 protein
    Masaru Togashi
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Nephron Exp Nephrol 107:e65-72. 2007
    ..The aim of this study was to identify novel binding partners for alpha-actinin-4 (actinin-4), an essential component of the glomerular filtration barrier...
  61. doi request reprint Progressive glomerulopathy with unusual deposits of striated structures: a new disease entity?
    Hiroshi Ohtani
    Department of Nephrology and Dialysis, Akita Kumiai General Hospital, Akita, Japan
    Nephrol Dial Transplant 25:2016-9. 2010
    ..All known disease entities with non-amyloid non-immunoglobulin-derived organized glomerular deposits were excluded. Progressive glomerulopathy in our patient might be a new disease entity...
  62. ncbi request reprint Characterization of the 105-kDa molecular chaperone. Identification, biochemical properties, and localization
    Mika Matsumori
    Department of Biochemistry, Department of Pediatrics, First Department of Internal Medicine, Third Department of Internal Medicine, Department of Gynecology, and Department of Neurosurgery, Akita University School of Medicine, Akita City, Japan
    Eur J Biochem 269:5632-41. 2002
    ..Although the 105-kDa protein was localized in all rat brain segments, the expression pattern was fast in the cerebral cortex and hippocampus and slow in the cerebellum...
  63. doi request reprint Angioimmunoblastic T-cell lymphoma and membranous nephropathy: a still unreported association
    Masaru Togashi
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Akita, 010 8543, Japan
    Clin Exp Nephrol 14:288-93. 2010
    ..Glomerular manifestations have rarely been reported in association with AITL. To our knowledge, this is the first reported case of nephrotic syndrome due to MN associated with AITL...
  64. ncbi request reprint Amyloid arthropathy resembling seronegative rheumatoid arthritis in a patient with IgD-kappa multiple myeloma
    Masumi Fujishima
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543
    Intern Med 42:121-4. 2003
    ..She was diagnosed with amyloid arthropathy (AmyA) secondary to IgD-kappa multiple myeloma. It is important to pay attention to AmyA due to multiple myeloma in patients with seronegative RA...
  65. ncbi request reprint Successful renal transplantation in the right iliac fossa 2 years after serious deep venous thrombosis in a patient with systemic lupus erythematosus
    Norihiko Tsuchiya
    Department of Urology, Akita University School of Medicine, Akita, Japan
    Int J Urol 12:912-6. 2005
    ..However, one should be aware of the risk factors and the adequate management of thrombosis in renal transplantation because of the serious complications of DVT and the poor prognosis of allograft vein thrombosis...
  66. ncbi request reprint [Minimal change nephrotic syndrome: Pathogenesis, pathophysiology and therapy]
    Hideki Wakui
    Third Department of Internal Medicine, Akita University School of Medicine
    Nihon Rinsho 64:408-12. 2006
  67. ncbi request reprint Differences between myeloperoxidase-specific and -nonspecific P-ANCA-associated renal disease
    Hiroshi Ohtani
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Ren Fail 29:183-7. 2007
    ..P-ANCA without a specificity for MPO are also found in a minority of patients with this form of glomerulonephritis, but their clinicopathological features remain poorly delineated...
  68. doi request reprint Delayed addition of tumor necrosis factor (TNF) antagonists inhibits the generation of CD11c+ dendritic cells derived from CD34+ cells exposed to TNF-alpha
    Yong Mei Guo
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Hondo 1 1 1, Akita, 010 8543, Japan
    Int J Hematol 91:61-8. 2010
    ..These findings may contribute to a great understanding of anti-TNF therapy in patients with an overproduction of cytokines such as hemophagocytic syndromes...
  69. doi request reprint Thrombotic microangiopathy developing in early stage after renal transplantation with a high trough level of tacrolimus
    Mitsuru Saito
    Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Clin Exp Nephrol 12:312-5. 2008
    ..Renal function and hemolytic parameters improved by solely a decrease of the TAC trough level. When TAC-associated TMA develops in renal transplant recipients, we recommend a decrease of the TAC trough level before changing to CyA...
  70. ncbi request reprint 49, XXXXY syndrome with unilateral renal aplasia, proteinuria, and venous thromboembolism
    Shin Okuyama
    Third Department of Internal Medicine, Akita University School of Medicine, Akita
    Intern Med 43:1186-90. 2004
    ..This is the first case of the 49, XXXXY syndrome complicated with unilateral renal aplasia, proteinuria, and venous thromboembolism...
