K Imai

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. doi CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin
    Akihiko Ichikawa
    Department of Biological Informatics and Experimental Therapeutics, Akita University Graduate School of Medicine, Japan
    Am J Respir Crit Care Med 187:65-77. 2013
  2. ncbi Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis
    Yumiko Imai
    Department of Biological Informatics and Experimental Therapeutics, the Global COE program, Akita University Graduate School of Medicine, Japan
    Circ J 74:405-10. 2010
  3. ncbi Adhesion between cells and extracellular matrix with special reference to hepatic stellate cell adhesion to three-dimensional collagen fibers
    K Imai
    Department of Anatomy, Akita University School of Medicine, Japan
    Cell Struct Funct 25:329-36. 2000
  4. ncbi Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in Long-Evans cinnamon-like colored (LEC) rats
    K Imai
    Department of Anatomy, Akita University School of Medicine, Akita 010 8543, Japan
    Anat Rec 258:338-48. 2000
  5. ncbi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
  6. ncbi Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture
    M Sato
    Department of Anatomy, Akita University School of Medicine, Akita, 010 8543, Japan
    Cell Biol Int 22:115-25. 1998
  7. ncbi Molecular mechanisms in the reversible regulation of morphology, proliferation and collagen metabolism in hepatic stellate cells by the three-dimensional structure of the extracellular matrix
    H Senoo
    Department of Anatomy, Akita University School of Medicine, Japan
    J Gastroenterol Hepatol 13:S19-32. 1998
  8. ncbi Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in Arctic animals
    M Sato
    Department of Anatomy, Akita University School of Medicine, Japan
    Cell Struct Funct 26:71-7. 2001
  9. doi Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters
    Keiji Kuba
    Department of Biological Informatics and Experimental Therapeutics, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Pharmacol Ther 128:119-28. 2010
  10. ncbi Angiotensin-converting enzyme 2 in lung diseases
    Keiji Kuba
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, A 1030 Vienna, Austria
    Curr Opin Pharmacol 6:271-6. 2006

