Affiliation: Ajinomoto Co
- Plasma amino acid analysis for diagnosis and amino acid-based metabolic networksTakeshi Kimura
Quality Assurance and External Scientific Affairs Department, Ajinomoto Co, Inc, Tokyo, Japan
Curr Opin Clin Nutr Metab Care 12:49-53. 2009..To highlight the usefulness of amino acid profiling in clinical diagnosis and current developments in analysis revealing underlying metabolic relationships...
- Prolonged oral treatment with an essential amino acid L-leucine does not affect female reproductive function and embryo-fetal development in ratsKazunori Mawatari
Amino Acids Department, Ajinomoto Co, Inc, 1 15 1 Chuo ku, Tokyo 104 8315, Japan
Food Chem Toxicol 42:1505-11. 2004..These results suggested that L-leucine, administered orally during organogenesis at doses up to 1000 mg/kg body weight, did not affect the outcome of pregnancy and did not cause fetotoxicity in rats...
- Summary of workshop discussions on establishing upper limits for amino acids with specific attention to available data for the essential amino acids leucine and tryptophanTakeshi Kimura
Ajinomoto Co, Inc, Chuo Ku, Tokyo, Japan
J Nutr 142:2245S-2248S. 2012..Animal results obtained in pigs and rodents were discussed and 2 possible strategies for applying those outcomes to humans were described...
- The 7th workshop on the assessment of adequate intake of dietary amino acids: summary of general discussionTakeshi Kimura
Ajinomoto Co, Inc, Quality Assurance and External Scientific Affairs Department, 104 8315 Tokyo, Japan
J Nutr 138:2050S-2205S. 2008..There was recognition that regardless of the available data, there is regulatory pressure for setting upper levels of intake for amino acids and that much more data are required...
- Screening of toxicity biomarkers for methionine excess in ratsSakino Toue
Ajinomoto Co, Inc, Institute of Life Sciences, Kawasaki, Japan
J Nutr 136:1716S-1721S. 2006..Collectively from these results, homocysteine appeared to be the most plausible biomarker to assess methionine excess as a surrogate marker both for toxicity and for setting a metabolic upper limit...
- Potential approaches to the assessment of amino acid adequacy in rats: a progress reportRyosei Sakai
Institute of Life Sciences and Research Institute for Health Fundamentals, Ajinomoto Co, Inc, Kawasaki, Japan
J Nutr 134:1651S-1655S; discussion 1664S-1666S, 1667S-1672S. 2004..This suggested that >8.9 g/kg BW, the catabolism of L-leucine changed and this approximately coincided with the dose above which a statistically significant decrease in body weight was seen...
- Metabolomics and its potential for assessment of adequacy and safety of amino acid intakeYasushi Noguchi
Research Institute for Health Fundamentals and Institute of Life Sciences, Ajinomoto Co, Inc, Tokyo 210 8681, Japan
J Nutr 133:2097S-2100S. 2003..We suggest that these basic concepts and methods could serve as the basis for a metabolomic approach for the assessment of the range of adequacy of amino acid intakes...