  71. ncbi request reprint Bone marrow-derived cells mobilized by granulocyte-colony stimulating factor facilitate vascular regeneration in mouse kidney after ischemia/reperfusion injury
    Susumu Akihama
    Department of Urology, Akita University School of Medicine, Akita, Japan
    Tohoku J Exp Med 213:341-9. 2007
    ..In conclusion, BMDC are recruited into endothelial cell in I/R renal injury without apparent renal tubular cell regeneration, and G-CSF facilitates the endothelial cell regeneration...
  72. ncbi request reprint Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome
    Shin Okuyama
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Nephrol Dial Transplant 20:539-44. 2005
    ..Minimal-change nephrotic syndrome (MCNS) is considered to be associated with T-cell dysfunction and with the abnormal secretion of putative glomerular permeability factors; however, the nature of such factors remains elusive...
  73. doi request reprint Hypertrophic cranial pachymeningitis in a patient with Cogan's syndrome
    Masaru Togashi
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    Clin Rheumatol 27:S33-5. 2008
    ..Magnetic resonance imaging of the brain showed hypertrophic cranial pachymeningitis (HCP). After steroid pulse therapy, HCP was improved. To our knowledge, this is the first case of CS complicated with HCP...
  74. doi request reprint Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Am J Nephrol 28:539-47. 2008
    ..It is hypothesized that minimal change nephrotic syndrome (MCNS) is a consequence of immune cell dysfunction that may lead to release of glomerular permeability factors. However, the nature of such factors remains uncertain...
  75. doi request reprint Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition
    Soh Yamamoto
    Department of Life Science, Faculty of Engineering and Resource Science, Akita University, Akita City, Japan
    FEBS Lett 584:645-51. 2010
    ..These results indicated that GM inhibits the chaperone activity of HSP70 and may suppress protein folding via inhibition of HSP70 in vivo...
  76. ncbi request reprint Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome
    Nobuki Maki
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Nephrol Dial Transplant 19:1761-6. 2004
    ..To date, almost 90 mutations have been identified. It is possible that there is a population-specific distribution of mutations. In this study, we analysed mutations in the NCCT gene of seven Japanese patients with GS...
  77. ncbi request reprint [Recovery from chronic hearing disturbance after the steroid therapy in a patient with Cogan's syndrome]
    Masaru Togashi
    Third Department of Internal Medicine, Akita University School of Medicine, Akita
    Nihon Naika Gakkai Zasshi 96:986-7. 2007
  78. ncbi request reprint Adrenal insufficiency complicated with antiphospholipid syndrome (APS)
    Naohito Fujishima
    Third Department of Internal Medicine, Akita University School of Medicine
    Intern Med 45:963-6. 2006
    ..Platelet counts and aPTT were also normalized. To our knowledge, this is the second Japanese case of APS complicated with bilateral adrenal hemorrhage. APS should be considered an important underlying cause of adrenal insufficiency...
  79. ncbi request reprint 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin
    Toshio Miyazaki
    Department of Material process Engineering and Applied Chemistry for Environment, Akita University Faculty of Engineering and Resource Science, 1 1 Tegata Gakuen Town, Akita City 010 8502, Japan
    J Biol Chem 279:17295-300. 2004
    ..Our results suggest that the specific association between HSP73 and GM may reduce the chaperone activity of HSP73 in vitro and/or in vivo, and this may have an interaction with GM toxicity in kidneys with GM-induced acute tubular injury...
  80. ncbi request reprint Nephronophthisis: diagnostic difficulties and recent advances in molecular genetic diagnostics
    Atsushi Komatsuda
    Clin Exp Nephrol 9:340-2. 2005
  81. ncbi request reprint Rapidly progressed secondary amyloidosis in a patient with mixed connective tissue disease
    Hirotaka Kimura
    Department of Internal Medicine, Ugo Municipal Hospital, Ogachi gun
    Intern Med 43:878-82. 2004
    ..This might be associated with the early onset and progression of secondary amyloidosis in our case, just like cases reported in rheumatoid arthritis...
  82. ncbi request reprint Monitoring the expression profiles of doxorubicin-resistant K562 human leukemia cells by serial analysis of gene expression
    Yoshikazu Ichikawa
    Department of Internal Medicine III, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Int J Hematol 79:276-82. 2004
    ....
  83. ncbi request reprint A multicenter prospective cohort study of tonsillectomy and steroid therapy in Japanese patients with IgA nephropathy: a 5-year report
    Mariko Miyazaki
    Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
    Contrib Nephrol 157:94-8. 2007
    ..We concluded that the goal should be cure and release from disease at an earlier stage of IgAN...