Collaborators

Detail Information

Publications31

  1. doi CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin
    Akihiko Ichikawa
    Department of Biological Informatics and Experimental Therapeutics, Akita University Graduate School of Medicine, Japan
    Am J Respir Crit Care Med 187:65-77. 2013
    ..CXCL10 may not be a bystander to the severe virus infection but may directly contribute to the pathogenesis of neutrophil-mediated, excessive pulmonary inflammation...
  2. ncbi Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis
    Yumiko Imai
    Department of Biological Informatics and Experimental Therapeutics, the Global COE program, Akita University Graduate School of Medicine, Japan
    Circ J 74:405-10. 2010
    ..This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis...
  3. ncbi Adhesion between cells and extracellular matrix with special reference to hepatic stellate cell adhesion to three-dimensional collagen fibers
    K Imai
    Department of Anatomy, Akita University School of Medicine, Japan
    Cell Struct Funct 25:329-36. 2000
    ..Information on the three-dimensional structures of ECM is transmitted via three-dimensional adhesive structures containing the integrins...
  4. ncbi Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in Long-Evans cinnamon-like colored (LEC) rats
    K Imai
    Department of Anatomy, Akita University School of Medicine, Akita 010 8543, Japan
    Anat Rec 258:338-48. 2000
    ..Our present data are consistent with our previous hypothesis that there is an antagonistic relationship between the storage of vitamin A and the production of collagen in stellate cells...
  5. ncbi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  6. ncbi Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture
    M Sato
    Department of Anatomy, Akita University School of Medicine, Akita, 010 8543, Japan
    Cell Biol Int 22:115-25. 1998
    ..The lipid droplets and vitamin A-autofluorescence were increased by retinyl acetate addition to the culture medium, suggesting an important role of processes in hepatic stellate cell function...
  7. ncbi Molecular mechanisms in the reversible regulation of morphology, proliferation and collagen metabolism in hepatic stellate cells by the three-dimensional structure of the extracellular matrix
    H Senoo
    Department of Anatomy, Akita University School of Medicine, Japan
    J Gastroenterol Hepatol 13:S19-32. 1998
    ..Molecular mechanisms in the reversible regulation of stellate cells by ECM imply cell surface integrin binding to ECM components followed by signal transduction processes and then cytoskeleton assembly...
  8. ncbi Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in Arctic animals
    M Sato
    Department of Anatomy, Akita University School of Medicine, Japan
    Cell Struct Funct 26:71-7. 2001
    ....
  9. doi Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters
    Keiji Kuba
    Department of Biological Informatics and Experimental Therapeutics, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Pharmacol Ther 128:119-28. 2010
    ..In this review, we will discuss the multiple biological functions of ACE2...
  10. ncbi Angiotensin-converting enzyme 2 in lung diseases
    Keiji Kuba
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, A 1030 Vienna, Austria
    Curr Opin Pharmacol 6:271-6. 2006
    ..Thus, the RAS appears to play a critical role in the pathogenesis of acute lung injury. Indeed, increasing ACE2 activity might be a novel approach for the treatment of acute lung failure in several diseases...
  11. ncbi Angiotensin-converting enzyme 2 protects from severe acute lung failure
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A 1030, Austria
    Nature 436:112-6. 2005
    ..Our data identify a critical function for ACE2 in acute lung injury, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year...
  12. ncbi Lessons from SARS: control of acute lung failure by the SARS receptor ACE2
    Keiji Kuba
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030, Vienna, Austria
    J Mol Med (Berl) 84:814-20. 2006
    ..Here we review the role of ACE2 in disease pathogenesis, including lung diseases and cardiovascular diseases...
  13. doi The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice
    Yumiko Imai
    The Global Center of Excellence program, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Exp Physiol 93:543-8. 2008
    ....
  14. ncbi A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
    Keiji Kuba
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Med 11:875-9. 2005
    ..These results provide a molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses...
  15. doi Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice
    Masahide Takeda
    Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan
    J Allergy Clin Immunol 123:805-12. 2009
    ..Although some investigations of the involvement between the pathogenesis of asthma and PI3K have been performed, it is unknown whether PI3Kgamma, a PI3K isoform, is involved in the pathogenesis of asthma...
  16. ncbi A new function of green tea: prevention of lifestyle-related diseases
    N Sueoka
    Saitama Cancer Center Research Institute, Japan
    Ann N Y Acad Sci 928:274-80. 2001
    ..These data suggest that green tea has preventive effects on both chronic inflammatory diseases and lifestyle-related diseases (including cardiovascular disease and cancer), resulting in prolongation of life span...
  17. pmc Sequence and expression of transcripts of the T-cell antigen receptor alpha-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma
    K Imai
    Proc Natl Acad Sci U S A 83:8708-12. 1986
    ....
  18. ncbi Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice
    U Helwig
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 11:60-3. 1995
    ..This example of digenic inheritance may explain the often sporadic nature of spina bifida in humans...
  19. ncbi Effects of 15-deoxyspergualin in vitro and in vivo on cytokine gene expression
    X Zhu
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 58:1104-9. 1994
    ..It was conceivable that IL-6 supported thrombopoiesis in concert with other cytokines. On the contrary, increased IFN-gamma, IL-2, IL-3, IL-4, and IL-10 mRNA expression may play an immunosuppressive role in vivo...
  20. ncbi Mapping of the Mod-1 locus on mouse chromosome 9
    S J Nass
    Max Planck Institute of Immunobiology, Freiburg, FRG
    Mamm Genome 4:333-7. 1993
    ..6 +/- 0.6 cm...
  21. ncbi A new Pax gene, Pax-9, maps to mouse chromosome 12
    J Wallin
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Mamm Genome 4:354-8. 1993
    ....
  22. ncbi High expression of GADD-45alpha and VEGF induced tumor recurrence via upregulation of IL-2 after photodynamic therapy using NPe6
    K Ohtani
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan
    Int J Oncol 32:397-403. 2008
    ..Therefore, it is speculated that the use of an IL-2 inhibitor may improve the efficacy of NPe6-PDT...
  23. ncbi Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells
    M Adachi
    First Department of Internal Medicine, Graduate School of Medicine, Sapporo Medical University, Sapporo, Japan
    Histol Histopathol 22:437-42. 2007
    ..In this paper, we propose that increased ROS generation is one of the key mechanisms for NSAIDs-mediated anticancer effects on various cancer cells...
  24. ncbi The Rasgrf1-repeat sequence (D9Ncvs53) maps between Mod1 and Rbp1 on mouse chromosome 9 and may define a putative imprinted region
    R S Pearsall
    Roswell Park Cancer Institute, Department of Molecular and Cellular Biology, Buffalo, New York 14263 0001, USA
    Mamm Genome 9:261-2. 1998
  25. ncbi Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema
    K Imai
    Division of Molecular Medicine Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Crit Care Med 163:786-91. 2001
    ..In addition, the induction of a proteolytic enzyme within the Type II pneumocyte suggests that the cells within the lung itself are capable of producing degradative enzymes in this disease process...
  26. ncbi Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium
    K Kobayashi
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8543, Japan
    J Pathol 209:376-83. 2006
    ..We conclude that MMP-3 and MMP-10 play a causal role in excess tissue destruction in colitis. Specific inhibition of these MMPs should provide novel therapeutics against IBD...
  27. ncbi Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    K Moriya
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Cancer Res 61:4365-70. 2001
    ..The HCV core protein thus alters the oxidant/antioxidant state in the liver in the absence of inflammation and may thereby contribute to or facilitate, at least in part, the development of HCC in HCV infection...
  28. ncbi Lipid peroxidation may predict restenosis after coronary balloon angioplasty
    K Imai
    Third Department of Internal Medicine, Nagoya University, School of Medicine, Japan
    Jpn Circ J 65:495-9. 2001
    ..57, p<0.01). Our results suggest that oxidative stress contributes to restenosis and indicate that an elevated plasma level of TBARS may be a reliable predictor of restenosis...
  29. ncbi Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment
    H Yamamoto
    Department of Molecular Psychiatry, Tokyo Intstitute of Psychiatry, Tokyo, Japan
    Ann N Y Acad Sci 1025:92-101. 2004
    ..These data suggest that long-lasting alterations of the period-related gene expressions in the hippocampus might play an important role in methamphetamine addiction...
  30. ncbi The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription
    K Chowdhury
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, FRG
    Mech Dev 39:129-42. 1992
    ..The presence of both a transcriptional activating domain and 7 DNA binding zinc fingers, coupled with the cell type(s) specific expression pattern, suggests that Zfp-38 has the potential to regulate transcription during spermatogenesis...